The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds

Gülçin, İlhami

doi:10.1080/09637480500450248

Cited by 323Piperaceae Chemical and Biological StudiesPhytochemicals and Antioxidant ActivitiesFree Radicals and Antioxidants

The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds

Gülçin, İlhami·2005·International Journal of Food Sciences and Nutrition

DOI 10.1080/09637480500450248

Open this paper in CoChat — free account

Abstract

Water and ethanol crude extracts from black pepper (Piper nigrum) were investigated for their antioxidant and radical scavenging activities in six different assay, namely, total antioxidant activity, reducing power, 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. Both water extract (WEBP) and ethanol extract (EEBP) of black pepper exhibited strong total antioxidant activity. The 75 microg/ml concentration of WEBP and EEBP showed 95.5% and 93.3% inhibition on peroxidation of linoleic acid emulsion, respectively. On the other hand, at the same concentration, standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and alpha-tocopherol exhibited 92.1%, 95.0%, and 70.4% inhibition on peroxidation of linoleic acid emulsion, respectively. Also, total phenolic content in both WEBP and EEBP were determined as gallic acid equivalents. The total phenolics content of water and ethanol extracts were determined by the Folin-Ciocalteu procedure and 54.3 and 42.8 microg gallic acid equivalent of phenols was detected in 1 mg WEBP and EEBP.

Integrity signals

Registry

Crossref · 10.1080/09637480500450248

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Black pepper seed powder, with active principle piperine, has antioxidant effects and increases the bioavailability of various nutrients.
“Black pepper seed powder (active principle, piperine) also has antioxidant effects and increases the bioavailability of various nutrients through a number of mechanisms [33].”
From ESSENS dyslipidemia: A placebo-controlled, randomized study of a nutritional supplement containing red yeast rice in subjects with newly diagnosed dyslipidemia (2016) · cites this paper as [33]

Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine.
Oyaizu, M. (1986) · The Japanese Journal of Nutrition and Dietetics · doi:10.5264/eiyogakuzashi.44.307 · Cited by 7,733 · see citing works
Total Phenol Analysis: Automation and Comparison with Manual Methods
Slinkard, K., & Singleton, V. L. (1977) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1977.28.1.49 · Cited by 4,382 · see citing works
Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products
Velioğlu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9801973 · Cited by 3,853 · see citing works
Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion
Shimada, K., Fujikawa, K., Yahara, K., & Nakamura, T. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00018a005 · Cited by 3,208 · see citing works
Action of Phenolic Derivatives (Acetaminophen, Salicylate, and 5-Aminosalicylate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers
Dinis, T. C. P., Madeira, V. M. C., & Almeida, L. M. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1485 · Cited by 2,727 · see citing works
Phenolic antioxidants
Shahidi, F., Janitha, P. K., & Wanasundara, P. D. (1992) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399209527581 · Cited by 2,238 · see citing works
Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea
Ruch, R. J., Cheng, S., & Klaunig, J. E. (1989) · Carcinogenesis · doi:10.1093/carcin/10.6.1003 · Cited by 2,102 · see citing works
Reactive oxygen species in living systems: Source, biochemistry, and role in human disease
Halliwell, B. B. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90279-7 · Cited by 1,811 · see citing works
Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
Gülçın, İ. (2005) · Toxicology · doi:10.1016/j.tox.2005.09.011 · Cited by 1,160 · see citing works
Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts
Oktay, M., Gülçın, İ., & Küfrevioğlu, Ö. İ. (2003) · LWT · doi:10.1016/s0023-6438(02)00226-8 · Cited by 1,070 · see citing works
Antioxidant and antiradical activities of l-carnitine
Gülçın, İ. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.103 · Cited by 995 · see citing works
Free radical scavenging activities of mushroom polysaccharide extracts
Liu, F., Ooi, V. E. C., & Chang, S. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00004-0 · Cited by 945 · see citing works
Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)
Gülçın, İ., Küfrevioğlu, Ö. İ., Oktay, M., & Büyükokuroğlu, M. E. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.09.028 · Cited by 854 · see citing works
Antioxidant Activity of Water Extract of Harng Jyur (Chrysanthemum morifolium Ramat)
Duh, P., Tu, Y.-Y., & Yen, G. (1999) · LWT · doi:10.1006/fstl.1999.0548 · Cited by 824 · see citing works
Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts
Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevioğlu, Ö. İ. (2003) · Food Chemistry · doi:10.1016/s0308-8146(03)00098-0 · Cited by 818 · see citing works
Natural antioxidants : chemistry, health effects, and applications
Shahidi, F. (1997) · Cited by 677 · see citing works
Spices as antioxidants
Madsen, H. L., & Bertelsen, G. (1995) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(00)89112-8 · Cited by 615 · see citing works
Antioxidative Action of Indole Compounds during the Autoxidation of Linoleic Acid
Mitsuda, H., YASUMOTO, K., & Iwami, K. (1966) · Eiyo to shokuryo/Eiyo To Shokuryo · doi:10.4327/jsnfs1949.19.210 · Cited by 576 · see citing works
Determination of antioxidant activity of lichen Cetraria islandica (L) Ach
Gülçın, İ., Oktay, M., Küfrevioğlu, Ö. İ., & Aslan, A. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00396-8 · Cited by 519 · see citing works
Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.)
GULCIN, W. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2003.12.008 · Cited by 487 · see citing works
Application of antioxidative Maillard reaction products from histidine and glucose to sardine products.
Tanaka, M., Chiu, W. K., Nagashima, Y., & Taguchi, T. (1988) · NIPPON SUISAN GAKKAISHI · doi:10.2331/suisan.54.1409 · Cited by 389 · see citing works
Relationship between antioxidant activity and maturity of peanut hulls
Yen, G., Duh, P., & Tsai, C. L. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00025a015 · Cited by 366 · see citing works
The contribution of plant food antioxidants to human health
Ramarathnam, N., Osawa, T., Ochi, H., & Kawakishi, S. (1995) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(00)88967-0 · Cited by 309 · see citing works
In vitroantioxidant properties of dantrolene sodium
Büyükokuroğlu, M. E., Gülçın, İ., Oktay, M., & Küfrevioğlu, Ö. İ. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0890 · Cited by 272 · see citing works
Antioxidant and analgesic activities of turpentine of Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe
Gülçın, İ., Büyükokuroğlu, M. E., Oktay, M., & Küfrevioğlu, Ö. İ. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00036-9 · Cited by 256 · see citing works
Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne
Gülçın, İ., Berashvili, D., & Gepdíremen, A. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.006 · Cited by 245 · see citing works
Metal chelating and hydrogen peroxide scavenging effects of melatonin
Gülçın, İ., Büyükokuroğlu, M. E., & Küfrevioğlu, Ö. İ. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00042.x · Cited by 224 · see citing works
Evaluation of antioxidant activity of cornelian cherry (Cornus Mas L.)
Gülçın, İ., Beydemir, Ş., Şat, G., & Küfrevioğlu, Ö. İ. (2005) · Acta Alimentaria · doi:10.1556/aalim.34.2005.2.13 · Cited by 145 · see citing works
Food Antioxidants
Hudson, B. J. F. (1990) · Springer eBooks · doi:10.1007/978-94-009-0753-9 · Cited by 108 · see citing works
Antimutagenic properties of bell and black peppers
Hamss, R. E., Idaomar, M., Alonso-Moraga, Á., & Serrano, A. M. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00216-8 · Cited by 82 · see citing works
Ribonuclease, cell-free translation-inhibitory and superoxide radical scavenging activities of the iron-binding protein lactoferrin from bovine milk
Ye, X. Y., Wang, H. X., Liu, F., & Ng, T. B. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00131-4 · Cited by 58 · see citing works
Black Pepper, Piper nigrum. Medicinal and Aromatic Plants—Industrial Profiles
Deans, S. G. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00241-2 · Cited by 24 · see citing works
Carcinogenicity Testing of Black Pepper (Piper nigrum) Using the Egyptian Toad (Bufo regularis) as a Quick Biological Test Animal
El‐Mofty, M. M., Soliman, A., Abdel-Gawad, A. F., Sakr, S. A., & Shwaireb, M. H. (2009) · Oncology · doi:10.1159/000226570 · Cited by 6 · see citing works
Untitled work
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7

Flagged first, then by citations

1 of the 35 references couldn’t be matched to a known paper.

