Cited by 303Proteoglycans and glycosaminoglycans researchNeurogenesis and neuroplasticity mechanismsOsteoarthritis Treatment and Mechanisms

The DOI matches its Crossref record; 110 of the 111 references it cites were found in a registry or an index.

The NG2 proteoglycan: Past insights and future prospects

Stallcup, William B.·2002·Journal of Neurocytology

DOI 10.1023/a:1025731428581

Open this paper in CoChat — free account

Abstract

The NG2 chondroitin sulfate proteoglycan is a valuable marker for several types of incompletely-differentiated precursor cells, including oligodendrocyte progenitors in the central nervous system, developing mesenchymal cells in cartilage, muscle, and bone, and pericytes/smooth muscle cells in developing vasculature. In addition to extending our knowledge about the developmental roles of these cell types, current studies on NG2 are also providing information about the molecular mechanisms through which the proteoglycan itself influences progenitor development. This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration.

Integrity signals

Registry

Crossref · 10.1023/a:1025731428581

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,414
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,616
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
OʼReilly, M. (1994) · Cell · doi:10.1016/0092-8674(94)90200-3 · Cited by 3,344
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.14.3047 · Cited by 1,750
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Manser, E. J., Leung, T., Salihuddin, H., Zhao, Z.-S., & Lim, L. (1994) · Nature · doi:10.1038/367040a0 · Cited by 1,541
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
Structural basis for the binding of proline-rich peptides to SH3 domains
Yu, H., Chen, J., Feng, S., Dalgarno, D. C., Brauer, A. W., & Schrelber, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90367-0 · Cited by 1,003

Show all 111 references

Research works printed but not linked: 3

Nishiyama, A., Lin, X., Giese, N., Heldin, C.& Stallcup, W.(1996b) Interaction between NG2 proteoglycan and PDGFα-receptor on O2A cells is required for optimal response to PDGF. J. Neurosci. Res. 43, 315–330. · DOI
Nishiyama, A., Dahlin, K., Prince, J., Johnstone, S.& Stallcup, W. B.(1999a) Erratum to: The primary structure of NG2, a novel, membrane-spanning proteoglycan. J. Cell Biol. 145, 1116.
Richardson, W., Raff, M.& Noble, M.(1990) The oligodendrocyte/type-2 astrocyte lineage. Semin. Neurosci. 2, 445–454.

