Cited by 145Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior

Open access

Lubin, Deborah A., Elliot, Jay C., Black, Mitchell C., Johns, Josephine M.·2003·Behavioral Neuroscience

DOI 10.1037/0735-7044.117.2.195PMC PMC3109068

Open this paper in CoChat — free account

Abstract

Decreased oxytocin levels in the amygdalas of rat dams following chronic gestational cocaine exposure have been correlated with heightened maternal aggressive behavior. In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing. Behavior was compared among dams infused with OTA into target areas just outside the CNA and cocaine-treated dams (infused with buffer). Dams infused with 1,000 ng OTA attacked intruders significantly more often than buffer-infused dams. OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior.

Integrity signals

Registry

Crossref · 10.1037/0735-7044.117.2.195

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
What is the amygdala?
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
An Introduction to Behavioral Endocrinology
Nelson, R. J. (1994) · Cited by 749
The physiology of reproduction
Chalmers, J. A. (1973) · Springer eBooks · doi:10.1007/978-94-010-2351-1_3 · Cited by 624
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
Central effects of oxytocin
Richard, P., Moos, F., & Freund-Mercier, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.331 · Cited by 379 · cited 1×
“Projections from the CNA synapse on relevant brainstem and spinal cord nuclei that regulate autonomic activity (Richard et al., 1991).”
Background
Amygdaloid inhibition of maternal behavior in the nulliparous female rat☆
FLEMING, A., Vaccarino, F. J., & Luebke, C. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90377-7 · Cited by 271

