Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
Ruley, H. Earl·1983·Nature
DOI 10.1038/304602a0
Cited by (1,000)
Items 701–800 of 1,000
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- Establishment and characterization of a bovine mammary myoepithelial cell lineBoris Zavizion, Marilyn van Duffelen, Warren I. Schaeffer, I. Politis · 1996 · In Vitro Cellular & Developmental Biology - Animal
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- The current state of oncogenes and cancer: Experimental approaches for analyzing oncogenetic events in human cancerPaul J. Chiao, Farideh Z. Bischoff, Louise C. Strong, Michael A. Tainsky · 1990 · Cancer and Metastasis Reviews
- Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells.Ronald J. Weigel, Stephen H. Devoto, Joseph R. Nevins · 1990 · Proceedings of the National Academy of Sciences
- Structure and Function of the Adenovirus-2 GenomeGöran Akusjärvi, Ulf Pettersson, Richard J. Roberts · 1986 · Springer eBooks
- Molecular oncogenetics of metastasisT. Neil Dear, Richard F. Kefford · 1990 · Molecular Aspects of Medicine
- E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-beta 2 promoter activationFrank A.E. Kruyt, Gert E. Folkers, Albertha J.M. Walhout, B J van der Leede, Paul T. van der Saag · 1993 · Molecular Endocrinology
- Rapid turnover of adenovirus E1A is determined through a co‐translational mechanism that requires an aminoterminal domain.J. M. Slavicek, Nic Jones, Joel D. Richter · 1988 · The EMBO Journal
- Complementation of transforming domains in E1a/myc chimaerasRobert Ralston · 1991 · Nature
- Site-Specific Integration of H- ras in Transformed Rat Embryo CellsWilliam Gillies McKenna, Ken Nakahara, Ruth J. Muschel · 1988 · Science
- Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells.Lee E. Babiss, Wen‐Shing Liaw, Stephen G. Zimmer, Gabriel C. Godman, H S Ginsberg, Paul B. Fisher · 1986 · Proceedings of the National Academy of Sciences
- Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host rangeTomáš Jelı́nek, Frank L. Graham · 1992 · Journal of Virology
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- Induction of c-fos mRNA and AP-1 DNA-binding activity by cAMP in cooperation with either the adenovirus 243- or the adenovirus 289-amino acid E1A protein.D A Engel, U Muller, Richard W. Gedrich, J S Eubanks, Thomas E. Shenk · 1991 · Proceedings of the National Academy of Sciences
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- The effect of oncogenes on the growth and differentiation of oligodendrocyte type 2 astrocyte progenitor cells.Susan Carol Barnett, Dorothy H. Crouch · 1995 · PubMed
- Identification of a second transforming gene, rasn, in a human multiple myeloma line with a rearranged c-myc alleleTimothy J. Ernst, Adi F. Gazdar, Jerome Ritz, MA Shipp · 1988 · Blood
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- Amplification and enhanced expression of cellular oncogene c-Ki-ras-2 in a human epidermoid carcinoma of the lung.Michiko Miyaki, Chieko Sato, T Matsui, Morio Koike, Takeo Mori, Goro Kōsaki, Setsuo Takai, Akira Tonomura, Nobuo Tsuchida · 1985 · PubMed
- Oncogenes and multistep carcinogenesis.M Robertson · 1983 · BMJ
- Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells.Daniel Kalman, K Whittaker, J. Michael Bishop, P H O'Lague · 1993 · Molecular Biology of the Cell
- Immortalized cells as experimental models to study cancerJesse S. Boehm, William C. Hahn · 2004 · Cytotechnology
- The ras family of oncogenesChanning J. Der · 1989 · Cancer treatment and research
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- Clonal Osteoblastic Cell Lines from p53 Null Mouse Calvariae Are Immortalized and Dependent on Bone Morphogenetic Protein 2 for Mature Osteoblastic PhenotypeNandini Ghosh‐Choudhury, Marie A. Harris, John M. Wozney, Gregory R. Mundy, Stephen E. Harris · 1997 · Biochemical and Biophysical Research Communications
- Specific inhibition of simian virus 40 protein synthesis by heat and arsenite treatmentCharalampos E. Angelidis, Ioannis Lazaridis, Gerassimos N. Pagoulatos · 1988 · European Journal of Biochemistry
