A randomized controlled trial of central executive training (CET) versus inhibitory control training (ICT) for ADHD.
Open accessAbstract
OBJECTIVE: Executive function deficits are well-established in ADHD. Unfortunately, replicated evidence indicates that executive function training for ADHD has been largely unsuccessful. We hypothesized that this may reflect insufficient targeting, such that extant protocols do not sufficiently and specifically target the neurocognitive systems associated with phenotypic ADHD behaviors/impairments. METHOD: Children with ADHD ages 8-12 (M = 10.41, SD = 1.46; 12 girls; 74% Caucasian/Non-Hispanic) were randomized with allocation concealment to either central executive training (CET; n = 25) or newly developed inhibitory control training (ICT; n = 29). Detailed data analytic plans were preregistered. RESULTS: Both treatments were feasible/acceptable based on training duration, child-reported ease of use, and parent-reported high satisfaction. CET was superior to ICT for improving its primary intervention targets: phonological and visuospatial working memory (d = 0.70-0.84). CET was also superior to ICT for improving go/no-go (d = 0.84) but not stop-signal inhibition. Mechanisms of change analyses indicated that CET-related working memory improvements produced significant reductions in the primary clinical endpoints (objectively assessed hyperactivity) during working memory and inhibition testing (indirect effects: β ≥ -.11; 95% CIs exclude 0.0). CET was also superior to ICT on 3 of 4 secondary clinical endpoints (blinded teacher-rated ADHD symptoms; d = 0.46-0.70 vs. 0.16-0.42) and 2 of 4 feasibility/acceptability clinical endpoints (parent-reported ADHD symptoms; d = 0.96-1.42 vs. 0.45-0.65). CET-related gains were maintained at 2-4 month follow-up; ICT-related gains were maintained for attention problems but not hyperactivity/impulsivity per parent report. CONCLUSIONS: Results support the use of CET for treating executive function deficits and targeting ADHD behavioral symptoms in children with ADHD. Findings for ICT were mixed at best and indicate the need for continued development/study. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Targeted training of inhibitory control did not produce improvements in working memory for children with ADHD, whereas targeted training of working memory produced superior improvements in inhibitory control relative to active control training, albeit only on one of two inhibition tests.
“Similarly, a recent randomized control trial (RCT) found that targeted training of inhibitory control did not produce improvements in working memory for children with ADHD, whereas targeted training of working memory produced superior improvements in inhibitory control relative to the active, credible neurocognitive control training – albeit only on one of two inhibition tests (55).”
From Working memory and inhibitory control deficits in children with ADHD: an experimental evaluation of competing model predictions (2024) · cites this paper as [55]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredConclusions from ADHD cognitive training studies have been highly limited because most protocols have not shown large enough improvements in the trained/targeted cognitive abilities to realistically expect detectable downstream behavior changes, even if the causal models are correct.
“In contrast, conclusions from ADHD cognitive training studies have been highly limited because most protocols have not shown large enough improvements in the trained/targeted cognitive abilities to realistically expect detectable downstream behavior changes, even if the causal models are correct (for review see 119) – although newer neurocognitive training protocols appear to be showing more”
From Working memory and inhibitory control deficits in children with ADHD: an experimental evaluation of competing model predictions (2024) · cites this paper as [55]
Working memory appears to affect response speeds more similarly for children with ADHD and/or anxiety.
“In contrast, working memory appears to affect response speeds more similarly for children with ADHD and/or anxiety, which is broadly consistent with prior experimental and RCT findings (55, 85, 115).”
From Working memory and inhibitory control deficits in children with ADHD: an experimental evaluation of competing model predictions (2024) · cites this paper as [55]
The Method > Measures section describes working-memory tasks and reaction-time measures, while Method > Inclusion/Exclusion Criteria notes that some participants had comorbid anxiety. Neither section reports whether working memory affects response speed similarly in children with ADHD and/or anxiety. Searches for response speed, reaction time, and anxiety found no passage addressing that comparison. (LLM, conf=0.75)
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Cites
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“Notably, there have been several recent attempts to improve inhibitory control in children with ADHD (Azami et al., 2016; Dovis et al., 2015; Halperin et al., 2013; Hoekzema et al., 2010; Johnstone et al., 2010, 2012; Klingberg et al., 2002; Shalev et al., 2007; Rabiner et al., 2010; Tamm et al., 2019; van der Oord et…”
BackgroundDo “brain-training” programs work?
