Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells.

Soboll Hussey, Gisela; Ashton, Laura V.; Quintana, Ayshea M.; Van de Walle, Gerlinde R.; Osterrieder, Nikolaus; Lunn, David P.

doi:10.1016/j.virol.2014.05.023

Cited by 28Herpesvirus Infections and Treatmentsinterferon and immune responsesAnimal Virus Infections Studies

Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells.

Open access

Soboll Hussey, Gisela, Ashton, Laura V., Quintana, Ayshea M., Van de Walle, Gerlinde R., Osterrieder, Nikolaus, Lunn, David P.·2014·Virology

DOI 10.1016/j.virol.2014.05.023

Open this paper in CoChat — free account

Abstract

Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow cell-associated EHV-1 viremia. The salient observations are as follows: (i) EHV-1 significantly down-modulated MHC-I and MHC-II expression in equine respiratory epithelial cells (ERECs). MHC-I expression remained unaffected in PBMCs and MHC-II expression was increased. (ii) Infection with an EHV-1 ORF1 deletion mutant partially restored MHC-I and MHC-II expression and altered IFN-alpha and IL-10 mRNA expression. (iii) Deletion of EHV-1 ORF1 also significantly increased chemokine expression and chemotaxis of monocytes and neutrophils in ERECs. Collectively, these results suggest a role for EHV-1 pUL56 in modulation of antigen presentation, cytokine expression and chemotaxis at the respiratory epithelium, but not in PBMC.

Integrity signals

Registry

Crossref · 10.1016/j.virol.2014.05.023

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Infection with a deleted ORF1 mutant partially restored MHC I expression and significantly increased chemokine expression and chemotaxis of immune cells to EREC.
“Infection with a deleted ORF1 mutant partially restored MHC I expression and significantly increased chemokine expression and chemotaxis of immune cells to EREC (Soboll Hussey et al., 2014).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Soboll Hussey et al., 2014
EHV-1 infection significantly down-regulates MHC I expression in EREC.
“Soboll-Hussey and colleagues demonstrated that EHV-1 infection significantly down-regulates MHC I expression in EREC.”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Soboll Hussey et al., 2014