- Adenovirus tumor-specific transplantation antigen is a function of the E1A early region.Yoko Sawada, Deborah Urbanelli, Jana Rašková, Thomas E. Shenk, Karel Raska Jr · 1986 · The Journal of Experimental Medicine
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- Independent transformation activity by adenovirus-5 E1A-Conserved regions 1 or 2 mutantsCatharina Svensson, Maria Bondesson, Elisabeth Nyberg, Stig Linder, Nicholas C. Jones, Göran Akusjärvi · 1991 · Virology
- Genes and Gene Products Involved in Growth Regulation of Tumor CellsUlf Rüdiger Rapp, Tom I. Bonner, Karin Moelling, Hans Willi Jansen, Klaus Bister, James N. Ihle · 1985 · Recent results in cancer research/Recent Results in Cancer Research
- Transformation by SV40 and PolyomaRoger Monier · 1986 · Springer eBooks
- Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative OncogeneVadym Kavsan, Olena V. Balynska, Anton Iershov, Pavlo O. Areshkov, V. I. Rymar, Vladimir P. Baklaushev, Gaukhar M. Yusubalieva, Nadezhda F. Grinenko, Ilya V. Victorov, Vladimir Pavlovich Chekhonin et al. · 2011 · International Journal of Biomedical Science
- Transformation and Tumorigenesis Mediated by the Adenovirus E1A and E1B OncogenesRobert P. Ricciardi · 1995 · Infectious agents and pathogenesis
- Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion geneR.Nagaraja Rao, Nancy B. Stamm, Keith A. Otto, Steve Kovacevic, Scott A. Watkins, Pam Rutherford, Stephanie Lemke, Kim Cocke, Richard Paul Beckmann, Keith A. Houck et al. · 1999 · Oncogene
- Rb function is required for E1A-induced S-phase checkpoint activationAlice Nemajerová, Flaminia Talos, Ute Martha Moll, Oleksi Petrenko · 2008 · Cell Death and Differentiation
- Phosphorylation of adenovirus E1A proteins by the p341 protein kinaseDaniel Dumont, Philip E. Branton · 1992 · Virology
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- Identification of a novel mechanism of regulation of the adherens junction by E1A, Rac1, and cortical actin filaments that contributes to tumor progression.Robert S Fischer, Margaret P. Quinlan · 1998 · PubMed
- Transformation affects superoxide dismutase activityDean P. Loven, Duane L. Guernsey, Larry W. Oberley · 1984 · International Journal of Cancer
- p21 Ras heterogeneous localization in transformed cellsSigrid E. Myrdal, Nelly Auersperg · 1985 · Experimental Cell Research
- Immortalization of bipotential glial progenitors and generation of permanent “blue” cell linesC. Evrard, Eric Galiana, Pierre Rouget · 1988 · Journal of Neuroscience Research
- Benzo(a)pyrene-7,8-diol-9,10-epoxide induced p53-independent necrosis via the mitochondria-associated pathway involving Bax and Bak activationW Zhang, N Liu, X Wang, X Jin, Hongyan Du, Gang Peng, Jun Feng Xue · 2014 · Human & Experimental Toxicology
- Failure to detect viral genomic sequences of three viruses (herpes simplex, simian virus 40 and adenovirus) in human and rat brain tumorsChristiane Chauvin, Martha Suh, C. Rémy, Alim‐Louis Benabid · 1990 · Neurological Sciences
- Cooperation in Oncogenesis between BK Virus Early Region Gene and the Activated Human c-Harvey ras OncogeneAlfredo Corallini, Monica Pagnani, Antonella Caputo, Massimo Negrini, Giuseppe Altavilla, Laura Catozzi, Giuseppe Barbanti-Brodano · 1988 · Journal of General Virology
- Malignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene.Richard D. Storer, Robert Benjamin Stein, Joseph F. Sina, John G. DeLuca, H L Allen, Matthews O. Bradley · 1986 · PubMed
- Studies on the Polyoma Virus Tumor-Specific Transplantation Antigen (Tsta)Tina Dalianis · 1990 · Advances in cancer research
- Dissecting Molecular Carcinogenesis: Development Of Transgenic Mouse Models By Epidermal Gene TargetingDavid A. Greenhalgh, Dennis R. Roop · 1994 · Advances in cancer research
- Oncogenes Result in Genomic Alterations That Activate a Transcriptionally Silent, Dominantly Selectable Reporter Gene (neo)Reed E. Drews, Victor Chan, Lowell E. Schnipper · 1992 · Molecular and Cellular Biology
- Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesisL.M. Kemp, Chris M. Preston, V. G. Preston, David S. Latchman · 1986 · Nucleic Acids Research
