Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny
Open accessAbstract
Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.
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Vaccination early in life and exposure to a variety of immunogens can affect response to pathogens and vaccines across the lifespan, sometimes unpredictably.
“Vaccination early in life, as well as exposure to a variety of immunogens, can also affect response to pathogens and vaccines across the lifespan, sometimes in unpredictable ways.23”
From SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges (2021) · cites this paper as [23]
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Skin Barrier Function in Neonates and Infants
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Roider, J., Maehara, T., Ngoepe, A., Ramsuran, D., Muenchhoff, M., Adland, E., Aicher, T. P., Kazer, S. W., Jooste, P., Karim, F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01975 · Cited by 38 · see citing works
Pagel, J., Twisselmann, N., Rausch, T. K., Waschina, S., Hartz, A., Steinbeis, M., Olbertz, J., Nagel, K., Steinmetz, A., Faust, K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565257 · Cited by 38 · see citing works
Elahi, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000710 · Cited by 37 · see citing works
França, Â. (2023) · Antibiotics · doi:10.3390/antibiotics12030554 · Cited by 40 · see citing works
Regan, A. K., & Muñoz, F. M. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1915138 · Cited by 38 · see citing works
Surfing on the waves of the human γδ T cell ontogenic sea
Sanchez, G. S., Tafesse, Y., Papadopoulou, M., & Vermijlen, D. (2023) · Immunological Reviews · doi:10.1111/imr.13184 · Cited by 36 · see citing works
Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance
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Self-citationBudeus, B., Kibler, A., Brauser, M., Homp, E., Bronischewski, K., Ross, J. A., Görgens, A., Weniger, M. A., Dunst, J., Kreslavsky, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100113 · Cited by 38 · see citing works
Precision Vaccine Development: Cues From Natural Immunity
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Self-citation
- Authors
- Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O.
- Affiliations
- University of British Columbia (CA)
- MRC Unit the Gambia (GM)
- California Institute of Technology (US)
- Université Libre de Bruxelles (BE)
- Boston Children's Hospital (US)
- Corresponding author
- Kollmann, Tobias R.
- Levy, Ofer
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 46
- Issue
- 3
- Pages
- 350-363
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2599501186
- Semantic Scholar
- e51f9b517003c880df24898208e6d4d93bb7cc87
- Cited by
- 478
- References
- 200
- Citations by year
- 2026: 62 · 2025: 45 · 2024: 54 · 2023: 51 · 2022: 40 · 2021: 67 · 2020: 69 · 2019: 39 · 2018: 36 · 2017: 15
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- Medical Research Council (MR/R005990/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immune ontogeny, neonatal immunity, host defense, immune plasticity, neonatal infection
- MeSH terms
- Animals, Communicable Diseases, Disease Susceptibility, Humans, Immune System, Infant, Infant, Newborn
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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