Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, Peter, Dor, Yuval, Herbert, Jean-Marc, Fukumura, Dai, Brusselmans, Koen, Dewerchin, Mieke, Neeman, Michal, Bono, Françoise +8 more·1998·Nature
DOI 10.1038/28867

Cited by (128)

Items 101–128 of 128

  1. Hypoxia-Inducible Factor-1α Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts
    Dang, Duyen T., Chen, Fang, Gardner, Lawrence B., Cummins, Jordan M., Rago, Carlo, Bunz, Fred, Kantsevoy, Sergey V., Dang, Long H. · 2006 · Cancer Research
  2. Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia
    Niu, Yi, Lin, Ziyou, Wan, Arabella, Sun, Lei, Yan, Shijia, Liang, Heng, Zhan, Siyue, Chen, Dongshi, Bu, Xianzhang, Liu, Peiqing et al. · 2021 · Hepatology
  3. Sleep apnea and subsequent cancer incidence
    Sillah, Arthur, Watson, Nathaniel F., Schwartz, Stephen M., Gozal, David, Phipps, Amanda I. · 2018 · Cancer Causes & Control
  4. Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin
    Cao, Yiting, Eble, Joseph M., Moon, Ejung, Yuan, Hong, Weitzel, Douglas H., Landon, Chelsea D., Yu-Chih Nien, Charleen, Hanna, Gabi, Rich, Jeremy N., Provenzale, James M. et al. · 2013 · Cancer Research
  5. Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment
    Hayashi, Toshiaki, Hideshima, Teru, Nguyen, Aaron N., Munoz, Olivier, Podar, Klaus, Hamasaki, Makoto, Ishitsuka, Kenji, Yasui, Hiroshi, Richardson, Paul, Chakravarty, Sarvajit et al. · 2004 · Clinical Cancer Research
  6. Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development
    Vinores, Stanley A., Xiao, Wei‐Hong, Aslam, Sadia, Shen, Jikui, Oshima, Yuji, Nambu, Hiroyuki, Liu, Hansheng, Carmeliet, Peter, Campochiaro, Peter A. · 2006 · Journal of Cellular Physiology
  7. Hypoxia-inducible Factor 1α and Antiangiogenic Activity of Farnesyltransferase Inhibitor SCH66336 in Human Aerodigestive Tract Cancer
    Han, Ji-Youn, Oh, Seung Hyun, Morgillo, Floriana, Myers, Jeffrey N., Kim, Edward, Hong, Waun Ki, Lee, Ho-Young · 2005 · JNCI: Journal of the National Cancer Institute
  8. Oxygen Sensing in Retinal Health and Disease
    Lange, Clemens A.K., Bainbridge, James W.B. · 2012 · Ophthalmologica
  9. The impact of hypoxia on cell death pathways
    Lenihan, Colin R., Taylor, Cormac T. · 2013 · Biochemical Society Transactions
  10. A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis
    Williams, Kaye J, Telfer, Brian A, Airley, Rachel E, Peters, Hans PW, Sheridan, Mary R, van der Kogel, Albert J, Harris, Adrian L, Stratford, Ian J · 2002 · Oncogene
  11. In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo
    Yao, K, Gietema, J A, Shida, S, Selvakumaran, M, Fonrose, X, Haas, N B, Testa, J, O'Dwyer, P J · 2005 · British Journal of Cancer
  12. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
    Tarhonskaya, Hanna, Rydzik, Anna M., Leung, Ivanhoe K. H., Loik, Nikita D., Chan, Mun Chiang, Kawamura, Akane, McCullagh, James S. O., Claridge, Timothy D. W., Flashman, Emily, Schofield, Christopher J. · 2014 · Nature Communications
  13. cDNA cloning, gene organization and variant specific expression of HIF-1α in high altitude yak (Bos grunniens)
    Dolt, Karamjit S., Mishra, Manoj K., Karar, Jayashree, Baig, Masroor A., Ahmed, Zakwan, Pasha, M.A. Qadar · 2007 · Gene
