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CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
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“This robustness (compatibility with a larger set of environmental conditions) can be a target of evolution, as argued by Waddington and others [36–38].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [36]
In the citing paper
“We frame this issue using the concept of developmental canalization88, whereby natural selection on developmental programmes in humans has led to robustness in a range of genetic or environmental perturbations89,90: typical development occurs along a ‘track’ (FIG. 1c).”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [88]
In the citing paper
“In addition, most studies recruit survivors of the original birth cohorts. This means all participants must have survived in order to observe whether they get the outcome of interest. Selection of participants on surviving their genetic make-up and the outcome of interest or a competing risk of the outcome effectively applies covariable adjustment on survival into the estimates.173–175”
From Mendelian randomization (2022) · cites this paper as [175]
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Items 801–900 of 1,001
Myths and Legends of the Baldwin Effect
Turney, P. D. (2002) · CogPrints (University of Southampton) · doi:10.48550/arxiv.cs/0212036 · Cited by 43
Scharloo, W., Hoogmoed, M. S., & Kuile, A. T. (1967) · Genetics · doi:10.1093/genetics/56.4.709 · Cited by 43
Gong, H., Rehman, F., Zhong, L., Liu, J., Yang, T., Liu, J., Li, H., Hu, Z., Ma, Q., Wu, Z., et al. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06207 · Cited by 42
Jarosz, D. F. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.11.001 · Cited by 41
Ligon, C. O., Moloney, R. D., & Meerveld, B. G. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.231670 · Cited by 43
“The term epigenetics describes phenotypic trait variations resulting from developmental or environmental cues rather than alterations to the genomic DNA sequence itself (Waddington, 1942).”
BackgroundBoglione, C., Pulcini, D., Scardi, M., Palamara, E., Russo, T., & Cataudella, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096983 · Cited by 43
“On the basis of this assumption, it could be hypothesized that the constant biotic and abiotic conditions experienced in captive environments make the high maintenance costs of phenotypic plasticity pointless, thus impairing genotype skill to generate different phenotypes under the thrust of changing external cues (a…”
BackgroundWeiss, L. C., Heilgenberg, E., Deussen, L., Becker, S. M., Kruppert, S., & Tollrian, R. (2016) · Hydrobiologia · doi:10.1007/s10750-016-2809-4 · Cited by 42
A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?
Selleri, L., Bartolomei, M. S., Bickmore, W. A., He, L., Stubbs, L. J., Reik, W., & Barsh, G. S. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006485 · Cited by 42
Decanalizing thinking on genetic canalization
Geiler‐Samerotte, K., Sartori, F. M. O., & Siegal, M. L. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.008 · Cited by 40
“The ability to modulate buffering also lies at the core of Waddington’s concept of genetic canalization, whereby a system evolves to become less sensitive to the effects of mutations [16,23].”
BackgroundBarco, B., & Clay, N. K. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01775 · Cited by 43
Lou, J., Yu, S., Feng, L., Guo, X., Wang, M., Branco, A. T., Li, T., & Lemos, B. (2021) · Environment International · doi:10.1016/j.envint.2021.106525 · Cited by 42
Using phenotypic plasticity to understand the structure and evolution of the genotype–phenotype map
Chevin, L., Leung, C., Rouzic, A. L., & Uller, T. (2021) · Genetica · doi:10.1007/s10709-021-00135-5 · Cited by 40
Insulin signalling underlies both plasticity and divergence of a reproductive trait inDrosophila
Green, D. A., & Extavour, C. G. M. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.2673 · Cited by 44
“One hypothesis is that common molecular mechanisms underlie both plasticity and interspecific variation in a trait, which would allow plasticity to promote diversification by providing a range of phenotypes whose underlying genetic variation can be subject to selection by genetic accommodation, genetic assimilation or…”
BackgroundAubret, F., Bonnet, X., & Shine, R. (2007) · Functional Ecology · doi:10.1111/j.1365-2435.2007.01310.x · Cited by 42
Experimental Evidence for the Rapid Evolution of Behavioral Canalization in Natural Populations
Edgell, T. C., Lynch, B. R., Trussell, G. C., & Palmer, A. R. (2009) · The American Naturalist · doi:10.1086/603639 · Cited by 42
Phenotypic neighborhood and micro-evolvability
Dichtel-Danjoy, M.-L., & Félix, M. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.03.010 · Cited by 42
Yampolsky, L. Y., Glazko, G. V., & Fry, J. D. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05697.x · Cited by 42
“One interpretation of this result is that selection directly favoured ‘canalization’ (Waddington 1942) of expression of individual genes in the selected populations.”
