Longitudinal change in cognitive performance among individuals with mild cognitive impairment.
Abstract
The authors used mixed-effects growth models to examine longitudinal change in neuropsychological performance over a 4-year period among 197 individuals who were either normal or had mild cognitive impairment (MCI) at baseline. At follow-up, the participants were divided into 4 groups: (a) controls: participants who were normal at both baseline and follow-up (n = 33), (b) stables: participants with MCI whose Clinical Dementia Rating-Sum of Boxes (CDR-SB) score did not differ between the first and last evaluations (n = 22), (c) decliners: participants with MCI whose CDR-SB score declined between the first and last evaluations (n = 95), and (d) converters: participants who received a clinical diagnosis of Alzheimer's disease during the follow-up period (n = 47). Only the Episodic Memory factor showed a significantly greater rate of decline over the follow-up period among the converters. Two other factors were significantly lower in converters at baseline in comparison with other groups (the executive function factor and the general knowledge factor), but the rate of decline over time did not differ. Individuals with an APOE epsilon4 allele scored lower on the episodic memory and executive function factors at baseline.
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Most people with mild cognitive impairment will eventually develop dementia, indicating that many people with major cognitive decline in old age may be showing preclinical symptoms of a dementing illness.
“Recent research argues that most people with mild cognitive impairment will eventually develop dementia, indicating that many people with major cognitive decline in old age may be showing preclinical symptoms of a dementing illness (Albert, Blacker, Moss, Tanzi, & McArdle, 2007; Lopez, Li, Shing, & Lindenberger, 2007; Petersen et al., 2006).”
From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Albert, Blacker, Moss, Tanzi, & McArdle, 2007
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Self-citationBDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
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- Authors
- Albert, M., Moss, M. B., Blacker, D., Tanzi, R., & McArdle, J. J.
- Affiliations
- Johns Hopkins University (US)
- Boston University (US)
- Harvard University (US)
- University of Southern California (US)
- Venue
- Neuropsychology
- Published
- 2007-03
- Volume
- 21
- Issue
- 2
- Pages
- 158-169
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- OpenAlex
- W2030989440
- Cited by
- 160
- References
- 6
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 21 · 2012: 14
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- mild cognitive impairment, longitudinal cognitive decline, episodic memory, executive function, general knowledge, APOE ε4, conversion to Alzheimer's disease, CDR-SB, neuropsychological performance
- MeSH terms
- Aged, Aged, 80 and over, Cognition, Cognition Disorders, Educational Status, Factor Analysis, Statistical, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Survival Analysis, Disease Progression, Apolipoprotein E4
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