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Cited by 163Bipolar Disorder and TreatmentNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

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Suhara, Tetsuya, Nakayama, Kazuhiko, Inoue, Osamu, Fukuda, Hiroshi, Shimizu, Makoto, Mori, Atuyoshi, Tateno, Yukio·1992·Psychopharmacology
DOI 10.1007/bf02253582
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Abstract

D1 dopamine receptor binding in mood disorders was studied by positron emission tomography (PET) using 11C-SCH23390. Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state. The patients were in euthymic (N = 6), depressed (N = 3) and manic (N = 1) states. Regional radioactivity in the brain was followed for 40 min by PET. A two-compartment model was used to obtain the binding potential (k3/k4) for the striatum and frontal cortex. The binding potentials for the frontal cortex for the patients were significantly lower than those for normal controls, whereas those for striatum were not significantly different. These findings suggest that D1 dopamine receptors in the frontal cortex may be in a different state in patients with bipolar mood disorders.

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  • Molecular-imaging studies of striatal DAT availability in bipolar disorder generally suggest increased functional DA throughput.

    “Molecular-imaging studies of striatal DAT availability in bipolar disorder generally suggest increased functional DA throughput (but Suhara et al. reported an exception [282]).”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [282]

  • The insula is involved in critical aspects underlying SUDs, such as interoception, decision making, anxiety, pain perception, cognition, mood, threat recognition, and conscious urges.

    “The insula, a region of the cerebral cortex, is known to be involved in critical aspects underlying SUDs, such as interoception, decision making, anxiety, pain perception, cognition, mood, threat recognition, and conscious urges.”

    From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Suhara et al., 1992

  • The insular cortex is involved in feelings of anxiety, pain, cognition, mood, threat recognition, and conscious urges.

    “The insular cortex is involved in feelings of anxiety, pain, cognition, mood, threat recognition, and conscious urges”

    From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Suhara et al., 1992

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Related

Authors
Suhara, T., Nakayama, K., Inoue, O., Fukuda, H., Shimizu, M., Mori, A., & Tateno, Y.
Affiliations
  • National Institute of Radiological Sciences (JP)
  • Jikei University School of Medicine (JP)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1992-01
Volume
106
Issue
1
Pages
14-18
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02253582
OpenAlex
W2042938639
Cited by
163
References
40
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2022: 2 · 2021: 27 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 10
FWCI
3.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
dopamine D1 receptor, mood disorders, bipolar disorder, receptor binding potential, frontal cortex, striatum, depression, mania, euthymia
MeSH terms
Adult, Aged, Aging, Animals, Benzazepines, Bipolar Disorder, Cerebral Cortex, Humans, Ketanserin, Male, Mice, Inbred Strains, Middle Aged, Models, Psychological, Receptors, Dopamine, Tomography, Emission-Computed, Receptors, Dopamine D1, Mice

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