Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation
Open accessAbstract
Constipation is a common and burdensome gastrointestinal disorder that may result from altered gastrointestinal motility. The effect of probiotics on constipation has been increasingly investigated in both animal and human studies, showing promising results. However, there is still uncertainty regarding the mechanisms of action of probiotics on gut motility and constipation. Several factors are vital to normal gut motility, including immune and nervous system function, bile acid metabolism and mucus secretion, and the gastrointestinal microbiota and fermentation; an imbalance or dysfunction in any of these components may contribute to aberrant gut motility and, consequently, symptoms of constipation. For example, adults with functional constipation have significantly decreased numbers of bifidobacteria (with one study showing a mean difference of 1 log 10/g) and lactobacilli (mean difference, 1.4 log 10/g) in stool samples, as well as higher breath methane, compared with control subjects. Modifying the gut luminal environment with certain probiotic strains may affect motility and secretion in the gut and, hence, provide a benefit for patients with constipation. Therefore, this review explores the mechanisms through which probiotics may exert an effect on gut motility and constipation. Nevertheless, the majority of current evidence is derived from animal studies, and therefore, further human studies are needed to determine the mechanisms through specific probiotic strains that might be effective in constipation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbiota plays a crucial role in gut motility.
“Gut microbiota, which comprises a complex community of micro-organisms inhabiting the gastrointestinal tract, including bacteria, viruses, fungi and other micro-organisms, plays a crucial role in gut motility.6”
Patients with chronic constipation often exhibit increased proliferation of T cells and lymphocytes such as CD4+ T cells and CD8+ T cells, indicating activation of T cell-mediated cellular immunity.
“Patients with chronic constipation often exhibit increased proliferation of T cells and lymphocytes such as CD4 + T cells and CD8 + T cells, indicating the activation of T cellmediated cellular immunity.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
Inflammation-induced adherence and immune responses by CD8+ T cells on intestinal neurons can lead to acute neuronal injury, colorectal dilation, and slowed colonic water transport, resulting in development or worsening of constipation symptoms.
“Inf lammation-induced adherence and immune responses by CD8 + T cells on intestinal neurons can lead to acute neuronal injury, colorectal dilation, and slowed colonic water transport, which can result in the development or worsening of constipation symptoms [27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
Substance P stored in visceral neurons stimulates smooth muscle contraction and amplifies visceral pain; when constipation occurs in central nervous system disorders, nerves containing SP are stimulated, leading to release of stored SP and resulting in abdominal pain.
“In addition, substance P (SP) stored in visceral neurons stimulates smooth muscle contraction and amplifies visceral pain; when constipation occurs in central nervous system disorders, nerves containing SP are stimulated, leading to the release of stored SP and resulting in abdominal pain [8,22,27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
The production of endogenous substances by the intestinal microbiota can affect intestinal motility.
“The production of endogenous substances by the intestinal microbiota can also affect intestinal motility [27,31,38].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 1× · see citing works
“The gastrointestinal microbiota plays a crucial role in the normal development of the CNS (23) and seems to interact with both the CNS and gut (24) through microbiota–enterochromaffin cells–vagal afferent nerve signaling (25).”
BackgroundConsumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Probiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H. S., & Salminen, S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,021 · see citing works
Chronic constipation: a survey of the patient perspective
JOHANSON, J. F., & KRALSTEIN, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03238.x · Cited by 617 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511 · see citing works
Pimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508 · see citing works
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496 · see citing works
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 493 · see citing works
Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats
Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya, M., Mantyh, C., Voss, M., Eubanks, S., Harris, M., Pappas, T. N., & Takahashi, T. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00442.2002 · Cited by 465 · see citing works
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · see citing works
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417 · see citing works
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396 · see citing works
KHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works
Structural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381 · see citing works
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works
Alemi, F., Poole, D. P., Chiu, J., Schoonjans, K., Cattaruzza, F., Grider, J. R., Bunnett, N. W., & Corvera, C. U. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.09.055 · Cited by 362 · see citing works
Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019)
Arunachalam, K. D., Gill, H., & Chandra, R. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600938 · Cited by 336 · see citing works
Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328 · see citing works
Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease
Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00230.x · Cited by 325 · see citing works
AGRAWAL, A., HOUGHTON, L. A., MORRIS, J., REILLY, B., GUYONNET, D., GOUPIL FEUILLERAT, N., SCHLUMBERGER, A., JAKOB, S., & WHORWELL, P. J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03853.x · Cited by 322 · cited 2× · see citing works
“Agrawal et al., 2009 (9) 41 Constipation (Rome III for IBS-C) B. lactis DN-173 010 (2.5 3 1010 CFU/d) Nonfermented dairy product 4 wk ROM technique (24 ROM/d for 3 d, X-ray on day 4) Gut transit time was significantly reduced in the probiotic group compared with the placebo group (mean difference:…”
BackgroundInfluentialHusebye, E., Hellström, P. M., Sundler, F., Chen, J., & Midtvedt, T. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.3.g368 · Cited by 319 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Self-citationShort-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
Cherbut, C., Ferrier, L., Rozé, C., Anini, Y., Blottière, H. M., Lecannu, G., & Galmiche, J. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1415 · Cited by 316 · see citing works
Brun, P., Giron, M. C., Qesari, M., Porzionato, A., Caputi, V., Zoppellaro, C., Banzato, S., Grillo, A. R., Spagnol, L., De Caro, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.047 · Cited by 300 · see citing works
Sensory transmission in the gastrointestinal tract
Blackshaw, L. A., Brookes, S. J., Grundy, D., & Schemann, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00871.x · Cited by 285 · see citing works
Histochemistry of the surface mucous gel layer of the human colon.
