Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
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There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context. The evidence reviewed here strongly suggests that MLT phenolic derivatives can act as both primary and secondary antioxidants, exerting their protection through diverse chemical routes. They all seem to be better free radical scavengers than MLT and Trolox, while some of them also surpass ascorbic acid and resveratrol. However, there are still many aspects that deserve further investigations for this kind of compounds.
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Melatonin increases the protective effects of glutathione, vitamin C, and trolox through regeneration by electron transfer processes.
“Melatonin also increases the protective effects of glutathione, vitamin C and trolox, through regeneration by electron transfer processes [69].”
From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [69]
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- Authors
- Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R.
- Affiliations
- Universidad Autónoma Metropolitana (MX)
- Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico
- Consejo Nacional de Ciencia y Tecnología (CONACYT)—Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Galano, Annia
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-10-29
- Volume
- 21
- Issue
- 11
- Pages
- 1442
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6274579
- OpenAlex
- W2543661053
- Cited by
- 60
- References
- 464
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Consejo Nacional de Ciencia y Tecnología (2015-2025)
- Universidad Autónoma Metropolitana unidad Iztapalapa
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- melatonin, oxidative stress, antioxidants, free radical scavenging, chemical protection, vitamin C, resveratrol, Trolox, melatonin metabolites
- MeSH terms
- Animals, Antioxidants, Chromans, Humans, Melatonin, Phenols, Free Radical Scavengers, Oxidative Stress
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