Show all 43 references

Research works printed but not linked: 1

Numan, 1994, Maternal behavior., 221

Sorted by citations

Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 480
“In contrast, in a different context in which smaller male intruder rats were introduced to dams and litters, amygdala OTA infusion instead increased maternal aggression and attack (Lubin et al. 2003).”
Background
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439
Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action
Bosch, O. J., & Neumann, I. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.002 · Cited by 400
Oxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338
Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism?
Whitaker‐Azmitia, P. M. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.07.022 · Cited by 277
Attachment, aggression and affiliation: the role of oxytocin in female social behavior
Campbell, A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.001 · Cited by 269
Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 219
Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids
CUSHING, B., & KRAMER, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.001 · Cited by 209
Biological Aspects of Social Bonding and the Roots of Human Violence
Pedersen, C. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.006 · Cited by 209
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Bosch, O. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0085 · Cited by 194
Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice
Choleris, E., Little, S. R., Mong, J. A., Puram, S. V., Langer, R., & Pfaff, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700670104 · Cited by 183
Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice
Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J.-Α., Korach, K. S., Muglia, L. J., & Pfaff, D. W. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00203.x · Cited by 182
The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco ( Ctenomys haigi and Ctenomys sociabilis )
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144
Corticotropin-Releasing Factor Inhibits Maternal Aggression in Mice.
Gammie, S. C., Negrón, A., Newman, S. M., & Rhodes, J. S. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.4.805 · Cited by 145
Vasopressin released within the central amygdala promotes maternal aggression
Bosch, O. J., & Neumann, I. D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07115.x · Cited by 139
Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence
Bosch, O. J., Krömer, S. A., Brunton, P. J., & Neumann, I. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.028 · Cited by 134
Intranasal administration of oxytocin increases human aggressive behavior
Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.015 · Cited by 121
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113
Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care
Buckley, S. J. (2015) · Issue Lab (Candid) · Cited by 113
Genes and Aggressive Behavior: Epigenetic Mechanisms Underlying Individual Susceptibility to Aversive Environments
Palumbo, S., Mariotti, V., Iofrida, C., & Pellegrini, S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00117 · Cited by 122
Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy
Light, K. C., Grewen, K., Amico, J. A., Boccia, M. L., Brownley, K. A., & Johns, J. M. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.02.062 · Cited by 109
Oxytocin and same-sex social behavior in female meadow voles
Beery, A. K., & Zucker, I. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.023 · Cited by 108
Changes in the intensity of maternal aggression and central oxytocin and vasopressin V1a receptors across the peripartum period in the rat
Caughey, S. D., Klampfl, S. M., Bishop, V. R., Pfoertsch, J., Neumann, I. D., Bosch, O. J., & Meddle, S. L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02224.x · Cited by 107
Effects of oxytocin microinjected into the central amygdaloid nucleus and bed nucleus of stria terminalis on maternal aggressive behavior in rats
Consiglio, A. R., Borsoi, A., Pereira, G. A. M., & Lucion, A. B. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.05.002 · Cited by 106
Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period
Sabihi, S., Dong, S. M., Durosko, N. E., & Leuner, B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00258 · Cited by 101
Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats
Nephew, B. C., & Bridges, R. S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.013 · Cited by 101
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100
Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females
Macbeth, A. H., Stepp, J. E., Lee, H.-J., Young, W. S., & Caldwell, H. K. (2010) · Behavioral Neuroscience · doi:10.1037/a0020799 · Cited by 98
Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice
Murakami, G., Hunter, R. G., Fontaine, C., Ribeiro, A., & Pfaff, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07761.x · Cited by 99
Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
Terenzi, M. G., & Ingram, C. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.004 · Cited by 91
The Speedometer of Life
Almeida, D. M., Piazza, J. R., Stawski, R. S., & Klein, L. C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380882-0.00012-7 · Cited by 87
Freezing suppression by oxytocin in central amygdala allows alternate defensive behaviours and mother-pup interactions
Rickenbacher, E., Perry, R. E., Sullivan, R. M., & Moita, M. A. (2017) · eLife · doi:10.7554/elife.24080 · Cited by 81
The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat
Johns, J. M., Joyner, P. W., McMurray, M. S., Elliott, D. L., Hofler, V. E., Middleton, C. L., Knupp, K., Greenhill, K. W., Lomas, L. M., & Walker, C. H. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.001 · Cited by 78
Oxytocin microinjected into the central amygdaloid nuclei exerts anti-aggressive effects in male rats
Calcagnoli, F., Stubbendorff, C., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.012 · Cited by 77
Antisocial oxytocin: Complex effects on social behavior
Beery, A. K. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.006 · Cited by 74
Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety
CHOLERIS, E., DEVIDZE, N., KAVALIERS, M., & PFAFF, D. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00424-x · Cited by 75
