Cited by 384Memory and Neural MechanismsStress Responses and CortisolAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.

McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, David M.·2004·Behavioral Neuroscience

DOI 10.1037/0735-7044.118.1.63

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Abstract

Cytotoxic ventral hippocampal lesions produced anxiolytic effects on 4 ethologically based, unconditioned tests of anxiety in the rat (hyponeophagia, black/white 2-compartment box test, a successive alleys test that represents a modified version of the elevated plus-maze, and a social interaction test). Dorsal hippocampal lesions did not produce anxiolytic effects on these tests, suggesting a distinct specialization of function within the hippocampus. Furthermore, the effects of ventral hippocampal lesions were also distinct from those of amygdala lesions. This suggests that the effects of ventral hippocampal lesions are not simply due to direct or indirect effects on the amygdala, and that these 2 brain areas contribute differentially to a brain system (or systems) associated with the processing of fearful and/or anxiogenic stimuli.

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Authors: McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M.
Affiliations: University of Oxford (GB)
ORCID: McHugh, S. B.
Bannerman, David M.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2004
Volume: 118
Issue: 1
Pages: 63-78
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.118.1.63
OpenAlex: W2076874426
Cited by: 384
References: 106
Citations by year: 2026: 10 · 2025: 9 · 2024: 17 · 2023: 8 · 2022: 19 · 2021: 27 · 2020: 17 · 2019: 12 · 2018: 21 · 2017: 30 · 2016: 11 · 2015: 24 · 2014: 22 · 2013: 18 · 2012: 21
FWCI: 8.95
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (087736)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: amygdala, ventral hippocampus, dorsal hippocampus, fear, anxiety, anxiolytic effects, lesion studies, elevated plus maze, social interaction
MeSH terms: Amygdala, Animals, Anxiety, Fear, Hippocampus, Male, Rats

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Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.

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