Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains.
Open accessAbstract
Abstract Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by Gd CA can be converted into resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of the Gd CA in the brain improves the contrast between different tissues and provides new contrasts in MR images. Gd-stained MRI detects amyloid plaques, one of the microscopic lesions of Alzheimer’s disease (AD), in APPSL/PS1M146Lmice or in primates. Numerous transgenic mice with various plaque typologies have been developed to mimic cerebral amyloidosis and comparison of plaque detection between animal models and humans with new imaging methods is a recurrent concern. Here, we investigated detection of amyloid plaques by Gd-stained MRI in five mouse models of amyloidosis (APPSL/PS1M146L, APP/PS1dE9, APP23, APPSwDI, and 3xTg) presenting with compact, diffuse and intracellular plaques as well as inpost mortemhuman-AD brains. The brains were then evaluated by histology to investigate the impact of size, compactness, and iron load of amyloid plaques on their detection by MRI. We show that Gd-stained MRI allows detection of compact amyloid plaques as small as 25 µm, independently of their iron load, in mice as well as in human-AD brains.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gadolinium-stained MRI can be used to detect amyloid plaques in both mouse AD models and human-AD brains.
“Dudeffant et al. (2017) demonstrated that Gadolinium (Gd)-stained MRI can be used to detect the amyloid plaques in both mouse AD models and human-AD brains.”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Dudeffant et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works
Intraneuronal Aβ42 Accumulation in Human Brain
Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991 · see citing works
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
Garcia-Alloza, M., Robbins, E. M., Zhang-Nunes, S. X., Purcell, S. M., Betensky, R. A., Raju, S., Prada, C., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.017 · Cited by 744 · see citing works
Neuron loss in APP transgenic mice
Calhoun, M. E., Wiederhold, K.-H., Abramowski, D., Phinney, A. L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., & Jucker, M. (1998) · Nature · doi:10.1038/27351 · Cited by 502 · see citing works
Klunk, W. E., Lopresti, B. J., Ikonomović, M. D., Lefterov, I. M., Koldamova, R. P., Abrahamson, E. E., Debnath, M. L., Holt, D. P., Huang, G.-F., Shao, L., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2990-05.2005 · Cited by 376 · see citing works
Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M. L., Zeigler, K., Zlokovic, B. V., & Van Nostrand, W. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312946200 · Cited by 373 · see citing works
In vivo detection of amyloid-β deposits by near-infrared imaging using an oxazine-derivative probe
Hintersteiner, M., Enz, A., Frey, P., Jaton, A.-L., Kinzy, W., Kneuer, R., Neumann, U., Rudin, M., Staufenbiel, M., Stoeckli, M., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1085 · Cited by 342 · see citing works
19F and 1H MRI detection of amyloid β plaques in vivo
Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., & Saido, T. C. (2005) · Nature Neuroscience · doi:10.1038/nn1422 · Cited by 339 · see citing works
Maeda, J., Ji, B., Irie, T., Tomiyama, T., Maruyama, M., Okauchi, T., Staufenbiel, M., Iwata, N., Ono, M., Saido, T. C., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0673-07.2007 · Cited by 300 · see citing works
Cerebrovascular disease in ageing and Alzheimer’s disease
Love, S., & Miners, J. S. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1522-0 · Cited by 299 · see citing works
Blanchard, V., Moussaoui, S., Czech, C., Touchet, N., Bonici, B., Planche, M., Canton, T., Jedidi, I., Gohin, M., Wirths, O., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00252-8 · Cited by 283 · see citing works
Self-citationSchrag, M., Mueller, C., Oyoyo, U. E., Smith, M. A., & Kirsch, W. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.001 · Cited by 266 · see citing works
Morris, E., Chalkidou, A., Hammers, A., Peacock, J. L., Summers, J. A., & Keevil, S. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3228-x · Cited by 249 · see citing works
Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome
Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E., & Troncoso, J. C. (2001) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2001-125-0489-iaapdo · Cited by 248 · see citing works
Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy
Benveniste, H., Einstein, G., Kim, K. R., Hulette, C., & Johnson, G. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14079 · Cited by 235 · see citing works
Molecular Targeting of Alzheimer's Amyloid Plaques for Contrast-Enhanced Magnetic Resonance Imaging
Poduslo, J. F., Wengenack, T. M., Curran, G. L., Wısnıewskı, T., Sigurdsson, E. M., Macura, S. I., Borowski, B., & Jack, C. R. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0550 · Cited by 216 · see citing works
Jack, C. R., Garwood, M., Wengenack, T. M., Borowski, B., Curran, G. L., Lin, J., Adriany, G., Gröhn, O. H. J., Grimm, R. C., & Poduslo, J. F. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20266 · Cited by 196 · see citing works
Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21731 · Cited by 176 · see citing works
cFos immunoreactivity is enhanced with biotin amplification.