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Infectious diseases of livestock
Coetzer, J. A. W., & Tustin, R. C. (2004) · Oxford University Press eBooks · Cited by 1,226 · see citing works
Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites
Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 484 · see citing works
The innate immune response of the respiratory epithelium: Innate immunity in the airway
Diamond, G., Legarda, D., & Ryan, L. K. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917304.x · Cited by 422 · see citing works
Recognition of herpesviruses by the innate immune system
Paludan, S. R., Bowie, A., Horan, K., & Fitzgerald, K. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri2937 · Cited by 353 · see citing works
Potent Immunosuppressive Activities of Cytomegalovirus- Encoded Interleukin-10
Spencer, J. V., Lockridge, K. M., Barry, P. A., Lin, G., Tsang, M., Penfold, M. E. T., & Schall, T. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.3.1285-1292.2002 · Cited by 322 · see citing works
Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling
Koppelman, B., Neefjes, J., de Vries, J. E., & Malefyt, R. D. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80404-5 · Cited by 307 · see citing works
A point mutation in a herpesvirus polymerase determines neuropathogenicity.
Goodman, L. B., Loregian, A., Perkins, G. A., Nugent, J., Buckles, E. L., Mercorelli, B., Kydd, J. H., Palù, G., Smith, K. C., Osterrieder, N., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030160 · Cited by 223 · see citing works
Self-citation
Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing
Koppers‐Lalic, D., Reits, E. A., Ressing, M. E., Lipińska, A. D., Abele, R., Koch, J., Rezende, M. M., Admiraal, P. C., van Leeuwen, D., Bieńkowska-Szewczyk, K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501463102 · Cited by 187 · see citing works
Immature Monocyte-Derived Dendritic Cells Are Productively Infected with Herpes Simplex Virus Type 1
Mikloška, Z., Bosnjak, L., & Cunningham, A. L. (2001) · Journal of Virology · doi:10.1128/jvi.75.13.5958-5964.2001 · Cited by 179 · see citing works
Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10
Redpath, S., Angulo, A., Gascoigne, N. R. J., & Ghazal, P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6701 · Cited by 159 · see citing works
Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses
Wagner, B., & Freer, H. (2008) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2008.10.313 · Cited by 159 · see citing works
Report of the Second Equine Leucocyte Antigen Workshop, Squaw Valley, California, July 1995
Lunn, D. P., Holmes, M. A., Antczak, D. F., Agerwal, N., Baker, J., Bendali-Ahcéne, S., Blanchard-Channell, M., Byrne, K. M., Cannizzo, K., Davis, W. C., et al. (1998) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(97)00160-8 · Cited by 141 · see citing works
Self-citation
Modulation of Major Histocompatibility Class II Protein Expression by Varicella-Zoster Virus
Abendroth, A., Slobedman, B., Lee, E. Y., Mellins, E., Wallace, M. R., & Arvin, A. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1900-1907.2000 · Cited by 139 · see citing works
Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses.
Allen, G. P. (2008) · American Journal of Veterinary Research · doi:10.2460/ajvr.69.12.1595 · Cited by 135 · see citing works
Human Immunodeficiency Virus Type 1 Vpr Impairs Dendritic Cell Maturation and T-Cell Activation: Implications for Viral Immune Escape
Majumder, B., Janket, M. L., Schafer, E. A., Schaubert, K. L., Huang, X.-L., Kan‐Mitchell, J., Rinaldo, C. R., & Ayyavoo, V. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.7990-8003.2005 · Cited by 127 · see citing works
Distribution of Equid herpesvirus-1 (EHV-1) in respiratory tract associated lymphoid tissue: implications for cellular immunity.
KYDD, J. H., SMITH, K. C., HANNANT, D., LIVESAY, G. J., & MUMFORD, J. A. (1994) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1994.tb04052.x · Cited by 122 · see citing works
IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses
McBride, J., Jung, T., de Vries, J. E., & Aversa, G. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(02)00007-2 · Cited by 115 · see citing works
Cell Surface Major Histocompatibility Complex Class II Proteins Are Regulated by the Products of the γ134.5 and UL41 Genes of Herpes Simplex Virus 1