Sorted by citations

Antioxidants and antioxidant methods: an updated overview
Gulcin, İ. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02689-3 · Cited by 2,205 · see citing works
Antioxidant activity of food constituents: an overview
Gülçın, İ. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0774-2 · Cited by 1,675 · see citing works
DPPH Radical Scavenging Assay
Gulcin, I., & Alwasel, S. (2023) · Processes · doi:10.3390/pr11082248 · Cited by 1,324 · see citing works
Radical scavenging and antioxidant activity of tannic acid
Gülçın, İ., Huyut, Z., Elmastaş, M., & Aboul-Enein, H. Y. (2009) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2009.12.008 · Cited by 977 · see citing works
Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications
Salehi, B., Zakaria, Z. A., Gyawali, R., Ibrahim, S. A., Rajković, J., Shinwari, Z. K., Khan, T., Sharifi‐Rad, J., Ozleyen, A., TÜRKDÖNMEZ, E., et al. (2019) · Molecules · doi:10.3390/molecules24071364 · Cited by 554 · see citing works
Evaluation of antioxidant and anticancer activity of copper oxide nanoparticles synthesized using medicinally important plant extracts
Rehana, D., Dharmasivam, M., Kumar, R. S., & Rahiman, A. K. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.101 · Cited by 498 · see citing works
Antioxidant Activity of Spices and Their Impact on Human Health: A Review
Yashin, A. Y., Yashin, Y. I., Xia, X., & Nemzer, B. V. (2017) · Antioxidants · doi:10.3390/antiox6030070 · Cited by 509 · see citing works
Antioxidant Activity of Eugenol: A Structure–Activity Relationship Study
Gülçın, İ. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0197 · Cited by 491 · see citing works
Antioxidant activity of clove oil – A powerful antioxidant source
Gülçın, İ., Elmastaş, M., & Aboul-Enein, H. Y. (2010) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2010.09.016 · Cited by 471 · see citing works
Metal Ions, Metal Chelators and Metal Chelating Assay as Antioxidant Method
Gülçın, İ., & Alwasel, S. H. (2022) · Processes · doi:10.3390/pr10010132 · Cited by 448 · see citing works
Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey
Gülçın, İ., Bursal, E., Şehitoğlu, M. H., Bílsel, M., & Gören, A. C. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.053 · Cited by 440 · see citing works
In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview
Ch, S., & Dave, R. A. (2009) · African Journal of Microbiology Research · doi:10.5897/ajmr.9000401 · Cited by 406 · see citing works
Antioxidants: a comprehensive review
Gülçın, İ. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-03997-2 · Cited by 490 · see citing works
Biological role of Piper nigrum L. (Black pepper): A review
Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60524-3 · Cited by 378 · see citing works
A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications
Takooree, H., Aumeeruddy, M. Z., Rengasamy, K. R. R., Venugopala, K. N., Jeewon, R., Zengin, G., & Mahomoodally, M. F. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1565489 · Cited by 336 · see citing works
Polyphenol contents and in vitro antioxidant activities of lyophilised aqueous extract of kiwifruit (Actinidia deliciosa)
Bursal, E., & Gülçın, İ. (2011) · Food Research International · doi:10.1016/j.foodres.2011.03.031 · Cited by 335 · see citing works
Determination of antioxidant and radical scavenging activity of Basil ( Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies
Gülçın, İ., Elmastaş, M., & Aboul-Enein, H. Y. (2007) · Phytotherapy Research · doi:10.1002/ptr.2069 · Cited by 319 · see citing works
Antioxidant Activity of Some Common Plants
Khalaf, N. A., Shakya, A. K., Al-Othman, A., Elagbar, Z. A., & Farah, H. S. (2008) · DergiPark (Istanbul University) · Cited by 311 · see citing works
Antioxidant activity of taxifolin: an activity–structure relationship
Topal, F., Nar, M., Göçer, H., Kalın, P., Koçyiğit, Ü. M., Gülçın, İ., & Alwasel, S. H. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1057723 · Cited by 306 · see citing works
Garlic, green tea and turmeric extracts-mediated green synthesis of silver nanoparticles: Phytochemical, antioxidant and in vitro cytotoxicity studies
Selvan, D. A., Dharmasivam, M., Kumar, R. S., & Rahiman, A. K. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.02.014 · Cited by 292 · see citing works
Antioxidant activity of l-adrenaline: A structure–activity insight
Gülçın, İ. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.023 · Cited by 280 · see citing works
Assessment of in vitro antioxidant capacity and polyphenolic composition of selected medicinal herbs from Leguminosae family in Peninsular Malaysia
Chew, Y.-L., Goh, J.-K., & Lim, Y.-Y. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.01.091 · Cited by 275 · see citing works
Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic Thermopsis turcica
Aksoy, L., Kolay, E., Ağılönü, Y., Karakuş, Z., & Kargıoğlu, M. (2013) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2013.02.003 · Cited by 239 · see citing works
