CoChat
Sign Up
Cited by 60

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Wnt modulation in bone healing

Schupbach, Drew, Comeau-Gauthier, Marianne, Harvey, Edward, Merle, Geraldine·2020·Bone
DOI 10.1016/j.bone.2020.115491
Open this paper in CoChat — free account

Abstract

Genetic studies have been instrumental in the field of orthopaedics for finding tools to improve the standard management of fractures and delayed unions. The Wnt signaling pathway that is crucial for development and maintenance of many organs also has a very promising pathway for enhancement of bone regeneration. The Wnt pathway has been shown to have a direct effect on stem cells during bone regeneration, making Wnt a potential target to stimulate bone repair after trauma. A more complete view of how Wnt influences animal bone regeneration has slowly come to light. This review article provides an overview of studies done investigating the modulation of the canonical Wnt pathway in animal bone regeneration models. This not only includes a summary of the recent work done elucidating the roles of Wnt and β-catenin in fracture healing, but also the results of thirty transgenic studies, and thirty-eight pharmacological studies. Finally, we discuss the discontinuation of sclerostin clinical trials, ongoing clinical trials with lithium, the results of Dkk antibody clinical trials, the shift into combination therapies and the future opportunities to enhance bone repair and regeneration through the modulation of the Wnt signaling pathway.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bone.2020.115491

