D₂ dopamine receptor involvement in the rough-and-tumble play behavior of juvenile rats.
Abstract
By using dorsal contacts and pinning to quantify play behavior in juvenile rats, it was found that the D2 agonist, quinpirole, reduced both measures of play at doses greater than 0.05 mg/kg. Eticlopride, a D2 antagonist, also reduced both measures of play and blocked the reduction caused by quinpirole. The effect of quinpirole on play was largely unaffected by concurrent administration of either a D1 agonist (SKF 38393) or a D1 antagonist (SCH 23390), suggesting that D1 and D2 receptors are functionally independent with respect to play behavior. Quinpirole also reduced overall activity, suggesting that the effects on play may not be selective to neural circuitry responsible for play behavior. Although low doses of quinpirole (0.001--0.03 mg/kg) had a tendency to increase pinning, this effect was not very robust. These data suggest that D2 dopamine receptors may not have a major role in the control of play behavior in juvenile rats.
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Treatment with dopamine D2 and alpha-1 receptor antagonists inhibits social play, whereas treatment with an alpha-2 adrenoceptor antagonist enhances it.
“Treatment with dopamine D2 and alpha-1 receptor antagonists has previously been shown to inhibit social play, whereas treatment with an alpha-2 adrenoceptor antagonist actually enhances it (Siviy et al. 1994; -1996).”
From Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia (2025) · cites this paper as Siviy et al. 1996
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- Authors
- Siviy, S. M., Fleischhauer, A. E., Kerrigan, L. A., & Kuhlman, S. J.
- Affiliations
- Gettysburg College (US)
- Venue
- Behavioral Neuroscience
- Published
- 1996-10
- Volume
- 110
- Issue
- 5
- Pages
- 1168-1176
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2020562528
- Cited by
- 47
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, rough-and-tumble play, young rats, quinpirole, eticlopride, dopamine D1 receptor, locomotor activity
- MeSH terms
- Age Factors, Aggression, Agonistic Behavior, Animals, Brain, Play and Playthings, Rats, Sprague-Dawley, Receptors, Dopamine D2, Rats
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