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Dudhatra, G., Mody, S. K., Awale, M., Patel, H. B., Modi, C. M., Kumar, A., Kamani, D. R., & Chauhan, B. N. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/637953 · Cited by 221 · see citing works
In vitro antioxidant activity of silymarin
Köksal, E., Gülçın, İ., Beyza, S., Sarikaya, Ö., & Bursal, E. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360802188081 · Cited by 218 · see citing works
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives
Öztaşkın, N., Çetinkaya, Y., Taslımı, P., Göksu, S., & Gülçın, İ. (2015) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2015.04.006 · Cited by 203 · see citing works
Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review
Ashokkumar, K., Murugan, M., Dhanya, M. K., Pandian, A., & Warkentin, T. D. (2021) · Clinical Phytoscience · doi:10.1186/s40816-021-00292-2 · Cited by 200 · see citing works
Black Pepper and Health Claims: A Comprehensive Treatise
Butt, M. S., Pasha, I., Sultan, M. T., Randhawa, M. A., Saeed, F., & Ahmed, W. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.571799 · Cited by 191 · see citing works
Synthesis, Antioxidant, and Antiacetylcholinesterase Activities of Sulfonamide Derivatives of Dopamine‐ R elated Compounds
Göçer, H., Akıncıoğlu, A., Öztaşkın, N., Göksu, S., & Gülçın, İ. (2013) · Archiv der Pharmazie · doi:10.1002/ardp.201300228 · Cited by 184 · see citing works
Development and characterization of biocomposite films made from kefiran, carboxymethyl cellulose and Satureja Khuzestanica essential oil
Hasheminya, S.-M., Mokarram, R. R., Ghanbarzadeh, B., Hamishekar, H., Kafil, H. S., & Dehghannya, J. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.03.076 · Cited by 177 · see citing works
Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS
Gülçın, İ., Kaya, R., Gören, A. C., Akıncıoğlu, H., Topal, M., Bingöl, Z., Çakmak, K. C., Sarıkaya, S. B. Ö., Durmaz, L., & Alwasel, S. H. (2019) · International Journal of Food Properties · doi:10.1080/10942912.2019.1656232 · Cited by 178 · see citing works
Antioxidant and Radical Scavenging Activity of Aerial Parts and Roots of Turkish Liquorice (Glycyrrhiza GlabraL.)
Tohma, H., & Gülçın, İ. (2010) · International Journal of Food Properties · doi:10.1080/10942911003773916 · Cited by 177 · see citing works
Antioxidant, Antimicrobial, Antifungal, and Antiradical Activities ofCyclotrichium Niveum(BOISS.) Manden and Scheng
Gülçın, İ., Tel, A. Z., & Kıreçcı, E. (2008) · International Journal of Food Properties · doi:10.1080/10942910701567364 · Cited by 163 · see citing works
Phytochemical Analysis and Free Radical Scavenging Potential of Herbal and Medicinal Plant Extracts
Soni, A., & Sosa, S. (2013) · Journal of Pharmacognosy and Phytochemistry · Cited by 160 · see citing works
Antioxidant activity and polyphenol content of Turkish thyme ( Thymus vulgaris ) monitored by liquid chromatography and tandem mass spectrometry
Köksal, E., Bursal, E., Gülçın, İ., Korkmaz, M., Çağlayan, C., Gören, A. C., & Alwasel, S. H. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1168438 · Cited by 158 · see citing works
Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline
Gülçın, İ., Élias, R., Gepdíremen, A., Chea, A., & Topal, F. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756360902932792 · Cited by 157 · see citing works
Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects
Karageçili, H., Yılmaz, M. A., Ertürk, A., Kızıltaş, H., Güven, L., Alwasel, S. H., & Gülçın, İ. (2023) · Molecules · doi:10.3390/molecules28041739 · Cited by 154 · see citing works
Antioxidant Activity of Cauliflower (Brassica oleracea L.)
Köksal, E., & Gülçın, İ. (2008) · DergiPark (Istanbul University) · Cited by 152 · see citing works
ANTIOXIDANT ACTIVITY OF MELISSA OFFICINALIS LEAVES
Köksal, E., & Bursal, E. (2011) · Ağrı İbrahim Çeçen University Institutional Repository · doi:10.5897/jmpr.9000199 · Cited by 147 · see citing works
Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients
Ajazuddin, M., Alexander, A., Qureshi, A., Kumari, L., Vaishnav, P., Sharma, M. K., Saraf, S., & Saraf, S. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.05.005 · Cited by 144 · see citing works
Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product
Balaydın, H. T., Gülçın, İ., Menzek, A., Göksu, S., & Şahi̇n, E. (2010) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756360903514164 · Cited by 141 · see citing works
Synthesis and Antioxidant Properties of (3,4‐Dihydroxyphenyl)(2,3,4‐trihydroxyphenyl)methanone and Its Derivatives
Çetinkaya, Y., Göçer, H., Menzek, A., & Gülçın, İ. (2011) · Archiv der Pharmazie · doi:10.1002/ardp.201100272 · Cited by 136 · see citing works
Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Öztaşkın, N., Taslımı, P., Maraş, A., Gülçın, İ., & Göksu, S. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.07.010 · Cited by 136 · see citing works
Antioxidant activities of different solvent extracts of Piper retrofractum Vahl. using DPPH assay
