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Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
Abstract
The emotional reactivity of rats with lesions of the dorsal portion of medial prefrontal cortex (mPFC) was examined using a classical fear conditioning paradigm. Conditioned fear behavior (freezing responses) was measured during both the acquisition and extinction phases of the task. Lesions enhanced fear reactivity to both the conditioned stimulus (CS) and contextual stimuli during both phases, suggesting that dorsal mPFC lesions produce a general increase in fear reactivity in response to fear conditioning. M. A. Morgan, L. M. Romanski, and J. E. LeDoux (1993) found that lesions just ventral to the present lesions had no effect during acquisition of the same task and prolonged the fear response to the CS (but not the context) during extinction. Thus, both dorsal and ventral regions of mPFC are involved in the fear system, but each modulates different aspects of fear responsivity.
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“Conversely, lesions of the mPFC enhance behavioral, sympathetic, and endocrine responses to stressors or fearconditioned stimuli in rats (Morgan and LeDoux, 1995;Sullivan and Gratton, 1999).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Morgan and LeDoux, 1995
In the citing paper
“Conversely, lesions of the right or bilateral mPFC enhance behavioral, sympathetic, and endocrine responses to stressors or fear-conditioned stimuli in rats (Morgan and LeDoux 1995; Sullivan and Gratton 1999).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Morgan and LeDoux 1995
In the citing paper
“Evidence also exists showing that vmPFC activity in some specific locales correlates positively with negative emotions,26,27”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [27]
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Metadata
- Authors
- Morgan, M. A., & LeDoux, J. E.
- Affiliations
- New York University (US)
- ORCID
- LeDoux, Joseph E.
- Venue
- Behavioral Neuroscience
- Published
- 1995-08
- Volume
- 109
- Issue
- 4
- Pages
- 681-688
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1968784545
- Cited by
- 717
- References
- 4
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 15 · 2023: 8 · 2022: 7 · 2021: 19 · 2020: 19 · 2019: 21 · 2018: 17 · 2017: 14 · 2016: 20 · 2015: 32 · 2014: 25 · 2013: 38 · 2012: 31
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial prefrontal cortex, dorsomedial prefrontal cortex, ventromedial prefrontal cortex, fear conditioning, fear extinction, fear reactivity, freezing behavior, cortical lesions, contextual fear, rats
- MeSH terms
- Animals, Association Learning, Brain Mapping, Conditioning, Classical, Extinction, Psychological, Fear, Male, Motor Activity, Mental Recall, Social Environment, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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