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 7 references

Research works printed but not linked: 175

  1. Tannoury, 2014, Complications with use of bone morphogenetic protein-2 (BMP-2) in spine surgery, The spine journal: official journal of the North American Spine Society, 14, 10.1016/j.spinee.2013.08.060 · DOI
  2. Xu, 2014, Role of Wnt signaling in fracture healing, BMB Rep., 47, 666, 10.5483/BMBRep.2014.47.12.193 · DOI
  3. Gao, 2015, Lentivirus-mediated Wnt10b overexpression enhances fracture healing in a rat atrophic non-union model, Biotechnol. Lett., 37, 733, 10.1007/s10529-014-1703-2 · DOI
  4. Clifton, 2014, Effects of Wnt5a haploinsufficiency on bone repair, J. Orthop. Trauma, 28, e191, 10.1097/BOT.0000000000000041 · DOI
  5. Gaur, 2009, Secreted frizzled related protein 1 is a target to improve fracture healing, J. Cell. Physiol., 220, 174, 10.1002/jcp.21747 · DOI
  6. Heilmann, 2013, The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing, PLoS One, 8, 10.1371/journal.pone.0084232 · DOI
  7. Li, 2011, Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene, Bone, 49, 1178, 10.1016/j.bone.2011.08.012 · DOI
  8. McGee-Lawrence, 2013, Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification, Biochem. Biophys. Res. Commun., 441, 886, 10.1016/j.bbrc.2013.10.155 · DOI
  9. Alzahrani, 2016, Does sclerostin depletion stimulate fracture healing in a mouse model?, Clin. Orthop. Relat. Res., 474, 1294, 10.1007/s11999-015-4640-z · DOI
  10. Morse, 2015, Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength, Bone, 71, 155, 10.1016/j.bone.2014.10.018 · DOI
  11. Collette, 2016, Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells, Bone, 88, 20, 10.1016/j.bone.2016.04.005 · DOI
  12. Chen, 2007, Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing, PLoS Med., 4, 10.1371/journal.pmed.0040249 · DOI
  13. Kim, 2007, Bone regeneration is regulated by wnt signaling, J. Bone Miner. Res., 22, 1913, 10.1359/jbmr.070802 · DOI
  14. Intini, 2015, Dkk1 haploinsufficiency requires expression of Bmp2 for bone anabolic activity, Bone, 75, 151, 10.1016/j.bone.2015.01.008 · DOI
  15. Salazar, 2019, Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche, eLife, 8, 10.7554/eLife.42386 · DOI
  16. Haffner-Luntzer, 2014, Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice, PLoS One, 9, 10.1371/journal.pone.0116282 · DOI
  17. Komatsu, 2010, Modulation of Wnt signaling influences fracture repair, J. Orthop. Res., 28, 928, 10.1002/jor.21078 · DOI
  18. Liedert, 2014, Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice, PLoS One, 9, 10.1371/journal.pone.0103250 · DOI
  19. Burgers, 2016, Mice with a heterozygous Lrp6 deletion have impaired fracture healing, Bone research, 4, 16025, 10.1038/boneres.2016.25 · DOI
  20. Wang, 2015, Loss of Gi G-protein-coupled receptor signaling in osteoblasts accelerates bone fracture healing, J. Bone Miner. Res., 30, 1896, 10.1002/jbmr.2540 · DOI
  21. Arioka, 2013, Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β, Biochem. Biophys. Res. Commun., 440, 677, 10.1016/j.bbrc.2013.09.126 · DOI
  22. McGee-Lawrence, 2014, Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice, Bone, 66, 277, 10.1016/j.bone.2014.06.022 · DOI
  23. Minear, 2010, Wnt proteins promote bone regeneration, Science translational medicine, 2, 10.1126/scitranslmed.3000231 · DOI
  24. Loiselle, 2013, Inhibition of GSK-3beta rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice, PLoS One, 8, 10.1371/journal.pone.0081399 · DOI
  25. Huang, 2012, Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice, J. Orthop. Res., 30, 304, 10.1002/jor.21505 · DOI
  26. Bao, 2017, An appropriate Wnt/β-catenin expression level during the remodeling phase is required for improved bone fracture healing in mice, Sci. Rep., 7, 2695, 10.1038/s41598-017-02705-0 · DOI
  27. Jin, 2015, Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling, Bone, 71, 63, 10.1016/j.bone.2014.07.039 · DOI
  28. Ghadakzadeh, 2016, β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications, The FASEB Journal, 30, 3227, 10.1096/fj.201500190RR · DOI
  29. Baht, 2017, Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair, Bone, 98, 31, 10.1016/j.bone.2017.02.012 · DOI
  30. Kobayashi, 2008, Roles of Wnt signaling in bone formation and resorption, Japanese Dental Science Review, 44, 76, 10.1016/j.jdsr.2007.11.002 · DOI
  31. Y. Kobayashi, S. Uehara, N.J.J.o.O.B. Udagawa, Roles of non-canonical Wnt signaling pathways in bone resorption, 60(2) (2018) 31–35. · DOI