Matsuo, K., Ota, H., Akamatsu, T., Sugiyama, A., & Katsuyama, T. (1997) · Gut · doi:10.1136/gut.40.6.782 · Cited by 271 · see citing works
Microbial endocrinology and infectious disease in the 21st century
Lyte, M. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2003.11.004 · Cited by 268 · see citing works
Attaluri, A., Jackson, M., Valestin, J., & Rao, S. S. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.655 · Cited by 261 · see citing works
Changes of the human gut microbiome induced by a fermented milk product
Veiga, P., Pons, N., Agrawal, A., Oozeer, R., Guyonnet, D., Brazeilles, R., Faurie, J., Vlieg, J. E. T. V. H., Houghton, L. A., Whorwell, P. J., et al. (2014) · Scientific Reports · doi:10.1038/srep06328 · Cited by 257 · see citing works
Methanogens, Methane and Gastrointestinal Motility
Triantafyllou, K., Chang, C., & Pimentel, M. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2014.20.1.31 · Cited by 254 · see citing works
Marteau, P., Cuillerier, E., Meance, S., Gerhardt, M. F., Myara, A., Bouvier, M., Bouley, C., Tondu, F., Bommelaer, G., & Grimaud, J. C. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01188.x · Cited by 254 · see citing works
Effect of the Normal Microbial Flora on Gastrointestinal Motility.
Abrams, G. D., & Bishop, J. E. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-126-32430 · Cited by 242 · see citing works
Kidd, M. S., Modlin, I. M., Gustafsson, B. I., Drozdov, I. A., Hauso, Ø., & Pfragner, R. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00056.2008 · Cited by 234 · see citing works
Liu, M., Rothstein, J. D., Gershon, M. D., & Kirchgessner, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04764.1997 · Cited by 224 · see citing works
Ibnou-Zekri, N., Blum, S., Schiffrin, E. J., & von der Weid, T. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.428-436.2003 · Cited by 216 · see citing works
Contractile effect of short‐chain fatty acids on the isolated colon of the rat.
Yajima, T. (1985) · Journal of Physiology · doi:10.1113/jphysiol.1985.sp015882 · Cited by 215 · see citing works
Increasing butyrate concentration in the distal colon by accelerating intestinal transit
Lewis, S. J., & Heaton, K. W. (1997) · Gut · doi:10.1136/gut.41.2.245 · Cited by 213 · see citing works
Waller, P. A., Gopal, P. K., Leyer, G. J., Ouwehand, A. C., Reifer, C., Stewart, M. E., & Miller, L. E. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.584895 · Cited by 195 · see citing works
Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome
Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193 · see citing works
Ouwehand, A. C., Lagström, H., Suomalainen, T., & Salminen, S. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000063075 · Cited by 185 · see citing works
Kim, S.-E., Choi, S. C., Park, K. S., Park, M. I., Shin, J. E., Lee, T. H., Jung, K. W., Koo, H. S., & Myung, S.-J. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14048 · Cited by 180 · see citing works
Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat
Uribe, A., Alam, M., Johansson, O., Midtvedt, T., & Theodorsson, E. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90526-6 · Cited by 171 · see citing works
Lactulose, Lactic Acid Bacteria, Intestinal Microecology and Mucosal Protection
Salminen, S., & Salminen, E. K. (1997) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1997.11720717 · Cited by 170 · see citing works
Husebye, E., Hellström, P. M., & Midtvedt, T. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087542 · Cited by 169 · see citing works
The intestinal ecosystem in chronic functional constipation
Zoppi, G., Cinquetti, M., Luciano, A., Benini, A., Muner, A., & Minelli, E. B. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01547.x · Cited by 169 · see citing works
Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00965.x · Cited by 164 · see citing works
Short-Chain Fatty Acids Stimulate Ileal Motility in Humans
Kamath, P. S., Phillips, S. F., & Zinsmeister, A. R. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80068-4 · Cited by 153 · see citing works
Akiho, H., Deng, Y., Blennerhassett, P. A., Kanbayashi, H., & Collins, S. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.049 · Cited by 145 · see citing works
Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
Skehel, P., Fabian‐Fine, R., & Kandel, E. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1101 · Cited by 144 · see citing works
Principles of applied neurogastroenterology: physiology/motility–sensation
Kellow, J. E., Delvaux, M. M., Azpiroz, F., Camilleri, M., Quigley, E. M. M., & Thompson, D. G. (1999) · Gut · doi:10.1136/gut.45.2008.ii17 · Cited by 140 · see citing works
How to Interpret a Functional or Motility Test - Colon Transit Study
Kim, E. R., & Rhee, P. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.1.94 · Cited by 138 · see citing works
