Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
Ruley, H. Earl·1983·Nature
DOI 10.1038/304602a0
Cited by (1,000)
Items 301–400 of 1,000
- Normal Human Fibroblasts Are Resistant to RAS-Induced SenescenceBenanti, Jennifer A., Galloway, Denise A. · 2004 · Molecular and Cellular Biology
- Escape from premature senescence is not sufficient for oncogenic transformation by RasDaniel S. Peeper, Jan‐Hermen Dannenberg, Sirith Douma, Hein te Riele, René Bernards · 2001 · Nature Cell Biology
- ΔNp73 Facilitates Cell Immortalization and Cooperates with Oncogenic Ras in Cellular Transformation In VivoOleksi Petrenko, Alexander I. Zaika, Ute Martha Moll · 2003 · Molecular and Cellular Biology
- Simian virus 40 origin DNA-binding domain on large T antigenEva Paucha, Daniel Kalderon, R W Harvey, Alan E. Smith · 1986 · Journal of Virology
- Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vectorMichael P. Kriegler, Carl F. Perez, Chris Hardy, Michael R. Botchan · 1984 · Cell
- Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenesMitsuo Oshimura, Tona M. Gilmer, J. Carl Barrett · 1985 · Nature
- Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RASG12V oncogeneFranz S. Schreiber, Thérèse B. Deramaudt, Thomas Baptist Brunner, Michael I. Boretti, Keith J. Gooch, Doris A. Stoffers, Eric J. Bernhard, Anil K. Rustgi · 2004 · Gastroenterology
- MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activityHui Bin Sun, Yuan Xiao Zhu, Tinggui Yin, George W. Sledge, Yu‐Chung Yang · 1998 · Proceedings of the National Academy of Sciences
- An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cellsKatherine R. Spindler, Carol Eng, Arnold J. Berk · 1985 · Journal of Virology
- Anchorage‐independent growth of primary rat embryo cells is induced by platelet‐derived growth factor and inhibited by type‐beta transforming growth factorMario A. Anzano, Anita B. Roberts, Michael B. Sporn · 1986 · Journal of Cellular Physiology
- Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Tariq Hamid, Mohammed T. Malik, Sham S. Kakar · 2005 · Molecular Cancer
- Transformation by human adenovirusesPhilip E. Branton, S. T. Bayley, Frank L. Graham · 1984 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.Isabel Guerrero, Alfredo Villasanté, Victor G. Corces, Àngel Pellicer · 1985 · Proceedings of the National Academy of Sciences
- Activation of c-myc and c-K-ras Oncogenes in Primary Rat Tumors induced by Ionizing RadiationMary Jean Sawey, Andrew T. Hood, Fredric J. Burns, SEYMOUR J. GARTE · 1987 · Molecular and Cellular Biology
- E1A Induces Phosphorylation of the Retinoblastoma Protein Independently of Direct Physical Association between the E1A and Retinoblastoma ProductsHongjie Wang, Giulio Francesco Draetta, Ellen M Moran · 1991 · Molecular and Cellular Biology
- Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus.Shigeo Ohno, Shunsuke Migita, F. Wiener, Magda Babonits, George Klein, J. Frederic Mushinski, Michael Potter · 1984 · The Journal of Experimental Medicine
- Construction and functional characterization of polyomavirus genomes that separately encode the three early proteinsZhe Zhu, Geertruida M. Veldman, Alison Cowie, Antony M. Carr, Brian S. Schaffhausen, Robert Kamen · 1984 · Journal of Virology
- Transformation of mouse bone marrow cells by transfection with a human oncogene related to c‐myc is associated with the endogenous production of macrophage colony stimulating factor 1Marshall D. Sklar, Allan Tereba, Ben D.‐M. Chen, W. S. G. Walker · 1985 · Journal of Cellular Physiology
- NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells.Narciso R. Mejia, Robert E. MacKenzie · 1985 · Journal of Biological Chemistry
- Chapter 16 Regulation of Protein Activities by Fusion to Steroid Binding DomainsTiziana Mattioni, Jean-François Louvion, Didier Picard · 1994 · Methods in cell biology
- A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2FElizabeth A. Veal, Michael S. Eisenstein, Zian H. Tseng, Grace Gill · 1998 · Molecular and Cellular Biology
- Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation?Montserrat Corominas, Hideko Kamino, Javier León, Àngel Pellicer · 1989 · Proceedings of the National Academy of Sciences
- Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin AJohn A. Howe, Stanley T. Bayley · 1992 · Virology
- Regulation of Transcription of the Adenovirus EII Promoter by EIa Gene Products: Absence of Sequence SpecificityRobert E. Kingston, Randal J. Kaufman, Phillip A. Sharp · 1984 · Molecular and Cellular Biology
- Genetic and cellular basis of multistep carcinogenesisJeff A. Boyd, J. Carl Barrett · 1990 · Pharmacology & Therapeutics
- Adenovirus E1A negatively and positively modulates transcription of AP‐1 dependent genes by dimer‐specific regulation of the DNA binding and transactivation activities of Jun.Bertine M. Hagmeyer, Harald König, Ingrid Herr, Rienk Offringa, Alt ZANTEMA, Alex J. van der Eb, Peter A. Herrlich, Peter E. Angel · 1993 · The EMBO Journal
- Twisted epithelial–mesenchymal transition blocks senescenceRobert A. Weinberg · 2008 · Nature Cell Biology
- Cooperation between bovine leukaemia virus transactivator protein and Ha‐ras oncogene product in cellular transformation.Luc Willems, Hubertine Heremans, G. Chen, Daniel Portetelle, An Billiau, Arsène Burny, Richard Kettmann · 1990 · The EMBO Journal
- Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenesSarah Drayton, Janice Rowe, Rebecca Jones, Radost Vatcheva, Darren Heavens, John F. Marshall, Mike Fried, Gordon G. Peters · 2003 · Cancer Cell
- Transformation-sensitive and Growth-related Changes of Protein Synthesis in REF52 CellsJames I. Garrels, B. Robert Franza · 1989 · Journal of Biological Chemistry
- The significance of telomerase activation and cellular immortalization in human cancerR. F. Newbold · 2002 · Mutagenesis
- Targeting HER2: Recent developments and future directions for breast cancer patientsShao-Chun Wang, Lisha Zhang, Gabriel N. Hortobágyi, Mien‐Chie Hung · 2001 · Seminars in Oncology
- Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin woundingEric Kenneth Parkinson · 1985 · British Journal of Cancer
- Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth ArrestHuey-Jen L. Lin, Valerie T. Eviner, George C. Prendergast, Eileen White · 1995 · Molecular and Cellular Biology
- Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigenJiabin Zhu, P W Rice, Lisa C. Gorsch, M Abate, Charles N. Cole · 1992 · Journal of Virology
- Oncogenic Ras Induces p19ARF and Growth Arrest in Mouse Embryo Fibroblasts Lacking p21Cip1 and p27Kip1 without Activating Cyclin D-dependent KinasesAnja Groth, Jason D. Weber, Berthe M. Willumsen, Charles J. Sherr, Martine F. Roussel · 2000 · Journal of Biological Chemistry
- Requirement for the Simian Virus 40 Small Tumor Antigen in Tumorigenesis in Transgenic MiceYongwon Choi, I C Lee, Susan R. Ross · 1988 · Molecular and Cellular Biology
- Identification of a region of simian virus 40 large T antigen required for cell transformationS Chen, Eva Paucha · 1990 · Journal of Virology
