The DOI matches its Crossref record; 110 of the 111 references it cites were found in a registry or an index.
The NG2 proteoglycan: Past insights and future prospects
Abstract
The NG2 chondroitin sulfate proteoglycan is a valuable marker for several types of incompletely-differentiated precursor cells, including oligodendrocyte progenitors in the central nervous system, developing mesenchymal cells in cartilage, muscle, and bone, and pericytes/smooth muscle cells in developing vasculature. In addition to extending our knowledge about the developmental roles of these cell types, current studies on NG2 are also providing information about the molecular mechanisms through which the proteoglycan itself influences progenitor development. This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration.
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“One feature shared by PCs is the expression of the cell surface glycoprotein NG2 [18]”
From New advances of NG2-expressing cell subset in marrow mesenchymal stem cells as novel therapeutic tools for liver fibrosis/cirrhosis (2024) · cites this paper as [18]
Citations
Cites
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Research works printed but not linked: 3
- Nishiyama, A., Lin, X., Giese, N., Heldin, C.& Stallcup, W.(1996b) Interaction between NG2 proteoglycan and PDGFα-receptor on O2A cells is required for optimal response to PDGF. J. Neurosci. Res. 43, 315–330. · DOI
- Nishiyama, A., Dahlin, K., Prince, J., Johnstone, S.& Stallcup, W. B.(1999a) Erratum to: The primary structure of NG2, a novel, membrane-spanning proteoglycan. J. Cell Biol. 145, 1116.
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Cited by
The role of pericytes in blood-vessel formation and maintenance
Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922
“With an important role in angiogenesis where it promotes ECmigration and proliferation (Fukushi et al., 2004; Stallcup, 2002), NG2 expressionmay not be static but rather induced in pericytes during angiogenesis and microvascular remodeling (Murfee et al.”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 825
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575
Metadata
- Authors
- Stallcup, W. B.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Stallcup, William B.
- ORCID
- Stallcup, William B.
- Venue
- Journal of Neurocytology
- Published
- 2002-07
- Volume
- 31
- Issue
- 6-7
- Pages
- 423 ppl=-435
- ISSN
- 0300-4864 (ISSN-L)
- 1573-7381
- OpenAlex
- W91126227
- Cited by
- 296
- References
- 111
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 17 · 2013: 29 · 2012: 12
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neurocytology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns021990-15, 5r01ar044400-04, 5r01ns032767-04)
- National Cancer Institute (R01 CA95287, R01CA095287)
- National Institute of Neurological Disorders and Stroke (R01 NS21990, R01 NS32767)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR44400)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 25938, P01HD025938)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- NG2 proteoglycan, chondroitin sulfate proteoglycans, oligodendrocyte progenitors, mesenchymal progenitor cells, pericytes, smooth muscle cells, cell proliferation, cell migration, intracellular signaling, central nervous system development, chondrogenesis, skeletal development, vascular development
- MeSH terms
- Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Differentiation, Cell Division, Cell Movement, Central Nervous System, Humans, Proteoglycans, Stem Cells, Molecular Structure, Signal Transduction
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
