The impact of hypoxia on cell death pathways
Abstract
Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury. In these diseases, the presence of hypoxia can significantly affect the rate of cell death and thus may make a significant contribution to disease progression. In the present review, we discuss the complex relationship that exists between the presence of hypoxia and the regulation of cell death pathways.
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When hypoxia is prolonged or adaptive capacity is exceeded, failure to restore oxygen homeostasis triggers programmed cell death pathways.
“When hypoxia is prolonged or adaptive capacity is exceeded, the failure to restore oxygen homeostasis triggers programmed cell death pathways”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [13]
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- Authors
- Lenihan, C. R., & Taylor, C. T.
- Affiliations
- University College Dublin (IE)
- ORCID
- Taylor, Cormac T.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2013-03-21
- Volume
- 41
- Issue
- 2
- Pages
- 657-663
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2082219347
- Semantic Scholar
- 2975946bf36b130a481bf31b6d0ccfb5ac40c7fa
- Cited by
- 90
- References
- 64
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 11 · 2016: 16 · 2015: 9 · 2014: 8 · 2013: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- hypoxia, programmed cell death, apoptosis, cell death pathways, cancer, chronic inflammation, myocardial infarction, stroke, disease progression
- MeSH terms
- Animals, Humans, Transcription, Genetic, Signal Transduction, Cell Hypoxia, NF-kappa B, Cell Death, Hypoxia-Inducible Factor 1
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