- Transformation of rat hepatocytes by transfection with simian virus 40 DNA to yield proliferating differentiated cells.Craig D. Woodworth, Timothy E. Secott, Harriet C. Isom · 1986 · PubMed
- Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.Karen H. Vousden, C. J. Marshall · 1984 · The EMBO Journal
- Oncogenes and Cancer: The p21rasGenesThomas Y. Shih, Maureen O. Weeks · 1984 · Cancer Investigation
- Repression of Insulin Gene Expression by Adenovirus Type 5 Ela ProteinsRoland W. Stein, Edward Benjamin Ziff · 1987 · Molecular and Cellular Biology
- Transformation by and Oncogenicity of Human AdenovirusesFrank L. Graham · 1984 · Springer eBooks
- Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytomaLynn M. Corcoran, Suzanne Cory, Jerry M. Adams · 1985 · Cell
- A novel adenovirus‐2 E1A mRNA encoding a protein with transcription activation properties.Per Johan Ulfendahl, Stig Linder, Jan‐Peter Kreivi, Katarina Nordqvist, C. Sevensson, Hans Hultberg, Göran Akusjärvi · 1987 · The EMBO Journal
- Potentiation of growth factor activity by exogenous c-myc expression.Vincenzo Sorrentino, VLADIMIR DROZDOFF, M D McKinney, Louis Zeitz, E Fleissner · 1986 · Proceedings of the National Academy of Sciences
- Cytomegalovirus infection and viral‐induced transformation of human endothelial cellsM. Lynn Smiley, Eng‐Chun Mar, Eng‐Shang Huang · 1988 · Journal of Medical Virology
- Expression of the v-erbA oncogene in chicken embryo fibroblasts stimulates their proliferation in vitro and enhances tumor growth in vivoOlivier Gandrillon, Pierre Jurdic, M. Benchaibi, J.H. Xiao, Jacques Ghysdael, Jacques Samarut · 1987 · Cell
- Interactions Between Cell Growth-Regulating Domains in the Products of the Adenovirus E1A OncogeneB Moran, Brad R. Zerler · 1988 · Molecular and Cellular Biology
- Lentivector-Mediated Transfer of Bmi-1 and Telomerase in Muscle Satellite Cells Yields a Duchenne Myoblast Cell Line with Long-Term Genotypic and Phenotypic StabilityChristophe Cudré-Mauroux, Teresa Occhiodoro, Stéphane König, Patrick Salmon, Laurent Bernheim, Didier Trono · 2003 · Human Gene Therapy
- Regulation of early adenovirus gene expressionJoseph R. Nevins · 1987 · Microbiological Reviews
- Molecular cloning of the avian acute transforming retrovirus MH2 reveals a novel cell‐derived sequence (v‐mil) in addition to the myc oncogeneJean Coll, M. Righi, Charles de Taisne, Colette Dissous, Anne Gégonne, D. Stéhelin · 1983 · The EMBO Journal
- Tumor suppression by p53: making cells senescent.Yingjuan Qian, Xinbin Chen · 2010 · PubMed
- Expression and interactions of human adenovirus oncoproteinsPierre A. Boulanger, G. Eric Blair · 1991 · Biochemical Journal
- Adenovirus Type 5 E1A Gene Products Act as Transformation Suppressors of the neu OncogeneDihua Yu, Kathleen A. Scorsone, Mien‐Chie Hung · 1991 · Molecular and Cellular Biology
- Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells.Minoru Koi, J. Carl Barrett · 1986 · Proceedings of the National Academy of Sciences
- Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosisWei-Ping Lee, Yong Wen, Brian C. Varnum, Mien‐Chie Hung · 2002 · Oncogene
- Immortalization and Transformation of Human CellsWilliam C. Hahn · 2002 · Molecules and Cells
- Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formationLidia F. Hernandez, Serguei Kozlov, Graziella Piras, Colin L. Stewart · 2003 · Proceedings of the National Academy of Sciences
- Somatic cell fusion as a source of genetic rearrangement leading to metastatic variantsLidia Larizza, Volker Schirrmacher · 1984 · Cancer and Metastasis Reviews