  32. Weivoda, 2016, Wnt signaling inhibits osteoclast differentiation by activating canonical and noncanonical cAMP/PKA pathways, J. Bone Miner. Res., 31, 65, 10.1002/jbmr.2599 · DOI
  33. Houschyar, 2019, Wnt pathway in bone repair and regeneration – what do we know so far, Frontiers in Cell and Developmental Biology, 6
  34. MacDonald, 2009, Wnt/beta-catenin signaling: components, mechanisms, and diseases, Dev. Cell, 17, 9, 10.1016/j.devcel.2009.06.016 · DOI · Paper page
  35. He, 2004, LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way, Development (Cambridge, England), 131, 10.1242/dev.01117 · DOI · Paper page
  36. Schulte, 2007, The Frizzled family of unconventional G-protein-coupled receptors, Trends Pharmacol. Sci., 28, 518, 10.1016/j.tips.2007.09.001 · DOI · Paper page
  37. Clevers, 2006, Wnt/beta-catenin signaling in development and disease, Cell, 127, 469, 10.1016/j.cell.2006.10.018 · DOI · Paper page
  38. Reya, 2005, Wnt signalling in stem cells and cancer, Nature, 434, 843, 10.1038/nature03319 · DOI · Paper page
  39. Kramps, 2002, Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex, Cell, 109, 47, 10.1016/S0092-8674(02)00679-7 · DOI
  40. Parker, 2002, Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila, Development (Cambridge, England), 129, 10.1242/dev.129.11.2565 · DOI
  41. Thompson, 2002, A new nuclear component of the Wnt signalling pathway, Nat. Cell Biol., 4, 367, 10.1038/ncb786 · DOI
  42. Piven, 2017, The canonical way to make a heart: beta-catenin and plakoglobin in heart development and remodeling, Experimental biology and medicine (Maywood, N.J.), 242, 1735, 10.1177/1535370217732737 · DOI
  43. Lehmann, 2016, WNT signaling in lung aging and disease, Annals of the American Thoracic Society, 13, S411, 10.1513/AnnalsATS.201608-586AW · DOI
  44. Hussain, 2017, Wnt/beta-catenin signaling links embryonic lung development and asthmatic airway remodeling, Biochimica et biophysica acta. Molecular basis of disease, 1863, 3226, 10.1016/j.bbadis.2017.08.031 · DOI
  45. Zuo, 2018, New insights into the role and mechanism of Wnt/beta-catenin signalling in kidney fibrosis, Nephrology (Carlton, Vic.), 23, 38, 10.1111/nep.13472 · DOI
  46. Nishikawa, 2018, Wnt/beta-catenin signaling as a potential target for the treatment of liver cirrhosis using antifibrotic drugs, Int. J. Mol. Sci., 19, 10.3390/ijms19103103 · DOI
  47. Burgess, 2011, Wnt signaling and colon tumorigenesis—a view from the periphery, Exp. Cell Res., 317, 2748, 10.1016/j.yexcr.2011.08.010 · DOI
  48. Wang, 2014, Wnt and the Wnt signaling pathway in bone development and disease, Frontiers in bioscience (Landmark edition), 19, 379, 10.2741/4214 · DOI
  49. Kim, 2007, Bone regeneration is regulated by wnt signaling, Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research, 22, 1913, 10.1359/jbmr.070802 · DOI
  50. Wu, 2000, Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling, Current Biology: CB, 10, 1611, 10.1016/S0960-9822(00)00868-X · DOI
  51. Hsieh, 1999, A new secreted protein that binds to Wnt proteins and inhibits their activities, Nature, 398, 431, 10.1038/18899 · DOI · Paper page
  52. Uren, 2000, Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling, J. Biol. Chem., 275, 4374, 10.1074/jbc.275.6.4374 · DOI
  53. Piccolo, 1999, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals, Nature, 397, 707, 10.1038/17820 · DOI
  54. Semenov, 2005, SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor, J. Biol. Chem., 280, 26770, 10.1074/jbc.M504308200 · DOI · Paper page
  55. Xu, 2004, Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair, Cell, 116, 883, 10.1016/S0092-8674(04)00216-8 · DOI · Paper page
  56. Kazanskaya, 2004, R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis, Dev. Cell, 7, 525, 10.1016/j.devcel.2004.07.019 · DOI · Paper page
  57. Kawano, 2003, Secreted antagonists of the Wnt signalling pathway, J. Cell Sci., 116, 2627, 10.1242/jcs.00623 · DOI · Paper page
  58. Escott, 2016, The role of glycogen synthase kinase-3 inhibitors on bone remodeling, The Biology and Therapeutic Application of Mesenchymal Cells, 148, 10.1002/9781118907474.ch13 · DOI
  59. Pai, 2004, Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness, Mol. Biol. Cell, 15, 2156, 10.1091/mbc.e03-12-0894 · DOI
  60. Takemaru, 2003, Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway, Nature, 422, 905, 10.1038/nature01570 · DOI
