The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Some Consequences of the RNA World Hypothesis
Abstract
It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one can learn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, and one can speculate that the monomers of earlier genetic polymers might be recognizable as important biochemicals. This suggests that the construction of replicating polymers from simple, not necessarily standard, aminoacids should be explored.
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“Alternatively, polyesters, which have a considerably lower energy for bond formation (~0 kcal mol−1 [54]), have been considered as possible ancestral precursors of peptides [36,55].”
From Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry (2020) · cites this paper as [55]
Citations
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Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
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Cited by
Sorted by citations
Prebiotic chemistry and the origin of the RNA world.
Leslie E., O. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490460765 · Cited by 1,124
Self-citationWolf, Y. I., & Koonin, E. V. (2007) · Biology Direct · doi:10.1186/1745-6150-2-14 · Cited by 235
“In 1986, Gilbert coined the term "RNA world" to designate this hypothetical stage in life's evolution [44], and the idea caught up big way, becoming the leading, in fact, almost universally accepted hypothesis on the early stages of life's evolution [45-48].”
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Chemistry of Abiotic Nucleotide Synthesis
Yadav, M., Kumar, R., & Krishnamurthy, R. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00546 · Cited by 225
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Metadata
- Authors
- Orgel, L. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Orgel, Leslie E.
- Venue
- Origins of life and evolution of the biosphere
- Published
- 2003-04
- Volume
- 33
- Issue
- 2
- Pages
- 211-218
- ISSN
- 0169-6149 (ISSN-L)
- 1573-0875
- OpenAlex
- W1567188373
- Cited by
- 124
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 1 · 2012: 7
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Origins of Life and Evolution of Biospheres (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA world, prebiotic chemistry, origin of life, nucleotide polymerization, amino acids, ribozymes, protein synthesis
- MeSH terms
- Amino Acids, Models, Theoretical, Polymers, RNA
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