The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605

The Pharmacological Basis of Therapeutics

(1976) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/33.4.373a · Cited by 8,209

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979

NF-κB: Ten Years After

Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,001

The stress-activated protein kinase subfamily of c-Jun kinases

Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,596

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M., Mann, M., Manning, A., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,040

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,897

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,812

Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs

Gao, J., Mfuh, A., Amako, Y., & Woo, C. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11639 · Cited by 102

New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy

Petersen, K. F., & Shulman, G. I. (2006) · Obesity · doi:10.1038/oby.2006.280 · Cited by 87

Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction

Paccani, S. R., Boncristiano, M., Ulivieri, C., D'Elios, M. M., Del Prete, G., & Baldari, C. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110676200 · Cited by 84

Novel agents for the treatment of type 2 diabetes

DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.2.100 · Cited by 83

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

Smith, B. K., Ford, R. J., Desjardins, E. M., Green, A. E., Hughes, M. C., Houde, V. P., Day, E. A., Marcinko, K., Crane, J. D., Mottillo, E. P., et al. (2016) · Diabetes · doi:10.2337/db16-0564 · Cited by 79

Nutraceutical Activation of Sirt1: A Review

DiNicolantonio, J. J., McCarty, M. F., & O'Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2022-002171 · Cited by 65

Relevance of new drug discovery to reduce NF-κB activation in cardiovascular disease

Madonna, R., & De Caterina, R. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.005 · Cited by 46

Effect of essential oils and isolated compounds from Pimpinella species on NF‐ κ B: a target for antiinflammatory therapy

Tabanca, N., Ma, G., Pasco, D. S., Bedir, E., Kirimer, N., Baser, K. H. C., Khan, I. A., & Khan, S. I. (2007) · Phytotherapy Research · doi:10.1002/ptr.2154 · Cited by 41

Mechanism of glucagon-like peptide 1 improvements in type 2 diabetes mellitus and obesity.

Nolen-Doerr, E., Stockman, M.-C., & Rizo, I. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00350-4 · Cited by 32

EGF‐R is Expressed and AP‐1 and NF‐κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX‐2 and VEGF

Konstantinopoulos, P. A., Vandoros, G. P., Karamouzis, M. V., Gkermpesi, M., Sotiropoulou-Bonikou, G., & Papavassiliou, A. G. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/831416 · Cited by 32

Autophagy-mediated metabolic effects of aspirin

Castoldi, F., Humeau, J., Martins, I., Lachkar, S., Loew, D., Dingli, F., Durand, S., Enot, D., Bossut, N., Chery, A., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00365-0 · Cited by 27

Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder

Greaney, J. L., Saunders, E. F. H., & Alexander, L. M. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00643.2021 · Cited by 17