BackgroundTowards an empirical measure of evolvability
Reisinger, J., Stanley, K. O., & Miikkulainen, R. P. (2005) · Genetic and Evolutionary Computation Conference Companion (GECCO Companion) · doi:10.1145/1102256.1102315 · Cited by 42
Extensive Phenotypic Variation in Early Flowering Mutants of Arabidopsis
Pouteau, S., Ferret, V., Gaudin, V., Lefebvre, D., Sabar, M., Zhao, G., & Prunus, F. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.039453 · Cited by 42
Kozbelt, A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316274385.010 · Cited by 42
Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems
Whitacre, J. M., & Bender, A. (2010) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-7-20 · Cited by 56
“Discussion There is a long-standing interest in the origins of robustness and resilience within CAS in general and biological systems in particular [28,45,46,48-59].”
BackgroundGenetic variability in reaction norms in fishes
Oomen, R. A., & Hutchings, J. A. (2015) · Environmental Reviews · doi:10.1139/er-2014-0077 · Cited by 41
“This variation is attributed to a loss of plasticity in the derived freshwater deme and provides indirect evidence of genetic assimilation, a rarely documented mechanism by which an environmentally induced phenotype becomes canalized such that the environmental stimulus is no longer necessary for expression in subsequ…”
BackgroundEarly Homo , plasticity and the extended evolutionary synthesis
Antón, S. C., & Kuzawa, C. W. (2017) · Interface Focus · doi:10.1098/rsfs.2017.0004 · Cited by 41
Chen, Y., Shen, Y., Lin, P., Ding, T., Zhao, Y., Allesina, S., Shen, X., & Wu, C. (2019) · National Science Review · doi:10.1093/nsr/nwz076 · Cited by 45
“Fourth, and perhaps most importantly, GRN stability may underlie the ‘developmental canalization’ proposed byWaddington [4].”
BackgroundSexual partner preference in animals and humans
Balthazart, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.024 · Cited by 41
“This canalization (sensu (Waddington, 1942)) is potentially mediated by micro RNAs that are known to modulate sex differences in mRNA concentrations in the mouse brain (McCarthy and Nugent, 2015) and by epigenetic marks (Nugent et al.”
BackgroundConith, A. J., Kidd, M. R., Kocher, T. D., & Albertson, R. C. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-01648-x · Cited by 41
“Alternatively, if plasticity retains a particular pattern of modularity or level of integration, this may facilitate rapid morphological change along a ‘line of least resistance’ in the feeding apparatus of a population via genetic assimilation in order to adapt to a new habitat [35, 36].”
BackgroundOakes, L. M., & Rakison, D. H. (2019) · doi:10.1093/oso/9780195391893.001.0001 · Cited by 80
“Ant” and “Grasshopper” Life-History Strategies in Saccharomyces cerevisiae
Spor, A., Wang, S., Dillmann, C., de Vienne, D., & Sicard, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001579 · Cited by 41
“If plasticity were adaptive, a second step of adaptation to new environments would be the conversion of non-heritable environmentally induced variation into heritable variation [36], by the process often referred to as Baldwin Effect, or genetic assimilation [37,38].”
BackgroundGilbert, S. F. (2000) · American Zoologist · doi:10.1668/0003-1569(2000)040[0729:dbmedc]2.0.co;2 · Cited by 41
Asymmetry ofa-b ridge count and behavioral discordance of monozygotic twins
Rose, R. J., Reed, T., & Bogle, A. (1987) · Behavior Genetics · doi:10.1007/bf01065992 · Cited by 41
Tissue Biology: In Search of a New Paradigm
Adler, M., Chavan, A. R., & Medzhitov, R. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-113830 · Cited by 40
Epigenetic Modifications in Plant Development and Reproduction
Brukhin, V. B., & Albertini, E. (2021) · Epigenomes · doi:10.3390/epigenomes5040025 · Cited by 40
“In Waddington’s terms, meristematic totipotent plant cells are polyvalent and can follow many trajectories of the epigenetic landscape [10,11].”