Wong, B. S., Camilleri, M., McKinzie, S., Burton, D., Graffner, H., & Zinsmeister, A. R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.285 · Cited by 133 · see citing works
Jahng, J., Jung, I. S., Choi, E. J., Conklin, J. L., & Park, H. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01819.x · Cited by 132 · see citing works
Grasa, L., Abecia, L., Forcén, R., Castro, M., de Jalón, J. A. G., Latorre, E., Alcalde, A. I., & Murillo, M. D. (2015) · Microbial Ecology · doi:10.1007/s00248-015-0613-8 · Cited by 128 · see citing works
Ng, S. C., Benjamin, J. L., McCarthy, N. E., Hedin, C. R. H., Koutsoumpas, A. L., Plamondon, S., Price, C. L., Hart, A. L., Kamm, M. A., Forbes, A., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21590 · Cited by 122 · see citing works
Self-citationDinning, P., Wiklendt, L., Maslen, L., Patton, V., Lewis, H., Arkwright, J., Wattchow, D., Lubowski, D., Costa, M., & Bampton, P. (2015) · Neurogastroenterology and Motility · doi:10.1111/nmo.12502 · Cited by 119 · see citing works
Applied Principles of Neurogastroenterology: Physiology/Motility Sensation
Kellow, J. E., Azpiroz, F., Delvaux, M. M., Gebhart, G. F., Mertz, H. R., Quigley, E. M. M., & Smout, A. J. P. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.061 · Cited by 117 · see citing works
Bär, F., Von Koschitzky, H., Roblick, U., Bruch, H. P., Schulze, L., Sonnenborn, U., Böttner, M., & Wedel, T. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01258.x · Cited by 113 · see citing works
Decreased substance P levels in rectal biopsies from patients with slow transit constipation
Tzavella, K., Riepl, R. L., Klauser, A. G., Voderholzer, W. A., Schindlbeck, N. E., & ller-Lissner, S. A. M. U. (1996) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199612000-00014 · Cited by 109 · see citing works
Decreased colonic mucus in rats with loperamide-induced constipation
Shimotoyodome, A., Meguro, S., Hase, T., Tokimitsu, I., & Sakata, T. (2000) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(00)00194-x · Cited by 108 · see citing works
Dinning, P. G., Zárate-López, N., Hunt, L. M., Fuentealba, S. E., Mohammed, S. D., Szczesniak, M. M., Lubowski, D. Z., Preston, S. L., Fairclough, P. D., Lunniss, P. J., et al. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01597.x · Cited by 101 · see citing works
Self-citationImpact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys
Kieffer, D. A., Martin, R. J., & Adams, S. H. (2016) · Advances in Nutrition · doi:10.3945/an.116.013219 · Cited by 100 · see citing works
Wang, B., Mao, Y., Diorio, C. J., Pasyk, M., Wu, R., Bienenstock, J., & Kunze, W. (2010) · The FASEB Journal · doi:10.1096/fj.09-153841 · Cited by 98 · see citing works
O'Morain, C. A., Bishop, A. E., McGregor, G. P., Levi, A. J., Bloom, S. R., Polak, J. M., & Peters, T. J. (1984) · Gut · doi:10.1136/gut.25.1.57 · Cited by 93 · see citing works
Upper gastrointestinal motor activity in patients with slow-transit constipation
Bassotti, G., Stanghellini, Chiarioni, G., Germani, U., GIORGIO, R. D., Vantini, I., Morelli, A., & Corinaldesi, R. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02093603 · Cited by 88 · see citing works
Crohn's disease: A scanning electron microscopic study
Dvořàk, A. M., Connell, A. B., & Dickersin, G. R. (1979) · Human Pathology · doi:10.1016/s0046-8177(79)80006-4 · Cited by 87 · see citing works
Matsumoto, K., Takada, T., Shimizu, K., Kado, Y., Kawakami, K., Makino, I., Yamaoka, Y., Hirano, K., Nishimura, A., Kajimoto, O., et al. (2006) · Bioscience and Microflora · doi:10.12938/bifidus.25.39 · Cited by 86 · see citing works
Short chain fatty acids stimulate feline colonic smooth muscle contraction
Rondeau, M. P., Meltzer, K., Michel, K. E., McManus, C. M., & Washabau, R. J. (2003) · Journal of Feline Medicine and Surgery · doi:10.1016/s1098-612x(03)00002-0 · Cited by 85 · see citing works
Riezzo, G., Orlando, A., D’Attoma, B., Guerra, V., Valerio, F., Lavermicocca, P., & de Candia, S. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04970.x · Cited by 84 · see citing works
Ishizuka, A., Tomizuka, K., Aoki, R., Nishijima, T., Saito, Y., Inoue, R., Ushida, K., Mawatari, T., & Ikeda, T. (2012) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2011.12.016 · Cited by 73 · see citing works
Keely, S. J., Scharl, M. M., Bertelsen, L. S., Hagey, L. R., Barrett, K. E., & Hofmann, A. F. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00076.2006 · Cited by 72 · see citing works
Pimentel, M., Kong, Y., & Park, S. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000011607.24171.c0 · Cited by 68 · see citing works
Abrahamsson, H., Östlund-Lindqvist, A.-M., Nilsson, R., Simrén, M., & Gillberg, P.-G. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802321212 · Cited by 67 · see citing works