  61. Hadjiargyrou, 2002, Transcriptional profiling of bone regeneration insight into the molecular complexity of wound repair, J. Biol. Chem., 277, 30177, 10.1074/jbc.M203171200 · DOI
  62. Wise, 2010, Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration, PLoS One, 5, 10.1371/journal.pone.0012987 · DOI
  63. Macsai, 2012, Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair, Bone, 50, 1081, 10.1016/j.bone.2012.02.013 · DOI
  64. Zhong, 2006, Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation, Bone, 39, 5, 10.1016/j.bone.2005.12.008 · DOI
  65. French, 2004, WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair, Am. J. Pathol., 165, 855, 10.1016/S0002-9440(10)63348-2 · DOI
  66. Dean, 2010, Distinct functionalities of bone morphogenetic protein antagonists during fracture healing in mice, J. Anat., 216, 625, 10.1111/j.1469-7580.2010.01214.x · DOI
  67. Baht, 2015, Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin, Nat. Commun., 6, 7131, 10.1038/ncomms8131 · DOI
  68. Marsell, 2011, The biology of fracture healing, Injury, 42, 551, 10.1016/j.injury.2011.03.031 · DOI · Paper page
  69. Nakamura, 2008, The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology, J. Cell. Mol. Med., 12, 391, 10.1111/j.1582-4934.2007.00201.x · DOI
  70. Montjovent, 2013, Expression of antagonists of WNT and BMP signaling after non-rigid fixation of osteotomies, Bone, 53, 79, 10.1016/j.bone.2012.11.027 · DOI
  71. Sampson, 2011, Alcohol induced epigenetic perturbations during the inflammatory stage of fracture healing, Exp. Biol. Med., 236, 1389, 10.1258/ebm.2011.011207 · DOI
  72. Lauing, 2014, Exogenous activation of Wnt/β-Catenin signaling attenuates binge alcohol-induced deficient bone fracture healing, Alcohol Alcohol., 49, 399, 10.1093/alcalc/agu006 · DOI
  73. Loiselle, 2013, Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing, J. Orthop. Res., 31, 147, 10.1002/jor.22178 · DOI
  74. Kakar, 2007, Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures, J. Bone Miner. Res., 22, 1903, 10.1359/jbmr.070724 · DOI
  75. Dixit, 2015, Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of notch and Wnt canonical signaling pathways, PLoS One, 10, 10.1371/journal.pone.0144541 · DOI
  76. Yukata, 2014, Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment, Bone, 62, 79, 10.1016/j.bone.2014.02.002 · DOI
  77. Liu, 2019, Different effects of Wnt/β-catenin activation and parathyroid hormone on diaphyseal and metaphyseal in the early phase of femur bone healing of mice, Clin. Exp. Pharmacol. Physiol., 46, 652, 10.1111/1440-1681.13088 · DOI
  78. Demirkan, 2014, Local rhBMP-2 injection after drill-hole injury in rats: does it have systemic effects?, Int. J. Immunopathol. Pharmacol., 27, 253, 10.1177/039463201402700212 · DOI
  79. Feng, 2015, Systemic administration of sclerostin monoclonal antibody accelerates fracture healing in the femoral osteotomy model of young rats, Int. Immunopharmacol., 24, 7, 10.1016/j.intimp.2014.11.010 · DOI
  80. Chen, 2007, β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation, Journal of Biological Chemistry, 282, 526, 10.1074/jbc.M602700200 · DOI
  81. Wang, 2017, Fracture-targeted delivery of beta-catenin agonists via peptide-functionalized nanoparticles augments fracture healing, ACS Nano, 11, 9445, 10.1021/acsnano.7b05103 · DOI
  82. Low, 2017, Healing efficacy of fracture-targeted GSK3beta inhibitor-loaded micelles for improved fracture repair, Nanomedicine (London, England), 12, 185, 10.2217/nnm-2016-0340 · DOI
  83. Beier, 2014, Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing, Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society, 32, 1397, 10.1002/jor.22677 · DOI
  84. Bernick, 2014, Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents, J. Bone Joint Surg. Am., 96, 1990, 10.2106/JBJS.N.00057 · DOI
  85. Vachhani, 2018, Design of experiments confirms optimization of lithium administration parameters for enhanced fracture healing, J. Biomech., 66, 153, 10.1016/j.jbiomech.2017.09.043 · DOI
  86. Arioka, 2014, Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis, Biochem. Pharmacol., 90, 397, 10.1016/j.bcp.2014.06.011 · DOI
  87. Sisask, 2013, Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation, Bone, 54, 126, 10.1016/j.bone.2013.01.019 · DOI
  88. Phiel, 2001, Molecular targets of lithium action, Annu. Rev. Pharmacol. Toxicol., 41, 789, 10.1146/annurev.pharmtox.41.1.789 · DOI
  89. Zhang, 2003, Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3, The Journal of Biological Chemistry, 278, 10.1074/jbc.M212635200 · DOI
