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Cited by 162Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

In search of the neurobiological substrates for social playfulness in mammalian brains

Siviy, Stephen M., Panksepp, Jaak·2011·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2011.03.006
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Abstract

Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this behavior have been identified, and in this review this progress. A primary-process executive circuit for play in the rat that includes thalamic intralaminar nuclei, frontal cortex and striatum can be gleaned from these data. Other neural areas that may interact with this putative circuit include amygdala, ventral hypothalamus, periaqueductal gray (PAG), and deep tectum, as well as ascending dopamine systems which participate in all types of seeking urges. At the neurochemical level, considerable evidence points to specific cholinergic and dopaminergic controls, but also endogenous opioids and cannabinoids as having a positive modulatory influence over playfulness, with all neuropeptides known to have aversive effects to reduce play. Monoamines such as norepinephrine and serotonin certainly modulate play, but they influence all psychobehavioral systems, suggesting non-specific effects. We proceed to discuss how increased insights into the neurobiological mechanisms of play can inform our understanding of normal and abnormal childhood development.

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Crossref · 10.1016/j.neubiorev.2011.03.006

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  • Rough-and-tumble play in rats involves competition to gain access to the partner's nape of the neck, which is nuzzled with the snout if contacted.

    “As shown in Figure 1, RTP in rats involves competition to gain access to the partner's nape of the neck, which is nuzzled with the snout if contacted (Pellis and Pellis, 1987; Siviy and Panksepp, 2011).”

    From The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain (2022) · cites this paper as Siviy and Panksepp, 2011

  • Laboratory rats have been an important model species for studying the neurobiology of rough-and-tumble play.

    “Laboratory rats have been an important model species with which to study the neurobiology of RTP (Siviy and Panksepp, 2011; Siviy, 2016; Vanderschuren et al., 2016).”

    From The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain (2022) · cites this paper as Siviy and Panksepp, 2011

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Authors
Siviy, S. M., & Panksepp, J.
Affiliations
  • Gettysburg College (US)
  • Washington State University (US)
Corresponding author
Siviy, Stephen M.
ORCID
Siviy, Stephen M.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2011-10
Volume
35
Issue
9
Pages
1821-1830
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2011.03.006
OpenAlex
W2068121174
Cited by
162
References
12
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 20 · 2014: 9 · 2013: 16 · 2012: 6
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • The Cupola: Scholarship at Gettysburg College (Gettysburg College) (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
play behavior, rough-and-tumble play, young rats, neural correlates, frontal cortex, striatum, amygdala, ventral hypothalamus, periaqueductal gray, dopaminergic system, cholinergic modulation, endogenous opioids, cannabinoids, norepinephrine, serotonin, child development
MeSH terms
Animals, Brain, Competitive Behavior, Emotions, Mammals, Nervous System, Nervous System Physiological Phenomena, Play and Playthings, Social Behavior, Neurotransmitter Agents, Rats

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