Hemispheric asymmetry reduction in older adults: The HAROLD model.

Abstract

A model of the effects of aging on brain activity during cognitive performance is introduced. The model is called HAROLD (hemispheric asymmetry reduction in older adults), and it states that, under similar circumstances, prefrontal activity during cognitive performances tends to be less lateralized in older adults than in younger adults. The model is supported by functional neuroimaging and other evidence in the domains of episodic memory, semantic memory, working memory, perception, and inhibitory control. Age-related hemispheric asymmetry reductions may have a compensatory function or they may reflect a dedifferentiation process. They may have a cognitive or neural origin, and they may reflect regional or network mechanisms. The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging.

Cites (5)

1. The processing-speed theory of adult age differences in cognition
   Salthouse, Timothy A. · 1996 · Psychological Review
2. Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET
   Reuter-Lorenz, Patricia A., Jonides, John, Smith, Edward E., Hartley, Alan, Miller, Andrea, Marshuetz, Christina, Koeppe, Robert A. · 2000 · Journal of Cognitive Neuroscience
3. Education and Other Measures of Socioeconomic Status and Risk of Incident Alzheimer Disease in a Defined Population of Older Persons
   Evans, D. A., Hebert, L. E., Beckett, L. A., Scherr, P. A., Albert, M. S., Chown, M. J., Pilgrim, D. M., Taylor, J. O. · 1997 · Archives of Neurology
4. Cortical Language Activation in Stroke Patients Recovering From Aphasia With Functional MRI
   Cao, Yue, Vikingstad, Eric M., George, K. Paige, Johnson, Alex F., Welch, K. M. A. · 1999 · Stroke
5. Effects of Age on Brain Activation During Auditory-Cued Thumb-to-Index Opposition: A Positron Emission Tomography Study
   Calautti, C., Serrati, C., Baron, J-C. · 2001 · Stroke

Show all 5 references

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