Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats

The Pharmacological Basis of Therapeutics

(1976) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/33.4.373a · Cited by 9,216 · see citing works

Goodman and Gilman's the Pharmacological Basis of Therapeutics

Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796 · see citing works

The Journal of Neuropsychiatry and Clinical Neurosciences

Bowden, V. M. (1992) · JAMA · doi:10.1001/jama.1992.03490110111047 · Cited by 1,236 · see citing works

The Health consequences of smoking: nicotine addiction: a report of the Surgeon General

(1989) · Choice Reviews Online · doi:10.5860/choice.27-1560 · Cited by 882 · see citing works

Growing Up Tobacco Free

Institute of Medicine (1994) · National Academies Press eBooks · doi:10.17226/4757 · Cited by 320 · see citing works

The Biological bases of drug tolerance and dependence

Pratt, J. (1991) · Cited by 47 · see citing works

HPA function in adolescence: Role of sex hormones in its regulation and the enduring consequences of exposure to stressors

McCormick, C. M., & Zovkic, I. B. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.012 · Cited by 373 · see citing works

Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine

Levine, A., Huang, Y., Drisaldi, B., Griffin, E. A., Pollak, D. D., Xu, S., Yin, D., Schaffran, C., Kandel, D. B., & Kandel, E. R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003062 · Cited by 280 · see citing works

Wheel-running attenuates intravenous cocaine self-administration in rats Sex differences

Cosgrove, K. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00853-5 · Cited by 213 · see citing works

If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?

Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206 · see citing works

Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products

England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works

Probability and predictors of the cannabis gateway effect: A national study

Secades‐Villa, R., García–Rodríguez, O., Jin, C. J., Wang, S., & Blanco, C. (2014) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2014.07.011 · Cited by 175 · see citing works

TESTING THE GATEWAY HYPOTHESIS

Kandel, D. B., Yamaguchi, K., & Klein, L. C. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01426.x · Cited by 153 · see citing works

Animal models of periadolescent substance abuse

Smith, R. F. (2003) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00349-5 · Cited by 126 · see citing works

Adult vs. adolescent rats differ in biobehavioral responses to chronic nicotine administration.

Faraday, M., Elliott, B. M., & Grunberg, N. (2001) · Pharmacology, Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00642-6 · Cited by 116 · see citing works

Stress during adolescence enhances locomotor sensitization to nicotine in adulthood in female, but not male, rats

McCormick, C. M., Robarts, D., Gleason, E., & Kelsey, J. E. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.05.004 · Cited by 105 · see citing works

Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experiment

Klein, L. C., Stine, M. M., Vandenbergh, D. J., Whetzel, C. A., & Kamens, H. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.01.005 · Cited by 95 · see citing works

Tobacco Cessation Interventions and Smoke-Free Policies in Mental Health and Substance Abuse Treatment Facilities — United States, 2016

Marynak, K., VanFrank, B. K., Tetlow, S. M., Mahoney, M. R., Phillips, E., Jamal, A., Schecter, A., Tipperman, D., & Babb, S. D. (2018) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6718a3 · Cited by 92 · see citing works

Differential behavioral effects of nicotine exposure in adolescent and adult rats

Schochet, T. L., Kelley, A. E., & Landry, C. F. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1831-9 · Cited by 84 · see citing works

Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase

Xu, Z., Seidler, F. J., Cousins, M. M., Slikker, W., & Slotkin, T. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03174-8 · Cited by 82 · see citing works

A psychobiological framework of the substrates that mediate nicotine use during adolescence

O'Dell, L. E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.039 · Cited by 81 · see citing works

Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats

Collins, S. L., Montano, R. E., & Izenwasser, S. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.08.004 · Cited by 71 · see citing works

Does Prenatal Nicotine Exposure Sensitize the Brain to Nicotine-Induced Neurotoxicity in Adolescence?