Trgovcich, J., Johnson, D. C., & Roizman, B. (2002) · Journal of Virology · doi:10.1128/jvi.76.14.6974-6986.2002 · Cited by 100 · see citing works
Pre-infection frequencies of equine herpesvirus-1 specific, cytotoxic T lymphocytes correlate with protection against abortion following experimental infection of pregnant mares
Kydd, J. H., Wattrang, E., & Hannant, D. (2003) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2003.08.004 · Cited by 91 · see citing works
Airway Epithelial Cells Regulate the Functional Phenotype of Locally Differentiating Dendritic Cells: Implications for the Pathogenesis of Infectious and Allergic Airway Disease
Rate, A., Upham, J. W., Bosco, A., McKenna, K. L., & Holt, P. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.72 · Cited by 88 · see citing works
Identification and Characterization of the UL56 Gene Product of Herpes Simplex Virus Type 2
Koshizuka, T., Goshima, F., Takakuwa, H., Nozawa, N., Daikoku, T., Koiwai, O., & Nishiyama, Y. (2002) · Journal of Virology · doi:10.1128/jvi.76.13.6718-6728.2002 · Cited by 81 · see citing works
Viral suppression of the interferon system
Weber, F., & Haller, O. (2007) · Biochimie · doi:10.1016/j.biochi.2007.01.005 · Cited by 75 · see citing works
Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant.
Hussey, G. S., Hussey, S. B., Wagner, B., Horohov, D. W., Van de Walle, G. R., Osterrieder, N., Goehring, L. S., Rao, S., & Lunn, D. P. (2011) · Veterinary Research · doi:10.1186/1297-9716-42-23 · Cited by 73 · see citing works
Self-citation
An outbreak of paresis in mares and geldings associated with equid herpesvirus 1.
Crowhurst, F. A., Dickinson, G., & Burrows, R. (1981) · PubMed · Cited by 71 · see citing works
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A
Koshizuka, T., Kawaguchi, Y., & Nishiyama, Y. (2005) · Journal of General Virology · doi:10.1099/vir.0.80633-0 · Cited by 65 · see citing works
Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells
Novak, N., & Peng, W. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02927.x · Cited by 56 · see citing works
Summary Report of the Second Equine Leucocyte Antigen Workshop
Lunn, D. P., Holmes, M. A., & Antczak, D. F. (1996) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(96)05674-7 · Cited by 55 · see citing works
Self-citation
Immunological characterization of the equine airway epithelium and of a primary equine airway epithelial cell culture model
Quintana, A. M., Landolt, G. A., Annis, K. M., & Hussey, G. S. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2010.12.008 · Cited by 55 · see citing works
Self-citation
Herpesvirus chemokine-binding glycoprotein G (gG) efficiently inhibits neutrophil chemotaxis in vitro and in vivo.
Van de Walle, G. R., May, M. L., Sukhumavasi, W., von Einem, J., & Osterrieder, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4161 · Cited by 55 · see citing works
Self-citation
Peptide transport activity of the transporter associated with antigen processing (TAP) is inhibited by an early protein of equine herpesvirus-1
Ambagala, A. P. N., Gopinath, R. S., & Srikumaran, S. (2004) · Journal of General Virology · doi:10.1099/vir.0.19563-0 · Cited by 54 · see citing works
Toll-like receptor sensing of human herpesvirus infection
West, J. A., Gregory, S. M., & Damania, B. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00122 · Cited by 53 · see citing works
Identification and Characterization of Equine Herpesvirus Type 1 pUL56 and Its Role in Virus-Induced Downregulation of Major Histocompatibility Complex Class I
Ma, G., Feineis, S., Osterrieder, N., & de Walle, G. R. V. (2012) · Journal of Virology · doi:10.1128/jvi.06994-11 · Cited by 49 · see citing works
Self-citation
Immune escape of equine herpesvirus 1 and other herpesviruses of veterinary importance
van der Meulen, K. M., Favoreel, H. W., Pensaert, M. B., & Nauwynck, H. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.01.006 · Cited by 48 · see citing works
Herpes simplex virus type 1 (HSV-1) UL56 gene is involved in viral intraperitoneal pathogenicity to immunocompetent mice
Berkowitz, C., Moyal, M., R�sen-Wolff, A., Darai, G., & Becker, Y. (1994) · Archives of Virology · doi:10.1007/bf01379108 · Cited by 46 · see citing works
Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
Wiertz, E., Devlin, R., Collins, H., & Ressing, M. (2006) · Journal of Virology · doi:10.1128/jvi.01525-06 · Cited by 46 · see citing works
Stat2-Dependent Regulation of MHC Class II Expression