  90. Noble, 2005, Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo, Proc. Natl. Acad. Sci. U. S. A., 102, 6990, 10.1073/pnas.0500466102 · DOI · Paper page
  91. Cohen, 1998, Lithium carbonate therapy is not a risk factor for osteoporosis, Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme, 30
  92. Zamani, 2009, Lithium’s effect on bone mineral density, Bone, 44, 331, 10.1016/j.bone.2008.10.001 · DOI
  93. Vestergaard, 2005, Reduced relative risk of fractures among users of lithium, Calcif. Tissue Int., 77, 1, 10.1007/s00223-004-0258-y · DOI
  94. Meng, 2010, Protective effects of lithium chloride on bone loss in hindlimb unloading rats, Acta Academiae Medicinae Militaris Tertiae, 2010, 11
  95. Warden, 2010, Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels, Bone, 46, 985, 10.1016/j.bone.2009.12.031 · DOI
  96. Clement-Lacroix, 2005, Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice, Proc. Natl. Acad. Sci. U. S. A., 102, 17406, 10.1073/pnas.0505259102 · DOI
  97. Vachhani, 2018, Low-dose lithium regimen enhances endochondral fracture healing in osteoporotic rodent bone, Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 36, 1783, 10.1002/jor.23799 · DOI
  98. Marsell, 2012, GSK-3 inhibition by an orally active small molecule increases bone mass in rats, Bone, 50, 619, 10.1016/j.bone.2011.11.007 · DOI
  99. Kulkarni, 2006, Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo, J. Bone Miner. Res., 21, 910, 10.1359/jbmr.060316 · DOI
  100. Zhou, 2013, GSK-3α is a central regulator of age-related pathologies in mice, J. Clin. Invest., 123, 1821, 10.1172/JCI64398 · DOI
  101. M.D. Hoffman, M. Takahata, D.S.M. Benoit, 6-Bromoindirubin-3′-oxime (BIO) induces proliferation of human mesenchymal stem cells (hMSCs), IEEE, pp. 1–2. · DOI
  102. Lumetti, 2014, Pharmacological GSK-3beta inhibition improves osteoblast differentiation on titanium surfaces, J. Biol. Regul. Homeost. Agents, 28, 489
  103. Hoffman, 2015, Agonism of Wnt–β-catenin signalling promotes mesenchymal stem cell (MSC) expansion, J. Tissue Eng. Regen. Med., 9, E13, 10.1002/term.1736 · DOI
  104. Gunn, 2006, A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma, Stem Cells (Dayton, Ohio), 24, 10.1634/stemcells.2005-0220 · DOI
  105. Neves, 2017, Promotion of natural tooth repair by small molecule GSK3 antagonists, Sci. Rep., 7, 39654, 10.1038/srep39654 · DOI
  106. Newman, 2016, Local and targeted drug delivery for bone regeneration, Curr. Opin. Biotechnol., 40, 125, 10.1016/j.copbio.2016.02.029 · DOI
  107. Kyllonen, 2015, Local drug delivery for enhancing fracture healing in osteoporotic bone, Acta Biomater., 11, 412, 10.1016/j.actbio.2014.09.006 · DOI
  108. Duchartre, 2016, The Wnt signaling pathway in cancer, Crit. Rev. Oncol. Hematol., 99, 141, 10.1016/j.critrevonc.2015.12.005 · DOI
  109. Kahn, 2014, Can we safely target the WNT pathway?, Nat. Rev. Drug Discov., 13, 513, 10.1038/nrd4233 · DOI
  110. Low, 2015, Biodistribution of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture healing, Biomacromolecules, 16, 3145, 10.1021/acs.biomac.5b00777 · DOI
  111. ten Dijke, 2008, Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling, JBJS, 90, 31, 10.2106/JBJS.G.01183 · DOI
  112. Balemans, 2002, Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease, J. Med. Genet., 39, 91, 10.1136/jmg.39.2.91 · DOI · Paper page
  113. Hoeppner, 2009, Wnt signaling as a therapeutic target for bone diseases, Expert Opin. Ther. Targets, 13, 485, 10.1517/14728220902841961 · DOI
  114. McClung, 2017, Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential, Therapeutic advances in musculoskeletal disease, 9, 263, 10.1177/1759720X17726744 · DOI
  115. Shoback, 2020, Pharmacological management of osteoporosis in postmenopausal women: an endocrine society guideline update, The Journal of Clinical Endocrinology & Metabolism, 105, 587, 10.1210/clinem/dgaa048 · DOI
  116. Morse, 2015, Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength, Bone, 71, 155, 10.1016/j.bone.2014.10.018 · DOI
  117. McGee-Lawrence, 2013, Sclerostin deficient mice rapidly heal bone defects by activating beta-catenin and increasing intramembranous ossification, Biochem. Biophys. Res. Commun., 441, 886, 10.1016/j.bbrc.2013.10.155 · DOI
  118. Yee, 2016, Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model, Bone, 82, 122, 10.1016/j.bone.2015.04.048 · DOI
  119. Florio, 2016, A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair, Nat. Commun., 7, 11505, 10.1038/ncomms11505 · DOI