BackgroundB chromosomes and cranial variability in yellow-necked field mice (Apodemus flavicollis)
Jojić, V., Blagojević, J., & Vujošević, M. (2011) · Journal of Mammalogy · doi:10.1644/10-mamm-a-158.1 · Cited by 40
“Canalization refers to the buffering of developmental processes against environmental and mutational perturbations (Waddington 1942, 1957; Wagner et al. 1997), and DS is the ability of developmental processes to buffer random noise that arises within the developmental processes themselves…”
BackgroundShaw, J. R., Hampton, T. H., King, B. L., Whitehead, A., Gálvez-Montosa, F., Gross, R., Keith, N., Notch, E. G., Jung, D., Glaholt, S., et al. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu241 · Cited by 42
Lack, J., Monette, M. J., Johanning, E. J., Sprengelmeyer, Q. D., & Pool, J. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515964113 · Cited by 39
“For all strains used in mutagenesis testing, we used PCR to test whether any of nine common inversions were segregating within the inbred strain: In(1)A, In(1)Be, In(2L)t, In(2R)NS, In(3L)Ok, In(3L)P, In(3R)K, In(3R)Mo, and In(3R)P.”
MethodHistone deacetylases control module-specific phenotypic plasticity in beetle weapons
Ozawa, T., Mizuhara, T., Arata, M., Shimada, M., Niimi, T., Okada, K., Okada, Y., & Ohta, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615688114 · Cited by 40
Kok, E. M. A., Burant, J. B., Dekinga, A., Manche, P., Saintonge, D., Piersma, T., & Mathot, K. J. (2019) · The American Naturalist · doi:10.1086/704593 · Cited by 40
“Though less often considered, increased repeatability during development may also result from decreasing withinindividual variance, or canalization (Waddington 1942).”
BackgroundMethodInfluentialNichol, D., Robertson‐Tessi, M., Jeavons, P., & Anderson, A. R. A. (2016) · Genetics · doi:10.1534/genetics.116.193474 · Cited by 39
“If this is the case, then to identify the biological mechanisms responsible for hedging we will need to move beyond the gene–centric perspective and begin to identify those interactions responsible for stochastic determination of phenotypes.”
BackgroundMcManus, I. C. (2022) · Symmetry · doi:10.3390/sym14040814 · Cited by 39
Are Reptiles Predisposed to Temperature- Dependent Sex Determination?
Georges, A., Ezaz, T., Quinn, A. E., & Sarre, S. D. (2010) · Sexual Development · doi:10.1159/000279441 · Cited by 40
“The regulatory program of strict GSD species, where sex remains concordant with chromosomal sex established at the time of conception, must be resistant to these perturbations, that is, the male and female regulatory programs must each be strongly canalized [sensu Waddington, 1942].”
BackgroundHsp90 Regulates Nongenetic Variation in Response to Environmental Stress
Hsieh, Y.-Y. P., Hung, P.-H., & Leu, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.026 · Cited by 40
“Waddington: phenotypic invariance in spite of genetic or environmental perturbations during organismal development (Cowen and Lindquist, 2005; Jarosz et al., 2010; Waddington, 1942).”
BackgroundOn the origins of morphological variation, canalization, robustness, and evolvability
Salazar‐Ciudad, I. (2007) · Integrative and Comparative Biology · doi:10.1093/icb/icm075 · Cited by 39
‘Optimal thermal range’ in ectotherms: Defining criteria for tests of the temperature-size-rule
Walczyńska, A., Kiełbasa, A., & Sobczyk, M. (2016) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2016.06.006 · Cited by 40
Chaperones as Buffering Agents?
Mitchell‐Olds, T., & Knight, C. A. (2002) · Science · doi:10.1126/science.1073846 · Cited by 41
Commentary: The epigenotype—a dynamic network view of development
Jablonka, E., & Lamm, E. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr185 · Cited by 40
Liufu, Z., Zhao, Y., Guo, L., Miao, G., Xiao, J., Lyu, Y., Chen, Y., Shi, S., Tang, T., & Wu, C. (2017) · Genome Research · doi:10.1101/gr.222505.117 · Cited by 40
“Waddington CH. 1942.”
The enduring puzzle of the human chin
Pampush, J. D., & Daegling, D. J. (2016) · Evolutionary Anthropology: Issues, News, and Reviews · doi:10.1002/evan.21471 · Cited by 40
Griffiths, P. E. (2011) · The MIT Press eBooks · doi:10.7551/mitpress/9780262015141.003.0030 · Cited by 39
Tan, H. Y., Chen, A. G., Chen, Q., Browne, L. B., Verchinski, B. A., Kolachana, B. S., Zhang, F., Apud, J. A., Callicott, J. H., Mattay, V. S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.91 · Cited by 39
RPL1, a Gene Involved in Epigenetic Processes Regulates Phenotypic Plasticity in Rice
Zhang, C., Yuan, W., & Zhang, Q. (2011) · Molecular Plant · doi:10.1093/mp/ssr091 · Cited by 40
“In 1942, Waddington coined ‘canalization’, which aided to understand it (Waddington, 1942).”