Zhao, W., Cha, E. N., Lee, C., Park, C. Y., & Schindler, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.463 · Cited by 40 · see citing works
Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains
Wagner, B., Wimer, C. L., Freer, H., Osterrieder, N., & Erb, H. N. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.06.032 · Cited by 38 · see citing works
Self-citation
Innate immune responses of airway epithelial cells to infection with Equine herpesvirus-1
Soboll Hussey, G., Ashton, L. V., Quintana, A. M., Lunn, D. P., Goehring, L. S., Annis, K., & Landolt, G. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.01.018 · Cited by 37 · see citing works
Self-citation
Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression
Wimer, C. L., DAMIANI, A. M., Osterrieder, N., & Wagner, B. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.01.009 · Cited by 37 · see citing works
Self-citation
CCL3 and Viral Chemokine-Binding Protein gG Modulate Pulmonary Inflammation and Virus Replication during Equine Herpesvirus 1 Infection
de Walle, G. R. V., Sakamoto, K., & Osterrieder, N. (2007) · Journal of Virology · doi:10.1128/jvi.02137-07 · Cited by 33 · see citing works
Self-citation
Absence of viral envelope proteins in equine herpesvirus 1-infected blood mononuclear cells during cell-associated viremia.
van der Meulen, K., Caij, B., Pensaert, M., & Nauwynck, H. (2006) · Veterinary Microbiology · doi:10.1016/j.vetmic.2005.11.048 · Cited by 32 · see citing works
Restitution of the UL56 gene expression of HSV-1 HFEM led to restoration of virulent phenotype; deletion of the amino acids 217 to 234 of the UL56 protein abrogates the virulent phenotype
Kehm, R., Rösen‐Wolff, A., & Darai, G. (1996) · Virus Research · doi:10.1016/0168-1702(96)80248-6 · Cited by 29 · see citing works
Pseudorabies virus US3- and UL49.5-dependent and -independent downregulation of MHC I cell surface expression in different cell types
Deruelle, M., den Broeke, C. V., Nauwynck, H., Mettenleiter, T. C., & Favoreel, H. W. (2009) · Virology · doi:10.1016/j.virol.2009.09.019 · Cited by 28 · see citing works
Equine Herpesvirus Type 4 UL56 and UL49.5 Proteins Downregulate Cell Surface Major Histocompatibility Complex Class I Expression Independently of Each Other
Said, A., Azab, W., DAMIANI, A. M., & Osterrieder, N. (2012) · Journal of Virology · doi:10.1128/jvi.00891-12 · Cited by 27 · see citing works
Self-citation
The Density of the Class II MHC T Cell Receptor Ligand Influences IFN-γ/IL-4 Ratios in Immune Responsesin Vivo
DiMolfetto, L., Neal, H. A., Wu, A., Reilly, C. R., & Lo, D. D. (1998) · Cellular Immunology · doi:10.1006/cimm.1997.1231 · Cited by 23 · see citing works
The relationship of corneal Langerhans cells to herpes simplex antigens during dendritic keratitis
Pepose, J. S. (1989) · Current Eye Research · doi:10.3109/02713688909000875 · Cited by 22 · see citing works
Expression of late viral proteins is restricted in nasal mucosal leucocytes but not in epithelial cells during early-stage equine herpes virus-1 infection.
Gryspeerdt, A. C., Vandekerckhove, A. P., Baghi, H. B., Van de Walle, G. R., & Nauwynck, H. J. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.01.022 · Cited by 18 · see citing works
Analysis of the Herpesvirus Chemokine-binding Glycoprotein G Residues Essential for Chemokine Binding and Biological Activity
de Walle, G. R. V., Kaufer, B. B., Chbab, N., & Osterrieder, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808127200 · Cited by 17 · see citing works
Self-citation
Evaluation of infectivity of a canine lineage H3N8 influenza A virus in ponies and in primary equine respiratory epithelial cells
Quintana, A. M., Hussey, S. B., Burr, E. C., Pecoraro, H. L., Annis, K. M., Rao, S., & Landolt, G. A. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.8.1071 · Cited by 17 · see citing works
Self-citation
The role of secreted glycoprotein G of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in immune modulation and virulence
Thormann, N., de Walle, G. R. V., Azab, W., & Osterrieder, N. (2012) · Virus Research · doi:10.1016/j.virusres.2012.07.029 · Cited by 14 · see citing works
Self-citation
Contrasting effects of IFNα on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter
Pisapia, L., Pozzo, G. D., Barba, P., Citro, A., Harris, P. E., & Maffei, A. (2012) · Results in Immunology · doi:10.1016/j.rinim.2012.09.001 · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 53 references couldn’t be matched to a known paper.