- SV40 transformation of Swiss 3T3 cells can cause a stable reduction in the calcium requirement for growth.N. B. Nicholson, S Chen, George Blanck, Robert Pollack · 1984 · The Journal of Cell Biology
- Isolation and characterization of novel adenovirus type 12 ElA mRNAs by cDNA PCR techniqueDieter Brockmann, Barbara Tries, Helmut Esche · 1990 · Virology
- Transformation of diploid human fibroblasts by DNA transfection with the v‐sis oncogeneDennis G. Fry, Lonnie D. Milam, Veronica M. Maher, J. Justin McCormick · 1986 · Journal of Cellular Physiology
- Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblastsMason, Douglas X., Keppler, Daniel, Zhang, Jun, Jackson, Tonya J., Seger, Yvette R., Matsui, Seiichi, Abreo, Fleurette, Cowell, John K., Hannon, Gregory J., Lowe, Scott W. et al. · 2006 · Carcinogenesis
- Opposing oncogenic activities of small DNA tumor virus transforming proteinsG. Chinnadurai · 2011 · Trends in Microbiology
- c-myc and Functionally Related Oncogenes Induce Both High Rates of Sister Chromatid Exchange and Abnormal Karyotypes in Rat FibroblastsCh. Cerni, Evelyne Mougneau, Marielba Zerlin, Michael Julius, Kenneth B. Marcu, François Cuzin · 1986 · Current topics in microbiology and immunology
- Genetic and Molecular Studies of Cellular ImmortalizationJames R. Smith, Olivia M. Pereira‐Smith · 1990 · Advances in cancer research
- Reduced microfilament organization in adenovirus type 5-infected rat embryo cells: a function of early region 1aP Jackson, A. J. D. Bellett · 1985 · Journal of Virology
- Transformation of differentiated rat hepatocytes with adenovirus and adenovirus DNACraig D. Woodworth, Harriet C. Isom · 1987 · Journal of Virology
- Transformation of Primary BRK Cells by Human Papillomavirus Type 16 and EJ-ras is Increased by Overexpression of the Viral E2 ProteinEmma M. Lees, K. Osborn, Lawrence Banks, Lionel Crawford · 1990 · Journal of General Virology
- Cellular and Molecular Effects of Radon and Other Alpha Particle EmittersHelen H. Evans · 1991 · Advances in mutagenesis research
- Deconstructing oncogenesisJi Luo, Stephen Joseph Elledge · 2008 · Nature
- Primary transfection as a mechanism for transformation of host cells by human tumor cells implanted in nude mice.V. D. Gupta, Srinivasan Rajaraman, Preston F. Gadson, John J. Costanzi · 1987 · PubMed
- Co‐operation in cell transformation between BK virus and the human C‐harvey‐ras oncogeneMonica Pagnani, Alfredo Corallini, Antonella Caputo, Giuseppe Altavilla, Rita Selvatici, Laura Catozzi, L Possati, Giuseppe Barbanti-Brodano · 1988 · International Journal of Cancer
- Transformation of diploid human fibroblasts by transfection with the v-sis, PDGF2/c-sis, or T24 H-ras genesDennis G. Fry, Peter J. Hurlin, Veronica M. Maher, J. Justin McCormick · 1988 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Tumorigenicity of human lymphoblastoid cell lines, acquired during in vitro culture and associated with chromosome gainsJohn Morten, Joanne Hay, C. Michael Steel, M. E. Foster, C. L. De, A. Busuttil · 1984 · International Journal of Cancer
- Repression of the c-Jun trans-Activation Function by the Adenovirus Type 12 E1A 52R Protein Correlates with the Inhibition of Phosphorylation of the c-Jun Activation DomainDieter Brockmann, Carsten Bury, Gabriele Kröner, Hans-Christoph Kirch, Helmut Esche · 1995 · Journal of Biological Chemistry
- Stability and change through DNA repairSteven G. Sedgwick · 1986 · Springer eBooks
- Plasmid-Directed Synthesis of Genuine Adenovirus 2 Early-Region 1A and 1B Proteins in Escherichia coliJ L Ko, Marian L. Harter · 1984 · Molecular and Cellular Biology
- Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1.Robert S Fischer, Yi Zheng, Margaret P. Quinlan · 1998 · PubMed
- Permanent expression of p53 in FR 3T3 rat cells but cell cycle‐dependent association with large‐T antigen in simian virus 40 transformants.François Coulier, Jean Imbert, J. Albert, E. Jeunet, J.J. Lawrence, Lionel Crawford, F Birg · 1985 · The EMBO Journal
- The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expressionGuy R. Adami, Lee E. Babiss · 1990 · Journal of Virology
