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Cited by 68Gastrointestinal motility and disordersGut microbiota and healthDigestive system and related health

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

IBS Subjects with Methane on Lactulose Breath Test Have Lower Postprandial Serotonin Levels Than Subjects with Hydrogen

Pimentel, Mark, Kong, Yuthana, Park, Sandy·2004·Digestive Diseases and Sciences
DOI 10.1023/b:ddas.0000011607.24171.c0
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Abstract

We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serotonin in methane producing IBS subjects. Rome I-positive IBS subjects were recruited into the study after exclusion criteria were met. A fasting LBT was performed after subjects filled out a questionnaire rating the degree of constipation and diarrhea. Within 7 days of this test, subjects returned fasting for determination of serotonin before and after a 75-g oral glucose meal. The serotonin response was compared between hydrogen and methane producing IBS subjects. After 2 subjects were excluded for inadequate blood samples, 18 subjects completed the study. Four of 18 subjects produced methane. The postprandial serotonin level in methane producing IBS subjects was lower than in hydrogen producers (P < 0.05). Methane producers had a reduction in serotonin after glucose. Methane producing IBS subjects have reduced postprandial serotonin. Whether methane is a surrogate marker of constipation or contributing to the reduced serotonin remains to be determined.

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Crossref · 10.1023/b:ddas.0000011607.24171.c0

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30 of 30 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 7

  1. Lin HC, Pimentel M, Chen JH: Intestinal transit is slowed by luminal methane. Neurogastroenterol Motil 4:437, 2002
  2. Levitt MD, French P, Donaldson RM Jr: Use of hydrogen and methane excretion in the study of the intestinal flora. J Lab Clin Med 72:988, 1968 (abstr)
  3. Bond JH Jr, Engel RR, Levitt MD: Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. J Exp Med 133:572–588, 1971 · DOI
  4. Bjorneklett A, Jenssen E: Relationship between hydrogen (H2) and methane (CH4) production in man. Scand J Gastroenterol 17:985–992, 1982
  5. Bertaccini G: Tissue 5-hydroxytryptamine and urinary 5-hydroxyindoleacetic acid after partial or total removal of the gastrointestinal tract in the rat. J Physiol (Lond) 153:239–249, 1960 · DOI
  6. Espramer V, Testini A: Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. J Pharm Pharmacol 11:618–623, 1959 · DOI
  7. Kim D-Y, Camilleri M. Serotonin: A mediator of the brain-gut connection. Am J Gastroenterol 95:2698–2709, 2000 · DOI

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Metadata

Authors
Pimentel, M., Kong, Y., & Park, S.
Affiliations
Cedars-Sinai Medical Center (US)
Corresponding author
Pimentel, Mark
ORCID
Pimentel, Mark
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2004-01
Volume
49
Issue
1
Pages
84-87
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/b:ddas.0000011607.24171.c0
OpenAlex
W1972282778
Cited by
68
References
30
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 7
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Beatrice and Samuel A. Seaver Foundation
  • Cedars-Sinai Medical Center
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Keywords
irritable bowel syndrome, methane, hydrogen, lactulose breath test, constipation, small intestinal transit, glucose tolerance, gut microbiota, Rome I criteria
MeSH terms
Adolescent, Adult, Aged, Breath Tests, Chromatography, High Pressure Liquid, Constipation, Diarrhea, Female, Humans, Hydrogen, Lactulose, Male, Methane, Middle Aged, Surveys and Questionnaires, Serotonin, Postprandial Period, Irritable Bowel Syndrome

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