Sorted by citations

Equine Herpesvirus 1 Myeloencephalopathy
Pusterla, N., & Hussey, G. S. (2014) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2014.08.006 · Cited by 84 · see citing works
The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1
Laval, K., Poelaert, K. C. K., Van Cleemput, J., Zhao, J., Vandekerckhove, A. P., Gryspeerdt, A. C., Garré, B., van der Meulen, K., Baghi, H. B., Dubale, H. N., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.662686 · Cited by 54 · see citing works
Intranasal IgG4/7 antibody responses protect horses against equid herpesvirus-1 (EHV-1) infection including nasal virus shedding and cell-associated viremia
Perkins, G. A., Babasyan, S., Stout, A. E., Freer, H., Rollins, A., Wimer, C. L., & Wagner, B. (2019) · Virology · doi:10.1016/j.virol.2019.03.014 · Cited by 41 · see citing works
Viral genes and cellular markers associated with neurological complications during herpesvirus infections
Holz, C. L., Nelli, R. K., Wilson, M. E., Zarski, L. M., Azab, W., Baumgardner, R., Osterrieder, N., Pease, A., Zhang, L., Hession, S., et al. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000773 · Cited by 34 · see citing works
Self-citation
The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses
Wimer, C. L., Schnabel, C. L., Perkins, G. A., Babasyan, S., Freer, H., Stout, A. E., Rollins, A., Osterrieder, N., Goodman, L. B., Glaser, A. L., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206679 · Cited by 33 · see citing works
Self-citation
Equine Herpesvirus-1 Myeloencephalopathy
Pusterla, N., Hussey, G. S., & Goehring, L. S. (2022) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2022.05.006 · Cited by 30 · see citing works
Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity
Schnabel, C. L., Wimer, C. L., Perkins, G. A., Babasyan, S., Freer, H., Watts, C., Rollins, A., Osterrieder, N., & Wagner, B. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1563-4 · Cited by 29 · see citing works
Self-citation
Viral replication and innate immunity of feline herpesvirus-1 virulence-associated genes in feline respiratory epithelial cells
Lee, Y., Maes, R. K., Tai, S., & Hussey, G. S. (2019) · Virus Research · doi:10.1016/j.virusres.2019.02.013 · Cited by 28 · see citing works
Equine PBMC Cytokines Profile after In Vitro α- and γ-EHV Infection: Efficacy of a Parapoxvirus Ovis Based-Immunomodulator Treatment
Hue, E. S., Richard, E. A., Fortier, C. I., Fortier, G. D., Paillot, R., Raue, R., & Pronost, S. L. (2017) · Vaccines · doi:10.3390/vaccines5030028 · Cited by 17 · see citing works
Contribution of the immune response to the pathogenesis of equine herpesvirus-1 (EHV-1): Are there immune correlates that predict increased risk or protection from EHV-1 myeloencephalopathy?
Hussey, G. S., & Giessler, K. S. (2022) · The Veterinary Journal · doi:10.1016/j.tvjl.2022.105827 · Cited by 16 · see citing works
Impact of the host immune response on the development of equine herpesvirus myeloencephalopathy in horses
Giessler, K. S., Goehring, L. S., Jacob, S. I., Davis, A., Esser, M. M., Lee, Y., Zarski, L. M., Weber, P. S. D., & Hussey, G. S. (2024) · Journal of General Virology · doi:10.1099/jgv.0.001987 · Cited by 17 · see citing works
Equid herpesvirus 1 (EHV1) infection of equine mesenchymal stem cells induces a pUL56-dependent downregulation of select cell surface markers
Claessen, C., Favoreel, H. W., Ma, G., Osterrieder, N., Schauwer, C. D., Piepers, S., & de Walle, G. R. V. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.12.013 · Cited by 16 · see citing works
Self-citation
The pseudorabies virus protein, pUL56, enhances virus dissemination and virulence but is dispensable for axonal transport
Daniel, G. R., Sollars, P. J., Pickard, G. E., & Smith, G. A. (2015) · Virology · doi:10.1016/j.virol.2015.11.014 · Cited by 15 · see citing works
Equine Herpesvirus type 1 modulates cytokine and chemokine profiles of mononuclear cells for efficient dissemination to target organs.
Pavulraj, S., Kamel, M., Stephanowitz, H., Liu, F., Plendl, J., Osterrieder, N., & Azab, W. (2020) · Viruses · doi:10.3390/v12090999 · Cited by 13 · see citing works
Self-citation
Unmasking the ongoing challenge of equid herpesvirus- 1 (EHV-1): A comprehensive review
Afify, A. F., Hassanien, R. T., Naggar, R. F. E., Rohaim, M. A., & Munir, M. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106755 · Cited by 13 · see citing works
Transcriptomic Profiling of Equine and Viral Genes in Peripheral Blood Mononuclear Cells in Horses during Equine Herpesvirus 1 Infection
Zarski, L. M., Weber, P. S. D., Lee, Y., & Hussey, G. S. (2021) · Pathogens · doi:10.3390/pathogens10010043 · Cited by 12 · see citing works
Equine herpesvirus 1 elicits a strong pro-inflammatory response in the brain of mice
Mesquita, L. P., Costa, R. C., Zanatto, D. A., Bruhn, F. R. P., Mesquita, L. L. R., Lara, M. D. C. C. D. S. H., Villalobos, E. M. C., Massoco, C. D. O., Mori, C. M. C., Mori, Ê., et al. (2021) · Journal of General Virology · doi:10.1099/jgv.0.001556 · Cited by 12 · see citing works
Equid herpesvirus-1 Distribution in Equine Lymphoid and Neural Tissues 70 Days Post Infection
Samoilowa, S., Giessler, K. S., Medina‐Torres, C. E., Hussey, G. S., Allum, A. J., Fux, R., Jerke, C., Kiupel, M., Matiasek, K., Sledge, D. G., et al. (2021) · Pathogens · doi:10.3390/pathogens10060707 · Cited by 10 · see citing works
The pUL56 of pseudorabies virus variant induces downregulation of swine leukocyte antigen class I molecules through the lysosome pathway
Zhao, H., Wang, S., Liu, C., Han, J., Tang, J., Zhou, L., Ge, X., Guo, X., & Yang, H. (2018) · Virus Research · doi:10.1016/j.virusres.2018.04.007 · Cited by 9 · see citing works
EHV-1 Pathogenesis: Current in vitro Models and Future Perspectives
Kamel, M. S., Pavulraj, S., Osterrieder, N., & Azab, W. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00251 · Cited by 9 · see citing works
Self-citation
Absence of relationship between type-I interferon suppression and neuropathogenicity of EHV-1
Oladunni, F. S., Sarkar, S., Reedy, S. E., Balasuriya, U. B. R., Horohov, D. W., & Chambers, T. M. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.01.007 · Cited by 8 · see citing works
A Live-Attenuated Equine Influenza Vaccine Stimulates Innate Immunity in Equine Respiratory Epithelial Cell Cultures That Could Provide Protection From Equine Herpesvirus 1
Zarski, L. M., VAALA, W. E., Barnett, D. C., Bain, F. T., & Hussey, G. S. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.674850 · Cited by 7 · see citing works
Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-Terminal 181L-185L and Plays a Negative Regulation Role during Viral Lytic Infection
Lyu, C., Li, W., Shu-wen, W., Peng, J., Yang, Y., Tian, Z., & Cai, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093148 · Cited by 6 · see citing works
Double and quadruple deletion mutant of EHV-1 is highly attenuated and induces optimal immune response
Balena, V., Pradhan, S. S., Bera, B. C., Anand, T., Sansanwal, R., Khetmalis, R. S., Madhwal, A., Bernela, M., Supriya, K., Pavulraj, S., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2022.12.044 · Cited by 4 · see citing works
Equine Herpesviruses (Herpesviridae)
Hussey, G. S., Osterrieder, N., & Azab, W. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20977-1 · Cited by 2 · see citing works
Self-citation
Development and Characterization of a Live-attenuated Vaccine to Combat Equine Herpesvirus Type-1 infections
Liu, S. (2015) · doi:10.31390/gradschool_dissertations.3816
Evaluation of Viral Migration of Different Variants of Equid Alphaherpesvirus 1 in the Central Nervous System of Hamsters by Immunohistochemistry
da Silva, A. A. (2019) · Animal and Veterinary Sciences · doi:10.11648/j.avs.20190702.15
Immunity to selected equine viruses
Tizard, I. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44863-8.00029-6

