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Cited by 49Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

Clemmensen, Christoffer, Madsen, Andreas N., Smajilovic, Sanela, Holst, Birgitte, Bräuner-Osborne, Hans·2012·Amino Acids
DOI 10.1007/s00726-011-1199-1
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Abstract

L-Arginine (L-Arg) is a conditionally essential amino acid and a natural constituent of dietary proteins. Studies in obese rats and type 2 diabetic humans have indicated that dietary supplementation with L-Arg can diminish gain in white adipose tissue (WAT) and improve insulin sensitivity. However, the effects of L-Arg on glucose homeostasis, body composition and energy metabolism remain unclear. In addition, no studies have, to our knowledge, examined whether L-Arg has beneficial effects as a dietary supplement in the mouse model. In the present study, we investigated the effects of L-Arg supplementation to male C57BL/6 mice on an array of physiological parameters. L-Arg supplemented mice were maintained on a low-protein diet and body composition, appetite regulation, glucose tolerance, insulin sensitivity and energy expenditure were evaluated. A significant reduction in epididymal WAT was observed in L-Arg supplemented mice compared with mice fed an isocaloric control diet. Surprisingly, the L-Arg supplemented animals were hyperphagic corresponding to a highly significant decrease in feed efficiency, as body weight developed in a similar pattern in both experimental groups. Glucose homeostasis experiments revealed a major effect of L-Arg supplementation on glucose tolerance and insulin sensitivity, interestingly, independent of a parallel regulation in whole-body adiposity. Increased L-Arg ingestion also raised energy expenditure; however, no concurrent effect on locomotor activity, substrate metabolism or expression of uncoupling proteins (UCP1 and UCP2) in adipose tissues was displayed. In conclusion, dietary L-Arg supplementation substantially affects an array of metabolic-associated parameters including a reduction in WAT, hyperphagia, improved insulin sensitivity and increased energy expenditure in mice fed a low-protein diet.

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  • L-arginine feeding reduces white adipose tissue mass, improves insulin sensitivity, and increases energy expenditure in mice despite promoting hyperphagia.

    “Despite promoting hyperphagia, L-arginine feeding reduced white adipose tissue mass, improved insulin sensitivity, and increased energy expenditure in mice [278].”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [278]

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Authors
Clemmensen, C., Madsen, A. N., Smajilovic, S., Holst, B., & Bräuner-Osborne, H.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2011-12-27
Volume
43
Issue
3
Pages
1265-1275
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-011-1199-1
OpenAlex
W2012999911
Cited by
49
References
50
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 2
FWCI
4.71
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Ministerio de Ciencia e Innovación
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
L-arginine, dietary supplementation, low-protein diet, white adipose tissue, glucose tolerance, insulin sensitivity, energy expenditure, hyperphagia, body composition, obesity, type 2 diabetes, uncoupling proteins, C57BL/6 mice
MeSH terms
Animals, Arginine, Blood Glucose, Energy Intake, Energy Metabolism, Glucose, Homeostasis, Hyperphagia, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Mice, Inbred C57BL, Mitochondria, Motor Activity, Oxygen Consumption, Gene Expression, Diet, Protein-Restricted, Dietary Supplements, Adiposity, Genes, Mitochondrial, Mice, Adipose Tissue, White

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