cDNA cloning, gene organization and variant specific expression of HIF-1α in high altitude yak (Bos grunniens)
Abstract
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factor consisting of HIF-1alpha and HIF-1beta subunits. HIF-1alpha is the oxygen-regulated subunit of HIF-1, which regulates the transcription of genes involved in oxygen homeostasis in response to hypoxia. Yak (Bos grunniens), a mammal native to high altitude (HA) region ( approximately 3500-5500 m), has successfully adapted over many generations to the chronic hypoxia of HA. In the present work, cDNA encoding HIF-1alpha has been cloned from the blood of yak. Tissue specific expression of the mRNA was analyzed in blood, heart, lung, liver and kidney by RT-PCR with primers from three different regions of cDNA. The HIF-1alpha expression was liver and blood specific. The HIF-1alpha mRNA contains 823 bp long 3'UTR that is AU-rich and contains ten AUUUA pentamers and two overlapping copies of the nonamer UUAUUUAUUUAUU. Three potential microRNAs, hsa-miR-107/mmu-miR-107/rno-miR-107, hsa-miR-18b and hsa-miR-135a/mmu-miR-135a/rno-miR-135a, targeting 3'UTR of yak HIF-1alpha, were identified by using target prediction software. The CDS encodes for 823 residues of amino acids and showed 99%, 95%, 92%, 90% and 90% similarity to domestic cattle, human, plateau pika, mouse and rat HIF-1alpha, respectively. HIF-1alpha cDNA, cloned and sequenced in the present work has revealed the evolutionary conservation through multiple sequence alignment. Liver and blood specific stability of HIF-1alpha mRNA appears miR-107 regulated.
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Yaks have numerous anatomical and physiological traits that equip them for life at high altitude, including large lungs and hearts, lack of hypoxic pulmonary vasoconstriction, increased foraging ability, strong environmental sense and high energy metabolism.
“Yaks have numerous anatomical and physiological traits that equip them for life at high altitude, including large lungs and hearts 1 , lack of hypoxic pulmonary vasoconstriction 5 , increased foraging ability 6 , strong environmental sense 1 and high energy metabolism 1,7 .”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [5]
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works
Multiple sequence alignment with hierarchical clustering.
Corpet, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.22.10881 · Cited by 5,575 · see citing works
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502 · see citing works
Cellular and developmental control of O <sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113 · see citing works
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works
Regulation of Mammalian O <sub>2</sub> Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works
HIF‐1α is required for solid tumor formation and embryonic vascularization
Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works
Tanimoto, K., Makino, Y., Pereira, T., & Poellinger, L. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4298 · Cited by 928 · see citing works
Mechanism, origin, and evolution of anoxia tolerance in animals☆
Hochachka, P. W., & Lutz, P. L. (2001) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00408-0 · Cited by 500 · see citing works
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
Palmer, L. A., Semenza, G. L., Stoler, M. H., & Johns, R. A. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.2.l212 · Cited by 327 · see citing works
Probing microRNAs with microarrays: tissue specificity and functional inference
BABAK, T., ZHANG, W., MORRIS, Q., BLENCOWE, B. J., & HUGHES, T. R. (2004) · RNA · doi:10.1261/rna.7119904 · Cited by 327 · see citing works
Frevel, M. A. E., Bakheet, T. M., Silva, A. M., Hissong, J. G., Khabar, K. S. A., & Williams, B. R. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.425-436.2003 · Cited by 288 · see citing works
The Double Lives of Shuttling mRNA Binding Proteins
Shyu, A., & Wilkinson, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00018-0 · Cited by 237 · see citing works
Shimoda, L. A., Manalo, D. J., Sham, J. S. K., Semenza, G. L., & Sylvester, J. T. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l202 · Cited by 202 · see citing works
Chronic hypoxia decreases KVchannel expression and function in pulmonary artery myocytes
Platoshyn, O., Yu, Y., Golovina, V. A., McDaniel, S. S., Krick, S., Li, L., Wang, J., Rubin, L. J., & Yuan, J. X. ‐. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.4.l801 · Cited by 174 · see citing works
HIF-1: master and commander of the hypoxic world
Mazure, N. M., Brahimi-Horn, M. C., Berta, M., Benizri, E. I., Bilton, R. L., Dayan, F., Ginouvès, A., Berra, E., & Pouysségur, J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.022 · Cited by 152 · see citing works
Regulated ARE-Mediated mRNA Decay in Saccharomyces cerevisiae
Vasudevan, S., & Peltz, S. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00279-9 · Cited by 127 · see citing works
The effect of sequences with high AU content on mRNA stability in tobacco.