Jadid, N., Hidayati, D., Hartanti, S. R., Arraniry, B. A., Rachman, R. Y., & Wikanta, W. (2017) · AIP conference proceedings · doi:10.1063/1.4985410 · Cited by 131 · see citing works
Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS
Karageçili, H., İzol, E., Kıreçcı, E., & Gülçın, İ. (2023) · Life · doi:10.3390/life13030735 · Cited by 130 · see citing works
Analytical techniques combined with chemometrics for authentication and determination of contaminants in condiments: A review
Reinholds, I., Bartkevičs, V., Silvis, I. C. J., van Ruth, S. M., & Esslinger, S. (2015) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2015.05.004 · Cited by 128 · see citing works
Phytochemical Evaluation and Antioxidant activity of Piper cubeba and Piper nigrum
Nahak, G. (2011) · Cited by 126 · see citing works
Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts
Predes, F. D. S., Ruiz, A. L. T. G., de Carvalho, J. E., Foglio, M. A., & Dolder, H. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-25 · Cited by 125 · see citing works
Effects of Black Pepper (Piper Nigrum), Turmeric Powder (Curcuma Longa) and Coriander Seeds (Coriandrum Sativum) and Their Combinations as Feed Additives on Growth Performance, Carcass Traits, Some Blood Parameters and Humoral Immune
Abou-Elkhair, R., Ahmed, H. A., & Selim, S. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13644 · Cited by 126 · see citing works
Effects of fertilizer on yield, essential oil composition, total phenolic content and antioxidant activity in Satureja hortensis L. (Lamiaceae) cultivated in Iran
Alizadeh, A., Khosh-Khui, M., Javidnia, K., Firuzi, O., Tafazoli, E., & Khalighi, A. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr09.361 · Cited by 122 · see citing works
Antioxidant and Antimicrobial Activities of an Aquatic Plant: Duckweed (Lemna minor L.)
Gülçın, İ., Kıreçcı, E., Akkemik, E., Topal, F., & Hisar, O. (2010) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-0806-7 · Cited by 120 · see citing works
Depigmenting Effect of Kojic Acid Esters in Hyperpigmented B16F1 Melanoma Cells
Lajis, A. F. B., Hamid, M., & Ariff, A. B. (2012) · BioMed Research International · doi:10.1155/2012/952452 · Cited by 117 · see citing works
Green Synthesis of Silver Nanoparticles Using Aqueous Extract of Rosa brunonii Lindl and Their Morphological, Biological and Photocatalytic Characterizations
Bhagat, M., Anand, R., Datt, R., Gupta, V., & Arya, S. K. (2018) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-018-0994-5 · Cited by 108 · see citing works
Synthesis of dimeric phenol derivatives and determination ofin vitroantioxidant and radical scavenging activities
GÜLÇİN, İ., & Daştan, A. (2007) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360601164903 · Cited by 102 · see citing works
Self-citation
Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: A randomized, double‐blind, controlled clinical trial
Heidari‐Beni, M., Moravejolahkami, A. R., Gorgian, P., Askari, G., Tarrahi, M. J., & Bahreini, N. (2020) · Phytotherapy Research · doi:10.1002/ptr.6671 · Cited by 103 · see citing works
Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS
Köksal, E., Tohma, H., Kılıç, Ö., Alan, Y., Aras, A., Gülçın, İ., & Bursal, E. (2017) · Scientia Pharmaceutica · doi:10.3390/scipharm85020024 · Cited by 99 · see citing works
Antioxidant activity, nitric oxide scavenging activity and phenolic contents of Ocimum gratissimum leaf extract
Francis, M., & rew, W. V. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr10.262 · Cited by 97 · see citing works
Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS
Bingöl, Z., Kızıltaş, H., Gören, A. C., Köse, L. P., Topal, M., Durmaz, L., Alwasel, S. H., & Gülçın, İ. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06986 · Cited by 88 · see citing works
Evaluation of the in vitro antioxidant, antidiabetic and anticholinergic properties of rosmarinic acid from rosemary (Rosmarinus officinalis L.)
Topal, M., & Gülçın, İ. (2022) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2022.102417 · Cited by 85 · see citing works
Molecular marker based adulteration detection in traded food and agricultural commodities of plant origin with special reference to spices.
Dhanya, K., & Sasikumar, B. (2010) · Current Trends in Biotechnology and Pharmacy · Cited by 83 · see citing works
Evaluation of the Antioxidant and Antiradical Properties of Some Phyto and Mammalian Lignans
Köse, L. P., & Gülçın, İ. (2021) · Molecules · doi:10.3390/molecules26237099 · Cited by 82 · see citing works
Inactivation of Escherichia coli O157:H7 and Salmonella Typhimurium in black pepper and red pepper by gamma irradiation
Song, W., Sung, H.-J., Kim, S.-Y., Kim, K.-P., Ryu, S., & Kang, D. (2013) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2013.11.017 · Cited by 82 · see citing works
Acethylcholinesterase inhibitory potential and antioxidant properties of pyrogallol
Sarıkaya, S. B. Ö. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.965700 · Cited by 76 · see citing works
