MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands
Abstract
Key Points: An in vitro system for the engulfment of pyrenocytes was established using erythroblastic islands. MerTK, a receptor kinase, was essential for the engulfment of pyrenocytes by the central macrophages at erythroblastic islands.
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Erythroblasts expel their nuclei during differentiation and these are taken up by EIM after phosphatidylserine exposure via Tim4 and MerTK.
“It is well characterized that erythroblasts expel their nuclei during differentiation and that these are taken up by EIM after phosphatidylserine exposure via Tim4 and MER proto-oncogene, tyrosine kinase (MerTK) [234, 254].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [234]
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“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
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- Authors
- Toda, S., Segawa, K., & Nagata, S.
- Affiliations
- Kyoto University (JP)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-06-19
- Volume
- 123
- Issue
- 25
- Pages
- 3963-3971
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2091012866
- Cited by
- 80
- References
- 42
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22000013)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- erythroblastic islands, definitive erythropoiesis, MERTK, protein S, phosphatidylserine, engulfment, enucleation, alpha4beta1 integrin, VCAM-1, efferocytosis
- MeSH terms
- c-Mer Tyrosine Kinase, Animals, Cell Line, Cell Nucleus, Cells, Cultured, Erythroblasts, Erythrocyte Membrane, Erythrocytes, Erythropoiesis, Humans, Macrophages, Mice, Inbred C57BL, Phagocytosis, Protein Binding, Proto-Oncogene Proteins, Reticulocytes, Apoptosis, Protein S, Mice, Knockout, Microscopy, Confocal, Vascular Cell Adhesion Molecule-1, Receptor Protein-Tyrosine Kinases, Integrin alpha4beta1, NIH 3T3 Cells, Microscopy, Electron, Transmission, Mice, HEK293 Cells
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