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Metal chelating and hydrogen peroxide scavenging effects of melatonin
Abstract
Abstract: Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H 2 O 2) scavenging activity of melatonin. The metal chelating and H 2 O 2 scavenging activity increased with increasing concentrations of melatonin (20–60 μ g/mL). α‐Tocopherol, butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) were used as standards. Sixty micrograms per milliliter concentration of melatonin exhibited 95% chelating effect on ferrous ions and scavenged 83% of H 2 O 2. On the other hand, the same concentration of α‐tocopherol, BHA, and BHT exhibited 58, 61, and 72% inhibition, respectively, of the formation of the Fe 2+–ferrozine complex and scavenged 48, 20, and 23%, respectively, of H 2 O 2. Based on these results, it is concluded that melatonin is an effective metal chelating agent and scavenger of H 2 O 2. These properties may be major reasons for the melatonin's ability to inhibit lipid peroxidation.
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Citations
Cites
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
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Self-citationKell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds
Gülçin, İ. (2005) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480500450248 · Cited by 323
Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R. (2016) · Molecules · doi:10.3390/molecules21111442 · Cited by 60
Metadata
- Authors
- Gulcin, İ., Buyukokuroglu, M. E., & Kufrevioglu, O. I.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2003-03-26
- Volume
- 34
- Issue
- 4
- Pages
- 278-281
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1573881090
- Cited by
- 221
- References
- 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gulcin, İ., Buyukokuroglu, M. E., & Kufrevioglu, O. I. (2003). Metal chelating and hydrogen peroxide scavenging effects of melatonin. Journal of Pineal Research. https://doi.org/10.1034/j.1600-079x.2003.00042.x
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