Antioxidant and Cytotoxic Activities of Carob Tree Fruit Pulps Are Strongly Influenced by Gender and Cultivar
Custódio, L. M. B., Fernandes, E., Escapa, A. L., Fajardo, A., Aligué, R., Alberício, F., Neng, N. R., Nogueira, J. M. F., & Romano, A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200838f · Cited by 73 · see citing works
Chemical composition and antioxidant capacity of black pepper pericarp
Lee, J.-G., Chae, Y., Shin, Y., & Kim, Y. (2020) · Applied Biological Chemistry · doi:10.1186/s13765-020-00521-1 · Cited by 73 · see citing works
Management of stroke as described by Ibn Sina (Avicenna) in the Canon of Medicine
Zargaran, A., Zarshenas, M. M., Karimi, A., Yarmohammadi, H., & Borhani‐Haghighi, A. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.115 · Cited by 72 · see citing works
Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity
Özaslan, M. S., Sağlamtaş, R., Demir, Y., Genç, Y., Saraçoğlu, İ., & Gülçın, İ. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200280 · Cited by 71 · see citing works
Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
Murata, K., Nakao, K., Hirata, N., Namba, K., Nomi, T., Kitamura, Y., Moriyama, K., Shintani, T., Iinuma, M., & Matsuda, H. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0331-y · Cited by 71 · see citing works
A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury
Akdemi̇r, F. N. E., Gülçın, İ., Öztürk, B., Soslu, R., & Alwasel, S. H. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1220378 · Cited by 71 · see citing works
Acetylcholinesterase Inhibitory and Antioxidant Activities of Novel Symmetric Sulfamides Derived from Phenethylamines
Aksu, K., Topal, F., Gülçın, İ., Tümer, F., & Göksu, S. (2015) · Archiv der Pharmazie · doi:10.1002/ardp.201500035 · Cited by 70 · see citing works
Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract
S, A. M. K. S. (2015) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000268 · Cited by 69 · see citing works
Pistachio (Pistacia veraL.) Gum: a potent inhibitor of reactive oxygen species
Şehitoğlu, M. H., Han, H., Kalın, P., Gülçın, İ., Ozkan, A., & Aboul-Enein, H. Y. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.915395 · Cited by 68 · see citing works
Effect of drying method and extraction solvent on the total phenolics and antioxidant activity of cauliflower ( Brassica oleracea L.) extracts
Mushtaq, M. A., & Mehmood, T. (2013) · International Food Research Journal · Cited by 68 · see citing works
Fe3+–Fe2+ Transformation Method: An Important Antioxidant Assay
Gülçın, İ. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1441-8_17 · Cited by 67 · see citing works
Apoptotic, antioxidant and cytotoxic properties of synthesized AgNPs using green tea against human testicular embryonic cancer stem cells
Mobaraki, F., Momeni, M., Jahromi, M., Kasmaie, F. M., Barghbani, M., Yazdi, M. E. T., Meshkat, Z., Shandiz, F. H., & Hosseini, S. M. (2022) · Process Biochemistry · doi:10.1016/j.procbio.2022.05.021 · Cited by 66 · see citing works
Effect of drying methods and storage with agro-ecological conditions on phytochemicals and antioxidant activity of fruits: a review
Vidinamo, F., Fawzia, S., & Karim, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1816891 · Cited by 65 · see citing works
LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)
Kızıltaş, H., Bingöl, Z., Gören, A. C., Köse, L. P., Durmaz, L., Topal, F., Alwasel, S. H., & Gülçın, İ. (2021) · Molecules · doi:10.3390/molecules26092469 · Cited by 64 · see citing works
Inhibitory Effects of Black Pepper ( Piper Nigrum ) Extracts and Compounds on Human Tumor Cell Proliferation, Cyclooxygenase Enzymes, Lipid Peroxidation and Nuclear Transcription Factor-kappa-B
Liu, Y., Yadev, V. R., Aggarwal, B. B., & Nair, M. G. (2010) · Natural Product Communications · doi:10.1177/1934578x1000500822 · Cited by 63 · see citing works
A comprehensive review on medicinal plants possessing antioxidant potential
Zafar, F., Asif, H. M., Shaheen, G., Ghauri, A. O., Rajpoot, S. R., Tasleem, M. W., Shamim, T., Hadi, F., Noor, R., Ali, T., et al. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13743 · Cited by 62 · see citing works
The potential role of turmeric and black pepper powder diet supplements in reversing cadmium-induced growth retardation, ATP depletion, hepatorenal damage, and testicular toxicity in Clarias gariepinus
El-Houseiny, W., Khalil, A. A., Abd‐Elhakim, Y. M., & Badr, H. A. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.05.045 · Cited by 62 · see citing works
Antioxidant Capacity of Extracts from Wild and Crop Plants of the Mediterranean Region
Mohamed, R., Pineda, M., & Aguilar, M. R. (2006) · Journal of Food Science · doi:10.1111/j.1750-3841.2006.00207.x · Cited by 60 · see citing works
Quercetin protects rat skeletal muscle from ischemia reperfusion injury
Akdemi̇r, F. N. E., Gülçın, İ., Öztürk, B., & Soslu, R. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1193735 · Cited by 59 · see citing works
