The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
Abstract
The emotional reactivity of rats with lesions of the dorsal portion of medial prefrontal cortex (mPFC) was examined using a classical fear conditioning paradigm. Conditioned fear behavior (freezing responses) was measured during both the acquisition and extinction phases of the task. Lesions enhanced fear reactivity to both the conditioned stimulus (CS) and contextual stimuli during both phases, suggesting that dorsal mPFC lesions produce a general increase in fear reactivity in response to fear conditioning. M. A. Morgan, L. M. Romanski, and J. E. LeDoux (1993) found that lesions just ventral to the present lesions had no effect during acquisition of the same task and prolonged the fear response to the CS (but not the context) during extinction. Thus, both dorsal and ventral regions of mPFC are involved in the fear system, but each modulates different aspects of fear responsivity.
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“Conversely, lesions of the mPFC enhance behavioral, sympathetic, and endocrine responses to stressors or fearconditioned stimuli in rats (Morgan and LeDoux, 1995;Sullivan and Gratton, 1999).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Morgan and LeDoux, 1995
In the citing paper
“Conversely, lesions of the right or bilateral mPFC enhance behavioral, sympathetic, and endocrine responses to stressors or fear-conditioned stimuli in rats (Morgan and LeDoux 1995; Sullivan and Gratton 1999).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Morgan and LeDoux 1995
In the citing paper
“Evidence also exists showing that vmPFC activity in some specific locales correlates positively with negative emotions,26,27”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [27]
Citations
Cites
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Self-citationCircuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897
Self-citationEfferent projections of the infralimbic cortex of the rat
Hurley, K. M., Herbert, H., Moga, M. M., & Saper, C. B. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903080210 · Cited by 777
Cited by
Sorted by citations
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203
Self-citationStress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Metadata
- Authors
- Morgan, M. A., & LeDoux, J. E.
- Affiliations
- New York University (US)
- ORCID
- LeDoux, Joseph E.
- Venue
- Behavioral Neuroscience
- Published
- 1995-08
- Volume
- 109
- Issue
- 4
- Pages
- 681-688
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1968784545
- Cited by
- 717
- References
- 4
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 15 · 2023: 8 · 2022: 7 · 2021: 19 · 2020: 19 · 2019: 21 · 2018: 17 · 2017: 14 · 2016: 20 · 2015: 32 · 2014: 25 · 2013: 38 · 2012: 31
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial prefrontal cortex, dorsomedial prefrontal cortex, ventromedial prefrontal cortex, fear conditioning, fear extinction, fear reactivity, freezing behavior, cortical lesions, contextual fear, rats
- MeSH terms
- Animals, Association Learning, Brain Mapping, Conditioning, Classical, Extinction, Psychological, Fear, Male, Motor Activity, Mental Recall, Social Environment, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
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