Cited by 303Proteoglycans and glycosaminoglycans researchNeurogenesis and neuroplasticity mechanismsOsteoarthritis Treatment and Mechanisms

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The NG2 proteoglycan: Past insights and future prospects

Stallcup, William B.·2002·Journal of Neurocytology

DOI 10.1023/a:1025731428581

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Abstract

The NG2 chondroitin sulfate proteoglycan is a valuable marker for several types of incompletely-differentiated precursor cells, including oligodendrocyte progenitors in the central nervous system, developing mesenchymal cells in cartilage, muscle, and bone, and pericytes/smooth muscle cells in developing vasculature. In addition to extending our knowledge about the developmental roles of these cell types, current studies on NG2 are also providing information about the molecular mechanisms through which the proteoglycan itself influences progenitor development. This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration.

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Goretzki, L., Lombardo, C. R., & Stallcup, W. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002290200 · Cited by 69
Self-citation
Antisera specific for cell lines with mixed neuronal and glial properties
Wilson, S.-S., Baetge, E. E., & Stallcup, W. B. (1981) · Developmental Biology · doi:10.1016/s0012-1606(81)80017-6 · Cited by 61
Self-citation
Interaction of the NG2 proteoglycan with the actin cytoskeleton
Lin, X., Dahlin‐Huppe, K., & Stallcup, W. B. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19961215)63:4 · Cited by 61
Self-citation
Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization
Stallcup, W. B., & Dahlin‐Huppe, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.12.2315 · Cited by 59
Self-citation
Co-localization of von Willebrand factor and type VI collagen in human vascular subendothelium.
Rand, J. H., Wu, X.-X., Potter, B. J., Uson, R. R., & Gordon, R. E. (1993) · PubMed Central · Cited by 54
Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas
Majumdar, M., Vuori, K., & Stallcup, W. B. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00045-1 · Cited by 49
Self-citation
Electrical properties of a clonal cell line as determined by measurement of ion fluxes
Stallcup, W. B., & Cohn, M. (1976) · Experimental Cell Research · doi:10.1016/0014-4827(76)90439-0 · Cited by 46
Self-citation
Expression of NG2 proteoglycan during endochondral and intramembranous ossification
Fukushi, J., Inatani, M., Yamaguchi, Y., & Stallcup, W. B. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10359 · Cited by 45
Self-citation
NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration.
Lin, X., Grako, K. A., Burg, M. A., & Stallcup, W. B. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.12.1977 · Cited by 41
Self-citation
The chondroitin sulfate proteoglycan NG2 is a tumour-specific antigen on the chemically induced rat chondrosarcoma HSN
Léger, O. J. P., Johnson‐Léger, C., Jackson, E., Coles, B., & Dean, C. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580514 · Cited by 33
Human melanoma/NG2 chondroitin sulfate proteoglycan is expressed in the sarcolemma of postnatal human skeletal myofibers
Petrini, S., Tessa, A., Carrozzo, R., Verardo, M., Pierini, R., Rizza, T., & Bertini, E. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00033-2 · Cited by 32
Osteogenic potential of vascular pericytes
Schor, A. M., & Canfield, A. E. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623219.010 · Cited by 32
Chondroitin Sulfate Proteoglycans in the Nervous System
Yamaguchi, Y. (2000) · CRC Press eBooks · doi:10.1201/9780203909720.ch15 · Cited by 30
Oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells from neonatal and adult rat optic nerve differ in their responsiveness to platelet-derived growth factor
Chan, C. L., Wigley, C. B., & Berry, M. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90209-h · Cited by 28
γ-Irradiation-induced cell cycle arrest and cell death in a human submandibular gland cell line: Effect of E2F1 expression
O’Connell, A. C., Lillibridge, C. D., Zheng, C., Baum, B. J., O'Connell, B. C., & Ambudkar, I. S. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199811)177:2 · Cited by 26
Self-citation
Cell-Associated Proteoglycans in Human Malignant Melanoma
Harper, J. R., & Reisfeld, R. A. (1987) · Elsevier eBooks · doi:10.1016/b978-0-12-750650-0.50016-1 · Cited by 21
Rubidium efflux from neural cell lines through voltage-dependent potassium channels
Arner, L. S., & Stallcup, W. B. (1981) · Developmental Biology · doi:10.1016/s0012-1606(81)80016-4 · Cited by 19
Self-citation
Untitled work
(1999) · doi:10.1002/(sici)1097-4547(19990815)57:4

Research works printed but not linked: 3

Nishiyama, A., Lin, X., Giese, N., Heldin, C.& Stallcup, W.(1996b) Interaction between NG2 proteoglycan and PDGFα-receptor on O2A cells is required for optimal response to PDGF. J. Neurosci. Res. 43, 315–330. · DOI
Nishiyama, A., Dahlin, K., Prince, J., Johnstone, S.& Stallcup, W. B.(1999a) Erratum to: The primary structure of NG2, a novel, membrane-spanning proteoglycan. J. Cell Biol. 145, 1116.
Richardson, W., Raff, M.& Noble, M.(1990) The oligodendrocyte/type-2 astrocyte lineage. Semin. Neurosci. 2, 445–454.

The role of pericytes in blood-vessel formation and maintenance
Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922
“With an important role in angiogenesis where it promotes ECmigration and proliferation (Fukushi et al., 2004; Stallcup, 2002), NG2 expressionmay not be static but rather induced in pericytes during angiogenesis and microvascular remodeling (Murfee et al.”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 825
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575

See all 303

Authors: Stallcup, W. B.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Stallcup, William B.
ORCID: Stallcup, William B.
Venue: Journal of Neurocytology
Publisher: Springer Science and Business Media LLC
Published: 2002-07
Volume: 31
Issue: 6-7
Pages: 423 ppl=-435
ISSN: 0300-4864 (ISSN-L)
1573-7381
DOI: 10.1023/a:1025731428581
OpenAlex: W91126227
Cited by: 296
References: 111
Citations by year: 2026: 2 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 17 · 2013: 29 · 2012: 12
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Neurocytology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns021990-15, 5r01ar044400-04, 5r01ns032767-04)
National Cancer Institute (R01 CA95287, R01CA095287)
National Institute of Neurological Disorders and Stroke (R01 NS21990, R01 NS32767)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR44400)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 25938, P01HD025938)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: NG2 proteoglycan, chondroitin sulfate proteoglycans, oligodendrocyte progenitors, mesenchymal progenitor cells, pericytes, smooth muscle cells, cell proliferation, cell migration, intracellular signaling, central nervous system development, chondrogenesis, skeletal development, vascular development
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Differentiation, Cell Division, Cell Movement, Central Nervous System, Humans, Proteoglycans, Stem Cells, Molecular Structure, Signal Transduction

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The NG2 proteoglycan: Past insights and future prospects

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