The Relationship of Nitrogen and C/N Ratio with Secondary Metabolites Levels and Antioxidant Activities in Three Varieties of Malaysian Kacip Fatimah (Labisia pumila Blume)
Ibrahim, M. H., & Jaafar, H. Z. E. (2011) · Molecules · doi:10.3390/molecules16075514 · Cited by 57 · see citing works
Traditional Uses of Spices: An Overview
Kunnumakkara, A. B., Koca, C., Dey, S., Gehlot, P., Yodkeeree, S., Danda, D., Sung, B., & Aggarwal, B. B. (2009) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812837912_0001 · Cited by 57 · see citing works
Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves – phytochemical content by LC-MS/MS analysis
Köse, L. P., Bingöl, Z., Kaya, R., Gören, A. C., Akıncıoğlu, H., Durmaz, L., Köksal, E., Alwasel, S. H., & Gülçın, İ. (2020) · International Journal of Food Properties · doi:10.1080/10942912.2020.1761829 · Cited by 56 · see citing works
Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine
Wang, D., Zhang, L., Huang, J., Himabindu, K., Tewari, D., Horbańczuk, J. O., Xu, S., Chen, Z., & Atanasov, A. G. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.11.024 · Cited by 55 · see citing works
De Novo Assembly and Characterization of Fruit Transcriptome in Black Pepper (Piper nigrum)
Hu, L., Hao, C., Fan, R., Wu, B., Tan, L., & Wu, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129822 · Cited by 53 · see citing works
Isolation of piperdine from Piper nigrum and its antiproliferative activity.
Reshmi, S. K., Sathya, E., & Devi, P. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr10.033 · Cited by 53 · see citing works
Preparation of black pepper oleoresin inclusion complexes based on beta-cyclodextrin for antioxidant and antimicrobial delivery applications using kneading and freeze drying methods: A comparative study
Özdemır, N., Pola, C. C., Teixeira, B. N., Hill, L. E., Bayrak, A., & Gomes, C. L. (2018) · LWT · doi:10.1016/j.lwt.2018.01.046 · Cited by 53 · see citing works
Antioxidant, antidiabetic, antiglaucoma, and anticholinergic effects of Tayfi grape (Vitis vinifera): A phytochemical screening by LC-MS/MS analysis
Karageçili, H., İzol, E., Kıreçcı, E., & Gülçın, İ. (2023) · Open Chemistry · doi:10.1515/chem-2023-0120 · Cited by 49 · see citing works
Synthesis and Characterization of Nano‐Encapsulated Black Pepper Oleoresin using Hydroxypropyl Beta‐Cyclodextrin for Antioxidant and Antimicrobial Applications
Teixeira, B. N., Özdemır, N., Hill, L. E., & Gomes, C. L. (2013) · Journal of Food Science · doi:10.1111/1750-3841.12312 · Cited by 49 · see citing works
Polyphenol oxidase activity and antioxidant properties of Yomra apple (Malus communisL.) from Turkey
Can, Z., Dinçer, B., Şahin, H., Baltaş, N., Yıldız, O., & Kolaylı, S. (2013) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2013.858144 · Cited by 49 · see citing works
Role of phyto-stabilised silver nanoparticles in suppressing adjuvant induced arthritis in rats
Mani, A., Vasanthi, C., Gopal, V., & Chellathai, D. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.10.013 · Cited by 49 · see citing works
Microbial decontamination of black peppercorns by simultaneous treatment with cold plasma and ultraviolet C
Bang, I. H., Kim, Y. E., Lee, S. Y., & Min, S. C. (2020) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2020.102392 · Cited by 48 · see citing works
The Inhibitory Effects of L-Adrenaline on Lactoperoxidase Enzyme Purified from Bovine Milk
Şişecioğlu, M., Gülçın, İ., Çankaya, M., & Özdemіr, H. (2011) · International Journal of Food Properties · doi:10.1080/10942912.2010.511924 · Cited by 46 · see citing works
Sahlep (Dactylorhiza osmanica): Phytochemical Analyses by LC-HRMS, Molecular Docking, Antioxidant Activity, and Enzyme Inhibition Profiles
Kızıltaş, H., Gören, A. C., Alwasel, S. H., & Gülçın, İ. (2022) · Molecules · doi:10.3390/molecules27206907 · Cited by 45 · see citing works
Green synthesized Cobalt oxide nanoparticles using Curcuma longa for anti-oxidant, antimicrobial, dye degradation and anti-cancer property
Shanmuganathan, R., Sathiyavimal, S., Le, Q. H., Al‐Ansari, M. M., Al-Humaid, L. A., Jhanani, G. K., Lee, J., & Barathi, S. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116747 · Cited by 43 · see citing works
Assessment of Antioxidant and Cytotoxicity Activities of Saponin and Crude Extracts of Chlorophytum borivilianum
Ashraf, M. F., Aziz, M. A., Stanslas, J., Ismail, I., & Kadir, M. A. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/216894 · Cited by 43 · see citing works
A current opinion on the antimicrobial importance of popular pepper essential oil and its application in food industry
Myszka, K., Leja, K., & Majcher, M. A. (2018) · Journal of Essential Oil Research · doi:10.1080/10412905.2018.1511482 · Cited by 42 · see citing works
Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
Stasiłowicz-Krzemień, A., Tykarska, E., Lewandowska, K., Kozak, M., Miklaszewski, A., Kobus‐Cisowska, J., Szymanowska, D., Plech, T., Jenczyk, J., & Cielecka‐Piontek, J. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1801670 · Cited by 42 · see citing works