Berghorn, K. A., Bonnett, J. H., & Hoffman, G. E. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.12.7983364 · Cited by 161 · see citing works
Zeineh, M. M., Chen, Y., Kitzler, H. H., Hammond, R., Vogel, H., & Rutt, B. K. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.022 · Cited by 151 · see citing works
Jack, C. R., Wengenack, T. M., Reyes, D. A., Garwood, M., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Adriany, G., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2588-05.2005 · Cited by 148 · see citing works
Histological Co-Localization of Iron in A� Plaques of PS/APP Transgenic Mice
Falangola, M. F., Lee, P., Nixon, R. A., Duff, K., & Helpern, J. A. (2005) · Neurochemical Research · doi:10.1007/s11064-004-2442-x · Cited by 122 · see citing works
MR Imaging Features of Amyloid-Related Imaging Abnormalities
Barakos, J. A., Sperling, R. A., Salloway, S., Jack, C. R., Gass, A., Fiebach, J. B., Tampieri, D. I., Melançon, D., Miaux, Y., Rippon, G. A., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3500 · Cited by 120 · see citing works
Wadghiri, Y. Z., Li, J., Wang, J., Hoang, D. M., Sun, Y., Xu, H., Tsui, W., Li, Y., Boutajangout, A., Wang, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057097 · Cited by 114 · see citing works
Nakada, T., Matsuzawa, H., Igarashi, H., Fujii, Y., & Kwee, I. L. (2007) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2007.00179.x · Cited by 92 · see citing works
Kuntner, C., Kesner, A., Bauer, M., Kremslehner, R., Wanek, T., Mandler, M., Karch, R., Stanek, J., Wolf, T., Müller, M., et al. (2009) · Molecular Imaging and Biology · doi:10.1007/s11307-009-0198-z · Cited by 90 · see citing works
Rojas, S., Herance, J. R., Gispert, J. D., Abad, S., Llongarriu, È. T., Jiménez, X., Pareto, D., Perpiñá, U., Sarroca, S., Rodrı́guez, E., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.027 · Cited by 87 · see citing works
Tayara, N. E. T. E., Delatour, B., Cudennec, C. L., Guégan, M., Volk, A., & Dhénain, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.013 · Cited by 85 · see citing works
Snellman, A., Lopez‐Picon, F. R., Rokka, J., Salmona, M., Forloni, G., Scheinin, M., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.110163 · Cited by 82 · see citing works
PET imaging with [18F]AV-45 in an APP/PS1-21 murine model of amyloid plaque deposition
Poisnel, G., Dhilly, M., Moustié, O., Delamare, J., Abbas, A., Guilloteau, D., & Barré, L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.024 · Cited by 75 · see citing works
Senile plaques do not induce susceptibility effects in T2*‐weighted MR microscopic images
Dhénain, M., Privat, N., Duyckaerts, C. J., & Jacobs, R. E. (2002) · NMR in Biomedicine · doi:10.1002/nbm.760 · Cited by 72 · see citing works
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
Borthakur, A., Gur, T., Wheaton, A. J., Corbo, M. T., Trojanowski, J. Q., Lee, V. M. ‐., & Reddy, R. D. (2006) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20751 · Cited by 69 · see citing works
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
Sigurdsson, E. M., Wadghiri, Y. Z., Mosconi, L., Blind, J. A., Knudsen, E., Asuni, A. A., Scholtzova, H., Tsui, W. H., Li, Y., Sadowski, M. J., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.018 · Cited by 66 · see citing works
Beckmann, N., Gérard, C., Abramowski, D., Cannet, C., & Staufenbiel, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4936-10.2011 · Cited by 65 · see citing works
Chamberlain, R., Reyes, D. A., Curran, G. L., Marjańska, M., Wengenack, T. M., Poduslo, J. F., Garwood, M., & Jack, C. R. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21951 · Cited by 62 · see citing works
Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice
Dhénain, M., Tayara, N. E. T. E., Wu, T., Guégan, M., Volk, A., Quintana, C., & Delatour, B. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.018 · Cited by 56 · see citing works
Multiphoton in vivo imaging of amyloid in animal models of Alzheimer’s disease
Dong, J., Revilla-Sanchez, R., Moss, S. J., & Haydon, P. G. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.007 · Cited by 50 · see citing works
Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice
Petiet, A., Santin, M. D., Bertrand, A., Wiggins, C. J., Petit, F., Houitte, D., Hantraye, P., Bénavidès, J., Debeir, T., Rooney, T., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.009 · Cited by 50 · see citing works
Self-citationRegional differences in MRI detection of amyloid plaques in AD transgenic mouse brain
Wengenack, T. M., Reyes, D. A., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Gilles, E. J., Chamberlain, R., Marjanska, M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.033 · Cited by 41 · see citing works
Nabuurs, R. J. A., Hegeman, I., Natté, R., van Duinen, S. G., van Buchem, M. A., van der Weerd, L., & Webb, A. G. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1598 · Cited by 39 · see citing works
Dhénain, M., Delatour, B., Walczak, C., & Volk, A. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20810 · Cited by 36 · see citing works
Santin, M. D., Debeir, T., Bridal, S. L., Rooney, T., & Dhénain, M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.106 · Cited by 34 · see citing works
Morphological and carbogen‐based functional MRI of a chemically induced liver tumor model in mice
Thomas, C. D., Chenu, E., Walczak, C., et al. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10555 · Cited by 28 · see citing works
Luo, F., Rustay, N. R., Seifert, T. R., Roesner, B., Hradil, V. P., Hillen, H., Ebert, U., Severin, J. M., Cox, B. F., Llano, D. A., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172932 · Cited by 27 · see citing works
Bertrand, A., Pasquier, A., Petiet, A., Wiggins, C. J., Kraska, A., Joseph‐Mathurin, N., Aujard, F., Mestre‐Francés, N., & Dhénain, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056593 · Cited by 26 · see citing works
Santin, M. D., Vandenberghe, M. E., Herard, A.-S., Pradier, L., Cohen, C., Debeir, T., Delzescaux, T., Rooney, T., & Dhenain, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00055 · Cited by 20 · see citing works
Self-citationNabuurs, R. J. A., Natté, R., de Ronde, F. M., Hegeman-Kleinn, I. M., Dijkstra, J., van Duinen, S. G., WEBB, A. G., Rozemüller, A. J. M., van Buchem, M. A., & van der Weerd, L. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122215 · Cited by 19 · see citing works
Delatour, B., Epelbaum, S., Petiet, A., & Dhénain, M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/604853 · Cited by 16 · see citing works
MRI detection of prion protein plaques in variant Creutzfeldt-Jakob disease
Hyare, H., So, P., Brandner, S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000000304 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuroimaging of mouse models of Alzheimer’s disease
Jullienne, A., Trinh, M. V., & Obenaus, A. (2022) · Biomedicines · doi:10.3390/biomedicines10020305 · Cited by 32 · see citing works
Kim, E., Di Censo, D., Baraldo, M., Simmons, C., Rosa, I., Randall, K., Ballard, C., Dickie, B. R., Williams, S. C. R., Killick, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91899-5 · Cited by 15 · see citing works
Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging
Maharjan, S., Tsai, A. P., Lin, P. B., Ingraham, C., Jewett, M. R., Landreth, G. E., Oblak, A. L., & Wang, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.964654 · Cited by 11 · see citing works
- Authors
- Dudeffant, C., Vandesquille, M., Herbert, K., Garin, C. M., Alves, S., Blanchard, V., Comoy, E. E., Petit, F., & Dhenain, M.
- Affiliations
- Université Paris-Sud (FR)
- Sanofi (France) (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Venue
- Scientific Reports
- Published
- 2017-07-10
- Volume
- 7
- Issue
- 1
- Pages
- 4955-4955
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5504006
- OpenAlex
- W2727977265
- Cited by
- 34
- References
- 55
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 5
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- Bpifrance
- China Scholarship Council
- Association France Parkinson
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid plaques, Alzheimer's disease, gadolinium-enhanced MRI, APP23 mice, 3xTg-AD mice, plaque detection, transgenic mouse model
- MeSH terms
- Alzheimer Disease, Amyloidosis, Animals, Autopsy, Contrast Media, Disease Models, Animal, Gadolinium, Humans, Iron, Magnetic Resonance Imaging, Mice, Transgenic, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