Marsono, Y., Illman, R. J., Clarke, J. M., Trimble, R. P., & Topping, D. L. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930144 · Cited by 65 · see citing works
Furnari, M., Savarino, E. V., Bruzzone, L., Moscatelli, A., Gemignani, L., Giannini, E. G., Zentilin, P., Dulbecco, P., & Savarino (2012) · PubMed · Cited by 63 · see citing works
de la Serna, H., Porras, M., & Vergara, P. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104620 · Cited by 60 · see citing works
Lee, K.-M., Paik, C.-N., Chung, W. C., Yang, J.-M., & Choi, M.-G. (2013) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835eb916 · Cited by 59 · see citing works
Shimotoyodome, A., Meguro, S., Hase, T., Tokimitsu, I., & Sakata, T. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010644021888 · Cited by 58 · see citing works
Evidence for a functional cholinergic deficit in human colonic tissue resected for constipation
Burleigh, D. E. (1988) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1988.tb05151.x · Cited by 56 · see citing works
Effect of Lactobacillus casei Shirota on colonic transit time in patients with chronic constipation
Krammer, H.-J., von Seggern, H., Schaumburg, J., & Neumer, F. (2011) · coloproctology · doi:10.1007/s00053-011-0177-0 · Cited by 54 · see citing works
The nervous system and gastrointestinal function
Altaf, M. A., & Sood, M. R. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.15 · Cited by 53 · see citing works
Effects of bacterial flora on cecal size and transit rate of intestinal contents in mice.
Iwaï, H., Ishihara, Y., YAMANAKA, J., & Ito, T. (1973) · PubMed · Cited by 51 · see citing works
Rebollar, E., Arruebo, M. P., Plaza, M. Á., & Murillo, M. D. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00364.x · Cited by 45 · see citing works
Sakai, T., Makino, H., Ishikawa, E., Oishi, K., & Kushiro, A. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.542408 · Cited by 44 · see citing works
Effect of Acute Mucosal Exposure to Lactobacillus rhamnosus GG on Human Colonic Smooth Muscle Cells
Guarino, M. P. L., Altomare, A., Stasi, E., Marignani, M., Severi, C., Alloni, R., Dicuonzo, G., Morelli, L., Coppola, R., & Cicala, M. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817e1cac · Cited by 40 · see citing works
Effect of deoxycholic acid on colonic motility in the rabbit
Snape, W. J., Shiff, S. J., & Cohen, S. (1980) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1980.238.4.g321 · Cited by 38 · see citing works
Karlström, L., Cassuto, J., Jodal, M., & Lundgren, O. (1986) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528609003083 · Cited by 36 · see citing works
Canonici, A., Pellegrino, E., Siret, C., Terciolo, C., Czerucka, D., Bastonero, S., Marvaldi, J. L., Lombardo, D., Rigot, V., & André, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045047 · Cited by 34 · see citing works
Giuliani, S., Santicioli, P., Tramontana, M., Geppetti, P., & Maggi, C. A. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12241.x · Cited by 32 · see citing works
Farmer, S. G., Jm, B., & Pollock, D. (1983) · PubMed · Cited by 32 · see citing works
Jouët, P., Moussata, D., Duboc, H., Boschetti, G., Attar, A., Gorbatchef, C., Sabate, J., Coffin, B., & Flourié, B. (2013) · Neurogastroenterology and Motility · doi:10.1111/nmo.12212 · Cited by 29 · see citing works
Liu, Z.-M., Xu, Z.-Y., Han, M., & Guo, B.-H. (2015) · International Dairy Journal · doi:10.1016/j.idairyj.2014.08.009 · Cited by 29 · see citing works
Chronic constipation: Lessons from animal studies
Zárate, N., & Spencer, N. J. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.12.003 · Cited by 24 · see citing works
The stressed gut: Contributions of intestinal stress peptides to inflammation and motility
Bunnett, N. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503092102 · Cited by 21 · see citing works
Neuroendocrine control of intestinal mucosal mast cells under physiological conditions
Vergara, P., Saavedra, Y., & Juanola, C. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00300.x · Cited by 18 · see citing works
Microflora of Patients with Stool Abnormality
Shimoyama, T., Hori, S., Tamura, K., Yamamura, M., Tanaka, M., & YAMAZAKI, K. (1984) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.3.1_35 · Cited by 15 · see citing works
Merenstein, D. J., D'Amico, F. J., Palese, C., Hahn, A., Sparenborg, J., Tan, T., Scott, H., Polzin, K. M., Kolberg, L. W., & Roberts, R. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002237 · Cited by 12 · see citing works
Probiotics: assessing health professionals' knowledge and understanding
Johnson, N., Thomas, L. V., & Jordan, D. (2016) · Gastrointestinal Nursing · doi:10.12968/gasn.2016.14.1.26 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14.
- Farmer SG. The effect of betamethasone on altered responsiveness of isolated intestine from rats infected with Nippostrongylus brasiliensis (abstr). Br J Pharmacol 1982;76:192P.
Cited by
Sorted by citations
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102534 · Cited by 642 · see citing works
Advancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 322 · see citing works
Probiotics in Medicine: A Long Debate
Stavropoulou, E., & Bezirtzoglou, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02192 · Cited by 295 · see citing works
Postbiotics in Human Health: A Narrative Review
Ma, L., Tu, H., & Chen, T. (2023) · Nutrients · doi:10.3390/nu15020291 · Cited by 237 · see citing works
Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study
Tan, A. H., Lim, S.-Y., Chong, K. K., A Manap, M. A. A., Hor, J. W., Lim, J. L., Low, S. C., Chong, C. W., Mahadeva, S., & Lang, A. E. (2021) · Neurology · doi:10.1212/wnl.0000000000010998 · Cited by 226 · see citing works
Blue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, F., Leeming, E. R., Dimidi, E., Mazidi, M., Franks, P. W., Khatib, H. A., Valdes, A. M., Davies, R., Bakker, E., Francis, L., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323877 · Cited by 208 · see citing works
Self-citationWernimont, S., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D., MacLeay, J., Jewell, D., & Suchodolski, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 173 · see citing works
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health
Wan, Z., Zheng, J., Zhu, Z., Sang, L., Zhu, J., Luo, S., Zhao, Y., Wang, R., Zhang, Y., Hao, K., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1031502 · Cited by 201 · see citing works
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases
Biazzo, M., & Deidda, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144119 · Cited by 166 · see citing works
Probiotics for Parkinson’s Disease
Gazerani, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174121 · Cited by 152 · see citing works
Cisplatin Mouse Models: Treatment, Toxicity and Translatability
Perše, M. (2021) · Biomedicines · doi:10.3390/biomedicines9101406 · Cited by 141 · see citing works
Horve, P. F., Lloyd, S., Mhuireach, G. Á., Dietz, L. G., Fretz, M., MacCrone, G., Wymelenberg, K. G. V. D., & Ishaq, S. L. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-019-0157-y · Cited by 134 · see citing works
Ballini, A., Santacroce, L., Cantore, S., Bottalico, L., Dipalma, G., Topi, S., Saini, R., Vito, D. D., & Inchingolo, F. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666181221150352 · Cited by 132 · see citing works
Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131 · see citing works
Wang, L., Cen, S., Wang, G., Lee, Y. K., Zhao, J., Zhang, H., & Chen, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103953 · Cited by 123 · see citing works
Pesticide exposure and the microbiota-gut-brain axis
Matsuzaki, R., Gunnigle, E., Geissen, V., Clarke, G. A., Nagpal, J. K., & Cryan, J. F. (2023) · The ISME Journal · doi:10.1038/s41396-023-01450-9 · Cited by 117 · see citing works
Probiotic mechanisms of action
Halloran, K., & Underwood, M. A. (2019) · Early Human Development · doi:10.1016/j.earlhumdev.2019.05.010 · Cited by 116 · see citing works
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 121 · see citing works
Dixon, A., Robertson, K., Yung, A. E., Que, M. S., Randall, H., Wellalagodage, D., Cox, T., Robertson, D., Chi, C., & Sun, J. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01080-y · Cited by 112 · see citing works
Probiotics for constipation and gut microbiota in Parkinson's disease
Du, Y., Li, Y., Xu, X., Li, R., Zhang, M., Cui, Y., Zhang, L., Wei, Z. Z., Wang, S., & Tuo, H. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.08.022 · Cited by 103 · see citing works
Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation
Wang, J.-K., & Yao, S.-K. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/5560310 · Cited by 98 · see citing works
Rao, S. S. C., & Brenner, D. M. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001222 · Cited by 97 · see citing works
Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review
Zimmermann, P., & Curtis, N. C. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316659 · Cited by 97 · see citing works
Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review
Senn, V., Bassler, D., Choudhury, R. A., Scholkmann, F., Righini‐Grunder, F., Vuille-dit-Bille, R. N., & Restin, T. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.573735 · Cited by 97 · see citing works
Wang, J., Liang, Q., Zhao, Q., Tang, Q., Ahmed, A. F., Zhang, Y., & Kang, W. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112305 · Cited by 96 · see citing works
Wegh, C. A. M., Baaleman, D. F., Tabbers, M. M., Smidt, H., & Benninga, M. A. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.09.010 · Cited by 100 · see citing works