Oxytocin and Aggression
A, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 76
Maternal Behavior
Numan, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63
Enhanced maternal aggression and associated changes in neuropeptide gene expression in multiparous rats.
Nephew, B. C., Bridges, R. S., Lovelock, D. F., & Byrnes, E. M. (2009) · Behavioral Neuroscience · doi:10.1037/a0016734 · Cited by 64
Neurobiology of sociability
Caldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58
Oxytocin, vasopressin and estrogen receptor gene expression in relation to social recognition in female mice
Clipperton‐Allen, A. E., Lee, A. W., Reyes, A., Devidze, N., Phan, A., Pfaff, D. W., & Choleris, E. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.025 · Cited by 63
Estrogen receptor‐β gene disruption potentiates estrogen‐inducible aggression but not sexual behaviour in male mice
Nomura, M. J., Andersson, S., Korach, K. S., Gustafsson, J.-Α., Pfaff, D. W., & Ogawa, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04703.x · Cited by 62
Neurophysiological and cognitive changes in pregnancy
Grattan, D. R., & Ladyman, S. R. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00002-3 · Cited by 70
Raphe serotonin neuron‐specific oxytocin receptor knockout reduces aggression without affecting anxiety‐like behavior in male mice only
Pagani, J. H., Williams, S. K., Cui, Z., Song, J., Mezey, É., Senerth, J. M., Baumann, M. H., & Young, W. S. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12202 · Cited by 61
Medial amygdala lesions modify aggressive behavior and immediate early gene expression in oxytocin and vasopressin neurons during intermale exposure
Wang, Y., He, Z., Zhao, C., & Li, L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.002 · Cited by 59
The Role of the Medial and Central Amygdala in Stress-Induced Suppression of Pulsatile LH Secretion in Female Rats
Lin, Y., Li, X., Lupi, M., Kinsey‐Jones, J. S., Shao, B., Lightman, S. L., & O'Byrne, K. T. (2010) · Endocrinology · doi:10.1210/en.2010-1003 · Cited by 55
Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor
Dhakar, M. B., Rich, M. E., Reno, E. L., Lee, H.-J., & Caldwell, H. K. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.007 · Cited by 54
Maternal representations and emotional availability among drug‐abusing and nonusing mothers and their infants
Flykt, M. S., Punamäki, R., Belt, R. H., Biringen, Z. C., Salo, S., Posa, T., & Pajulo, M. (2012) · Infant Mental Health Journal · doi:10.1002/imhj.21313 · Cited by 54
Alcohol and aggressive behavior in men–moderating effects of oxytocin receptor gene (OXTR) polymorphisms
Johansson, A., Bergman, H., Corander, J., Waldman, I. D., Karrani, N., Salo, B., Jern, P., Ålgars, M., Sandnabba, K. N., Santtila, P. O., et al. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00744.x · Cited by 59
Vasopressin interactions with oxytocin in the control of female sexual behavior
Pedersen, C. A., & Boccia, M. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.002 · Cited by 68
GABAA receptor signaling in the lateral septum regulates maternal aggression in mice.
Lee, G., & Gammie, S. C. (2009) · Behavioral Neuroscience · doi:10.1037/a0017535 · Cited by 53
Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats.
Johns, J. M., Elliott, D. L., Hofler, V. E., Joyner, P., McMurray, M. S., Jarrett, T. M., Haslup, A., Middleton, C., Elliott, J., & Walker, C. H. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1605 · Cited by 51
Oxytocin antagonist disrupts male mouse medial amygdala response to chemical-communication signals
Samuelsen, C. L., & Meredith, M. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.030 · Cited by 51
Oxytocin null mice ingest enhanced amounts of sweet solutions during light and dark cycles and during repeated shaker stress
Billings, L. B., Spero, J. A., Vollmer, R. R., & Amico, J. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.028 · Cited by 47
Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples
Hovey, D., Lindstedt, M., Zettergren, A., Jönsson, L., Johansson, A., Melke, J., Kerekes, N., Anckarsäter, H. S., Lichtenstein, P., Lundström, S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.144 · Cited by 47
Hypocretin‐1 Dose‐Dependently Modulates Maternal Behaviour in Mice
D'Anna‐Hernandez, K., & Gammie, S. C. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01448.x · Cited by 44
Gestational ethanol and nicotine exposure: Effects on maternal behavior, oxytocin, and offspring ethanol intake in the rat
McMurray, M. S., Williams, S. K., Jarrett, T. M., Cox, E., Fay, E., Overstreet, D. H., Walker, C. H., & Johns, J. M. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.07.001 · Cited by 43
Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams
McMurray, M. S., Joyner, P., Middleton, C. W., Jarrett, T. M., Elliott, D. L., Black, M. A., Hofler, V. E., Walker, C. H., & Johns, J. M. (2008) · Stress · doi:10.1080/10253890701850239 · Cited by 43
Neurotensin inversely modulates maternal aggression
Gammie, S. C., D'Anna‐Hernandez, K., Gerstein, H. C., & Stevenson, S. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.045 · Cited by 42
Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice
Arakawa, H., Blanchard, D. C., & Blanchard, R. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.016 · Cited by 42
Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats
Dumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 42
Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
Cid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 40
Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption
Johansson, A., Westberg, L., Sandnabba, K. N., Jern, P., Salo, B., & Santtila, P. O. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.009 · Cited by 37
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36
Glucocorticoids Disrupt Neuroendocrine and Behavioral Responses during Lactation
Vilela, F. C., & Giusti‐Paiva, A. (2011) · Endocrinology · doi:10.1210/en.2011-1096 · Cited by 35
Oxytocin mechanisms of stress response and aggression in a territorial finch
Goodson, J. L., Schrock, S. E., & Kingsbury, M. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.016 · Cited by 34
Central Oxytocin, Vasopressin, and Corticotropin-Releasing Factor Receptor Densities in the Basal Forebrain Predict Isolation Potentiated Startle in Rats