Ohme‐Takagi, M., Taylor, C. B., Newman, T. C., & Green, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11811 · Cited by 121 · see citing works
Functional and structural adaptation of the yak pulmonary circulation to residence at high altitude
Durmowicz, A. G., Hofmeister, S. E., Кадыралиев, Т. К., Aldashev, A. A., & Stenmark, K. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.5.2276 · Cited by 115 · see citing works
HIFs, Hypoxia, and Vascular Development
Covello, K. L., & Simon, M. C. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)62002-3 · Cited by 113 · see citing works
Comparative physiology of hypoxic pulmonary hypertension: historical clues from brisket disease
Rhodes, J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01017.2004 · Cited by 107 · see citing works
Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α
Gothié, E., Richard, D. E., Berra, E., Pagès, G., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6922 · Cited by 100 · see citing works
Number and location of AUUUA motifs: role in regulating transiently expressed RNAs
Akashi, M., Shaw, G. D., Hachiya, M., Elstner, E., Suzuki, G., & Koeffler, H. P. (1994) · Blood · doi:10.1182/blood.v83.11.3182.3182 · Cited by 94 · see citing works
The genetic factor influencing pulmonary hypertension in cattle at high altitude
Weir, Ε. K., Tucker, A., Reeves, J. Τ., Will, D. H., & Grover, R. F. (1974) · Cardiovascular Research · doi:10.1093/cvr/8.6.745 · Cited by 88 · see citing works
Wenger, R. H., Rolfs, A., Spielmann, P., Zimmermann, D. R., & Gassmann, M. (1998) · Blood · doi:10.1182/blood.v91.9.3471 · Cited by 75 · see citing works
Pulmonary haemodynamics of the yak, cattle, and cross breeds at high altitude.
Anand, I. S., Harris, E., Ferrari, R., Pearce, P. C., & Harris, P. J. F. (1986) · Thorax · doi:10.1136/thx.41.9.696 · Cited by 64 · see citing works
Inherited susceptibility of cattle to high-altitude pulmonary hypertension
Will, D. H., Hicks, J., Card, C. S., & Alexander, A. F. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.38.3.491 · Cited by 56 · see citing works
From Erythropoietin to Oxygen: Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway
Ratcliffe, P. J. (2002) · Blood Purification · doi:10.1159/000065201 · Cited by 53 · see citing works
The pulmonary arteries of the yak
HEATH, D., WILLIAMS, D., & DICKINSON, J. (1984) · Cardiovascular Research · doi:10.1093/cvr/18.3.133 · Cited by 48 · see citing works
PULMONARY CIRCULATION IN ANIMALS AND MAN AT HIGH ALTITUDE*
Grover, R. F. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb49429.x · Cited by 48 · see citing works
Molecular characterization of the murine Hif-1 alpha locus.