BackgroundRouleau, N., & Dotta, B. T. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00084 · Cited by 39
“Waddington’s epigenetic landscape metaphor was originally employed as a method of describing developmental gene regulation of this sort (Waddington, 1942).”
MethodBetween holism and reductionism: a philosophical primer on emergence
Pigliucci, M. (2013) · Biological Journal of the Linnean Society · doi:10.1111/bij.12060 · Cited by 40
The Formation of Social Conventions in Real-Time Environments
Hawkins, R. X. D., & Goldstone, R. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151670 · Cited by 39
“A second interaction across temporal scales observed in biology is “canalization”, which refers to the robustness of a population’s phenotype with respect to changes in its environment and genotype [25].”
BackgroundRole of epigenetics in zebrafish development
Balasubramanian, S., Raghunath, A., & Perumal, E. (2019) · Gene · doi:10.1016/j.gene.2019.144049 · Cited by 42
Taylor, M. A., Wilczek, A. M., Roe, J. L., Welch, S. M., Runcie, D. E., Cooper, M. D., & Schmitt, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902731116 · Cited by 38
Levels and mechanisms of behavioural variability
Kappeler, P. M., & Kraus, C. (2010) · Springer eBooks · doi:10.1007/978-3-642-02624-9_21 · Cited by 39
Regulatory patterns in molecular interaction networks
Murrugarra, D., & Laubenbacher, R. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.08.015 · Cited by 39
“These rules, so-called nested canalyzing functions , capture the spirit of Waddington’s concept of canalyzation in gene regulation [30].”
BackgroundDufour, M. A., Woodhouse, A., Amendola, J., & Goaillard, J. (2014) · eLife · doi:10.7554/elife.04059 · Cited by 43
“This observation is particularly interesting and consistent with the idea of canalization of development formulated by the English embryologist Conrad Hal Waddington (Waddington, 1942, 1957; Debat and David, 2001).”
Can phenotypic plasticity in Rubisco performance contribute to photosynthetic acclimation?
Cavanagh, A. P., & Kubien, D. S. (2013) · Photosynthesis Research · doi:10.1007/s11120-013-9816-3 · Cited by 41
How might epigenetics contribute to ecological speciation?
Smith, G., & Ritchie, M. G. (2013) · Current Zoology · doi:10.1093/czoolo/59.5.686 · Cited by 38
“Waddington (1942) originally used this word in the context of ‘epigenesis’, or how phenotypes arise during the development of an organism from the zygote.”
Ethylene-induced hyponastic growth inArabidopsis thalianais controlled by ERECTA
van Zanten, M., Snoek, B. L., Stouten, E. A., Proveniers, M. C. G., Torii, K. U., Voesenek, L. A. C. J., Peeters, A. J. M., & Millenaar, F. F. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04035.x · Cited by 39
Heckel, K. V., Stephan, W., & Hütter, S. (2016) · BMC Genomics · doi:10.1186/s12864-016-2866-0 · Cited by 38
“The phenomenon that results in this phenotypic robustness has been termed canalization [1].”
BackgroundViable Mice with Compound Mutations in the Wnt/Dvl Pathway Antagonists nkd1 and nkd2
Zhang, S. J., Çağatay, T., Amanai, M., Zhang, M., Kline, J., Castrillón, D. H., Ashfaq, R., Öz, O. K., & Wharton, K. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00133-07 · Cited by 40
Noise, delays, robustness, canalization and all that
Kerszberg, M. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.06.001 · Cited by 39
Mendelian randomization: the use of genes in instrumental variable analyses
von Hinke, S., Smith, G. D., Lawlor, D. A., Propper, C., & Windmeijer, F. (2011) · Health Economics · doi:10.1002/hec.1746 · Cited by 40
Understanding asthma and allergies by the lens of biodiversity and epigenetic changes
Fiuza, B. S. D., Fonseca, H. F., Meirelles, P. M., Marques, C. R., da Silva, T. M., & Figueiredo, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623737 · Cited by 38
“Since the first Waddington epigenetics works (163, 164), many studies have been conducted to determine the influences of epigenetics in several conditions.”