Bajramagić, S., Hodžić, E., Mulabdić, A., Holjan, S., Vinčević-Smajlović, S., & Rovcanin, A. (2019) · Medical Archives · doi:10.5455/medarh.2019.73.316-320 · Cited by 91 · see citing works
Dimidi, E., Scott, S. M., & Whelan, K. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000934 · Cited by 89 · see citing works
Self-citationA key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation
Zhang, C., Yu, L., Ma, C., Jiang, S., Zhang, Y., Wang, S., Tian, F., Xue, Y., Zhao, J., Zhang, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.10.011 · Cited by 90 · see citing works
Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review
Cheng, J., Laitila, A., & Ouwehand, A. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790561 · Cited by 90 · see citing works
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R., Dimidi, E., Fikree, A., Ford, A. C., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14050 · Cited by 93 · see citing works
Self-citationDimidi, E., Zdanaviciene, A., Christodoulides, S., Taheri, S., Louis, P., Duncan, P. I., Emami, N., Crabbé, R., De Castro, C. A., McLean, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15073 · Cited by 80 · see citing works
Self-citationAction Mode of Gut Motility, Fluid and Electrolyte Transport in Chronic Constipation
Zhao, Q., Chen, Y., Xu, D., Yue, S., Fu, R., Yang, J., Xing, L.-M., & Tang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.630249 · Cited by 78 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79 · see citing works
Leta, V., Chaudhuri, К. R., Milner, O., Chung‐Faye, G., Metta, V., Pariante, C. M., & Borsini, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.026 · Cited by 77 · see citing works
Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B. R., Shen, B., Liao, Q., Xie, Z., & Hong, Y. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110569 · Cited by 74 · see citing works
Takeda, T., Asaoka, D., Nojiri, S., Yanagisawa, N., Nishizaki, Y., Osada, T., Koido, S., Nagahara, A., Katsumata, N., Odamaki, T., et al. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002028 · Cited by 74 · see citing works
Saviano, A., Brigida, M., Migneco, A., Gunawardena, G., Zanza, C., Candelli, M., Franceschi, F., & Ojetti, V. (2021) · Medicina · doi:10.3390/medicina57070643 · Cited by 73 · see citing works
Wang, G., Yang, S., Sun, S., Si, Q., Wang, L., Zhang, Q., Wu, G., Zhao, J., Zhang, H., & Chen, W. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00423 · Cited by 72 · see citing works
Xu, Y., Shao, M., Fang, X., Tang, W., Zhou, C., Hu, X., Zhang, X., & Su, K. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.014 · Cited by 70 · see citing works
Chamberlain, C. A., Hatch, M., & Garrett, T. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222393 · Cited by 69 · see citing works
Chu, J. R., Kang, S.-Y., Kim, S.-E., Lee, S.-J., Lee, Y., & Sung, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i40.6129 · Cited by 70 · see citing works
Dysbiosis in Functional Bowel Disorders
Enck, P., & Mazurak, N. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000488773 · Cited by 68 · see citing works
Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice
Wang, L., Chai, M., Wang, J., Yu, Q., Wang, G., Zhang, H., Zhao, J., & Chen, W. (2022) · Food & Function · doi:10.1039/d1fo04151g · Cited by 66 · see citing works
Chronic Kidney Disease, Gut Dysbiosis, and Constipation: A Burdensome Triplet
Ikee, R., Sasaki, N., Yasuda, T., & Fukazawa, S. (2020) · Microorganisms · doi:10.3390/microorganisms8121862 · Cited by 65 · see citing works
Chen, C.-M., Wu, C.-C., Huang, C.-L., Chang, M.-Y., Cheng, S.-H., Lin, C.-T., & Tsai, Y.-C. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09814-3 · Cited by 63 · see citing works
Characterization of gut contractility and microbiota in patients with severe chronic constipation
Рашидовна, Я. Д., Ulfatovich, S. M., Андреевич, С. К., Arzamastseva, A. A., Shaidullov, I. F., Markelova, M., Grigoryeva, T. V., Karpukhin, O. Y., & Ситдикова, Г. Ф. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235985 · Cited by 62 · see citing works
Musthaq, S., Mazuy, A., & Jakus, J. R. (2018) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2018.03.012 · Cited by 64 · see citing works
The Interaction of Microbiome and Pancreas in Acute Pancreatitis
Zhang, C., Li, G., Lu, T., Liu, L., Sui, Y., Bai, R., Li, L., & Sun, B. (2023) · Biomolecules · doi:10.3390/biom14010059 · Cited by 61 · see citing works
Zhang, X., Zheng, J., Jiang, N., Sun, G., Bao, X., Kong, M., Cheng, X., Lin, A., & Liu, H. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105676 · Cited by 60 · see citing works
Gu, Y., Qin, X., Zhou, G., Wang, C., Mu, C., Liu, X., Zhong, W., Xu, X. J., Wang, B., Jiang, K., et al. (2022) · Food & Function · doi:10.1039/d2fo01900k · Cited by 61 · see citing works
Yak Milk: Nutritional Value, Functional Activity, and Current Applications