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“, 2016) and producing reductions in ADHD symptoms beyond spurious gains associated with under-controlled and unblinded trials (Cortese et al., 2015; Melby-Lervåg et al., 2016; Sala & Gobet, 2017).”
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“…functions associated with ADHD-related symptoms/impairments (Chacko et al., 2014; Roberts et al., 2016) and producing reductions in ADHD symptoms beyond spurious gains associated with under-controlled and unblinded trials (Cortese et al., 2015; Melby-Lervåg et al., 2016; Sala & Gobet, 2017).”
BackgroundSergeant, J. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.010 · Cited by 589 · cited 2× · see citing works
“, 2010), or as a secondary impairment attributed to underlying deficits in state regulation (Sergeant, 2005) and/or working memory (Rapport et al.”
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“Each intervention targets a model-driven, theoretically important neurocognitive process (Barkley, 1997; Rapport et al., 2001) that is impaired in a large proportion of children with ADHD (Sonuga-Barke et al. 2010) and considered a core executive function in children (Karr et al., 2018).”
BackgroundInfluentialRapport, M. D., Orban, S. A., Kofler, M. J., & Friedman, L. M. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.08.005 · Cited by 517 · cited 12× · see citing works
“…given the well-documented neurocognitive heterogeneity in ADHD (Coghill et al., 2014), meta-analytic evidence indicates that cognitive training protocols for ADHD are significantly less effective when their potency is decreased by targeting multiple neurocognitive functions (Rapport et al., 2013).”
BackgroundResultInfluentialSelf-citationvan der Oord, S., Bögels, S. M., & Peijnenburg, D. (2012) · Journal of Child and Family Studies · doi:10.1007/s10826-011-9457-0 · Cited by 417 · see citing works
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Executive Functioning Heterogeneity in Pediatric ADHD
Kofler, M. J., Irwin, L. N., Soto, E. F., Groves, N. B., Harmon, S. L., & Sarver, D. E. (2019) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-018-0438-2 · Cited by 288 · see citing works
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“This prediction was based on the well-documented neurocognitive heterogeneity in ADHD (Coghill et al., 2014; Nigg et al., 2005) and presumed multiple pathways to the ADHD phenotype (Sonuga-Barke et al., 2010).”
BackgroundMethodInfluentialWorking memory training in typically developing children: A meta-analysis of the available evidence.
Sala, G., & Gobet, F. (2017) · Developmental Psychology · doi:10.1037/dev0000265 · Cited by 216 · cited 2× · see citing works
“…foundational assumption of all cognitive training protocols, including CET and ICT, is that adaptive and repeated training, practice, and feedback will result in meaningful and sustained improvements in neural systems that support the trained abilities (Sala & Gobet, 2017; Shipstead et al., 2012).”
BackgroundRapport, M. D., Chung, K.-M., Shore, G., & Isaacs, P. (2001) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3001_6 · Cited by 198 · cited 5× · see citing works
“Each intervention targets a model-driven, theoretically important neurocognitive process (Barkley, 1997; Rapport et al., 2001) that is impaired in a large proportion of children with ADHD (Sonuga-Barke et al. 2010) and considered a core executive function in children (Karr et al., 2018).”
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“…control as one of multiple targets and found either no evidence of improvements on tests of inhibitory control (e.g., Azami et al., 2016; Johnstone et al., 2012; Tamm et al., 2019), or reported improvements on some but not most inhibition tests (e.g., Dovis et al., 2012; Johnstone et al., 2010).”
BackgroundSarver, D. E., Rapport, M. D., Kofler, M. J., Raiker, J. S., & Friedman, L. M. (2015) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-015-0011-1 · Cited by 149 · cited 1× · see citing works
“This involved computing simple slopes that indexed overall change for each participant across the 3 time points as recommended (Sarver et al., 2015), averaged separately to estimate changes in working memory abilities, inhibitory control abilities, and objectivelyassessed hyperactivity during…”
MethodSelf-citationAlderson, R. M., Rapport, M. D., Hudec, K. L., Sarver, D. E., & Kofler, M. J. (2010) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-010-9387-0 · Cited by 117 · cited 4× · see citing works
“The finding that training working memory produced improvements in inhibitory control on at least one primary outcome measure adds to the mixed evidence regarding the extent to which working memory deficits are upstream from (Alderson et al., 2010; Tarle et al., 2019), downstream from (Alderson et al.”