BackgroundOrigin of evolutionary change in avian clutch size
Haywood, S. (2013) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12035 · Cited by 39
“(2) Genetic assimilation According to Waddington (1942), who used as an example the evolution of callosities on the ventral surface of the Ostrich (Struthio camelus), non-hereditary adaptations that are originally formed in response to a new environment can be converted, through environmental…”
MethodQuantifying the impact of development on phenotypic variation and evolution
Sears, K. E. (2014) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22592 · Cited by 38
Social selection and the evolution of cooperative groups: The example of the cellular slime moulds
Nanjundiah, V., & Sathe, S. (2011) · Integrative Biology · doi:10.1039/c0ib00115e · Cited by 38
Causal specificity and the instructive–permissive distinction
Calcott, B. (2017) · Biology & Philosophy · doi:10.1007/s10539-017-9568-0 · Cited by 38
“That is to say, they are adjusted so as to bring about one definite end-result regardless of minor variations in conditions during the course of the reaction (Waddington 1942).”
BackgroundEvolutionary Significance of Epigenetic Variation
Richards, C. L., Verhoeven, K. J. F., & Bossdorf, O. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1130-7_16 · Cited by 38
Ho, W.-C., & Zhang, J. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu131 · Cited by 37
Bonada, N., & Williams, D. D. (2002) · Hydrobiologia · doi:10.1023/a:1021297503935 · Cited by 38
Romiti, F., Zan, L. R. D., Piras, P., & Carpaneto, G. M. (2016) · Biological Journal of the Linnean Society · doi:10.1093/biolinnean/blw001 · Cited by 39
Takahashi, K. H. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.018 · Cited by 38
Epigenetics: A New Frontier in Probiotic Research
Morovic, W., & Budinoff, C. R. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.04.008 · Cited by 39
Starbuck, J. M., Llambrich, S., González, R., Albaigès, J., Sarlé, A., Wouters, J., González, A., Sevillano, X., Sharpe, J. A., de la Torre, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83757-1 · Cited by 34
(Epi)Genetic Mechanisms Underlying the Evolutionary Success of Eusocial Insects
Sieber, K. R., Dorman, T., Newell, N., & Yan, H. (2021) · Insects · doi:10.3390/insects12060498 · Cited by 38
“Specifically, this field aims to understand the molecular mechanisms and developmental processes occurring to establish diverse phenotypes without a change in genotype [4,5].”
BackgroundEvolution of cooperation facilitated by reinforcement learning with adaptive aspiration levels
Tanabe, S., & Masuda, N. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.10.020 · Cited by 39
“sarily founded on firm empirical evidence (Simpson, 1953; Weber & Depew, 2003), there exists a plethora of positive evidence of the Baldwin effect. Examples include fly’s morphological developments (Waddington, 1942), colonization of house finch in North America (Badyaev, 2009), and persistence of coastal juncos (Yeh…”
BackgroundCanalization and symmetry in Boolean models for genetic regulatory networks
Reichhardt, C. J. O., & Bassler, K. E. (2007) · Journal of Physics A Mathematical and Theoretical · doi:10.1088/1751-8113/40/16/006 · Cited by 37
Levels of Intraspecific Variation Within the Catarrhine Skeleton
Buck, L. T., Stock, J. T., & Foley, R. (2010) · International Journal of Primatology · doi:10.1007/s10764-010-9428-0 · Cited by 38
“Stabilizing selection leads to the production of a constant phenotype, despite environmental and genetic changes (Waddington 1942).”
BackgroundInstinct in the '50s: the British reception of Konrad Lorenz's theory of instinctive behavior*
Griffiths, P. E. (2004) · Biology & Philosophy · doi:10.1007/sbiph-004-0537-z · Cited by 38
Baverstock, K. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.04.005 · Cited by 43
Isolation disrupts social interactions and destabilizes brain development in bumblebees
Wang, Z. Y., McKenzie‐Smith, G. C., Liu, W., Cho, H. J., Pereira, T., Dhanerawala, Z. M., Shaevitz, J. W., & Kocher, S. D. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.066 · Cited by 37
Gahvora cradling in Tajikistan: Cultural practices and associations with motor development
Karasik, L. B., Adolph, K. E., Fernandes, S. N., Robinson, S. R., & Tamis‐LeMonda, C. S. (2023) · Child Development · doi:10.1111/cdev.13919 · Cited by 44
“Rather than eliminating movement, gahvora cra-dling may canalize experiences (Gottlieb, 1991; Waddington, 1942), with infants and children taking advantage of the opportunities available to them at different ages during different cultural activities.”
Environmentally robust cis -regulatory changes underlie rapid climatic adaptation
Ballinger, M. A., Mack, K. L., Durkin, S. M., Riddell, E. A., & Nachman, M. W. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214614120 · Cited by 38
Evolutionary convergence of sensory circuits in the pallium of amniotes
Rueda-Alaña, E., Senovilla-Ganzo, R., Grillo, M., Vázquez, E., Salas, S. M., Gallego‐Flores, T., Ordeñana-Manso, A., Ftara, A., Escobar, L., Benguría, A., et al. (2025) · Science · doi:10.1126/science.adp3411 · Cited by 39
Mechanisms of gap gene expression canalization in the Drosophila blastoderm
Gursky, V. V., Panok, L., Myasnikova, E. M., Manu, Samsonova, M. G., Reinitz, J., & Samsonov, A. M. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-118 · Cited by 37
“Waddington to propose that developmental processes have innate error-correction properties, which he called “canalization” [1].”
BackgroundExpression level polymorphisms: heritable traits shaping natural variation
Delker, C., & Quint, M. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.05.009 · Cited by 38
Robust selection of sensory organ precursors by the Notch–Delta pathway
Barad, O., Hornstein, E., & Barkai, N. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.005 · Cited by 37
Negative feedback buffers effects of regulatory variants
Bader, D. M., Wilkening, S., Lin, G., Tekkedil, M. M., Dietrich, K.-A., Steinmetz, L. M., & Gagneur, J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145844 · Cited by 39
Substance, History, and Politics
Black, C. J., Figueredo, A. J., & Jacobs, W. J. (2017) · Evolutionary Psychology · doi:10.1177/1474704916670402 · Cited by 37
“The model takes the form of a conditional-probabilistic path model, which permits multiple paths leading to increasing probabilities of particular outcomes, given particular conditions (canalization, see Waddington, 1942).”
Loison, L. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.009 · Cited by 37
Zambonino‐Infante, J., Panserat, S., Servili, A., Mouchel, O., Madec, L., & Mazurais, D. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.11.056 · Cited by 37
“This variation in the sea bass physiological response could be explained by the canalization hypothesis (Waddington, 1942; Stearns et al., 1995).”
BackgroundThe evolutionary advantage of heritable phenotypic heterogeneity
Carja, O., & Plotkin, J. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-05214-2 · Cited by 37
“Although the idea of phenotypic plasticity, and even subsequent genetic assimilation, dates back to Waddington [24], its critical role in microbial population dynamics has only recently been appreciated [25; 26; 27].”
Safron, A., & DeYoung, C. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819200-9.00010-7 · Cited by 34
DeVore, J. L., Crossland, M. R., Shine, R., & Ducatez, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100765118 · Cited by 37
SYMMETRY BREAKING IN INTERSPECIFIC DROSOPHILA HYBRIDS IS NOT DUE TO DEVELOPMENTAL NOISE
Rêgo, C., Matos, M., & Mauro Santos, A. (2006) · Evolution · doi:10.1111/j.0014-3820.2006.tb01153.x · Cited by 37
Cellular reprogramming for clinical cartilage repair
Driessen, B. J. H., Logie, C., & Vonk, L. A. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9382-0 · Cited by 37
“Nowadays, it is well-accepted that the core TFs—Oct4, Sox2 and Nanog homeobox (Nanog)—are the masters behind pluripotency, pushing the terminaldifferentiated cell back up the hill of Waddington’s epigenetic landscape (Waddington 1942; Ladewig et al. 2013; Niwa 2007).”
BackgroundA collision-based model of spiral phyllotaxis
Fowler, D. R., Prusinkiewicz, P., & Battjes, J. (1992) · ACM SIGGRAPH Computer Graphics · doi:10.1145/142920.134093 · Cited by 37
Metadata
- Authors
- WADDINGTON, C. H.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- WADDINGTON, C. H.
- Venue
- Nature
- Published
- 1942-11
- Volume
- 150
- Issue
- 3811
- Pages
- 563-565
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2094902224
- Cited by
- 3,255
- References
- 14
- Citations by year
- 2026: 111 · 2025: 127 · 2024: 122 · 2023: 109 · 2022: 162 · 2021: 140 · 2020: 168 · 2019: 162 · 2018: 168 · 2017: 145 · 2016: 149 · 2015: 192 · 2014: 150 · 2013: 172 · 2012: 127
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Social Sciences › Cultural Studies › Language and cultural evolution
- Keywords
- inheritance of acquired characteristics, Lamarckism, use and disuse, natural selection, random mutation, gene-environment interaction, adaptive evolution, heritable variation
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