The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
Abstract
Rats were trained in a previously validated behavioral vigilance task that required them to detect visual signals of variable length and to discriminate signal from nonsignal events. Baseline performance was characterized by a signal length-dependent ability to score hits, a decline in hits over time, and a correct rejection rate of approximately 70%. After the rats reached criterion performance in this task, the immunotoxin 192 IgG-saporin or its vehicle was infused into the area of the nucleus basalis/substantia innominata of the basal forebrain. Postoperative performance in lesioned rats was characterized by a decrease in their ability to detect signals while their ability to correctly reject nonsignals remained unaffected. The effect of the lesion did not recover in the course of over 180 sessions of postlesion testing. The overall performance of the rats correlated with acetylcholinesterase (AChE)-positive fiber density in all cortical areas measured except the cingulate and pyriform cortex. These findings help to elucidate the nature of the attentional impairments resulting from the loss of cortical cholinergic inputs.
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“In rodents, lesions of cholinergic inputs to the cortex impair tests of sustained attention, particularly across sensory modalities (McGaughy et al., 2002; McGaughy et al., 1996; Turchi and Sarter, 1997).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as McGaughy et al., 1996
In the citing paper
“At the same time, this deafferentation did not affect the animals’ response accuracy in blank trials (i.e., the correct reporting of the absence of a cue).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as McGaughy et al, 1996
In the citing paper
“While intact animals detected over 70–80% of the longest (500 ms) cues, cortical cholinergic deafferentation reduced the detection rate for all cues to about 30%, with no recovery despite several months of daily post-surgery practice (McGaughy et al, 1996).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as McGaughy et al, 1996
In the citing paper
“Removal of cortical cholinergic inputs selectively and persistently impaired the animals’ detection rate (or number of hits). In contrast, response accuracy in blank trials remained completely spared.”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as McGaughy et al, 1996
In the citing paper
“As orienting is not necessary for detection, the residual hit rate following cortical cholinergic deafferentation (McGaughy et al, 1996) may have been due to detections that occurred without the facilitating benefits of attentional orienting.”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as McGaughy et al, 1996
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Items 301–337 of 337
Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin
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“A sustained attention index (SI) was calculated based upon false alarms (fa/(cr + fa)) and hits (SI = (h − fa)/(2 × (h + fa) − (h + fa)2)) (McGaughy et al., 1996).”
Eck, S. R., Kokras, N., Wicks, B., Baltimas, P., Hall, A., van Bendegem, N., Salvatore, M., Cohen, S. R., Bergmann, J., Ceretti, A., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109280 · Cited by 2
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Moghaddam, B., & Pehrson, A. L. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0913-8_5 · Cited by 2
“Previous mechanistic investigations of the pathophysiology of schizophrenia have primarily focused on dopaminergic and cholinergic systems in different subregions of the PFC (Geraud et al. 1987; Goldman-Rakic 1987; Daniel et al. 1989, 1991; Lewis et al. 1992; McGaughy et al. 1996; Robbins 1998).”
BackgroundNervous System Research with RIP Conjugates
Lappi, D. A., Feldman, J. L., Sengelaub, D. R., & McGaughy, J. A. (2014) · Wiley eBooks · doi:10.1002/9781118847237.ch17 · Cited by 2
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Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0012 · Cited by 2
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Clement, M. K., Pimentel, C. S., & McGaughy, J. A. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16352 · Cited by 1
“Prior studies have assessed the effect of a 0.5 Hz visual, distractor session, for example, the predictable, visual distractor, (Plight; McGaughy et al., 1996; McGaughy & Sarter, 1995; Newman & McGaughy, 2008, 2011).”
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Petrosini, L., Bartolo, P. D., & Cutuli, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_79-1 · Cited by 2
Waite, J. J. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-896-0_3 · Cited by 1
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0007 · Cited by 1
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Psychopathology of psychosis: Towards integration from an idealist perspective
Behrendt, R., & Young, C. C. (2004) · Behavioral and Brain Sciences · doi:10.1017/s0140525x04440187
The Immunolesioned Animal as a Model of Transmitter Dysfunction
Wenk, G. L. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-691-1_4
Roles of cholinergic receptors during attentional modulation of cue detection
Burk, J. A. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i4.84
Validation of Animal Models of Dementia: Neurochemical Aspects
Pepeu, G., & Rosi, M. C. (2010) · Neuromethods · doi:10.1007/978-1-60761-898-0_10
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0004
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0003
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0013
Symptoms and syndromes of anxiety
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0011
Lana, D. (2016) · Premio Tesi dottorato/Premio Tesi di dottorato · doi:10.36253/978-88-6655-941-2
Borroni, B., & Premi, E. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718304416.793492100
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0001
Fanselow, M. S., & Rajbhandari, A. K. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733583795.793560179
Sah, P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726411676.793569751
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Preface to the paperback edition
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Scopolamine induced learning deficit in marmosetsPreprint
Harkins, H. E., Christopher, K., Matrov, D., Ingram, I. D., Saglio, E. B., Dold, G. R., & Chudasama, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.18.688868
“…(Drachman and Leavitt, 1974; Petersen, 1977; Beatty et al., 1986; Goldman Rakic, 1987; Pang et al., 1993; Muir et al., 1994; Voytko et al., 1994; McGaughy et al., 1996), including spatial perception, attention or response perseveration (Mishkin and Manning, 1978; Callahan et al., 1993;…”
Home-cage pharmacology in marmosets: behavioral effects of scopolamine
Harkins, H. E., Christopher, K., Matrov, D., Ingram, I. D., Saglio, E. B., Dold, G. R., & Chudasama, Y. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07054-3
Ascending Systems Controlling Attentional Functions
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Self-citationMcGaughy, J., Dalley, J. W., Morrison, C. H., Everitt, B. J., & Robbins, T. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01905.2002 · Cited by 311
“, 1995), divided (Turchi and Sarter, 1997), or sustained (McGaughy et al., 1996) attention in rats.”
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Metadata
- Authors
- McGaughy, J., Kaiser, T., & Sarter, M.
- Affiliations
- The Ohio State University (US)
- Venue
- Behavioral Neuroscience
- Published
- 1996-04
- Volume
- 110
- Issue
- 2
- Pages
- 247-265
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2075076974
- Cited by
- 435
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 28 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 17 · 2015: 13 · 2014: 15 · 2013: 15 · 2012: 16
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag010173-10)
- National Institute on Aging (AG10 173)
- National Institute of Mental Health (MH01072, K02MH001072)
- National Institute of Neurological Disorders and Stroke (NS32938, R01NS032938)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- 192 IgG-saporin, nucleus basalis of Meynert, substantia innominata, basal forebrain, attentional impairment, signal detection, visual discrimination, lesion recovery, rats
- MeSH terms
- Saporins, Acetylcholinesterase, Animals, Antibodies, Monoclonal, Immunotoxins, Attention, Brain Mapping, Carbolines, Cerebral Cortex, Cholinergic Fibers, Conditioning, Operant, Discrimination Learning, Male, N-Glycosyl Hydrolases, Rats, Inbred F344, Mental Recall, Substantia Innominata, Visual Perception, Prosencephalon, Cholinergic Agents, Rats, Ribosome Inactivating Proteins, Type 1
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