- Oncogenes in Retroviruses and Cells: Biochemistry and Molecular GeneticsKlaus Bister, Hans Willi Jansen · 1986 · Advances in cancer research
- Separation of Simian Virus 40 large-T-Antigen-Transforming and Origin-Binding Functions from the Ability to Block DifferentiationVan Cherington, M Brown, Eva Paucha, J St Louis, Bruce M. Spiegelman, Thomas M. Roberts · 1988 · Molecular and Cellular Biology
- Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activationTony N. Jelsma, John A. Howe, Carole M. Evelegh, Nina F. A. Cunniff, Mario H. Skiadopoulos, M. Floroff, Judy E. Denman, Stanley T. Bayley · 1988 · Virology
- Nuclear Envelope Localization of an Adenovirus Tumor Antigen Maintains the Integrity of Cellular DNAEileen White, Stephen H. Blose, Bruce Stillman · 1984 · Molecular and Cellular Biology
- Tumorigenicity of Fibroblast Lines Expressing the Adenovirus E1a, Cellular p53, or Normal c-myc GenesAmeeta Kelekar, Michael D. Cole · 1986 · Molecular and Cellular Biology
- The plasma-membrane-associated form of SV40 large tumor antigen: biochemical and biological propertiesJanet S. Butel, Donald L. Jarvis · 1986 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Subversion of growth regulatory pathways in malignant transformationCarl‐Henrik Heldin, Christer Betsholtz, Lena Claesson, Bengt Westermark · 1987 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Oncogene-Induced Transformation of C3H 10T1/2 Cells Is Enhanced by Tumor PromotersW.L. Wendy Hsiao, Sebastiano Gattoni‐Celli, I. Bernard Weinstein · 1984 · Science
- Immortalization by c- myc , H- ras , and Ela Oncogenes Induces Differential Cellular Gene Expression and Growth Factor ResponsesAmeeta Kelekar, Michael D. Cole · 1987 · Molecular and Cellular Biology
- Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.Eileen White, R Cipriani · 1989 · Proceedings of the National Academy of Sciences
- Expression of Cellular OncogenesRolf Müller, Inder M. Verma · 1984 · Current topics in microbiology and immunology
- Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci.Tseng-hui Timothy Chen, Jonathan Robert Brody, F. E. Romantsev, Jun Yu, A. E. Kayler, E Voneiff, Francis P. Kuhajda, Gary R. Pasternack · 1996 · Molecular Biology of the Cell
- Cell Transformation by Human AdenovirusesChristian Endter, Thomas Dobner · 2004 · Current topics in microbiology and immunology
- cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptideNobuyuki TAKEMORI, Christos Cladaras, B Bhat, Alan James Conley, William S.M. Wold · 1984 · Journal of Virology
- Expression of the Epstein-Barr virus nuclear protein 2 in rodent cellsT. R. Dambaugh, F Wang, Kevin Hennessy, E Woodland, A. B. Rickinson, Elliott D. Kieff · 1986 · Journal of Virology
- Regulation of human T cell leukemia virus expression 1Patrick L. Green, Irvin S. Y. Chen · 1990 · The FASEB Journal
- Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisJoanna L. Shisler, Penelope J. Duerksen-Hughes, T M Hermiston, William S.M. Wold, Linda R. Gooding · 1996 · Journal of Virology
- Amplifications of both c-Ki-ras with a point mutation and c-myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes.Hisashi Yamada, Hiromi Sakamoto, Masanori Taira, Susumu Nishimura, Yukío Shimosato, Masaaki Terada, Takashi Sügimura · 1986 · PubMed
- The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2Barbara Faha, Edward E. Harlow, Emma M. Lees · 1993 · Journal of Virology
- Biology of gliomas: heterogeneity, oncogenes, growth factors.Shapiro · 1986 · PubMed
