Cited by 384Memory and Neural MechanismsStress Responses and CortisolAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.

McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, David M.·2004·Behavioral Neuroscience

DOI 10.1037/0735-7044.118.1.63

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Abstract

Cytotoxic ventral hippocampal lesions produced anxiolytic effects on 4 ethologically based, unconditioned tests of anxiety in the rat (hyponeophagia, black/white 2-compartment box test, a successive alleys test that represents a modified version of the elevated plus-maze, and a social interaction test). Dorsal hippocampal lesions did not produce anxiolytic effects on these tests, suggesting a distinct specialization of function within the hippocampus. Furthermore, the effects of ventral hippocampal lesions were also distinct from those of amygdala lesions. This suggests that the effects of ventral hippocampal lesions are not simply due to direct or indirect effects on the amygdala, and that these 2 brain areas contribute differentially to a brain system (or systems) associated with the processing of fearful and/or anxiogenic stimuli.

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Background
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“…anxiety is not new (McNaughton and Gray 2000; Deacon et al 2002), there is now mounting evidence that the ventral HP plays an important role in a brain system associated with fear and/or anxiety (Bannerman, Deacon, et al 2002; Bannerman, Grubb, et al 2002; Kjelstrup et al 2002; McHugh et al 2004).”
d ‐amino acid oxidase knockout ( Dao −/− ) mice show enhanced short‐term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption
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Role of Ventral Hippocampal GABAA and NMDA Receptors in the Anxiolytic Effect of Carbamazepine in Rats Using the Elevated Plus Maze Test
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“Performance levels on these tests reflect, at least in part, activity in the ventral hippocampus [5,6,7,8,9] and these tests were chosen in order to interrogate an underlying”
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Controlled cortical impact before or after fear conditioning does not affect fear extinction in mice
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“Additional measures of anxiety (McHugh et al., 2004) are needed to more fully characterize the effects of CCI on anxiety.”
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Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus
Engin, E., & Treit, D. (2008) · Neuropeptides · doi:10.1016/j.npep.2008.04.004 · Cited by 32
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“Thus in rodents, the dorsal hippocampus (equivalent to human posterior) appears to be predominantly involved in the learning and processing of spatial information, while the ventral hippocampus (equivalent to human anterior) appears to regulate emotional and motivational behaviors (13, 15, 16).”
Background
Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response
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Effects of Human ES-Derived Neural Stem Cell Transplantation and Kindling in a Rat Model of Traumatic Brain Injury
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Microinjection of Naltrexone into the Central, but not the Basolateral, Amygdala Blocks the Anxiolytic Effects of Diazepam in the Plus Maze
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“In previous studies, lesions of the amygdala have failed to alter behavior in the elevated plus maze or other tests of novelty (McHugh et al, 2004; Treit et al, 1993a, b).”
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The sex differences of the behavior response to early Life immune stimulation: Microglia and astrocytes involvement
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Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal
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Alterations in spatial memory and anxiety in the MAM E17 rat model of hippocampal pathology in schizophrenia
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“In contrast, rats with ventral hippocampal lesions, which also display reduced anxiety (e.g. Bannerman et al. 2002, 2004; Kjelstrup et al. 2002; McHugh et al. 2004), are generally unaffected in the Morris watermaze task (see Moser et al.”
InfluentialSelf-citation
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Long-term consequences of soman poisoning in mice Part 1. Neuropathology and neuronal regeneration in the amygdala.
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Ventral Hippocampus Modulates Anxiety-Like Behavior in Male But Not Female C57BL/6 J Mice
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Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze
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“Present results also corroborate previous studies showing that amygdala lesions reduced the incidence of anxiety-related behavior in rats exposed either to the elevated T-maze [43,44] or the light-dark exploration test [43,45].”
Febrile convulsions in developing rats induce a hyperanxious phenotype later in life
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“In common, most of these studies have focused on hippocampal correlates of behavior; yet the role of the hippocampal formation extends beyond spatial memory tasks and, through interactions with other limbic regions, is determinant of other components of emotional and cognitive behavior [15–17].”
Background
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The anterior medial temporal lobes: Their role in food intake and body weight regulation
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Dopamine D1 receptor in the medial prefrontal cortex mediates anxiety-like behaviors induced by blocking glutamatergic activity of the ventral hippocampus in rats
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A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
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SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice
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“Also, reduced anxiety on tasks like the elevated plus maze and food neophobia is commonly seen in rodents with ventral hippocampal lesions (Bannerman et al. 2003, 2004; McHugh et al. 2004).”
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Left–right functional asymmetry of ventral hippocampus depends on aversiveness of situations
Sakaguchi, Y., & Sakurai, Y. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.028 · Cited by 24

Authors: McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M.
Affiliations: University of Oxford (GB)
ORCID: McHugh, S. B.
Bannerman, David M.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2004
Volume: 118
Issue: 1
Pages: 63-78
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.118.1.63
OpenAlex: W2076874426
Cited by: 384
References: 106
Citations by year: 2026: 10 · 2025: 9 · 2024: 17 · 2023: 8 · 2022: 19 · 2021: 27 · 2020: 17 · 2019: 12 · 2018: 21 · 2017: 30 · 2016: 11 · 2015: 24 · 2014: 22 · 2013: 18 · 2012: 21
FWCI: 8.95
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (087736)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: amygdala, ventral hippocampus, dorsal hippocampus, fear, anxiety, anxiolytic effects, lesion studies, elevated plus maze, social interaction
MeSH terms: Amygdala, Animals, Anxiety, Fear, Hippocampus, Male, Rats

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Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.

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