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Negative symptoms in first episode non‐affective psychosis

Malla, Ashok K., Takhar, Jatinder J., Norman, Ross M. G., Manchanda, Rahul, Cortese, Leonard, Haricharan, Raj, Verdi, Mary, Ahmed, Rashid·2002·Acta Psychiatrica Scandinavica

DOI 10.1034/j.1600-0447.2002.02139.x

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Abstract

Objective: To determine the prevalence of negative symptoms and to examine secondary sources of influence on negative symptoms and the role of specific negative symptoms in delay associated with seeking treatment in first episode non‐affective psychosis. Method: One hundred and ten patients who met Diagnostic Statistical Manual‐IV (DSM‐IV) criteria for a first episode of schizophrenia spectrum psychoses were rated for assessment of negative, positive, depressive and extrapyramidal symptoms, the premorbid adjustment scale and assessment of demographic and clinical characteristics including duration of untreated psychosis (DUP). Results: Alogia/flat affect and avolition/anhedonia were strongly influenced by parkinsonian and depressive symptoms, respectively. A substantial proportion (26.8%) of patients showed at a least moderate level of negative symptoms not confounded by depression and Parkinsonism. DUP was related only to avolition/anhedonia while flat affect/alogia was related to male gender, diagnosis of schizophrenia, age of onset and the length of the prodrome. Conclusion: Negative symptoms that are independent of the influence of positive symptoms, depression and extra pyramidal symptoms (EPS) are present in a substantial proportion of first episode psychosis patients and delay in seeking treatment is associated mainly with avolition and anhedonia.

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Negative v Positive Schizophrenia
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070025006 · Cited by 2,008
Molecular pathology of schizophrenia: more than one disease process?
Crow, T. J. (1980) · BMJ · doi:10.1136/bmj.280.6207.66 · Cited by 1,862
The Symptoms of Chronic Schizophrenia
Liddle, P. F. (1987) · The British Journal of Psychiatry · doi:10.1192/bjp.151.2.145 · Cited by 1,461
Deficit and nondeficit forms of schizophrenia: the concept
Carpenter, W. T., Heinrichs, D. W., & Wagman, A. M. I. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.5.578 · Cited by 1,329
A depression rating scale for schizophrenics
Addington, D. E., Addington, J., & Schıssel, B. (1990) · Schizophrenia Research · doi:10.1016/0920-9964(90)90005-r · Cited by 1,270
Measurement of Premorbid Adjustment in Chronic Schizophrenia
Cannon-Spoor, H. E., Potkin, S. G., & Wyatt, R. J. (1982) · Schizophrenia Bulletin · doi:10.1093/schbul/8.3.470 · Cited by 1,220
The Two-syndrome Concept: Origins and Current Status
Crow, T. J. (1985) · Schizophrenia Bulletin · doi:10.1093/schbul/11.3.471 · Cited by 841
The schedule for the deficit syndrome: An instrument for research in schizophrenia
Kirkpatrick, B. R., Buchanan, R. W., McKenny, P. D., Alphs, L. D., & Carpenter, W. T. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90153-4 · Cited by 802
IRAOS: an instrument for the assessment of onset and early course of schizophrenia
Häfner, H., Riecher‐Rössler, A., Hambrecht, M., Maurer, K., Meissner, S., Schmidtke, A., Fätkenheuer, B., Löffler, W., & der Heiden, W. A. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90004-o · Cited by 562
Schizophrenic syndromes, cognitive performance and neurological dysfunction
Liddle, P. F. (1987) · Psychological Medicine · doi:10.1017/s0033291700012976 · Cited by 552

Show all 37 references

Research works printed but not linked: 3

PERALTA MV, 1990, Sintomas esquizofrenicos positivos y negativos: un reanalisis del modelo dicotomos de la esquizofrenia, Actas Luso Esp Nevrol Psiquiatr Cienc A Fines, 18, 266
TANDONR JIBSONMD TAYLORSF DEQUARDOJR.Conceptual models of the relationships between positive and negative symptoms.In: SHRIQUI CL NASRALLAH HA eds. Contemporary issues in the treatment of schizophrenia. Washington DC: American Psychiatric Press 1995:109–124.
CHOUINARD G, 1980, Extrapyramidial symptom rating scale, Can J Neuro Sci, 7, 223

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Authors: Malla, A. K., Takhar, J. J., Norman, R. M. G., Manchanda, R., Cortese, L., Haricharan, R., Verdi, M., & Ahmed, R.
Affiliations: Western University (CA)
Corresponding author: Malla, Ashok K.
ORCID: Malla, Ashok K.
Norman, Ross M. G.
Manchanda, Rahul
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2002-06
Volume: 105
Issue: 6
Pages: 431-439
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1034/j.1600-0447.2002.02139.x
OpenAlex: W2062522511
Cited by: 118
References: 37
Citations by year: 2025: 3 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 14
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2305 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly Canada
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: negative symptoms, first-episode psychosis, schizophrenia, non-affective psychosis, alogia, flat affect, avolition, anhedonia, duration of untreated psychosis, treatment delay, depression, parkinsonism, extrapyramidal symptoms, prodromal symptoms, premorbid adjustment
MeSH terms: Adult, Affect, Female, Humans, Male, Psychiatric Status Rating Scales, Psychotic Disorders, Severity of Illness Index, Time Factors

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Negative symptoms in first episode non‐affective psychosis

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