Abreu-Villaça, Y., Seidler, F. J., & Slotkin, T. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300443 · Cited by 70 · see citing works

Maternal nicotine exposure increases nicotine preference in periadolescent male but not female C57Bl/6J mice

Klein, L. C., & Klein, L. C. (2003) · Nicotine & Tobacco Research · doi:10.1080/14622200307257 · Cited by 70 · see citing works

Subchronic nicotine exposure in adolescence induces long-term effects on hippocampal and striatal cannabinoid-CB1 and mu-opioid receptors in rats

Marco, E. M., Granstrem, O., Moreno, E., Llorente, R., Adriani, W., Giovanni Laviola, A., & Viveros, M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.013 · Cited by 67 · see citing works

Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behavior

Slawecki, C. J., Thorsell, A. K., Khoury, A. E., Mathé, A. A., & Ehlers, C. L. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.06.002 · Cited by 64 · see citing works

D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrusPreprint

Huang, Y. Y., Levine, A. A., Kandel, D. B., Yin, D., Colnaghi, L., Drisaldi, B., & Kandel, E. R. (2014) · Learning & Memory · doi:10.1101/lm.032292.113 · Cited by 56 · see citing works

Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice

Manhães, A. C., Guthierrez, M. C. S., Filgueiras, C. C., & Abreu‐Villaça, Y. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.018 · Cited by 54 · see citing works

Differential Effects of Psychoactive Drugs in Adolescents and Adults

Izenwasser, S. (2005) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v17.i2.10 · Cited by 44 · see citing works

Sex differences in response to nicotine in C57Bl/6:129SvEv mice

Isiegas, C., Mague, S. D., & Blendy, J. A. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp076 · Cited by 44 · see citing works

Studying Sex Differences in Rodent Models of Addictive Behavior

Radke, A. K., Sneddon, E. A., & Monroe, S. C. (2021) · Current Protocols · doi:10.1002/cpz1.119 · Cited by 42 · see citing works

The Effect of Medical Marijuana Laws on Marijuana, Alcohol, and Hard Drug Use

Wen, H., Hockenberry, J. M., & Cummings, J. R. (2014) · National Bureau of Economic Research · doi:10.3386/w20085 · Cited by 41 · see citing works

Nicotine primes the effect of cocaine on the induction of LTP in the amygdala

Huang, Y.-Y., Kandel, D. B., Kandel, E. R., & Levine, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.031 · Cited by 40 · see citing works

Endogenous opiates and behavior: 2001

Bodnar, R. J., & Hadjimarkou, M. M. (2002) · Peptides · doi:10.1016/s0196-9781(02)00306-6 · Cited by 36 · see citing works

Aversion-resistant fentanyl self-administration in mice

Monroe, S. C., & Radke, A. K. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05722-6 · Cited by 37 · see citing works

Stages of progression in drug abuse involvement across generations in Jeddah, Saudi Arabia

Bassiony, M. M. (2008) · Neurosciences · doi:10.17712/1658-3183.1552 · Cited by 29 · see citing works

Long-lasting effects of adolescent oxycodone exposure on reward-related behavior and gene expression in mice

Sanchez, V., Carpenter, M. D., Yohn, N. L., & Blendy, J. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4425-4 · Cited by 28 · see citing works

Sex differences in adult cognitive deficits after adolescent nicotine exposure in rats

Pickens, L. R. G., Rowan, J. D., Bevins, R. A., & Fountain, S. B. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.05.001 · Cited by 24 · see citing works

Adolescent nicotine challenge promotes the future vulnerability to opioid addiction: Involvement of lateral paragigantocellularis neurons

Torabi, M., Azizi, H., Ahmadi‐Soleimani, S. M., & Rezayof, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116784 · Cited by 22 · see citing works

Early adolescent subchronic low-dose nicotine exposure increases subsequent cocaine and fentanyl self-administration in Sprague–Dawley rats

Cardenas, A., Martinez, M., Saenz Mejia, A., & Lotfipour, S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000593 · Cited by 21 · see citing works

Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: Sex-selective effects on cerebrocortical serotonergic function