- Induction of mouse mammary tumours in a transplantation system by the sequential introduction of the myc and ras oncogenesJane M. Bradbury, Helen Sykes, Paul A. Edwards · 1991 · International Journal of Cancer
- Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene.Vincenzo Sorrentino, VLADIMIR DROZDOFF, Louis Zeitz, E Fleissner · 1987 · Proceedings of the National Academy of Sciences
- Isolation of vascular smooth muscle cell cultures with altered responsiveness to the antiproliferative effect of heparinBenjamin L. Caleb, Mitchell A. Hardenbrook, Van Cherington, John J. Castellot · 1996 · Journal of Cellular Physiology
- Co‐regulation of metastatic and transforming activity of normal and mutant ras genesSean E. Egan, James J. Broere, Lenka Jarolim, Jim A. Wright, Arnold H. Greenberg · 1989 · International Journal of Cancer
- Transfection with fragments of the adenovirus 12 gene induces tumorigenicity-associated alteration of N-linked sugar chains in rat cellsSen Hiraizumi, Seiichi Takasaki, Kazuko Shiroki, Naohisa Kochibe, Akira Kobata · 1990 · Archives of Biochemistry and Biophysics
- Transfer of ‘immortalizing’ oncogenes into rat fibroblasts induces both high rates of sister chromatid exchange and appearance of abnormal karyotypesCh. Cerni, Evelyne Mougneau, François Cuzin · 1987 · Experimental Cell Research
- Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?Kiyohiro Ando, Akira Nakagawara · 2021 · Biomolecules
- The C-terminal region of E1A: a molecular tool for cellular cartographyAhmed F. Yousef, Gregory J. Fonseca, Michael J. Cohen, Joe S. Mymryk · 2012 · Biochemistry and Cell Biology
- Backbone assignment of the N-terminal polyomavirus large T antigenKonstantin Knoblich, Sara B.‐M. Whittaker, Christian Ludwig, Paul J. A. Michiels, Tao Jiang, Brian S. Schaffhausen, Ulrich L. Günther · 2009 · Biomolecular NMR Assignments
- Human smooth muscle myosin light chain-2 gene expression is repressed in ras transformed fibroblast cells.C. Chandra Kumar, Cecile Chang · 1992 · PubMed
- Multipotential stem cells in the vertebrate CNSMartha J. Marvin, Ron D. G. McKay · 1992 · Seminars in Cell Biology
- Recombinant BALB and Harvey sarcoma viruses with normal proto-ras-coding regions transform embryo cells in culture and cause tumors in miceKlaus Cichutek, PETER H. DUESBERG · 1989 · Journal of Virology
- Relationship between organization of the actin cytoskeleton and the cell cycle in normal and adenovirus-infected rat cellsP Jackson, A. J. D. Bellett · 1989 · Journal of Virology
- Ability of a T-antigen transport-defective mutant of simian virus 40 to immortalize primary cells and to complement polyomavirus middle T in tumorigenesisJ Vass-Marengo, Annyck Ratiarson, Claude Asselin, Marcel Bastin · 1986 · Journal of Virology
- Functional and Sequence Similarities Between HPV16 E7 and Adenovirus E1AWilliam C. Phelps, Carole Yee, Karl Münger, Peter M. Howley · 1989 · Current topics in microbiology and immunology
- Activation of the Nuclear Oncogenes N- myc and c- jun in Cartinoid Tumors of Transgenic Mice Carrying the Human Adenovirus Type 12 E1 Region GeneMasashi Sagara, Fumihiro Sugiyama, Hisashi Horiguchi, Hiroshi Kamma, Takesaburo Ogata, Ken-ichi Yagami, Kazuo Murakami, Akiyoshi Fukamizu · 1995 · DNA and Cell Biology
- Analysis of the structure and expression of the c-myc oncogene in cervical tumor and in cervical tumor-derived cell linesKong‐Bung Choo, Kowit‐Yu Chong, Huar-Fen Chou, Lip-Nyin Liew, Chen-Chyi Liou · 1989 · Biochemical and Biophysical Research Communications
- Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expressionRonald J. Weigel, Joseph R. Nevins · 1990 · Nucleic Acids Research
- The polyomavirus early region gene in transgenic mice causes vascular and bone tumorsRongquan Wang, Victoria L. Bautch · 1991 · Journal of Virology
- Genetic Alterations in Colorectal TumorsKathleen R. Cho, Bert Vogelstein · 1990 · Springer eBooks
- Surprising Dependency for Retinoblastoma Protein in Ras-Mediated TumorigenesisJames V. DeGregori · 2006 · Molecular and Cellular Biology