Wang, D., Zhou, Y., Zheng, X., Guo, J., Duan, H., Zhou, S., & Yan, W. (2023) · Foods · doi:10.3390/foods12112090 · Cited by 60 · see citing works
Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies
Zhu, Y., Mei, Q., Fu, Y., & Zeng, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111850 · Cited by 64 · see citing works
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
Yang, L., Wan, Y., Li, W., Liu, C., Li, H., Dong, Z., Zhu, K., Jiang, S., Shang, E., Qian, D., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11813-5 · Cited by 59 · see citing works
Araújo, M. M., & Botelho, P. B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.935830 · Cited by 58 · see citing works
Pre-, pro- and synbiotics in cancer prevention and treatment—a review of basic and clinical research
Scott, A. J., Merrifield, C. A., Younes, J. A., & Pekelharing, E. P. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.869 · Cited by 58 · see citing works
Xie, L., Chen, X., Fan, Y., Li, Y., Wang, Y., Zhang, X., Yu, S., Wang, J., Chai, R., Zhao, Z., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03152-2 · Cited by 54 · see citing works
Revisiting the intestinal microbiome and its role in Diarrhea and constipation
Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53 · see citing works
Kang, S., Park, M. Y., Brooks, I., Lee, J., Kim, S. H., Kim, J. Y., Oh, B., Kim, J. W., & Kwon, O. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110428 · Cited by 53 · see citing works
Fu, R., Li, Z., Zhou, R., Li, C., Shao, S., & Li, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1973356 · Cited by 53 · see citing works
Pediococcus acidilactici Strains Improve Constipation Symptoms and Regulate Intestinal Flora in Mice
Qiao, Y., Qiu, Z., Tian, F., Yu, L., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.655258 · Cited by 50 · see citing works
Probiotics in Functional Gastrointestinal Disorders
Hojsak, I. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_321 · Cited by 51 · see citing works
Probiotic-driven advancement: Exploring the intricacies of mineral absorption in the human body
Varvara, R.-A., & Vodnar, D. C. (2023) · Food Chemistry X · doi:10.1016/j.fochx.2023.101067 · Cited by 48 · see citing works
Šola, K. F., Vladimir‐Knežević, S., Hrabač, P., Mucalo, I., Saso, L., & Verbanac, D. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-022-01189-0 · Cited by 47 · see citing works
Taverniti, V., Cesari, V., Gargari, G., Rossi, U. G., Biddau, C., Lecchi, C., Fiore, W., Arioli, S., Toschi, I., & Guglielmetti, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.706135 · Cited by 48 · see citing works
The protective effects of yellow tea extract against loperamide-induced constipation in mice
Cao, P.-Q., Li, X., Ouyang, J., Jiang, R., Huang, F.-F., Wen, B., Zhang, X.-N., Huang, J., & Liu, Z. (2021) · Food & Function · doi:10.1039/d0fo02969f · Cited by 47 · see citing works
Probiotics in Irritable Bowel Syndrome: A Review of Their Therapeutic Role
Kumar, L. S., Pugalenthi, L. S., Ahmad, M., Reddy, S., Barkhane, Z., & Elmadi, J. (2022) · Cureus · doi:10.7759/cureus.24240 · Cited by 52 · see citing works
Microbial treatment: the potential application for Parkinson’s disease
Fang, X. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3641-6 · Cited by 45 · see citing works
Botelho, P. B., Ferreira, M. V. R., Araújo, A. D. M., Mendes, M. M., & Nakano, E. Y. (2020) · Nutrition · doi:10.1016/j.nut.2020.110890 · Cited by 47 · see citing works
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight
Angoa‐Pérez, M., & Kuhn, D. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000144 · Cited by 44 · see citing works
Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism
Wang, M., Cha, R., Hao, W., Du, R., Zhang, P., Hu, Y., & Jiang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c05809 · Cited by 43 · see citing works
Qu, L., Li, Y., Liu, F., Fang, Y., He, J., Ma, J., Xu, T., Wang, L., Lei, P., Dong, H., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0823-2 · Cited by 46 · see citing works
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04894-5 · Cited by 43 · see citing works
Cao, J., Wang, K., Li, N., Zhang, L., Qin, L., He, Y., Wang, J., Qu, C., & Miao, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.243 · Cited by 42 · see citing works
Zhao, X., Qian, Y., Li, G., Yi, R., Park, K., & Song, J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15206 · Cited by 41 · see citing works
Constipation in chronic kidney disease: it is time to reconsider
Ikee, R., Yano, K., & Tsuru, T. (2019) · Renal Replacement Therapy · doi:10.1186/s41100-019-0246-3 · Cited by 40 · see citing works
Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15194230 · Cited by 40 · see citing works
Wegh, C. A. M., Benninga, M. A., & Tabbers, M. M. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001054 · Cited by 40 · see citing works
Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review
Jayanama, K., & Theou, O. (2019) · Current Clinical Pharmacology · doi:10.2174/1574884714666191120124548 · Cited by 40 · see citing works
Probiotic Potential of Bacillus licheniformis and Bacillus pumilus Isolated from Tibetan Yaks, China
Zeng, Z., Zhang, J., Li, Y., Li, K., Gong, S., Li, F., Wang, P., Iqbal, M., Kulyar, M. F., & Li, J. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09939-z · Cited by 39 · see citing works
Qi, B., Zhang, Y., Ren, D., Qin, X., Wang, N., & Yang, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07709 · Cited by 39 · see citing works
Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials
Hong, C., Chen, J., & Huang, T. (2022) · Aging · doi:10.18632/aging.204266 · Cited by 38 · see citing works
Food supplements and diet as treatment options in irritable bowel syndrome
Dimidi, E., & Whelan, K. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13951 · Cited by 38 · see citing works
Self-citationFang, S., Wu, S., Ji, L., Fan, Y., Wang, X., & Yang, K. (2021) · Medicine · doi:10.1097/md.0000000000025390 · Cited by 38 · see citing works
Liu, L., Tian, F., Li, G.-Y., Xu, W., & Xia, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1012087 · Cited by 39 · see citing works
Deidda, G., & Biazzo, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.753915 · Cited by 36 · see citing works
Effects of probiotics on loperamide-induced constipation in rats
Inatomi, T., & Honma, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02931-7 · Cited by 37 · see citing works
Efficacy and safety of probiotics in Parkinson’s constipation: A systematic review and meta-analysis
Xie, L., Chen, D., Xinghui, Z., & Cheng, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1007654 · Cited by 37 · see citing works
Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation
Wang, J., Wang, L., Yu, Q., Tang, N., Mei, C., Zhang, H., Wang, G., Lu, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15071779 · Cited by 36 · see citing works
Araújo, M. M., Montalvão-Sousa, T. M., Teixeira, P. D. C., Figueiredo, A. C. M. G., & Botelho, P. B. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac069 · Cited by 35 · see citing works
Guo, Y., Song, L., Huang, Y., Li, X., Xiao, Y., Wang, Z., & Ren, Z. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1039403 · Cited by 36 · see citing works
Fruit Juices as Probiotic Foods
Pimentel, T. C., Klososki, S. J., Rosset, M., Barão, C. E., & Marcolino, V. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815851-7.00014-0 · Cited by 35 · see citing works
Jomehzadeh, N., Javaherizadeh, H., Amin, M., Rashno, M. M., & Teimoori, A. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s250755 · Cited by 35 · see citing works
Tang, T., Wang, J., Jiang, Y., Zhu, X., Zhang, Z., Wang, Y., Shu, X., Deng, Y., & Zhang, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.890314 · Cited by 35 · see citing works
Probiotics alleviate constipation and inflammation in late gestating and lactating sows
Ma, T., Huang, W., Li, Y., Jin, H., Kwok, L., Sun, Z., & Zhang, H. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00434-z · Cited by 36 · see citing works
Zhang, J., Deji, C., Fan, J., Chang, L., Miao, X., Xiao, Y., Zhu, Y., & Li, S. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110058 · Cited by 34 · see citing works
Zhang, M., Zou, W., Xu, C., Jia, R., Liu, K., Xu, Q., & Xu, H. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002184 · Cited by 34 · see citing works
Yu, Z., Zhao, J., Qin, Y., Wang, Y., Zhang, Y., & Sun, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.850425 · Cited by 34 · see citing works
Chronic constipation and gut microbiota: current research insights and therapeutic implications
Xu, X., Wang, Y., Long, Y., & Cheng, Y. (2024) · Postgraduate Medical Journal · doi:10.1093/postmj/qgae112 · Cited by 32 · see citing works
- Authors
- Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K.
- Affiliations
- Queen Mary University of London (GB)
- King's College London (GB)
- Corresponding author
- Whelan, Kevin
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 8
- Issue
- 3
- Pages
- 484-494
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC5421123
- OpenAlex
- W2615801135
- Cited by
- 468
- References
- 108
- Citations by year
- 2026: 36 · 2025: 68 · 2024: 90 · 2023: 70 · 2022: 73 · 2021: 52 · 2020: 39 · 2019: 23 · 2018: 14 · 2017: 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, constipation, intestinal motility, gut microbiota, Bifidobacterium, lactobacilli, bile acid metabolism, mucus secretion, gut fermentation, breath methane, functional constipation, immune function, nervous system function
- MeSH terms
- Gastrointestinal Microbiome, Animals, Constipation, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Probiotics, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
