Cited by 422Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Peptides and Activities

The innate immune response of the respiratory epithelium: Innate immunity in the airway

Diamond, Gill, Legarda, Diana, Ryan, Lisa K.·2000·Immunological Reviews

Abstract

The respiratory epithelium maintains an effective antimicrobial environment to prevent colonization by microorganisms in inspired air. In addition to constitutively present host defenses which include antimicrobial peptides and proteins, the epithelial cells respond to the presence of microbes by the induction two complementary parts of an innate immune response. The first response is the increased production of antimicrobial agents, and the second is the induction of a signal network to recruit phagocytic cells to contain the infection. Inflammatory mediators released by the recruited cells as well as from the epithelium itself further induce the expression of the antimicrobial agents. The result is an effective prevention of microbial colonization. The epithelial cells recognize the pathogen-associated patterns on microbes by surface receptors such as CD14 and Toll-like receptors. Subsequent signal transduction pathways have been identified which result in the increased transcription of host defense response genes. Diseases such as cystic fibrosis, or environmental exposures such as the inhalation of air pollution particles, may create an environment that impairs the expression or activity of the host defenses in the airway. This can lead to increased susceptibility to airway infections.

Integrity signals

Registry

Crossref · 10.1034/j.1600-065x.2000.917304.x

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Abnormal repair processes of the airway epithelium leading to abnormal organization and integrity of the respiratory epithelium, with subsequent perturbations in innate immune functions, have been proposed as key mechanisms in the pathogenesis of chronic airway diseases such as asthma and COPD.

    “Abnormal repair processes of the airway epithelium leading to abnormal organization and integrity of the respiratory epithelium, with subsequent perturbations in innate immune functions, have been proposed as key mechanisms in the pathogenesis of chronic airway diseases such as asthma (38, 48) and COPD (221).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Diamond, G., Legarda, D., & Ryan, L. K.
Affiliations
Environmental Protection Agency (US)
Corresponding author
Diamond, Gill
Venue
Immunological Reviews
Publisher
Wiley
Published
2000-02
Volume
173
Issue
1
Pages
27-38
ISSN
0105-2896 (ISSN-L)
OpenAlex
W2157109210
Cited by
422
References
137
Citations by year
2026: 1 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 16 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 19
FWCI
5.49
Type
journal article
Language
en
Open access
closed
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl053400-03)
  • National Heart, Lung, and Blood Institute (HL53400)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords
respiratory epithelium, innate immunity, antimicrobial peptides, antimicrobial proteins, Toll-like receptors, CD14, phagocyte recruitment, inflammatory mediators, cystic fibrosis, microbial colonization
MeSH terms
Air Pollutants, Anti-Infective Agents, Bronchi, Gene Expression Regulation, Humans, Phagocytes, Signal Transduction, Inflammation Mediators, Respiratory Mucosa

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review