Luo, G., Gu, Y.-Z., Jain, S. R., Chan, W. K., Carr, K. M., Hogenesch, J. B., & Bradfield, C. A. (1997) · Europe PMC (PubMed Central) · Cited by 44 · see citing works
Han, X.-T., Xie, A.-Y., Bi, X.-C., Liu, S.-J., & Hu, L.-H. (2002) · British Journal of Nutrition · doi:10.1079/bjn2002610 · Cited by 37 · see citing works
Zhao, T., Ning, H., Zhu, S., Sun, P., Xu, S., Chang, Z., & Zhao, X. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.087 · Cited by 33 · see citing works
Embryo Transplanted Calves: The Pulmonary Hypertensive Trait Is Genetically Transmitted
Cruz, J. C., Reeves, J. Τ., Russell, B. E., Alexander, A. F., & Will, D. H. (1980) · Experimental Biology and Medicine · doi:10.3181/00379727-164-40837 · Cited by 16 · see citing works
Flagged first, then by citations
3 of the 42 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The yak genome and adaptation to life at high altitude
Qiu, Q., Zhang, G., Ma, T., Qian, W., Wang, J., Ye, Z., Cao, C., Hu, Q., Kim, J., Larkin, D. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2343 · Cited by 971 · see citing works
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α
Galbán, S., Kuwano, Y., Pullmann, R., Martindale, J. L., Kim, H. H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J. O., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-07 · Cited by 279 · see citing works
The yak grazing system on the Qinghai-Tibetan plateau and its status
Long, R., Ding, L., Shang, Z. H., & Guo, X. (2008) · The Rangeland Journal · doi:10.1071/rj08012 · Cited by 167 · see citing works
Adaptation Mechanisms of Yak (Bos grunniens) to High-Altitude Environmental Stress
Ayalew, W., Chu, M., Liang, C., Wu, X., & Yan, P. (2021) · Animals · doi:10.3390/ani11082344 · Cited by 117 · see citing works
High-Altitude Disorders: Pulmonary Hypertension
Pasha, M. A. Q., & Newman, J. H. (2010) · CHEST Journal · doi:10.1378/chest.09-2445 · Cited by 93 · see citing works
Self-citationThomas, P., & Rahman, M. S. (2009) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2009.07.008 · Cited by 82 · see citing works
Gonsalves, C. S., & Kalra, V. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902594 · Cited by 76 · see citing works
Ding, X., Liang, C., Guo, X., Wu, X., Wang, H. B., Johnson, K. A., & Yan, P. (2014) · Livestock Science · doi:10.1016/j.livsci.2014.01.012 · Cited by 73 · see citing works
Xue, X., Cao, A., Cao, X., Yao, S., Carlsen, E. D., Soong, L., Liu, C., Liu, X., Liu, Z., Duck, L. W., et al. (2013) · European Journal of Immunology · doi:10.1002/eji.201343717 · Cited by 69 · see citing works
Guan, J., Long, K., Ma, J., Zhang, J., He, D., Jin, L. G., Tang, Q., Jiang, A., Wang, X., Hu, Y., et al. (2017) · PeerJ · doi:10.7717/peerj.3959 · Cited by 69 · see citing works
Selection signatures for high‐altitude adaptation in ruminants
Friedrich, J., & Wiener, P. (2020) · Animal Genetics · doi:10.1111/age.12900 · Cited by 65 · see citing works
Wang, Y.-C., Xie, H., Zhang, Y.-C., Meng, Q.-H., Xiong, M.-M., Jia, M.-W., Peng, F., & Tang, D. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00373.2020 · Cited by 61 · see citing works
Guo, W., Zhou, M., Ma, T., Bi, S., Wang, W., Zhang, Y., Huang, X., Guan, L. L., & Long, R. (2020) · Animal Microbiome · doi:10.1186/s42523-020-00042-8 · Cited by 59 · see citing works
Fallone, F., Britton, S., Nieto, L., Salles, B., & Muller, C. (2012) · Oncogene · doi:10.1038/onc.2012.462 · Cited by 56 · see citing works
Different gene expressions between cattle and yak provide insights into high‐altitude adaptation
Wang, K., Yang, Y. P., Wang, L., Ma, T., Shang, H., Ding, L., Han, J., & Qiu, Q. (2015) · Animal Genetics · doi:10.1111/age.12377 · Cited by 51 · see citing works
Xin, J., Chai, Z., Zhang, C., Zhang, Q., Zhu, Y., Cao, H., Ji, Q., & Zhong, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-43773-8 · Cited by 50 · see citing works
Xiong, X., Fu, M., Lan, D., Li, J., Zi, X., & Zhong, J. (2015) · Animal Biotechnology · doi:10.1080/10495398.2014.1002563 · Cited by 42 · see citing works
High Altitude Adaptation: Genetic Perspectives
Stobdan, T., Karar, J., & Pasha, M. A. Q. (2008) · High Altitude Medicine & Biology · doi:10.1089/ham.2007.1076 · Cited by 38 · see citing works
Self-citationGenomic adaptation of Ethiopian indigenous cattle to high altitude
