The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.
Abstract
Cytotoxic ventral hippocampal lesions produced anxiolytic effects on 4 ethologically based, unconditioned tests of anxiety in the rat (hyponeophagia, black/white 2-compartment box test, a successive alleys test that represents a modified version of the elevated plus-maze, and a social interaction test). Dorsal hippocampal lesions did not produce anxiolytic effects on these tests, suggesting a distinct specialization of function within the hippocampus. Furthermore, the effects of ventral hippocampal lesions were also distinct from those of amygdala lesions. This suggests that the effects of ventral hippocampal lesions are not simply due to direct or indirect effects on the amygdala, and that these 2 brain areas contribute differentially to a brain system (or systems) associated with the processing of fearful and/or anxiogenic stimuli.
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Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462
Self-citationAdult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206
“, whereas those of the ventral hippocampus affect anxiety and have no effect on spatial learnin”
BackgroundSierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190
“It has been previously shown that vHPC lesions reduce anxiety (McHugh et al., 2004), but this is unlikely to explain reduced freezing given that we observed no effect of vHPC inactivation in our measure of anxiety.”
Hippocampal synaptic plasticity, spatial memory and anxiety
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3677 · Cited by 688
Self-citationAlcohol: Effects on Neurobehavioral Functions and the Brain
Oscar-Berman, M., & Marinković, K. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9038-6 · Cited by 619
“2002; Gray and McNaughton 2000), there is mounting evidence that the ventral hippocampus is part of a brain system associated with fear and/or anxiety (Bannerman et al. 2004; Kjelstrup et al. 2002; McHugh et al. 2004).”
Background
Metadata
- Authors
- McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M.
- Affiliations
- University of Oxford (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2004
- Volume
- 118
- Issue
- 1
- Pages
- 63-78
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2076874426
- Cited by
- 384
- References
- 106
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 17 · 2023: 8 · 2022: 19 · 2021: 27 · 2020: 17 · 2019: 12 · 2018: 21 · 2017: 30 · 2016: 11 · 2015: 24 · 2014: 22 · 2013: 18 · 2012: 21
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (087736)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- amygdala, ventral hippocampus, dorsal hippocampus, fear, anxiety, anxiolytic effects, lesion studies, elevated plus maze, social interaction
- MeSH terms
- Amygdala, Animals, Anxiety, Fear, Hippocampus, Male, Rats
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