Src family kinases in tumor progression and metastasis

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

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Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

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Three-dimensional structure of the tyrosine kinase c-Src

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DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

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Regulation, substrates and functions of src

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Crystal structure of the Src family tyrosine kinase Hck

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A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

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Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

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Identification of a transformation-specific antigen induced by an avian sarcoma virus

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Role of Src expression and activation in human cancer

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Dasatinib: An Anti-Tumour Agent via Src Inhibition

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CUB-domain–containing protein 1 (CDCP1) activates Src to promote melanoma metastasis

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Global Impact of Oncogenic Src on a Phosphotyrosine Proteome

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Src as a potential therapeutic target in non-small-cell lung cancer

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Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

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Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis

Gelman, I. H. (2010) · Genes & Cancer · doi:10.1177/1947601910392984 · Cited by 97

Phosphate derivative-induced supramolecular assembly and NIR-emissive behaviour of alkynylplatinum(ii) terpyridine complexes for real-time monitoring of enzymatic activities

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Progestin Effects on Breast Cancer Cell Proliferation, Proteases Activation, andin VivoDevelopment of Metastatic Phenotype All Depend on Progesterone Receptor Capacity to Activate Cytoplasmic Signaling Pathways

Carnevale, R. P., Proietti, C. J., Salatino, M., Urtreger, A. J., Peluffo, G., Edwards, D. P., Boonyaratanakornkit, V., Charreau, E. H., Joffé, E. B. D. K., Schillaci, R., et al. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0304 · Cited by 96

IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis

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Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells

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Targeting Epidermal Growth Factor Receptor and Src Pathways in Head and Neck Cancer

Egloff, A. M., & Grandis, J. R. (2008) · Seminars in Oncology · doi:10.1053/j.seminoncol.2008.03.008 · Cited by 95

ErbB3-Dependent Motility and Intravasation in Breast Cancer Metastasis

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Role of c-Src in Human MCF7 Breast Cancer Cell Tumorigenesis

González, L., Agulló-Ortuño, M. T., García-Martínez, J. M., Calcabrini, A., Gamallo, C., Palacios, J., Aranda, A., & Martı́n-Pérez, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601570200 · Cited by 95

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer

Thomas, S., Overdevest, J. B., Nitz, M. D., Williams, P. D., Owens, C. R., Sanchez-Carbayo, M., Frierson, H. F., Schwartz, M. A., & Theodorescu, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0730 · Cited by 92

Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents

El‐Karim, S. S. A., Anwar, M. M., Mohamed, N. A., Nasr, T., & Elseginy, S. A. (2015) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2015.08.006 · Cited by 92

Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches

Choi, H. J., Armaiz-Peña, G. N., Pradeep, S., Cho, M. S., Coleman, R. L., & Sood, A. K. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9538-9 · Cited by 92

Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic Cancer

Rajeshkumar, N. V., Tan, A. C., Oliveira, E. D., Womack, C., Wombwell, H., Morgan, S. R., Warren, M. V., Walker, J., Green, T. P., Jimeno, A., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3021 · Cited by 93

Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells

Pahujaa, M., Anikin, M., & Goldberg, G. S. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.09.010 · Cited by 88

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

Kim, M. P., Park, S. I., Kopetz, S., & Gallick, G. E. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0682-9 · Cited by 88

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

Ding, Q., Miyazaki, Y., Tsukasa, K., Matsubara, S., Yoshimitsu, M., & Takao, S. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-15 · Cited by 89

Locking the Active Conformation of c-Src Kinase through the Phosphorylation of the Activation Loop

Meng, Y., & Roux, B. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.10.001 · Cited by 89

Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer.

Planas-Silva, M., Bruggeman, R. D., Grenko, R. T., & Smith, J. S. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2005.12.164 · Cited by 97

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine‐based Compounds

Dalgarno, D. C., Stehle, T., Narula, S. S., Schelling, P., van Schravendijk, M. R., Adams, S. E., Andrade, L. J., Keats, J. A., Ram, M. K., Jin, L., et al. (2005) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2005.00316.x · Cited by 87

Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation

Fu, Y., Yang, G., Zhu, F., Peng, C., Li, W., Li, H., Kim, H.-G., Bode, A. M., Dong, Z., & Dong, Z. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.509 · Cited by 90

Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

Lü, G., Zhang, Q. H., Huang, Y., Song, J., Tomaino, R., Ehrenberger, T., Lim, E., Liu, W., Bronson, R. T., Bowden, M., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.06.026 · Cited by 87

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

Woodcock, S. A., Rooney, C., Liontos, M., Connolly, Y., Zoumpourlis, V. C., Whetton, A. D., Gorgoulis, V. G., & Malliri, A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.012 · Cited by 86

The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy

Lieu, C. H., & Kopetz, S. (2010) · Clinical Colorectal Cancer · doi:10.3816/ccc.2010.n.012 · Cited by 88

Bacteria and genetically modified bacteria as cancer therapeutics: Current advances and challenges

Nallar, S. C., Xu, D.-Q., & Kalvakolanu, D. V. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.002 · Cited by 89

Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer

Yu, W., Chai, H., Li, Y., Zhao, H., Xie, X., Zheng, H., Wang, C., Wang, X., Yang, G., Cai, X., et al. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.019 · Cited by 86

miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC

Wang, N., Liang, H., Zhou, Y., Wang, C., Zhang, S., Pan, Y., Wang, Y., Yan, X., Zhang, J., Zhang, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105570 · Cited by 87

Tyrosine kinase receptor RON in human pancreatic cancer

Camp, E. R., Yang, A. D., Gray, M. J., Fan, F., Hamilton, S. R., Evans, D. B., Hooper, A. T., PEREIRA, D. S., Hicklin, D. J., & Ellis, L. M. (2007) · Cancer · doi:10.1002/cncr.22490 · Cited by 85

Src oncogene activates MMP‐2 expression via the ERK/Sp1 pathway

Kuo, L., Chang, H., Leu, T., Maa, M., & Hung, W. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20616 · Cited by 85

Src in endosomal membranes promotes exosome secretion and tumor progression

Hikita, T., Kuwahara, A., Watanabe, R., Miyata, M., & Oneyama, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39882-z · Cited by 86

Elongation factor‐2 kinase regulates TG 2/β1 integrin/Src/u PAR pathway and epithelial–mesenchymal transition mediating pancreatic cancer cells invasion

Ashour, A. A., Gürbüz, N., Alpay, S. N., Abdel‐Aziz, A. H., Mansour, A. M., Huo, L., & Özpolat, B. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12361 · Cited by 84

Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer

Chellappa, K., Jankova, L., Schnabl, J. M., Pan, S., Brélivet, Y., Fung, C. L.-S., Chan, C., Dent, O. F., Clarke, S. J., Robertson, G. R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106799109 · Cited by 87

Modeling Breast Cancer–Associated c-Src and EGFR Overexpression in Human MECs: c-Src and EGFR Cooperatively Promote Aberrant Three-dimensional Acinar Structure and Invasive Behavior

Dimri, M., Naramura, M., Duan, L., Chen, J., Ortega-Cava, C. F., Chen, G., Goswami, R., Fernandes, N. D., Gao, Q., Dimri, G. P., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2580 · Cited by 87

Expression and Activity of Src Regulate Interleukin-8 Expression in Pancreatic Adenocarcinoma Cells: Implications for Angiogenesis

Trevino, J. G., Summy, J. M., Gray, M. J., Nilsson, M. B., Lesslie, D. P., Baker, C. H., & Gallick, G. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3858 · Cited by 83

Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma

Jia, D., Jing, Y., Zhang, Z., Liu, L., Ding, J., Zhao, F., Ge, C., Wang, Q., Chen, T., Yao, M., et al. (2013) · Cell Research · doi:10.1038/cr.2013.158 · Cited by 81

Src family kinases and paclitaxel sensitivity

Le, X.-F., & Bast, Jr. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.4.16430 · Cited by 79

Structure–Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity

Farhat, J., Alzyoud, L., Alwahsh, M., & Al‐Omari, B. (2022) · Cancers · doi:10.3390/cancers14092196 · Cited by 79

Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function

Ammer, A. G., Kelley, L. C., Hayes, K. E., Evans, J. V., Lopez-Skinner, L. A., Martin, K. H., Frederick, B. A., Rothschild, B. L., Raben, D., Elvin, P., et al. (2009) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000009 · Cited by 79

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

Summy, J. M., Trevino, J. G., Lesslie, D. P., Baker, C. H., Shakespeare, W. C., Wang, Y., Sundaramoorthi, R., Metcalf, C. A., Keats, J. A., Sawyer, T. K., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0171 · Cited by 82

Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts

Lee, Y.-C., Huang, C.-F., Murshed, M., Chu, K., Araujo, J. C., Ye, X., deCrombrugghe, B., Yu-Lee, L.-Y., Gallick, G. E., & Lin, S.-H. (2010) · Oncogene · doi:10.1038/onc.2010.73 · Cited by 79

Masitinib Combined with Standard Gemcitabine Chemotherapy: In Vitro and In Vivo Studies in Human Pancreatic Tumour Cell Lines and Ectopic Mouse Model

Humbert, M., Castéran, N., Letard, S., Hanssens, K., Iovanna, J., Finetti, P., Bertucci, F., Bader, T., Mansfield, C. D., Moussy, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009430 · Cited by 78

Src‐dependent Tks5 phosphorylation regulates invadopodia‐associated invasion in prostate cancer cells

Burger, K. L., Learman, B. S., Boucherle, A. K., Sirintrapun, S. J., Isom, S. P., Díaz, B., Courtneidge, S. A., & Seals, D. F. (2013) · The Prostate · doi:10.1002/pros.22735 · Cited by 78

Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

Rho, O., Kim, D. J., Kiguchi, K., & DiGiovanni, J. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20665 · Cited by 78

Functional Activation of Src Family Kinase Yes Protein Is Essential for the Enhanced Malignant Properties of Human Melanoma Cells Expressing Ganglioside GD3

Hamamura, K., Tsuji, M., Hotta, H., Ohkawa, Y., Takahashi, M., Shibuya, H., Nakashima, H., Yamauchi, Y., Hashimoto, N., Hattori, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164798 · Cited by 77

Ubiquitin ligases in cancer: Functions and clinical potentials

Duan, S., & Pagano, M. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.04.008 · Cited by 77

Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer

Bai, J., Zhou, Y., Chen, G., Zeng, J., Ding, J., Tan, Y., Zhou, J., & Li, G. (2010) · Human Pathology · doi:10.1016/j.humpath.2010.09.003 · Cited by 76

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Sánchez-Bailón, M. P., Calcabrini, A., Gómez-Domínguez, D., Morte, B., Martín-Forero, E., Goméz-López, G., Molinari, A., Wagner, K., & Martı́n-Pérez, J. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.011 · Cited by 76

Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells

Huang, Y., Yang, H., Huang, S.-W., Ou, G., Hsu, Y.-F., & Hsu, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158839 · Cited by 77

Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

Ischenko, I., Čamaj, P., Seeliger, H., Kleespies, A., Guba, M. O., Toni, E. N. D., Schwarz, B., Graeb, C., Eichhorn, M., Jauch, K. ‐., et al. (2008) · Oncogene · doi:10.1038/onc.2008.326 · Cited by 75

Computational Study of the “DFG-Flip” Conformational Transition in c-Abl and c-Src Tyrosine Kinases

Meng, Y., Lin, Y.-L., & Roux, B. (2014) · Journal of Physical Chemistry B · doi:10.1021/jp511792a · Cited by 71

An Update on Src Family of Nonreceptor Tyrosine Kinases Biology

Espada, J., & Martín-Pérez, J. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.009 · Cited by 80

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement

Serrels, A., Canel, M., Brunton, V. G., & Frame, M. C. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.4.17290 · Cited by 74

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as Dual Inhibitors of Src and Abl Kinases

Boschelli, D. H., Wang, Y. D., Johnson, S., Wu, B., Ye, F., Sosa, A. C. B., Golas, J. M., & Boschelli, F. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0499458 · Cited by 72

Targeting key steps in metastatic tumour progression

Eccles, S. A. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.001 · Cited by 73

Regional anaesthesia and cancer metastases: the implication of local anaesthetics

Votta-Velis, E. G., Piegeler, T., Minshall, R. D., Aguirre, J. A., Beck‐Schimmer, B., Schwartz, D. E., & Borgeat, A. (2013) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12210 · Cited by 73

Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer

Chen, Z., Cai, L., Zhu, J., Chen, M., Chen, J., Li, Z., Liu, X.-D., Wang, S., Bie, P., Jiang, P., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr088 · Cited by 74

Src controls tumorigenesis via JNK‐dependent regulation of the Hippo pathway in Drosophila