The role of pericytes in blood-vessel formation and maintenance
Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922
“With an important role in angiogenesis where it promotes ECmigration and proliferation (Fukushi et al., 2004; Stallcup, 2002), NG2 expressionmay not be static but rather induced in pericytes during angiogenesis and microvascular remodeling (Murfee et al.”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 825
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 490
Vesicular glutamate release from axons in white matter
Kukley, M., Capetillo‐Zarate, E., & Dietrich, D. (2007) · Nature Neuroscience · doi:10.1038/nn1850 · Cited by 475
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 387
Connective tissue fibroblasts and Tcf4 regulate myogenesis
Mathew, S. J., Hansen, J. M., Merrell, A. J., Murphy, M. M., Lawson, J. A., Hutcheson, D. A., Hansen, M. S. T., Angus-Hill, M. L., & Kardon, G. (2010) · Development · doi:10.1242/dev.057463 · Cited by 323
Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation
Birbrair, A., Zhang, T., Wang, Z., Messi, M. L., Enikolopov, G., Mintz, A., & Delbono, O. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0647 · Cited by 321
Neuroglia in neurodegeneration
Heneka, M. T., Rodriguez, J. J., & Verkhratsky, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 318
Pericytes: Pluripotent Cells of the Blood Brain Barrier
Dore‐Duffy, P. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705469 · Cited by 293
NG2‐positive cells in the mouse white and grey matter display distinct physiological properties
Chittajallu, R., Aguirre, A. A., & Gallo, V. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.074252 · Cited by 260
Morphology and Properties of Pericytes
Dore‐Duffy, P., & Cleary, K. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-938-3_2 · Cited by 222
Endothelial cell migration directs testis cord formation
Combes, A. N., Wilhelm, D., Davidson, T., Dejana, E., Harley, V. R., Sinclair, A. H., & Koopman, P. A. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.040 · Cited by 213
CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma
Price, M. A., Wanshura, L. E. C., Yang, J., Carlson, J. H., Xiang, B., Li, G., Ferrone, S., Dudek, A. Z., Turley, E. A., & McCarthy, J. B. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00929.x · Cited by 209
Synantocytes: the fifth element
Butt, A. M., Hamilton, N., Hubbard, P. S., Pugh, M., & Ibrahim, M. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00458.x · Cited by 208
Pericyte Dynamics during Angiogenesis: New Insights from New Identities
Stapor, P. C., Sweat, R. S., Dashti, D. C., Betancourt, A. M., & Murfee, W. L. (2014) · Journal of Vascular Research · doi:10.1159/000362276 · Cited by 194
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
Pellegatta, S., Savoldo, B., Ianni, N. D., Corbetta, C., Chen, Y., Patanè, M., Sun, C., Pollo, B., Ferrone, S., DiMeco, F., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao2731 · Cited by 187
Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium
MacFadyen, J. R., Haworth, O., Roberston, D., Hardie, D. L., Webster, M.-T., Morris, H. R., Panico, M., Sutton‐Smith, M., Dell, A., van der Geer, P., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.071 · Cited by 185
An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis
Virgintino, D., Girolamo, F., Errede, M., Capobianco, C., Robertson, D., Stallcup, W. B., Perris, R., & Roncali, L. (2007) · Angiogenesis · doi:10.1007/s10456-006-9061-x · Cited by 184
Self-citation
Novel NG2‐CreERT2 knock‐in mice demonstrate heterogeneous differentiation potential of NG2 glia during development
Huang, W., Zhao, N., Bai, X., Karram, K., Trotter, J., Goebbels, S., Scheller, A., & Kirchhoff, F. (2014) · Glia · doi:10.1002/glia.22648 · Cited by 185
Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis
Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180
Tissue specific origin, development, and pathological perspectives of pericytes
Yamazaki, T., & Mukouyama, Y.-S. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00078 · Cited by 175
Intestinal myofibroblasts: targets for stem cell therapy
Mifflin, R. C., Pinchuk, I. V., Saada, J. I., & Powell, D. W. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00474.2010 · Cited by 173
Polydendrocytes: NG2 Cells with Many Roles in Development and Repair of the CNS
Nishiyama, A. (2007) · The Neuroscientist · doi:10.1177/1073858406295586 · Cited by 168
Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair
Burnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 161
Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms
Yang, J., Price, M. A., Neudauer, C. L., Wilson, C. M., Ferrone, S., Hong, X., Iida, J., Simpson, M. A., & McCarthy, J. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403174 · Cited by 156
Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity
Jabs, R., Pivneva, T. A., Hüttmann, K., Wyczynski, A., Nolte, C., Kettenmann, H., & Steinhäuser, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02515 · Cited by 155
The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling
Chekenya, M., Krakstad, C., Svendsen, A., Netland, I. A., Staalesen, V., Tysnes, B. B., Selheim, F., Wang, J., Sakariassen, P. Ø., Sandal, T., et al. (2008) · Oncogene · doi:10.1038/onc.2008.157 · Cited by 152
