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An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior
Open accessAbstract
Decreased oxytocin levels in the amygdalas of rat dams following chronic gestational cocaine exposure have been correlated with heightened maternal aggressive behavior. In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing. Behavior was compared among dams infused with OTA into target areas just outside the CNA and cocaine-treated dams (infused with buffer). Dams infused with 1,000 ng OTA attacked intruders significantly more often than buffer-infused dams. OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior.
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“Chronic ICV administration of oxytocin receptor antagonists can reduce maternal aggression in strains of rats exhibiting high anxiety and higher levels of defensive aggression (Bosch et al., 2005 but see Lubin et al., 2003).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Lubin et al., 2003
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Metadata
- Authors
- Lubin, D. A., Elliot, J. C., Black, M. C., & Johns, J. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Behavioral Neuroscience
- Published
- 2003
- Volume
- 117
- Issue
- 2
- Pages
- 195-201
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC3109068
- OpenAlex
- W2040553957
- Cited by
- 145
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 10
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA13283-01A1, R01DA013362, DA13362-01, R29DA008456, R01DA013283)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin antagonist, central amygdala, maternal aggression, maternal behavior, intruder, oxytocin, rats
- MeSH terms
- Aggression, Amygdala, Anesthetics, Local, Animals, Behavior, Animal, Cocaine, Dose-Response Relationship, Drug, Female, Hormone Antagonists, Maternal Behavior, Oxytocin, Pregnancy, Time Factors, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats
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