The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Muscle strength, disability and mortality
Abstract
The aims of this review are to address (1) the role of muscle strength in the disablement process and (2) muscle strength as a predictor of length of life using data from prospective studies. Functional limitations, such as slow walking speed, predispose older people to disabilities. How much strength is needed for daily motor tasks such as walking varies according to other impairments present. For example, when postural balance is good, only minimum amount of strength is needed for walking. However, in the presence of balance impairment, having good level of strength may help to compensate for the deficit. Having strength well above the required level indicates reserve capacity. It was studied using data from the Honolulu Heart Program launched in 1965 among 8006 men initially aged 45–68 years, whether reserve of strength would be protective of development of future disability. All men with documented diseases at baseline were excluded from the analyses. Those men who were in the lowest third of the distribution of grip strength at baseline were at two to three times greater risk of developing disabilities assessed 25 years later compared to the highest third. It is possible that before they reach the disability level, those with greater reserve of strength may afford to lose more strength, for example following bed rest and inactivity associated with an illness. Midlife grip strength was also found to predict long‐term total mortality: those with poorer strength at baseline were more likely to die over the follow‐up period of 30 years. The association between muscle strength and disability is largely explained by biomechanical mechanisms. However, the mechanism explaining the association between muscle strength and mortality risk still remains to be explored.
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“In addition, sarcopenia is a major clinical problem in public health of older people; with some adverse outcomes such as disability, poor quality of life, and increased risk of death [2–4].”
From Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies (2017) · cites this paper as [4]
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Sorted by citations
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“Moreover, sarcopenia is related to functional impairment (12,13), disability (14,15), falls (16), and loss of independence (17) in older adults.”
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Cooper, R., Kuh, D., Hardy, R., Mortality Review Group, & teams, O. B. O. T. F. A. H. S. (2010) · BMJ · doi:10.1136/bmj.c4467 · Cited by 1,166
“No systematic review of the literature has been done to examine the associations of walking speed, standing balance, or chair rises with mortality. Existing reviews of grip strength have not done meta-analyses of results or investigated heterogeneity between studies.”
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“Sarcopenia also plays a predominant role in the etiology and pathogenesis of frailty, which is highly predictive of adverse events such as hospitalization, associated morbidity and disability and mortality (215, 216).”
BackgroundClinical definition of sarcopenia
Santilli, V. (2014) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2014.11.3.177 · Cited by 747
“However, some recent studies suggested that muscle function may be a more powerful predictor of disability and mortality than the muscle mass (37, 38).”
Background
Metadata
- Authors
- Rantanen, T.
- Affiliations
- University of Jyväskylä (FI)
- Corresponding author
- Rantanen, T.
- ORCID
- Rantanen, T.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2003-01-14
- Volume
- 13
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W2005358707
- Cited by
- 317
- References
- 41
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 17 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 24 · 2014: 18 · 2013: 25 · 2012: 14
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- muscle strength, grip strength, disability, mortality, functional limitations, older adults, walking speed, postural stability, reserve capacity, Honolulu Heart Program, biomechanical mechanisms
- MeSH terms
- Activities of Daily Living, Aging, Disability Evaluation, Humans, Mortality, Risk Factors, Muscle, Skeletal
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