Self-citation
Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and development
Agresti, C., Meomartini, M. E., Amadio, S., Ambrosini, E., Serafini, B., Franchini, L., Volonté, C., Aloisi, F., & Visentin, S. (2005) · Glia · doi:10.1002/glia.20160 · Cited by 152
Oligodendrocytes, their Progenitors and other Neuroglial Cells in the Aging Primate Cerebral Cortex
Peters, A. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh060 · Cited by 152
ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptors
Agresti, C., Meomartini, M. E., Amadio, S., Ambrosini, E., Volonté, C., Aloisi, F., & Visentin, S. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.005 · Cited by 151
Molecular biology of normal melanocytes and melanoma cells
Bandarchi, B., Jabbari, C., Vedadi, A., & Navab, R. (2013) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2013-201471 · Cited by 145
NG2+/Olig2+ Cells are the Major Cycle‐Related Cell Population of the Adult Human Normal Brain
Geha, S., Pallud, J., Junier, M., Devaux, B. C., Léonard, N., Chassoux, F., Chneiweiss, H., Daumas‐Duport, C., & Varlet, P. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00295.x · Cited by 146
Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ
Pendleton, J. C., Shamblott, M. J., Gary, D. S., Belegu, V., Hurtado, A., Malone, M. L., & McDonald, J. W. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.04.003 · Cited by 144
Biological functions of iduronic acid in chondroitin/dermatan sulfate
Thelin, M. A., Bartolini, B., Axelsson, J. B., Gustafsson, R., Tykesson, E., Pera, E. M., Oldberg, Å., Maccarana, M., & Malmström, A. (2013) · FEBS Journal · doi:10.1111/febs.12214 · Cited by 141
Sequence of oligodendrocyte development in the human fetal telencephalon
Jakovčevski, I., & Zečević, N. (2004) · Glia · doi:10.1002/glia.20134 · Cited by 140
The expression and functions of glycoconjugates in neural stem cells
Yanagisawa, M., & Yu, R. K. (2007) · Glycobiology · doi:10.1093/glycob/cwm018 · Cited by 136
Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration
Tong, X., Li, X., Zhou, B., Shen, W., Zhang, Z., Xu, T., & Duan, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811071 · Cited by 135
Proteoglycans in Normal and Healing Skin
Smith, M. M., & Melrose, J. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0464 · Cited by 135
A role for the NG2 proteoglycan in glioma progression
Stallcup, W. B., & Huang, F.-J. (2008) · Cell Adhesion & Migration · doi:10.4161/cam.2.3.6279 · Cited by 135
Self-citation
A Coarse-Grained Molecular Model for Glycosaminoglycans: Application to Chondroitin, Chondroitin Sulfate, and Hyaluronic Acid
Bathe, M., Rutledge, G. C., Grodzinsky, A. J., & Tidor, B. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.058800 · Cited by 133
A fourth type of neuroglial cell in the adult central nervous system
Peters, A. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000044195.64009.27 · Cited by 129
NG2 Glial Cells Provide a Favorable Substrate for Growing Axons
Yang, Z., Suzuki, R., Daniels, S. B., Brunquell, C. B., Sala, C. J., & Nishiyama, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4247-05.2006 · Cited by 125
Chondroitin sulphate proteoglycans: Key modulators of spinal cord and brain plasticity
Bartus, K., James, N. D., Bosch, K. D., & Bradbury, E. J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.008 · Cited by 123
The Transmembrane Protein Kon-tiki Couples to Dgrip to Mediate Myotube Targeting in Drosophila
Schnorrer, F., Adrian‐Kalchhauser, I., & Dickson, B. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.017 · Cited by 118
Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4
Campoli, M. R., Ferrone, S., & Wang, X. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380890-5.00003-x · Cited by 118
The GPR17 receptor in NG2 expressing cells: Focus on in vivo cell maturation and participation in acute trauma and chronic damage
Boda, E., Viganò, F., Rosa, P., Fumagalli, M., Labat-gest, V., Tempia, F., Abbracchio, M. P., Dimou, L., & Buffo, A. (2011) · Glia · doi:10.1002/glia.21237 · Cited by 118
Iduronic Acid in Chondroitin/Dermatan Sulfate
Malmström, A., Bartolini, B., Thelin, M. A., Pacheco, B., & Maccarana, M. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412459857 · Cited by 118
Roles for p53 and p73 during oligodendrocyte development
Billon, N., Terrinoni, A., Jolicoeur, C., McCarthy, A., Richardson, W. D., Melino, G., & RAFF, M. C. (2004) · Development · doi:10.1242/dev.01035 · Cited by 115
Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration
Makagiansar, I. T., Williams, S., Mustelin, T., & Stallcup, W. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612084 · Cited by 113
Self-citation
The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelination
Kuchárová, K., & Stallcup, W. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.014 · Cited by 107
Self-citation
Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice
Ehninger, D., Wang, L., Klempin, F., Römer, B., Kettenmann, H., & Kempermann, G. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1200-z · Cited by 105
Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression
Stritt, C., Stern, S., Harting, K., Manke, T., Sinske, D., Schwarz, H., Vingron, M., Nordheim, A., & Knöll, B. (2009) · Nature Neuroscience · doi:10.1038/nn.2280 · Cited by 105
Delayed myelination in a mouse model of fragile X syndrome
Pacey, L. K. K., Xuan, I. C. Y., Guan, S. A., Sussman, D., Henkelman, R. M., Chen, Y., Thomsen, C., & Hampson, D. R. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt246 · Cited by 105
Targeting Pericytes for Angiogenic Therapies
Kelly‐Goss, M. R., Sweat, R. S., Stapor, P. C., Peirce, S. M., & Murfee, W. L. (2013) · Microcirculation · doi:10.1111/micc.12107 · Cited by 104
Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans
Miller, G. M., & Hsieh‐Wilson, L. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.015 · Cited by 102
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, C., Spliid, C. B., Sand, N. T., Clausen, T. M., Salanti, A., & Agerbæk, M. Ø. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00749 · Cited by 99
N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis
Tillet, E., Vittet, D., Féraud, O., Moore, R. H., Kemler, R., & Huber, P. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.021 · Cited by 101
The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury
Chen, C., Sung, C., Huang, S., Feng, C., Hung, H.-C., Yang, S., Chen, N., Tai, M., Wen, Z., & Chen, W.-F. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.01.023 · Cited by 98
Melanoma Proteoglycan Modifies Gene Expression to Stimulate Tumor Cell Motility, Growth, and Epithelial-to-Mesenchymal Transition
Yang, J., Price, M. A., Li, G. Y., Bar‐Eli, M., Salgia, R., Jagedeeswaran, R., Carlson, J. H., Ferrone, S., Turley, E. A., & McCarthy, J. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4626 · Cited by 96
Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?
Pukos, N., Goodus, M. T., Sahinkaya, F. R., & McTigue, D. M. (2019) · Glia · doi:10.1002/glia.23702 · Cited by 95
Sox10‐iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage
Simon, C., Lickert, H., Götz, M., & Dimou, L. (2011) · genesis · doi:10.1002/dvg.22003 · Cited by 92
The regulatory mechanisms of NG2/CSPG4 expression
Ampofo, E., Schmitt, B., Menger, M. D., & Laschke, M. W. (2017) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-017-0035-3 · Cited by 89
Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension
Bordenave, J., Tu, L., Berrebeh, N., Thuillet, R., Cumont, A., Vely, B. L., Fadel, É., Nadaud, S., Savale, L., Humbert, M. J. C., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313715 · Cited by 89
Proteoglycans in brain development
Schwartz, N. B., & Domowicz, M. S. (2004) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000046278.34016.36 · Cited by 89
The neuroglial population in the primary visual cortex of the aging rhesus monkey
Peters, A., Verderosa, A., & Sethares, C. (2008) · Glia · doi:10.1002/glia.20686 · Cited by 87
NG2 cell response in the CNP‐EGFP mouse after contusive spinal cord injury
Lytle, J. M., Chittajallu, R., Wrathall, J. R., & Gallo, V. (2008) · Glia · doi:10.1002/glia.20755 · Cited by 87
Glutamatergic signaling in the brain's white matter
Bakiri, Y., Burzomato, V., Frugier, G., Hamilton, N. B., Káradóttir, R. T., & Attwell, D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.015 · Cited by 85
Excitatory GABAergic Activation of Cortical Dividing Glial Cells
Tanaka, Y., Tozuka, Y., Takata, T., Shimazu, N., Matsumura, N., Ohta, A., & Hisatsune, T. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn238 · Cited by 84
The genetics of Fraser syndrome and the blebs mouse mutants
Smyth, I., & Scambler, P. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi262 · Cited by 83
Accumulation of Macrophage-Like Cells Expressing NG2 Proteoglycan and Iba1 in Ischemic Core of Rat Brain after Transient Middle Cerebral Artery Occlusion
Matsumoto, H., Kumon, Y., Watanabe, H., Ohnishi, T., Shudou, M., Chuai, M., Imai, Y., Takahashi, H., & Tanaka, J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600519 · Cited by 82
Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain
Baroti, T., Zimmermann, Y., Schillinger, A., Liu, L., Lommes, P., Wegner, M., & Stolt, C. C. (2015) · Glia · doi:10.1002/glia.22919 · Cited by 81
Intracerebral Transplantation of Adult Mouse Neural Progenitor Cells into the Niemann-Pick-A Mouse Leads to a Marked Decrease in Lysosomal Storage Pathology
Shihabuddin, L. S., Numan, S., Huff, M. R., Dodge, J. C., Clarke, J. L., Macauley, S. L., Yang, W., Taksir, T. V., Parsons, G., Passini, M. A., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3584-04.2004 · Cited by 78
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23878-3 · Cited by 77
Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
Kuchárová, K., Chang, Y., Boor, A., Yong, V. W., & Stallcup, W. B. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-158 · Cited by 75
Self-citation
TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord
Church, J. S., Kigerl, K. A., Lerch, J. K., Popovich, P. G., & McTigue, D. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-16.2016 · Cited by 75
The NG2 Proteoglycan in Pericyte Biology
Stallcup, W. B. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-02601-1_2 · Cited by 76
Self-citation
CSPG4: a prototype oncoantigen for translational immunotherapy studies