Terefe, E., Belay, G., Han, J., Hanotte, O., & Tijjani, A. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.960234 · Cited by 36 · see citing works
Role of the Neuroendocrine System of Marine Bivalves in Their Response to Hypoxia
Kotsyuba, E. P., & Dyachuk, V. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021202 · Cited by 34 · see citing works
Huang, Y.-F., Yang, C., Huang, C., & Hsu, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392076 · Cited by 34 · see citing works
Li, H., Ren, Y., Guo, S., Cheng, L., Wang, D., Yang, J., Chang, Z., & Zhao, X. (2008) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.510 · Cited by 31 · see citing works
Gonsalves, C. S., & Kalra, V. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000660 · Cited by 30 · see citing works
Ge, Q., Guo, Y., Zheng, W., Cai, Y., Qi, X., & Zhao, S. (2021) · BMC Genomics · doi:10.1186/s12864-021-08044-9 · Cited by 29 · see citing works
Zhang, D., Li, J., Zhang, M., Gao, G., Zuo, Z., Yu, Y., Zhu, L. Y., Gao, J., & Huang, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365882 · Cited by 27 · see citing works
Huang, M., Zhang, X., Yan, W., Liu, J., & Wang, H. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e129 · Cited by 27 · see citing works
Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress
Wang, Z., Ma, T., Ma, J., Han, J., Ding, L., & Qiu, Q. (2015) · Gene · doi:10.1016/j.gene.2015.08.024 · Cited by 24 · see citing works
HIF2A Variants Were Associated with Different Levels of High-Altitude Hypoxia among Native Tibetans
Basang, Z., Wang, B., Li, L., Yang, L., Liu, L., Cui, C., Lanzi, G., Nima, Y., Duo, J., Zheng, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137956 · Cited by 23 · see citing works
Natural Climbers: Insights from Avian Physiology at High Altitude
Parr, N., Wilkes, M., & Hawkes, L. A. (2019) · High Altitude Medicine & Biology · doi:10.1089/ham.2019.0032 · Cited by 23 · see citing works
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y., Kim, M., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00203-4 · Cited by 20 · see citing works
Cai, T.-Y., Liu, X.-W., Zhu, H., Cao, J., Zhang, J., Ding, L., Lou, J.-S., He, Q.-J., & Yang, B. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0490 · Cited by 19 · see citing works
Yan, D., Wang, J., Du, K., Jia, T., Zhu, C., Zhang, Y., & Xu, F. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00440.2018 · Cited by 18 · see citing works
Xin, K.-Q., Tian, K., Yu, Q., Han, L., & Zang, Z. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14470 · Cited by 16 · see citing works
Ding, Y., Liu, J., Xu, Y.-Q., Dong, X., & Shao, B. (2020) · High Altitude Medicine & Biology · doi:10.1089/ham.2019.0076 · Cited by 16 · see citing works
Long, L., Zhu, Y.-P., Li, Z., Zhang, H., Liu, L., & Bai, J. (2020) · Journal of Veterinary Medical Science · doi:10.1292/jvms.19-0218 · Cited by 14 · see citing works
Li, F., & Liu, W. (2017) · Mammalian Genome · doi:10.1007/s00335-017-9683-x · Cited by 13 · see citing works
Key miRNAs and Genes in the High-Altitude Adaptation of Tibetan Chickens
Chen, B., Li, D., Ran, B., Zhang, P., & Wang, T. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.911685 · Cited by 13 · see citing works
Su, Y., Li, Q., Zheng, Z., Wei, X., & Hou, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-95909-4 · Cited by 12 · see citing works
Role of miR-107 and its signaling pathways in diseases
Jiang, Z., & Zhou, T. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.896383 · Cited by 12 · see citing works
Wang, C., Yang, Y. F., Cong, L., Jiang, Y., Du, N., & Zhang, H. (2021) · Microvascular Research · doi:10.1016/j.mvr.2021.104225 · Cited by 11 · see citing works
Hypoxia-induced brain cell damage in male albino wistar rat
Niu, X., Li, S., Zheng, S., Xiong, H., Lv, J., Zhang, H., & Liu, H. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.03.018 · Cited by 11 · see citing works
Ni, Q., Wang, D., Xie, L., Ge, H., & Dong, Z. (2022) · Aquaculture Research · doi:10.1111/are.16062 · Cited by 10 · see citing works
Zhang, L. F., Lian, L., Zhao, C., Li, J. Y., Bao, H., & Wu, C. (2007) · animal · doi:10.1017/s1751731107000687 · Cited by 9 · see citing works