Slotkin, T. A., Card, J., & Seidler, F. J. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.01.004 · Cited by 18 · see citing works

Mechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use

Lichenstein, S. D., Zakiniaeiz, Y., Yip, S. W., & Garrison, K. A. (2019) · Current Addiction Reports · doi:10.1007/s40429-019-00245-3 · Cited by 16 · see citing works

Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure

Sikic, A., Frie, J. A., Khokhar, J. Y., & Murray, J. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.921429 · Cited by 15 · see citing works

Availability Influences Initial and Continued Ingestion of Nicotine by Adolescent Female Rats

Biondolillo, K., & Pearce, A. R. (2007) · Neuropsychobiology · doi:10.1159/000103905 · Cited by 13 · see citing works

The effect of nicotine pre-exposure on demand for cocaine and sucrose in male rats

Schwartz, L. P., Kearns, D. N., & Silberberg, A. M. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000357 · Cited by 11 · see citing works

Tobacco use cessation for adolescents.

Adelman, W. P. (2006) · PubMed · doi:10.1016/j.admecli.2006.06.013 · Cited by 10 · see citing works

Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice

Downs, A. M., Kmiec, G., & McElligott, Z. A. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100182 · Cited by 9 · see citing works

Dual Use and Dual Truths: Categorizing the Adolescent Electronic Cigarette User

Adelman, W. P. (2019) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2019.05.009 · Cited by 6 · see citing works

Ethanol conditioned place preference and alterations in ΔFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment

Philpot, R. M., Engberg, M. E., & Wecker, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.014 · Cited by 5 · see citing works

Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption

Gannon, B. M., Shepard, M. E., Pressley, J. M., Shaw, H. E., Wolf, K. J., Avram, M., Moran, J. H., & Fantegrossi, W. E. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110562 · Cited by 4 · see citing works

Behavioral economics of polysubstance use: The role of orexin-1 receptors in nicotine-induced augmentation of synthetic opioid consumption

Honeycutt, S. C., Gilles‐Thomas, E. A., Lichte, D. D., McSain, S. L., Mukherjee, A., & Loney, G. C. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110467 · Cited by 2 · see citing works

Tobacco, the Smoking Gun?

Frost, E. A. M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0170-4_8 · Cited by 1 · see citing works

The relationship between inhalant use and adolescent gateway drug use sequencing: a latent transition analysis

Crankshaw, E. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/k1tf-y168 · Cited by 1 · see citing works

Nicotine Effects in Adolescents

Izenwasser, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00003-4 · Cited by 2 · see citing works

Efectos de la administración de nicotina sobre la eminencia media y el núcleo arcuato. Estudio con tirosina hidroxilasa y angiotensina II

Calero, E. M. C., Ruiz, A., González-Marrero, I., Carmona, H. D. P., Toledo, J. M. G., Garde, I. G., & Perdomo, A. L. C. (2007) · Majorensis: Revista Electrónica de Ciencia y Tecnología

Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine response in adult male and female rats.

Klein, L. C. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.9.3.251 · Cited by 11 · see citing works

Sex Differences and the Effects of Stress on Subsequent Opioid Consumption in Adult Rats Following Adolescent Nicotine Exposure: A Psychopharmacologic Examination of the Gateway Hypothesis

Klein, L. C. (1997) · Defense Technical Information Center (DTIC)

Early adolescent subchronic low-dose nicotine exposure increases subsequent cocaine and fentanyl self-administration in Sprague–Dawley rats

Cardenas, A., Martinez, M., Saenz Mejia, A., & Lotfipour, S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000593 · Cited by 21 · see citing works

Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets

Honeycutt, S. C., Mukherjee, A., Paladino, M. S., Gilles‐Thomas, E. A., & Loney, G. C. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100150 · Cited by 7 · see citing works

High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats

Renda, B., Andrade, A. K., Frie, J. A., Sgarbossa, C., Murray, J. E., & Khokhar, J. Y. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108215 · Cited by 13 · see citing works