Rolih, V., Barutello, G., Iussich, S., Maria, R. D., Quaglino, E., Buracco, P., Cavallo, F., & Riccardo, F. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1250-4 · Cited by 75
In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury
Gao, X., Wang, X., Xiong, W., & Chen, J. (2016) · Scientific Reports · doi:10.1038/srep22490 · Cited by 73
Activated microglia in a rat stroke model express NG2 proteoglycan in peri‐infarct tissue through the involvement of TGF‐β1
Sugimoto, K., Nishioka, R., Ikeda, A., Mise, A., Takahashi, H., Yano, H., Kumon, Y., Ohnishi, T., & Tanaka, J. (2013) · Glia · doi:10.1002/glia.22598 · Cited by 69
Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: A membrane proteomics approach
Seyfried, N. T., Huysentruyt, L. C., Atwood, J., Xia, Q., Seyfried, T. N., & Orlando, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.01.007 · Cited by 69
Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
Kato, S., Aoyama, M., Kakita, H., Hida, H., Kato, I., Ito, T., Goto, T., Hussein, M. H., Sawamoto, K., Togari, H., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22702 · Cited by 69
Phosphorylation of NG2 Proteoglycan by Protein Kinase C-α Regulates Polarized Membrane Distribution and Cell Motility
Makagiansar, I. T., Williams, S., Dahlin‐Huppe, K., Fukushi, J., Mustelin, T., & Stallcup, W. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411045200 · Cited by 69
Self-citation
NG2‐expressing cells in the nervous system: role of the proteoglycan in migration and glial–neuron interaction
Karram, K., Chatterjee, N., & Trotter, J. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00461.x · Cited by 66
Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats
Petrosyan, H. A., Hunanyan, A. S., Alessi, V., Schnell, L., Levine, J. M., & Arvanian, V. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4702-12.2013 · Cited by 61
The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo
Estrada, B., Gisselbrecht, S. S., & Michelson, A. M. (2007) · Development · doi:10.1242/dev.014027 · Cited by 60
Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma
Salnikov, A. V., Roswall, P., Sundberg, C., Gardner, H., Heldin, N., & Rubin, K. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700252 · Cited by 58
In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements
Naranjo, O., Osborne, O., Torices, S., & Toborek, M. J. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01113-3 · Cited by 57
Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury
Nishihara, T., Remacle, A. G., Angert, M., Shubayev, I., Shiryaev, S. A., Liu, H., Dolkas, J., Chernov, A. V., Strongin, A. Y., & Shubayev, V. I. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603431 · Cited by 57
Distribution of Corticosteroid Receptors in Mature Oligodendrocytes and Oligodendrocyte Progenitors of the Adult Mouse Brain
Matsusue, Y., Horii‐Hayashi, N., Kirita, T., & Nishi, M. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413517700 · Cited by 57
Cell-Surface Expression of Neuron-Glial Antigen 2 (NG2) and Melanoma Cell Adhesion Molecule (CD146) in Heterogeneous Cultures of Marrow-Derived Mesenchymal Stem Cells
Russell, K. C., Tucker, H. A., Bunnell, B. A., Andreeff, M., Schober, W., Gaynor, A. S., Strickler, K. L., Lin, S., Lacey, M. R., & O'Connor, K. C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0649 · Cited by 56
Human bone marrow mesenchymal cells express NG2: possible increase in discriminative ability of flow cytometry during mesenchymal stromal cell identification
Kozanoğlu, İ., Boğa, C., Özdoğu, H., Sözer, O., Maytalman, E., Yazıcı, A. C., & Şahin, F. İ. (2009) · Cytotherapy · doi:10.1080/14653240902923153 · Cited by 56
NG2 expression predicts the metastasis formation in soft‐tissue sarcoma patients
Benassi, M. S., Pazzaglia, L., Chiechi, A., Alberghini, M., Conti, A., Cattaruzza, S., Wassermann, B., Picci, P., & Perris, R. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20694 · Cited by 56
Biodiversity of CS–proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis
Hayes, A. J., Sugahara, K., Farrugia, B. L., Whitelock, J. M., Caterson, B., & Melrose, J. (2018) · Biochemical Journal · doi:10.1042/bcj20170820 · Cited by 56
Co-culture of human umbilical vein endothelial cells and human bone marrow stromal cells into a micro-cavitary gelatin-methacrylate hydrogel system to enhance angiogenesis
Liu, J., Chuah, Y. J., Fu, J., Zhu, W., & Wang, D. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.04.089 · Cited by 55
Diverse origins and activation of fibroblasts in cardiac fibrosis
Aujla, P. K., & Kassiri, Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109869 · Cited by 55
NG2 and Olig2 Expression Provides Evidence for Phenotypic Deregulation of Cultured Central Nervous System and Peripheral Nervous System Neural Precursor Cells
Dromard, C., Bartolami, S., Deleyrolle, L. P., Takebayashi, H., Ripoll, C., Simonneau, L., Prome, S., Puech, S., Ba, C. T. V., Duperray, C., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0556 · Cited by 54
The 6‐hydroxydopamine‐induced nigrostriatal neurodegeneration produces microglia‐like NG2 glial cells in the rat substantia nigra
Kitamura, Y., Inden, M., Minamino, H., Abe, M., Takata, K., & Taniguchi, T. (2010) · Glia · doi:10.1002/glia.21040 · Cited by 53