Nair, H. P., Gutman, A. R., Davis, M., & Young, L. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2524-05.2005 · Cited by 36
Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams
Jarrett, T. M., McMurray, M. S., Walker, C. H., & Johns, J. M. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.03.002 · Cited by 35
Use of fast-scan cyclic voltammetry to assess phasic dopamine release in rat models of early postpartum maternal behavior and neglect
Shnitko, T. A., Mace, K. D., Sullivan, K. M., Martin, W. K., Andersen, E., Williams, S. K., Johns, J. M., & Robinson, D. L. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000347 · Cited by 31
The influence of offspring, parity, and oxytocin on cognitive flexibility during the postpartum period
Albin-Brooks, C., Nealer, C., Sabihi, S., Haim, A., & Leuner, B. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.12.015 · Cited by 36
Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: Regulation by oxytocin
Bosch, O. J., Sartori, S. B., Singewald, N., & Neumann, I. D. (2007) · Stress · doi:10.1080/10253890701223197 · Cited by 34
Social and sexual motivation in the mouse.
Matthews, T. J., Abdelbaky, P., & Pfaff, D. W. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1628 · Cited by 32
Region-specific associations between sex, social status, and oxytocin receptor density in the brains of eusocial rodents
Mooney, S. J., Coen, C. W., Holmes, M. M., & Beery, A. K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.043 · Cited by 30
Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams
Johns, J. M., Lubin, D. A., Walker, C. H., Joyner, P., Middleton, C., Hofler, V. E., & McMurray, M. S. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.03.002 · Cited by 30
Evolutionary and neuroendocrine foundations of human aggression
Sarkar, A., & Wrangham, R. W. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.02.003 · Cited by 32
Neuroendocrinology and Adaptive Physiology of Maternal Care
Smiley, K. O., Ladyman, S. R., Gustafson, P. E., Grattan, D. R., & Brown, R. S. E. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_122 · Cited by 28
Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment
Keller, S. M., Doherty, T. S., & Roth, T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46539-4 · Cited by 29
Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction
Williams, S. K., & Johns, J. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.004 · Cited by 26
Nonapeptides mediate trade-offs in parental care strategy
DeAngelis, R., Dodd, L., & Rhodes, J. S. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104717 · Cited by 24
New Potential Therapeutic Approaches in Frontotemporal Dementia: Oxytocin, Vasopressin, and Social Cognition
Finger, E. C. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9550-2 · Cited by 30
Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats
Johns, J. M., McMurray, M. S., Joyner, P., Jarrett, T. M., Williams, S. K., Cox, E., Black, M. A., Middleton, C., & Walker, C. H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1877-9 · Cited by 25
Maternal Aggression
Gammie, S. C., & Lonstein, J. S. (2005) · doi:10.1093/acprof:oso/9780195168761.003.0011 · Cited by 24
Density‐induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species
HUANG, S., Li, G., Pan, Y., Song, M., Zhao, J., Wan, X., Krebs, C. J., Wang, Z., Han, W., & Zhang, Z. (2020) · Integrative Zoology · doi:10.1111/1749-4877.12467 · Cited by 23
Dysfunctions of brain oxytocin signaling: Implications for poor mothering
Sanson, A., & Bosch, O. J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109049 · Cited by 22
Genetic variants in oxytocin receptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in chinese adolescents
Zhang, Y., Wu, C., Chang, H., Yan, Q., Wu, L., Yuan, S., Xiang, J., Hao, W., & Yu, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.024 · Cited by 23
Modulation of expression of fear by oxytocin signaling in the central amygdala: From reduction of fear to regulation of defensive behavior style
van den Burg, E. H., & Hegoburu, C. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108130 · Cited by 19
Clinical potential of oxytocin in autism spectrum disorder: current issues and future perspectives
Benner, S., & Yamasue, H. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000341 · Cited by 19
Prenatal exposure to integerrimine N‐oxide impaired the maternal care and the physical and behavioral development of offspring rats
Sandini, T. M., Udo, M. S. B., Reis-Silva, T. M., Bernardi, M. M., & Spinosa, H. D. S. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.05.007 · Cited by 20
Rigorous tests of gene–environment interactions in a lab study of the oxytocin receptor gene (OXTR), alcohol exposure, and aggression
LoParo, D., Johansson, A., Walum, H., Westberg, L., Santtila, P. O., & Waldman, I. D. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32359 · Cited by 21
Alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin voles (Microtus mandarinus)
Feng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18
Effects of Cocaine on Maternal Behavior and Neurochemistry
Nephew, B. C., & Febo, M. (2012) · Current Neuropharmacology · doi:10.2174/157015912799362760 · Cited by 18
Effects of chronic cocaine on monoamine levels in discrete brain structures of lactating rat dams
Lubin, D. A., Cannon, J. B., Black, M. C., Brown, L. E., & Johns, J. M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01027-4 · Cited by 17

Authors: Lubin, D. A., Elliot, J. C., Black, M. C., & Johns, J. M.
Affiliations: University of North Carolina at Chapel Hill (US)
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2003
Volume: 117
Issue: 2
Pages: 195-201
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.117.2.195
PMC: PMC3109068
OpenAlex: W2040553957
Cited by: 145
References: 43
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 10
FWCI: 14.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Institute on Drug Abuse (DA13283-01A1, R01DA013362, DA13362-01, R29DA008456, R01DA013283)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin antagonist, central amygdala, maternal aggression, maternal behavior, intruder, oxytocin, rats
MeSH terms: Aggression, Amygdala, Anesthetics, Local, Animals, Behavior, Animal, Cocaine, Dose-Response Relationship, Drug, Female, Hormone Antagonists, Maternal Behavior, Oxytocin, Pregnancy, Time Factors, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks