Cited by 80Phagocytosis and Immune RegulationErythrocyte Function and PathophysiologyCell death mechanisms and regulation

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

Toda, Satoshi, Segawa, Katsumori, Nagata, Shigekazu·2014·Blood

Abstract

Key Points: An in vitro system for the engulfment of pyrenocytes was established using erythroblastic islands. MerTK, a receptor kinase, was essential for the engulfment of pyrenocytes by the central macrophages at erythroblastic islands.

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Crossref · 10.1182/blood-2014-01-547976

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Toda, S., Segawa, K., & Nagata, S.
Affiliations
Kyoto University (JP)
Venue
Blood
Published
2014-06-19
Volume
123
Issue
25
Pages
3963-3971
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2091012866
Cited by
80
References
42
Citations by year
2026: 3 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 2
FWCI
4.41
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (22000013)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
erythroblastic islands, definitive erythropoiesis, MERTK, protein S, phosphatidylserine, engulfment, enucleation, alpha4beta1 integrin, VCAM-1, efferocytosis
MeSH terms
c-Mer Tyrosine Kinase, Animals, Cell Line, Cell Nucleus, Cells, Cultured, Erythroblasts, Erythrocyte Membrane, Erythrocytes, Erythropoiesis, Humans, Macrophages, Mice, Inbred C57BL, Phagocytosis, Protein Binding, Proto-Oncogene Proteins, Reticulocytes, Apoptosis, Protein S, Mice, Knockout, Microscopy, Confocal, Vascular Cell Adhesion Molecule-1, Receptor Protein-Tyrosine Kinases, Integrin alpha4beta1, NIH 3T3 Cells, Microscopy, Electron, Transmission, Mice, HEK293 Cells

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