Neuron loss in APP transgenic mice

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Items 201–300 of 501

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2. APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS Disorder
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3. APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
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6. Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
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7. Mouse Genetic Models of Human Brain Disorders
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8. l-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-β peptide in rats
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9. Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
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10. Passive Immunization against β-Amyloid Peptide Protects Central Nervous System (CNS) Neurons from Increased Vulnerability Associated with an Alzheimer’s Disease-causing Mutation
    M. Hasan Mohajeri, Krishan Saini, Jan G. Schultz, Marc Axel Wollmer, Christoph Höck, Roger M. Nitsch · 2002 · Journal of Biological Chemistry
11. Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis
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12. Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease
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13. Beta-Amyloid and Oxidative Stress Jointly Induce Neuronal Death, Amyloid Deposits, Gliosis, and Memory Impairment in the Rat Brain
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14. Mitochondrion-Specific Antioxidants as Drug Treatments for Alzheimer Disease
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15. Coordinated Expression of Caspase 8, 3 and 7 mRNA in Temporal Cortex of Alzheimer Disease: Relationship to Formic Acid Extractable Aβ42 Levels
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16. Review: Experimental manipulations of microglia in mouse models of <scp>A</scp>lzheimer's pathology: activation reduces amyloid but hastens tau pathology
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17. Unbiased cell quantification reveals a continued increase in the number of neocortical neurones during early post‐natal development in mice
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18. Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw
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19. Inverse and distinct modulation of tau‐dependent neurodegeneration by presenilin 1 and amyloid‐β in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid‐β‐induced cell death
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20. Transgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development
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21. Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice
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22. Conversion of Synthetic Aβ toIn VivoActive Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model
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23. Age-related loss of noradrenergic neurons in the brains of triple transgenic mice
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24. Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
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25. Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau
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26. The Value of Transgenic Models for the Study of Neurodegenerative Diseases
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27. Neuropathology of Alzheimer's Disease
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28. Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of A lzheimer's disease
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29. Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice
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30. Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation
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31. Quercetin reduces eIF2α phosphorylation by GADD34 induction
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32. Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice
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33. MRI description of cerebral atrophy in mouse lemur primates
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34. Review on the APP/PS1KI mouse model: intraneuronal Aβ accumulation triggers axonopathy, neuron loss and working memory impairment
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35. Alzheimer’s Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment
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36. Animal models of mental retardation: from gene to cognitive function
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37. Animal Models in Biomedical Research
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38. Anti-inflammatory drugs: a hope for Alzheimer’s disease?
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39. Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease
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40. Accelerating Alzheimerʼs research through ‘natural’ animal models
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41. Amyloid β peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats
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42. Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model
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43. Insights on the Use of Transgenic Mice Models in Alzheimer’s Disease Research
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44. Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis
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45. Loss of presenilin function causes Alzheimer's disease‐like neurodegeneration in the mouse
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46. Mouse models of Alzheimer's disease: The long and filamentous road
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47. Selective vulnerability of different types of commissural neurons for amyloid  -protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
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48. Octodon degus : A Model for the Cognitive Impairment Associated with A lzheimer's Disease
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49. A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental Toxicity
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50. Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease
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51. Membrane-Anchored Aβ Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in Mice
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52. Acupuncture Improves Cognitive Deficits and Increases Neuron Density of the Hippocampus in Middle-Aged Samp8 Mice
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53. Parvalbumin-Positive Neuron Loss and Amyloid-β Deposits in the Frontal Cortex of Alzheimer’s Disease-Related Mice
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54. Quercetin Regulates the Integrated Stress Response to Improve Memory
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55. Transgenic Expression of Intraneuronal Aβ ₄₂ But Not Aβ ₄₀ Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology
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56. Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene Expression
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57. Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
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58. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia
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60. New developments in animal models of Alzheimer’s disease
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61. Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7
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62. Transgenic animal models of neurodegeneration based on human genetic studies
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63. The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease
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64. Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice
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65. Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models
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66. Cellular Cofactors for Amyloid β-Peptide-Induced Cell Stress
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67. Is there a future for vaccination as a treatment for Alzheimer's disease?
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68. Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models
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69. Molecular Pathology of Alzheimer’s Disease and Related Disorders
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70. Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze
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71. Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model
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72. Amyloid β peptides and central cholinergic neurons: functional interrelationship and relevance to Alzheimer's disease pathology
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73. BAG‐1M is up‐regulated in hippocampus of Alzheimer’s disease patients and associates with tau and APP proteins
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74. Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease
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75. The Tauopathies
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76. Lesion-Induced Axonal Sprouting in the Central Nervous System
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77. Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?
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78. Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains.
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79. Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease
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81. The Neuroprotective Activities of the Novel Multi-Target Iron-Chelators in Models of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis and Aging
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82. The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse
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83. Metalloproteins and neuronal death
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84. Stereological estimates of total neuron numbers in the hippocampus of adult reeler mutant mice: Evidence for an increased survival of Cajal‐Retzius cells
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85. Neurohormonal Signaling Pathways and the Regulation of Alzheimer β-Amyloid Precursor Metabolism
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86. Mechanisms of memory loss in Aβ and tau mouse models
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87. Why therapies for Alzheimer’s disease do not work: Do we have consensus over the path to follow?
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88. Age‐dependent time course of cerebral brain‐derived neurotrophic factor, nerve growth factor, and neurotrophin‐3 in APP23 transgenic mice
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90. Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits
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91. Preclinical and clinical challenges in the development of disease-modifying therapies for Alzheimer's disease
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92. What Can Rodent Models Tell Us About Cognitive Decline in Alzheimer's Disease?
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93. The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer’s disease
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95. Alzheimer's disease and other dementias
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96. Correlated Inflammatory Responses and Neurodegeneration in Peptide-Injected Animal Models of Alzheimer’s Disease
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98. Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile
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99. Suppressive Effects of SuHeXiang Wan on Amyloid-β42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic Drosophila Model of Alzheimer’s Disease
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100. Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the swedish mutation
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