Authors: Stallcup, W. B.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Stallcup, William B.
ORCID: Stallcup, William B.
Venue: Journal of Neurocytology
Publisher: Springer Science and Business Media LLC
Published: 2002-07
Volume: 31
Issue: 6-7
Pages: 423 ppl=-435
ISSN: 0300-4864 (ISSN-L)
1573-7381
DOI: 10.1023/a:1025731428581
OpenAlex: W91126227
Cited by: 296
References: 111
Citations by year: 2026: 2 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 17 · 2013: 29 · 2012: 12
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Neurocytology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns021990-15, 5r01ar044400-04, 5r01ns032767-04)
National Cancer Institute (R01 CA95287, R01CA095287)
National Institute of Neurological Disorders and Stroke (R01 NS21990, R01 NS32767)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR44400)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 25938, P01HD025938)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: NG2 proteoglycan, chondroitin sulfate proteoglycans, oligodendrocyte progenitors, mesenchymal progenitor cells, pericytes, smooth muscle cells, cell proliferation, cell migration, intracellular signaling, central nervous system development, chondrogenesis, skeletal development, vascular development
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Differentiation, Cell Division, Cell Movement, Central Nervous System, Humans, Proteoglycans, Stem Cells, Molecular Structure, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The NG2 proteoglycan: Past insights and future prospects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks

Data sources