Innate immune responses of airway epithelial cells to infection with Equine herpesvirus-1
Soboll Hussey, G., Ashton, L. V., Quintana, A. M., Lunn, D. P., Goehring, L. S., Annis, K., & Landolt, G. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.01.018 · Cited by 37 · see citing works
Self-citation
Equine Herpesvirus Type 1 (EHV-1) pUL56 Promotes Dynamin-dependent Endocytosis\nand Cooperates with pUL43 for Downregulation of Cell Surface MHC class I
Huang, T. (2015) · Refubium (Universitätsbibliothek der Freien Universität Berlin)
Equine Herpesvirus Type 1 (EHV-1) pUL56 Promotes Dynamin-dependent Endocytosis and Cooperates with pUL43 for Downregulation of Cell Surface MHC class I
Huang, T. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-15969
Equine Herpesvirus type 1 modulates cytokine and chemokine profiles of mononuclear cells for efficient dissemination to target organs.
Pavulraj, S., Kamel, M., Stephanowitz, H., Liu, F., Plendl, J., Osterrieder, N., & Azab, W. (2020) · Viruses · doi:10.3390/v12090999 · Cited by 13 · see citing works
Self-citation
Equine herpesvirus type 1
Ma, G. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7465 · Cited by 2 · see citing works

Authors: Soboll Hussey, G., Ashton, L. V., Quintana, A. M., Van de Walle, G. R., Osterrieder, N., & Lunn, D. P.
Affiliations: Colorado State University (US)
Freie Universität Berlin (DE)
North Carolina State University (US)
ORCID: Ashton, Laura V.
Osterrieder, Nikolaus
Lunn, David P.
Venue: Virology
Publisher: Elsevier BV
Published: 2014-09
Volume: 464-465
Pages: 76-86
ISSN: 0042-6822 (ISSN-L)
DOI: 10.1016/j.virol.2014.05.023
OpenAlex: W2029635735
Cited by: 28
References: 53
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2015: 2 · 2014: 2
FWCI: 1.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Virology (publishedVersion)
PubMed (publishedVersion)
Funders: Morris Animal Foundation
Agriculture and Food Research Initiative competitive (2012-67015-20498)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords: equine herpesvirus 1, ORF1, innate immunity, airway epithelial cells, MHC class I downregulation, MHC class II, antigen presentation, interferon-alpha, IL-10, chemokine expression, monocyte chemotaxis, neutrophil chemotaxis, viremia
MeSH terms: Animals, Epithelial Cells, Herpesvirus 1, Equid, Horse Diseases, Horses, Immunity, Innate, Leukocytes, Mononuclear, Viral Nonstructural Proteins, Chemokines, Respiratory Mucosa, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks