A gender-specific mechanism for pair bonding: oxytocin and partner preference formation in monogamous voles

In the citing paper

“Activation of D1-like DA receptors inhibits partner preference formation induced by either mating or by D2 activation [63, 64].”

In the citing paper

“Infusion of oxytocin into the brains of female prairie voles and vasopressin in males, for instance, facilitated pair-bonding even in the absence of actual mating (Cho et al. 1999; Insel and Hulihan 1995; Williams et al. 1994; Winslow et al. 1993).”

In the citing paper

“These findings are consistent with those reported for other mammals, particularly monogamous rodent species in which OT has shown to play a critical role in the formation of pair-bonds (Cho et al., 1999; Insel and Hulihan, 1995; Williams et al., 1994).”

In the citing paper

“Sex-specific responses to AVP and OXT manipulations in rodents have been reported for behaviors other than juvenile social play, including aggression (Ferris and Potegal, 1988; Gutzler et al., 2010), partner preference (Insel and Hulihan, 1995; Cho et al., 1999; Bales et al., 2013), alloparental behavior (Bales et al., 2004), and social recognition (Bluthé and Dantzer, 1990; Engelmann et al., 1998”

In the citing paper

“Sex differences in behavioral or brain responses were also found after manipulations of the OXT brain system in voles (Insel & Hulihan, 1995) and after intranasal OXT application in humans (Kubzansky et al., 2012; Lische et al., 2012).”

In the citing paper

“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”

In the citing paper

“ICV V1aR antagonist administration impaired partner preference in male voles only (Winslow et al., 1993; Insel & Hulihan, 1995)”

In the citing paper

“OT plays a stronger role in partner preference in female prairie voles compared to males (Winslow et al., 1993; Williams et al., 1994; Insel and Hulihan, 1995; Liu et al., 2001).”

In the citing paper

“In terms of pair bonding, female prairie vole mate preferences can be formed by oxytocin infusion (Williams et al., 1994) and blocked by an oxytocin agonist (Insel and Hulihan, 1995).”

In the citing paper

“While sex differences in responses to OT are pervasive in both adult voles (3,72) and in single-dose developmental studies (37,38,73)”

In the citing paper

“These studies have demonstrated that arginine vasopressin (AVP), oxytocin (OT), and dopamine (DA), along with their respective receptors, act within specific brain circuitry to facilitate social attachment in a gender-specific manner [9].”

In the citing paper

“Early pharmacological studies revealed that OTR signaling in the brain is critical for partner preference formation in female prairie voles (Insel and Hulihan, 1995; Williams et al., 1994).”

In the citing paper

“Previous work has suggested that the central OT system may modulate pair bonding in prairie voles in a sex-specific manner (Insel and Hulihan, 1995; Winslow and Insel, 1993), with central OTRs modulating pair bonding in females but not in males.”

In the citing paper

“The neuropeptide oxytocin (OT) is implicated in the modulation of many social responses (Ross and Young, 2009; Insel and Hulihan, 1995; Ferguson et al., 2001; Dölen et al., 2013).”

In the citing paper

“Such gender-specific effects of OT have been documented numerously in prairie voles (Microtus ochrogaster), and are verified to be centrally-mediated based on ventricular peptide manipulation experiments.”