Cited by 90Cell death mechanisms and regulationCancer, Hypoxia, and MetabolismCardiac Ischemia and Reperfusion

The impact of hypoxia on cell death pathways

Lenihan, Colin R., Taylor, Cormac T.·2013·Biochemical Society Transactions

Abstract

Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury. In these diseases, the presence of hypoxia can significantly affect the rate of cell death and thus may make a significant contribution to disease progression. In the present review, we discuss the complex relationship that exists between the presence of hypoxia and the regulation of cell death pathways.

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Crossref · 10.1042/bst20120345

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62 of 62 references verified0 citation errors · 0 not checkable

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  • When hypoxia is prolonged or adaptive capacity is exceeded, failure to restore oxygen homeostasis triggers programmed cell death pathways.

    “When hypoxia is prolonged or adaptive capacity is exceeded, the failure to restore oxygen homeostasis triggers programmed cell death pathways”

    From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [13]

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Authors
Lenihan, C. R., & Taylor, C. T.
Affiliations
University College Dublin (IE)
Venue
Biochemical Society Transactions
Published
2013-03-21
Volume
41
Issue
2
Pages
657-663
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
OpenAlex
W2082219347
Cited by
90
References
64
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 11 · 2016: 16 · 2015: 9 · 2014: 8 · 2013: 2
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Society Transactions (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
hypoxia, programmed cell death, apoptosis, cell death pathways, cancer, chronic inflammation, myocardial infarction, stroke, disease progression
MeSH terms
Animals, Humans, Transcription, Genetic, Signal Transduction, Cell Hypoxia, NF-kappa B, Cell Death, Hypoxia-Inducible Factor 1

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