Cao, D.-X., Wang, S.-L., WANG, R., Chai, S., Liu, S.-J., & Hao, L.-Z. (2019) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/109953/2019 · Cited by 7 · see citing works
Zhang, Y., Wu, Q., Yang, L., Chen, X., Wang, C., Zhang, Y., Zeng, Y., Xu, L., Lu, C., Zeng, C., et al. (2019) · Mitochondrial DNA Part B · doi:10.1080/23802359.2019.1568215 · Cited by 7 · see citing works
Comparisons of lung and gluteus transcriptome profiles between yaks at different ages
Xin, J., Chai, Z., Zhang, C., Zhang, Q., Zhu, Y., Cao, H., Ji, Q., & Zhong, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-50618-x · Cited by 7 · see citing works
Naz, S., Chatha, A. M. M., Ullah, Q., Farooq, M., Jamil, T., Muner, R. D., & Kiran, A. (2025) · Veterinary Sciences · doi:10.3390/vetsci12080714 · Cited by 6 · see citing works
Yak’s Resilience and Adaptation to High-Altitude Stress
He, L., Li, X., Liu, G., Cidan, Y.-J., Ullah, Q., Mushtaq, R., Xiu, Y., Sun, G., Luosang, D.-Z., & Jiang, N. (2024) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/20231201092818 · Cited by 6 · see citing works
Chuang, Z. H. O. U., Zheng, X., Peng, K., Feng, K., Yue, B., & Wu, Y. (2023) · Integrative Zoology · doi:10.1111/1749-4877.12795 · Cited by 4 · see citing works
Zhan, Y., Qi, X., Wu, Y., Gao, D., Zhao, L., Cao, S., Xue, Z., & Wang, W. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102459 · Cited by 3 · see citing works
Zhao, H., Gao, Y., Jiang, Q., Wang, J., Liu, W., Ju, Z., Wang, X., Wei, X., Gao, Y., & Huang, J. (2020) · Animal Biology · doi:10.1163/15707563-bja10046 · Cited by 3 · see citing works
Normobaric hypoxia-induced brain damage in wistar rat
Hu, D., Li, Q., Li, B., Dai, R., Geng, L., & Deng, Y. (2009) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2009.28092 · Cited by 3 · see citing works
Jiang, Y.-F., Chou, C., Lin, E.-C., & Chiu, C. (2010) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2010.10.003 · Cited by 2 · see citing works
St.George, M. C. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r33n20p02 · Cited by 2 · see citing works
Normobaric Hypoxia-induced Brain Damage and Mechanism in Wistar Rat
Hu, D., Li, Q., Li, B., Dai, R., Geng, L., & Deng, Y. (2009) · International Conference on Bioinformatics and Biomedical Engineering · doi:10.1109/icbbe.2009.5163120 · Cited by 1 · see citing works
Nelson, B. (2007) · eScholarship (California Digital Library)
MinQiang, Z. H. O. U., Zhang, Q., XingZhuo, Y. A. N. G., Yuan, M., Jia, C., & Li, M. (2018) · Scientia Sinica Vitae · doi:10.1360/n052017-00300
Adaptive Responses to Altitude and Walking Stress in Small Ruminants
Singh, S., & Malik, J. K. (2025) · Springer eBooks · doi:10.1007/978-981-96-6691-1_5
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592644
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592668
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592653
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592665
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592647
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592650
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592662
Kim, K. Y., Kim, Y. R., Choi, K. W., Lee, M., Lee, S., Im, W., Shin, J.-Y., Kim, J. Y., Hong, Y. H., Kim, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12592656
- Authors
- Dolt, K. S., Mishra, M. K., Karar, J., Baig, M. A., Ahmed, Z., & Pasha, M. A. Q.
- Affiliations
- Institute of Genomics and Integrative Biology (IN)
- Jamia Hamdard (IN)
- Defence Research and Development Organisation (IN)
- Corresponding author
- Pasha, M.A. Qadar
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 386
- Issue
- 1-2
- Pages
- 73-80
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2088344922
- Cited by
- 65
- References
- 42
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 15 · 2019: 6 · 2018: 1 · 2017: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- HIF-1α, yak, high-altitude adaptation, hypoxia, cDNA cloning, gene structure, miRNA target prediction, miR-107, miR-18b, miR-135a, tissue-specific gene expression, mRNA stability, oxygen homeostasis, evolutionary conservation
- MeSH terms
- Altitude, Animals, Base Sequence, Cattle, Gene Expression Regulation, Molecular Sequence Data, RNA, Messenger, Hypoxia-Inducible Factor 1, alpha Subunit
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