  120. Li, 2011, Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury, J. Bone Miner. Res., 26, 2610, 10.1002/jbmr.472 · DOI
  121. Tinsley, 2015, Systemic administration of sclerostin antibody enhances bone morphogenetic protein-induced femoral defect repair in a rat model, JBJS, 97, 1852, 10.2106/JBJS.O.00171 · DOI
  122. Holguin, 2016, CORR insights®: does sclerostin depletion stimulate fracture healing in a mouse model?, Clinical Orthopaedics and Related Research®, 474, 1303, 10.1007/s11999-016-4697-3 · DOI
  123. Ominsky, 2011, Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones, Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 26, 1012, 10.1002/jbmr.307 · DOI
  124. Cui, 2013, Time-dependent effects of sclerostin antibody on a mouse fracture healing model, J. Musculoskelet. Neuronal Interact., 13, 178
  125. Suen, 2014, Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats, Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 32, 997, 10.1002/jor.22636 · DOI
  126. McDonald, 2012, Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats, Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society, 30, 1541, 10.1002/jor.22109 · DOI
  127. Liu, 2016, Effects of sclerostin antibody on the healing of femoral fractures in ovariectomised rats, Calcif. Tissue Int., 98, 263, 10.1007/s00223-015-0085-3 · DOI
  128. Hamann, 2013, Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus, Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 28, 627, 10.1002/jbmr.1803 · DOI
  129. Morse, 2017, Sclerostin antibody increases callus size and strength but does not improve fracture union in a challenged open rat fracture model, Calcif. Tissue Int., 101, 217, 10.1007/s00223-017-0275-2 · DOI
  130. Jawad, 2013, Effects of sclerostin antibody on healing of a non-critical size femoral bone defect, Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society, 31, 155, 10.1002/jor.22186 · DOI
  131. Virk, 2013, Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model, J. Bone Joint Surg. Am., 95, 694, 10.2106/JBJS.L.00285 · DOI
  132. Alaee, 2014, Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model, Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 32, 197, 10.1002/jor.22498 · DOI
  133. Florio, 2016, A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair, Nat. Commun., 7, 11505, 10.1038/ncomms11505 · DOI
  134. Lin, 2009, Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/β-catenin signaling, J. Bone Miner. Res., 24, 1651, 10.1359/jbmr.090411 · DOI
  135. Kang, 2018, Loss of mechanosensitive sclerostin may accelerate cranial bone growth and regeneration, J. Neurosurg., 129, 1085, 10.3171/2017.5.JNS17219 · DOI
  136. Mao, 2002, Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling, Nature, 417, 664, 10.1038/nature756 · DOI · Paper page
  137. Schulze, 2010, Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2, PLoS One, 5, 10.1371/journal.pone.0010309 · DOI
  138. Kimura, 2016, CKAP4 is a Dickkopf1 receptor and is involved in tumor progression, J. Clin. Invest., 126, 2689, 10.1172/JCI84658 · DOI
  139. S.-W. Cha, E. Tadjuidje, Q. Tao, C. Wylie, J. Heasman, Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation, 135(22) (2008) 3719–3729. · DOI
  140. Glantschnig, 2010, Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo, J. Biol. Chem., 285, 40135, 10.1074/jbc.M110.166892 · DOI
  141. Brommage, 2010, Elevated bone mass in mice treated with anti-Dickkopf-1 neutralizing antibodies, Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 25, S81
  142. Glantschnig, 2011, A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody, J. Pharmacol. Exp. Ther., 338, 568, 10.1124/jpet.111.181404 · DOI
  143. Richards, 2011, Dkk1 inhibition promotes bone formation in growing, but not in aged osteopenic rats, Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 26
  144. Pepersack, 1994, Effects of lithium on bone resorption in cultured foetal rat long-bones, Eur. J. Clin. Investig., 24, 400, 10.1111/j.1365-2362.1994.tb02183.x · DOI
  145. Liedert, 2014, The role of midkine in skeletal remodelling, Br. J. Pharmacol., 171, 870, 10.1111/bph.12412 · DOI
  146. Ohta, 1999, Midkine is expressed during repair of bone fracture and promotes chondrogenesis, J. Bone Miner. Res., 14, 1132, 10.1359/jbmr.1999.14.7.1132 · DOI
  147. Haffner-Luntzer, 2016, Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus, Br. J. Pharmacol., 173, 2237, 10.1111/bph.13503 · DOI
  148. Haffner-Luntzer, 2016, Inhibition of midkine augments osteoporotic fracture healing, PLoS One, 11, 10.1371/journal.pone.0159278 · DOI