  14. Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
    Ioannou, M., Papamichali, R., Kouvaras, E., Mylonis, I., Vageli, D., Kerenidou, T., Barbanis, S., Daponte, A., Simos, G., Gourgoulianis, K. et al. · 2009 · Lung
  15. The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway
    Leek, Russell D., Stratford, Ian, Harris, Adrian L. · 2005 · Cancer Research
  16. Small molecules targeting HIF-1α pathway for cancer therapy in recent years.
    Tang, Wendi, Zhao, Guisen · 2020 · Bioorganic & Medicinal Chemistry
  17. The importance of mitochondrial DNA in aging and cancer
    Desler, Claus, Marcker, Maiken Lise, Singh, Keshav K., Rasmussen, Lene Juel · 2011 · Journal of Aging Research
  18. Hypoxia inducible factor‐1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study
    Matsuo, Yoichiro, Ding, Qiang, Desaki, Ryosuke, Maemura, Kosei, Mataki, Yuko, Shinchi, Hiroyuki, Natsugoe, Shoji, Takao, Sonshin · 2014 · Journal of Hepato-Biliary-Pancreatic Sciences
  19. Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity
    Gaoatswe, Gadintshware, Kent, Brian D., Corrigan, Michelle A., Nolan, Geraldine, Hogan, Andrew E., McNicholas, Walter T., O'Shea, Donal · 2015 · Sleep
  20. Increased incidence of colorectal cancer with obstructive sleep apnea: a nationwide population-based cohort study
    Chen, Chao-Yang, Hu, Je-Ming, Shen, Cheng-Jung, Chou, Yu-Ching, Tian, Yu-Feng, Chen, Yong-Chen, You, San-Lin, Hung, Chi-Feng, Lin, Tzu-Chiao, Hsiao, Cheng-Wen et al. · 2020 · Sleep Medicine
  21. Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma
    Wu, Jennifer, Contratto, Merly, Shanbhogue, Krishna P, Manji, Gulam A, O’Neil, Bert H, Noonan, Anne, Tudor, Robert, Lee, Ray · 2019 · World Journal of Clinical Oncology
  22. Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
    Zhou, Zhao-Li, Luo, Zhi-Guo, Yu, Bing, Jiang, Yi, Chen, Yi, Feng, Jian-Ming, Dai, Mei, Tong, Lin-Jiang, Li, Zheng, Li, Yuan-Chao et al. · 2010 · Molecular Cancer
  23. OVER EXPRESSION OF HYPOXIA-INDUCIBLE FACTOR-1α IN RENAL AND BLADDER CANCER CELLS INCREASES TUMORIGENIC POTENCY
    KONDO, YUKIHIRO, HAMADA, JUNKO, KOBAYASHI, CHIE, NAKAMURA, RYOSUKE, SUZUKI, YASUTOMO, KIMATA, RYOJI, NISHIMURA, TAIJI, KITAGAWA, TAKAYUKI, KUNIMOTO, MANABU, IMURA, NOBUMASA et al. · 2005 · Journal of Urology
  24. HIF gene expression in cancer therapy
    Chan, Denise A., Krieg, Adam J., Turcotte, Sandra, Giaccia, Amato J. · 2007 · Methods in Enzymology
  25. Hypoxia-inducible factor: roles in development, physiology, and disease
    Chandel, N S, Simon, M C · 2008 · Cell Death & Differentiation
  26. Metabolic profiling of hypoxia-inducible factor-1β-deficient and wild type Hepa-1 cells: Effects of hypoxia measured by 1H magnetic resonance spectroscopy
    Troy, Helen, Chung, Yuen-Li, Mayr, Manuel, Ly, Lucy, Williams, Kaye, Stratford, Ian, Harris, Adrian, Griffiths, John, Stubbs, Marion · 2006 · Metabolomics
  27. HIF1α is not a target of 14q deletion in clear cell renal cancer
    Shenoy, Niraj · 2020 · Scientific Reports
  28. Hypoxia‐inducible factor‐1α in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
    Swinson, Daniel E.B., Jones, J. Louise, Cox, Giles, Richardson, Donna, Harris, Adrian L., O'Byrne, Kenneth J. · 2004 · International Journal of Cancer