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Cited by 111Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat

Ohara, Peter T., Granato, Alberto, Moallem, Theodore M., Wang, Bai-Ren, Tillet, Yves, Jasmin, Luc·2003·Journal of Neurocytology
DOI 10.1023/b:neur.0000005598.09647.7f
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Abstract

Increasing evidence shows that the rostral agranular insular cortex (RAIC) is important in the modulation of nociception in humans and rats and that dopamine and GABA appear to be key neurotransmitters in the function of this cortical region. Here we use immunocytochemistry and path tracing to examine the relationship between dopamine and GABA related elements in the RAIC of the rat. We found that the RAIC has a high density of dopamine fibers that arise principally from the ipsilateral ventral tegmental area/substantia nigra (VTA/SN) and from a different set of neurons than those that project to the medial prefrontal cortex. Within the RAIC, there are close appositions between dopamine fibers and GABAergic interneurons. One target of cortical GABA appears to be a dense band of GABAB receptor-bearing neurons located in lamina 5 of the RAIC. The GABAB receptor-bearing neurons project principally to the amygdala and nucleus accumbens with few or no projections to the medial prefrontal cortex, cingulate gyrus, the mediodorsal thalamic nucleus or contralateral RAIC. The current anatomical data, together with previous behavioral results, suggest that part of the dopaminergic modulation of the RAIC occurs through GABAergic interneurons. GABA is able to exert specific effects through its action on GABAB receptor-bearing projection neurons that target a few subcortical limbic structures. Through these connections, dopamine innervation of the RAIC is likely to affect the motivational and affective dimensions of pain.

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Crossref · 10.1023/b:neur.0000005598.09647.7f

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Metadata

Authors
Ohara, P. T., Granato, A., Moallem, T. M., Wang, B.-R., Tillet, Y., & Jasmin, L.
Affiliations
  • University of California, San Francisco (US)
  • Università Cattolica del Sacro Cuore (IT)
  • Air Force Medical University (CN)
  • Centre National de la Recherche Scientifique (FR)
ORCID
Venue
Journal of Neurocytology
Publisher
Springer Science and Business Media LLC
Published
2003-02
Volume
32
Issue
2
Pages
131-141
ISSN
  • 0300-4864 (ISSN-L)
  • 1573-7381
DOI
10.1023/b:neur.0000005598.09647.7f
OpenAlex
W2031678730
Cited by
111
References
87
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 5
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Neurocytology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • National Institutes of Health (5r01ns039320-04)
  • University of California, San Francisco
  • National Institute of Neurological Disorders and Stroke (R01 NS39320)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
dopaminergic innervation, GABAergic interneurons, GABAB receptors, ventral tegmental area, substantia nigra, nociception, pain modulation, amygdala, nucleus accumbens, medial prefrontal cortex, limbic system
MeSH terms
Animals, Benzofurans, Cerebral Cortex, Dopamine, gamma-Aminobutyric Acid, Immunohistochemistry, Interneurons, Limbic System, Male, Neural Inhibition, Neural Pathways, Synaptic Transmission, Pain, Tyrosine 3-Monooxygenase, Rats, Sprague-Dawley, Ventral Tegmental Area, Presynaptic Terminals, Receptors, GABA-B, Rats

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