Enomoto, M., & Igaki, T. (2012) · EMBO Reports · doi:10.1038/embor.2012.185 · Cited by 73

Transition path theory analysis of c-Src kinase activation

Meng, Y., Shukla, D., Pande, V. S., & Roux, B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602790113 · Cited by 73

Development of Effective Therapeutics Targeting HER3 for Cancer Treatment

Liu, X., Liu, S., Lyu, H., Riker, A. I., Zhang, Y., & Liu, B. (2019) · Biological Procedures Online · doi:10.1186/s12575-019-0093-1 · Cited by 72

Protein Kinase G Type Iα Activity in Human Ovarian Cancer Cells Significantly Contributes to Enhanced Src Activation and DNA Synthesis/Cell Proliferation

Leung, E. L., Wong, J. C., Johlfs, M. G., Tsang, B. K., & Fiscus, R. R. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0178 · Cited by 72

Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors

Weisberg, E., Liu, Q., Nelson, E. A., Kung, A. L., Christie, A. L., Bronson, R. T., Sattler, M., Sanda, T., Zhao, Z., Hur, W., et al. (2012) · Leukemia · doi:10.1038/leu.2012.96 · Cited by 73

The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model

Minard, M. E., Herynk, M. H., Collard, J. G., & Gallick, G. E. (2005) · Oncogene · doi:10.1038/sj.onc.1208503 · Cited by 72

The cell surface glycoprotein CDCP1 in cancer—Insights, opportunities, and challenges

Wortmann, A., He, Y., Deryugina, E. I., Quigley, J. P., & Hooper, J. D. (2009) · IUBMB Life · doi:10.1002/iub.198 · Cited by 72

Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway

Masraksa, W., Tanasawet, S., Hutamekalin, P., Wongtawatchai, T., & Sukketsiri, W. (2020) · Nutrition Research and Practice · doi:10.4162/nrp.2020.14.2.127 · Cited by 72

The Inhibition of Src Family Kinase Suppresses Pancreatic Cancer Cell Proliferation, Migration, and Invasion

Je, D. W., Young Moon, O., Ji, Y. G., Cho, Y., & Lee, D. H. (2014) · Pancreas · doi:10.1097/mpa.0000000000000103 · Cited by 70

Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention

Eccles, S. A. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041820se · Cited by 71

YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib

Garmendia, I., Pajares, M. J., Hermida‐Prado, F., Ajona, D., Bértolo, C., Sainz, C., Lavín, A., Remírez, A., Valencia, K., Moreno, H., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1292oc · Cited by 73

Activation of KLF8 Transcription by Focal Adhesion Kinase in Human Ovarian Epithelial and Cancer Cells

Wang, X., Urvalek, A. M., Liu, J., & Zhao, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709300200 · Cited by 70

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation

Kelley, L. C., Ammer, A. G., Hayes, K. E., Martin, K. H., Machida, K., Jia, L., Mayer, B. J., & Weed, S. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.075200 · Cited by 70

3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities

Rao, V. K., Chhikara, B. S., Shirazi, A. N., Tiwari, R. K., Parang, K., & Kumar, A. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.05.010 · Cited by 70

Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors

Sharma, S., Singh, J., Ojha, R., Singh, H., Kaur, M., Bedi, P. M. S., & Nepali, K. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.02.018 · Cited by 70

DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties

Little, A. C., Sham, D., Hristova, M., Danyal, K., Heppner, D. E., Bauer, R., Sipsey, L., Habibovic, A., & van der Vliet, A. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.61 · Cited by 70

Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis

Carneiro, P. J., Clevelario, A. L., Padilha, G. A., Silva, J. D., Kitoko, J. Z., Olsen, P. C., Capelozzi, V. L., Rocco, P. R. M., & Cruz, F. F. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00159 · Cited by 70

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the ‘PTP-ome'Preprint

Lin, G., Aranda, V., Muthuswamy, S. K., & Tonks, N. K. (2011) · Genes & Development · doi:10.1101/gad.2018911 · Cited by 70

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization

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CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation

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Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells

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Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma

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Src family kinases differentially influence glioma growth and motility

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Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies

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Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors

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Transforming Potential of Src Family Kinases Is Limited by the Cholesterol-Enriched Membrane Microdomain

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Src Family Nonreceptor Tyrosine Kinases as Molecular Targets for Cancer Therapy

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