BackgroundResultInfluentialSelf-citationHalperin, J. M., Marks, D. J., Bedard, A.-C. V., Chacko, A., Curchack, J. T., Yoon, C. A., & Healey, D. M. (2013) · Journal of Attention Disorders · doi:10.1177/1087054711435681 · Cited by 106 · see citing works
Karalunas, S. L., Gustafsson, H. C., Dieckmann, N. F., Tipsord, J., Mitchell, S. H., & Nigg, J. T. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000292 · Cited by 104 · see citing works
Kofler, M. J., Raiker, J. S., Sarver, D. E., Wells, E. L., & Soto, E. F. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.04.004 · Cited by 88 · see citing works
Self-citationBrocki, K. C., Tillman, C. M., & Bohlin, G. (2010) · European Journal of Developmental Psychology · doi:10.1080/17405620801937764 · Cited by 53 · cited 2× · see citing works
“Of note, individual difference studies have produced more mixed results, with several studies reporting links between inhibitory control tests and informant-rated ADHD symptoms (Alderson et al., 2010; Brocki et al., 2010) but other studies failing to find significant associations cross-sectionally or longitudinally (e.”
ResultAlderson, R. M., Patros, C. H. G., Tarle, S. J., Hudec, K. L., Kasper, L. J., & Lea, S. E. (2017) · Child Neuropsychology · doi:10.1080/09297049.2015.1105207 · Cited by 33 · cited 2× · see citing works
“…primary outcome measure adds to the mixed evidence regarding the extent to which working memory deficits are upstream from (Alderson et al., 2010; Tarle et al., 2019), downstream from (Alderson et al., 2017), or sit in parallel with (Kofler, Irwin et al., 2019) inhibitory control deficits in ADHD.”
BackgroundTarle, S. J., Alderson, R. M., Patros, C. H. G., Lea, S. E., Hudec, K. L., & Arrington, E. F. (2017) · Neuropsychology · doi:10.1037/neu0000364 · Cited by 29 · see citing works
Tamm, L., Epstein, J. N., & Becker, S. P. (2019) · Child Neuropsychology · doi:10.1080/09297049.2018.1523379 · Cited by 13 · see citing works
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Executive function deficits in attention-deficit/hyperactivity disorder and autism spectrum disorder
Kofler, M. J., Soto, E. F., Singh, L. J., Harmon, S. L., Jaisle, E. M., Smith, J. N., Feeney, K. E., & Musser, E. D. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00350-9 · Cited by 51 · see citing works
“…evidence linking cognitive/behavioural models of executive function with important behavioural and functional outcomes in ADHD and ASD 25,33,89,155–158 , alternative executive function conceptualizations and measurement approaches (such as neurobiological and sociocultural insights) are…”
Self-citationKofler, M. J., Groves, N. B., Chan, E. S. M., Marsh, C. L., Cole, A. M., Gaye, F., Cibrian, E., Tatsuki, M. O., & Singh, L. J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1277583 · Cited by 35 · see citing works
Self-citationChan, E. S. M., Gaye, F., Cole, A. M., Singh, L. J., & Kofler, M. J. (2023) · Neuropsychology · doi:10.1037/neu0000918 · Cited by 6 · see citing works
Self-citation
- Authors
- Kofler, M. J., Wells, E. L., Singh, L. J., Soto, E. F., Irwin, L. N., Groves, N. B., Chan, E. S. M., Miller, C. E., Richmond, K. P., Schatschneider, C., & Lonigan, C. J.
- ORCID
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2020-08
- Volume
- 88
- Issue
- 8
- Pages
- 738-756
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- PMC
- PMC7384295
- OpenAlex
- W3044283726
- Cited by
- 44
- References
- 25
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 14 · 2022: 5 · 2021: 3
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH R01 MH115048)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- attention deficit hyperactivity disorder, inhibitory control training, executive function training, working memory, phonological working memory, visuospatial working memory, hyperactivity, impulsivity, children, therapeutic mechanisms, maintenance of treatment effects, feasibility and acceptability
- MeSH terms
- Cognitive Remediation, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Inhibition, Psychological, Male, Outcome and Process Assessment, Health Care, Executive Function
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