Cited by 1,248Virus-based gene therapy researchViral-associated cancers and disordersCancer-related Molecular Pathways

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. Earl·1983·Nature

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Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

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Authors: Ruley, H. E.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Ruley, H. Earl
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1983-08
Volume: 304
Issue: 5927
Pages: 602-606
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/304602a0
OpenAlex: W2117079180
Cited by: 1,248
References: 31
Citations by year: 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 13
FWCI: 102.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: polyomavirus middle T antigen, oncogenic transformation, primary cells, DNA-mediated gene transfer
MeSH terms: Adenoviridae, Animals, Antigens, Viral, Antigens, Viral, Tumor, Cell Transformation, Viral, Cells, Cultured, Cloning, Molecular, Gene Expression Regulation, Genes, Viral, Oncogenes, Plasmids, Polyomavirus, Transfection, Transformation, Genetic, Rats

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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