  149. Komiya, 2008, Wnt signal transduction pathways, Organogenesis, 4, 68, 10.4161/org.4.2.5851 · DOI · Paper page
  150. Lee, 2010, Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women, Menopause, 17, 1064, 10.1097/gme.0b013e3181da4da3 · DOI
  151. Ohnaka, 2009, Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women, Geriatr Gerontol Int, 9, 304, 10.1111/j.1447-0594.2009.00540.x · DOI
  152. Boudin, 2012, Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men, Mol. Genet. Metab., 106, 366, 10.1016/j.ymgme.2012.04.021 · DOI
  153. Sims, 2008, Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes, J. Bone Miner. Res., 23, 499, 10.1359/jbmr.071113 · DOI
  154. Bodine, 2007, Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1, J. Cell. Physiol., 210, 352, 10.1002/jcp.20834 · DOI
  155. Bodine, 2004, The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice, Mol. Endocrinol., 18, 1222, 10.1210/me.2003-0498 · DOI
  156. Bodine, 2009, A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation, Bone, 44, 1063, 10.1016/j.bone.2009.02.013 · DOI
  157. Moore, 2008, Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides, J. Med. Chem., 52, 105, 10.1021/jm801144h · DOI
  158. Li, 2007, Inhibition of SFRP1 reduces severity of periodontitis, J. Dent. Res., 86, 873, 10.1177/154405910708600913 · DOI
  159. Tinsley, 2015, Systemic administration of sclerostin antibody enhances bone morphogenetic protein-induced femoral defect repair in a rat model, J. Bone Joint Surg. Am., 97, 1852, 10.2106/JBJS.O.00171 · DOI
  160. Puolakkainen, 2017, Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model, PLoS One, 12, 10.1371/journal.pone.0180593 · DOI
  161. Teng, 2018, MiR-214-3p inhibits β-catenin signaling pathway leading to delayed fracture healing, Eur. Rev. Med. Pharmacol. Sci., 22, 17
  162. Ling, 2017, Increased Runx2 expression associated with enhanced Wnt signaling in PDLLA internal fixation for fracture treatment, Experimental and therapeutic medicine, 13, 2085, 10.3892/etm.2017.4216 · DOI
  163. Uslu, 2016, The effect of femoral nerve block on fracture healing via expressions of growth factors and β-catenin, Folia Histochem. Cytobiol., 54, 151, 10.5603/FHC.a2016.0017 · DOI
  164. Janda, 2017, Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling, Nature, 545, 234, 10.1038/nature22306 · DOI · Paper page
  165. Chen, 2020, Development of potent, selective surrogate WNT molecules and their application in defining frizzled requirements, Cell Chemical Biology, 27, 598, 10.1016/j.chembiol.2020.02.009 · DOI
  166. Luzi, 2008, Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor, J. Bone Miner. Res., 23, 287, 10.1359/jbmr.071011 · DOI
  167. Kapinas, 2010, miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop, Journal of Biological Chemistry, 285, 25221, 10.1074/jbc.M110.116137 · DOI
  168. Li, 2008, A microRNA signature for a BMP2-induced osteoblast lineage commitment program, Proc. Natl. Acad. Sci., 105, 13906, 10.1073/pnas.0804438105 · DOI
  169. Itoh, 2009, MicroRNA-141 and-200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5, J. Biol. Chem., 284, 19272, 10.1074/jbc.M109.014001 · DOI
  170. Williams, 2009, Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone, Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 24, 171, 10.1359/jbmr.081235 · DOI
  171. Richards, 2008, Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study, Lancet, 371, 1505, 10.1016/S0140-6736(08)60599-1 · DOI
  172. van Meurs, 2008, Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis, Jama, 299, 1277, 10.1001/jama.299.11.1277 · DOI
  173. Ai, 2005, Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling, Mol. Cell. Biol., 25, 4946, 10.1128/MCB.25.12.4946-4955.2005 · DOI
  174. Semenov, 2006, LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST, J. Biol. Chem., 281, 38276, 10.1074/jbc.M609509200 · DOI
  175. Gong, 2001, LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development, Cell, 107, 513, 10.1016/S0092-8674(01)00571-2 · DOI · Paper page

Cited by

Sorted by citations

See all 60

Metadata

Authors
Schupbach, D., Comeau-Gauthier, M., Harvey, E., & Merle, G.
Venue
Bone
Publisher
Elsevier BV
Published
2020-09
Volume
138
Pages
115491
ISSN
8756-3282
DOI
10.1016/j.bone.2020.115491
Cited by
60
References
7
Language
en
Licence
Funders
  • Fonds de Recherche du Québec - Santé
  • Orthopaedic Trauma Association

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review