- Synergism of v- myc and v-Ha- ras in the in Vitro Neoplastic Progression of Murine Lymphoid CellsRichard C. Schwartz, Lawrence Walter Stanton, Sylvia C. Riley, Kenneth B. Marcu, Owen N. Witte · 1986 · Molecular and Cellular Biology
- Neoplastic Conversion of Human Keratinocytes by Adenovirus 12-SV40 Virus and Chemical CarcinogensJohng Sik Rhim, Jun Fujita, Paul Arnstein, Stuart A. Aaronson · 1986 · Science
- Telomerase and tumorigenesisKenkichi Masutomi, William C. Hahn · 2003 · Cancer Letters
- Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene.Peter J. Hurlin, V M Maher, J. Justin McCormick · 1989 · Proceedings of the National Academy of Sciences
- Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutationHisashi Yamada, Teruhiko Yoshida, Hiromi Sakamoto, Masaaki Terada, Takashi Sügimura · 1986 · Biochemical and Biophysical Research Communications
- The effects of platelet‐derived transforming growth factor β on normal human diploid gingival fibroblastsJeffrey L. Wrana, Jaro Sodek, R. Ber, C.G. Bellows · 1986 · European Journal of Biochemistry
- Anti-peptide antibodies detect oncogene-related proteins in urine.Henry L. Niman, Alastair Mark Thompson, Alice Lin-Tsing Yu, Maurie Markman, J J Willems, Karl R. Herwig, Nagy Habib, C B Wood, R A Houghten, Richard Alan Lerner · 1985 · Proceedings of the National Academy of Sciences
- Promoter-Specific Zrans-Activation by the Adenovirus E1A12S Product Involves Separate E1A DomainsVirginia B. Kraus, Ellen M Moran, Joseph R. Nevins · 1992 · Molecular and Cellular Biology
- T cell cultures and the Hayflick limitRita B. Effros, Roy L. Walford · 1984 · Human Immunology
- Oncogenes, tumour suppressors and viruses in oral squamous carcinomaCrispian M. Scully · 1993 · Journal of Oral Pathology and Medicine
- The human papillomavirus E7 protein as a transforming and transactivating factorKarl Münger, William C. Phelps · 1993 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteinsEileen White, Bruce Stillman · 1987 · Journal of Virology
- Cell Cycle Regulation of Histone H1 Kinase Activity Associated with the Adenoviral Protein E1AAntonio Giordano, Joo Hun Lee, Judith A. Scheppler, Christine H. Herrmann, Ed Harlow, Ulrich Deuschle, David Beach, B. Robert Franza · 1991 · Science
- Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblastsClaude Asselin, Marcel Bastin · 1985 · Journal of Virology
- PI3K: A Crucial Piece in the RAS Signaling PuzzleAgata Adelajda Krygowska, Esther Castellano · 2017 · Cold Spring Harbor Perspectives in Medicine
- mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle DefectGuus Hateboer, E. Marielle Hijmans, Jeroen B.D. Nooij, Stephan Schlenker, Stefan Jentsch, René Bernards · 1996 · Journal of Biological Chemistry
- Functional Relation Between HTLV-II x and Adenovirus E1A Proteins in Transcriptional ActivationIrvin S. Y. Chen, Alan J. Cann, Neil P. Shah, Richard B. Gaynor · 1985 · Science
- Donor cell leukemia developing six years after marrow grafting for acute leukemiaRP Witherspoon, William H. Schubach, Paul E. Neiman, P Martin, E D Thomas · 1985 · Blood
- Induction of cellular DNA synthesis by purified adenovirus E1A proteinsLeszek Kaczmarek, B Ferguson, Martin J. Rosenberg, Renato Baserga · 1986 · Virology
- Chromosomal location of human genes encoding major heat-shock protein HSP70Gail S. Harrison, Harry A. Drabkin, Fa -Ten Kao, Judith A. Hartz, Iris M. Hart, Ernest H. Y. Chu, Barbara Wu, Richard I. Morimoto · 1987 · Somatic Cell and Molecular Genetics