In vitro antioxidant activity of pet ether extract of black pepper
Singh, R., Singh, N. P., Saini, B., & Rao, H. S. (2008) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.43160 · Cited by 70 · see citing works
Comparison of antioxidant activities and free radical scavenging potential of black and white pepper (Piper nigrum L.) essential oils.
Wang, Y., Zi-tao, J., Li, R., & GengHui, H. (2009) · Zhongguo tiaoweipin
Determination of Nutritional Facts, Polyphenolic Content and Radical Scavenging Activity of Black Pepper (Piper nigrum L) from Pakistan
Saeed, M. K., Zahra, N., Rasheed, A. A., Ijaz, A., Shehzad, K., Ahmad, I., & Abdi, S. H. I. (2026) · DIET FACTOR (Journal of Nutritional & Food Sciences) · doi:10.54393/df.v7i2.221
IDENTIFIKASI GOLONGAN KANDUNGAN SENYAWA KIMIA DAN UJI AKTIVITAS ANTIOKSIDAN BIJI LADA HITAM (Piper nigrum L.)
Rianto, B. (2015)
Comparative analysis of the in vitro antioxidant activity of white and black pepper
Agbor, G. A., Vinson, J. A., Oben, J. E., & Ngogang, J. Y. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.09.019 · Cited by 74 · see citing works

Authors: Gülçin, İ.
Venue: International Journal of Food Sciences and Nutrition
Publisher: Informa UK Limited
Published: 2005-01
Volume: 56
Issue: 7
Pages: 491-499
ISSN: 0963-7486 (ISSN-L)
1465-3478
DOI: 10.1080/09637480500450248
OpenAlex: W2073231015
Cited by: 323
References: 35
Citations by year: 2026: 7 · 2025: 26 · 2024: 18 · 2023: 31 · 2022: 26 · 2021: 21 · 2020: 27 · 2019: 14 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 18 · 2014: 15 · 2013: 17 · 2012: 9
FWCI: 4.23
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Food Sciences and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: black pepper, seeds, antioxidant activity, free radical scavenging, DPPH radical scavenging, superoxide radical scavenging, hydrogen peroxide scavenging, metal chelating activity, reducing power, total phenolic content, aqueous extract, ethanol extract
MeSH terms: Ethanol, Antioxidants, Chelating Agents, Oxidation-Reduction, Plant Extracts, Seeds, Water, Lipid Peroxidation, Free Radical Scavengers, Piper nigrum

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks