The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Advanced Chemical Methods in Melanin Determination
Open accessAbstract
Among the biopolymers, melanins are unique in many respects. The other essential biopolymers – proteins, nucleic acids, and carbohydrates – are chemically well characterized; their precursors (monomer units) and modes of connection between the monomer units are known, and sequences of their connection can be determined with well‐established methodologies. In contrast, we still do not have a method to determine accurately the ratio of various units present in melanins. This is largely because of the chemical properties of melanins, such as their insolubility over a broad range of pH, the heterogeneity in their structural features, and also because of the lack of methods that can split melanin polymers into their monomer units (all other biopolymers can be hydrolysed to the corresponding monomer units). To overcome this difficulty, we developed a rapid and sensitive method for quantitatively analysing eumelanin and pheomelanin in biological samples by chemical degradation methods followed by HPLC determination. This HPLC microanalytical method for characterizing eumelanin and pheomelanin has become a useful tool for the study of melanogenesis. This review will summarize the usefulness and limitations of the various chemical and spectrophotometric methods used to analyse melanins at the biochemical, cellular, and tissue levels. Emphasis is given on the usefulness of 4‐amino‐3‐hydroxyphenylalanine as a specific marker of pheomelanin.
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Palmer, J. S., Duffy, D. L., Box, N. F., Aitken, J. F., O'Gorman, L. E., Green, A. C., Hayward, N. K., Martin, N. G., & Sturm, R. A. (2000) · The American Journal of Human Genetics · doi:10.1086/302711 · Cited by 503
Biological aspects of reactive nitrogen species
Patel, R. P., McAndrew, J., Sellak, H., White, C. R., Jo, H., Freeman, B. A., & Darley-Usmar, V. M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00028-6 · Cited by 498
(Pheo)Melanin photosensitizes UVA–induced DNA damage in cultured human melanocytes
Wenczl, E., Smit, N. P. M., Pavel, S., Schothorst, A. A., Van der Schans, G. P., Timmerman, A. J., Roza, L., & Kolb, R. M. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00357.x · Cited by 186
Chemical degradation of melanins: Application to identification of dopamine-melanin
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Self-citationComparative analysis of melanins and melanosomes produced by various coat color mutants
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The physical and chemical properties of eumelanin
Meredith, P., & Sarna, T. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00345.x · Cited by 1,033
Synthesis and assembly of fungal melanin
Eisenman, H. C., & Casadevall, A. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3777-2 · Cited by 711
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659
Della Vecchia, N. F., Avolio, R., Alfè, M., Errico, M. E., Napolitano, A., & d'Ischia, M. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201202127 · Cited by 582
Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone†
Ito, S., & Wakamatsu, K. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00238.x · Cited by 503
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Metadata
- Authors
- Wakamatsu, K., & Ito, S.
- Venue
- Pigment Cell Research
- Publisher
- Wiley
- Published
- 2002-05-22
- Volume
- 15
- Issue
- 3
- Pages
- 174-183
- ISSN
- 0893-5785 (ISSN-L)
- 1600-0749
- OpenAlex
- W2087723473
- Cited by
- 350
- References
- 6
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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