Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease

Barbara, Giovanni; Stanghellini, Vincenzo; Brandi, Giovanni; Cremon, Cesare; Nardo, Giovanni Di; De Giorgio, Roberto; Corinaldesi, Roberto

doi:10.1111/j.1572-0241.2005.00230.x

Cited by 325Gastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods

Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease

Barbara, Giovanni, Stanghellini, Vincenzo, Brandi, Giovanni, Cremon, Cesare, Nardo, Giovanni Di, De Giorgio, Roberto, Corinaldesi, Roberto·2005·The American Journal of Gastroenterology

DOI 10.1111/j.1572-0241.2005.00230.x

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Abstract

Commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity. On the other hand, intestinal motility represents one of the major control systems of gut microflora, through the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bidirectional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth and intestinal pseudo-obstruction. Recent interest has also been directed to the potential role of intestinal microflora in the pathogenesis of the irritable bowel syndrome. Although the status of intestinal microflora in the irritable bowel syndrome remains unsettled, small intestinal bacterial overgrowth (as detected with breath testing) and increased fermentation of foods with gas production, provide indirect evidence that microflora may contribute to symptom generation in irritable bowel syndrome. The potential benefit of antibiotic and probiotic therapy is currently under investigation and opens new perspectives in irritable bowel syndrome treatment.

Integrity signals

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Crossref · 10.1111/j.1572-0241.2005.00230.x

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In the periphery, intestinal microbiota can affect the ENS directly via release of bacterial substances or metabolites, or indirectly by inducing the release of host-derived immune mediators that in turn impact the ENS.
“In the periphery, intestinal microbiota can affect the ENS directly via release of bacterial substances or metabolites, or indirectly by inducing the release of host-derived immune mediators that in turn impact the ENS (10, 155).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [10]
Metabolic products of intestinal bacteria, such as short-chain fatty acids or chemotactic peptides, are able to stimulate the enteric nervous system and influence the rate of gut transit.
“Metabolic products of intestinal bacteria, such as short-chain fatty acids or chemotactic peptides (for example, N-formylmethionyl–leucine–phenylalanine) are able to stimulate the enteric nervous system and influence the rate of gut transit.38-40”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [38]

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Authors: Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R.
Affiliations: IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
University of Bologna (IT)
Corresponding author: Barbara, Giovanni
ORCID: Barbara, Giovanni
Stanghellini, Vincenzo
Brandi, Giovanni
Cremon, Cesare
Nardo, Giovanni Di
Venue: The American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-11
Volume: 100
Issue: 11
Pages: 2560-2568
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1111/j.1572-0241.2005.00230.x
OpenAlex: W2034509430
Cited by: 325
References: 125
Citations by year: 2026: 5 · 2025: 16 · 2024: 8 · 2023: 22 · 2022: 22 · 2021: 23 · 2020: 22 · 2019: 18 · 2018: 18 · 2017: 23 · 2016: 13 · 2015: 16 · 2014: 16 · 2013: 19 · 2012: 12
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: commensal bacteria, gut microbiota, intestinal motility, small intestinal bacterial overgrowth, intestinal pseudo-obstruction, irritable bowel syndrome, probiotics, antibiotic therapy, breath test
MeSH terms: Gastrointestinal Motility, Humans, Intestinal Diseases, Intestinal Pseudo-Obstruction, Intestine, Small, Intestines, Bacterial Physiological Phenomena, Irritable Bowel Syndrome

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Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease

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