Cited by 49Mitochondrial Function and PathologyAutophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

The importance of mitochondrial DNA in aging and cancer

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Desler, Claus, Marcker, Maiken Lise, Singh, Keshav K., Rasmussen, Lene Juel·2011·Journal of Aging Research

Abstract

Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.

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Crossref · 10.4061/2011/407536

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  • Since ROS are important signalling molecules, the dose and target of the administered antioxidant would have to be considered to prevent the alteration of cellular homeostasis.

    “Since ROS are important signalling molecules [Desler et al., 2011; Fischer et al., 2012], the dose and target of the administered antioxidant would have to be considered to prevent the alteration of cellular homeostasis.”

    From Oxidative stress and ageing (2016) · cites this paper as Desler et al., 2011

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Authors
Desler, C., Marcker, M. L., Singh, K. K., & Rasmussen, L. J.
Affiliations
  • University of Copenhagen (DK)
  • Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark
  • Roswell Park Comprehensive Cancer Center (US)
Corresponding author
Rasmussen, Lene Juel
Venue
Journal of Aging Research
Publisher
Wiley
Published
2011
Volume
2011
Pages
1-9
ISSN
  • 2090-2204 (ISSN-L)
  • 2090-2212
OpenAlex
W2092919205
Cited by
49
References
108
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 3
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • Journal of Aging Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
National Institutes of Health (RO 1 CA121904)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
mitochondrial DNA, mitochondrial dysfunction, aging, cancer, premature aging, age-related diseases, tumor initiation, tumor progression, mitochondrial reactive oxygen species, apoptosis

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