Cited by 1,248Virus-based gene therapy researchViral-associated cancers and disordersCancer-related Molecular Pathways

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. Earl·1983·Nature

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Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
Rigby, P. W. J., Dieckmann, M., Rhodes, C., & Berg, P. R. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90052-3 · Cited by 11,400
A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels
Bonner, W. M., & Laskey, R. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03599.x · Cited by 8,589
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Transformation of mammalian cells with genes from procaryotes and eucaryotes
Wigler, M. H., Sweet, R. W., Sim, G.-K., Wold, B. J., Pellicer, À., Lacy, E., Maniatis, T., Silverstein, S. J., & Axel, R. (1979) · Cell · doi:10.1016/0092-8674(79)90093-x · Cited by 1,407
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
Reddy, E. P., Reynolds, R. K., Santos, E., & Barbacid, M. (1982) · Nature · doi:10.1038/300149a0 · Cited by 1,391

Show all 31 references

Research works printed but not linked: 3

Tooze, J. (ed.) Molecular Biology of Tumor Viruses Pt 2 (revised) (Cold Spring Harbor Laboratory, New York, 1981).
Rassoulzadegan, M. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning (Cold Spring Harbor Laboratory, New York, 1982).

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Transformation of Chicken Embryo Fibroblasts and Tumor Induction by the Middle T Antigen of Polyomavirus Carried in an Avian Retroviral Vector
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Functional genetics and experimental models of human cancer
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Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.
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HER2 overexpression and cancer targeting
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Adenovirus 5 early region 1A host range mutants hr3, hr4, and hr5 contain point mutations which generate single amino acid substitutions
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Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with Harvey murine sarcoma virus oncogene (v-Ha-ras).
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Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis
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Adenovirus: Transformation and oncogenicity
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Activated Ha-ras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts
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Genetic Analysis of Adenoviruses
Shenk, T. E., & Williams, J. (1984) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-69549-0_1 · Cited by 58
Rapid intracellular turnover of adenovirus 5 early region 1A proteins
Spindler, K. R., & Berk, A. J. (1984) · Journal of Virology · doi:10.1128/jvi.52.2.706-710.1984 · Cited by 56
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Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation.
Spergel, J. M., & Chen‐Kiang, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6472 · Cited by 56
Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones
Sistonen, L., Keski‐Oja, J., Ulmanen, I., Hölttä, E., Wikgren, B.-J., & Alitalo, K. K. (1987) · Experimental Cell Research · doi:10.1016/0014-4827(87)90024-3 · Cited by 57
The polyoma virus oncogenes
Cuzin, F. (1984) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(84)90084-8 · Cited by 56
Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene.
Barrandon, Y., Morgan, J. R., Mulligan, R. C., & Green, H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4102 · Cited by 55
Suppression of adenovirus type 5 E1A‐mediated transformation and expression of the transformed phenotype by caffeic acid phenethyl ester (CAPE)
Su, Z.-Z., Grünberger, D., & Fisher, P. B. (1991) · Molecular Carcinogenesis · doi:10.1002/mc.2940040310 · Cited by 55
Interaction of the E1A Oncoprotein with Yak1p, a Novel Regulator of Yeast Pseudohyphal Differentiation, and Related Mammalian Kinases
Zhang, Z., Smith, M. M., & Mymryk, J. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.699 · Cited by 54
Activated v-myc and v-ras Oncogenes Do Not Transform Normal Human Lymphocytes
Stevenson, M., & Volsky, D. J. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.10.3410 · Cited by 54
Mek1 Phosphorylation Site Mutants Activate Raf-1 in NIH 3T3 Cells
Alessandrini, A., Greulich, H. E., Huang, W., & Erikson, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31612 · Cited by 54
Efficient Expression of Heterologous Genes in Escherichia coli
Shatzman, A. R., & Rosenberg, M. J. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb15534.x · Cited by 54
B-myb rescues ras-induced premature senescence, which requires its transactivation domain
Masselink, H., Vastenhouw, N. L., & Bernards, R. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00631-0 · Cited by 54
High-level expression of the Epstein-Barr virus EBNA1 protein in CV1 cells and human lymphoid cells using a SV40 late replacement vector
Hammarskjöld, M., Shih-Chung, W., & Klein, G. (1986) · Gene · doi:10.1016/0378-1119(86)90006-5 · Cited by 53
Oncogenes in human primary hepatic cancer
Gu, J., Li-Fu, H., Yuan-Ching, C., & Da-Fong, W. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041290405 · Cited by 54
Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum
Quinlan, M. P., & Grodzicker, T. (1987) · Journal of Virology · doi:10.1128/jvi.61.3.673-682.1987 · Cited by 53
Transfection of the EJ ras Ha Gene into Keratinocytes Derived from Carcinogen-Induced Mouse Papillomas Causes Malignant Progression
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Adenovirus E1a ras Cooperation Activity Is Separate from Its Positive and Negative Transcription Regulatory Functions
Velcich, A., & Ziff, E. B. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.5.2177 · Cited by 53
Growth factors and oncogenes
Burgess, A. W. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90026-x · Cited by 53
Mapping of functional domains in adenovirus E1A proteins.
Krippl, B., Ferguson, B., Jones, N., Rosenberg, M. J., & Westphal, H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7480 · Cited by 53
Isolation of Transformation Suppressor Genes by cDNA Subtraction: Lumican Suppresses Transformation Induced by v- src and v-K- ras
Yoshioka, N., Inoue, H., Nakanishi, K., Oka, K., Yutsudo, M., Yamashita, A., Hakura, A., & Nojima, H. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.1008-1013.2000 · Cited by 52
Creating oral squamous cancer cells: A cellular model of oral–esophageal carcinogenesis
Goessel, G., Quante, M., Hahn, W. C., Harada, H., Heeg, S., Suliman, Y., Doebele, M., von Werder, A., Fulda, C., Nakagawa, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409730102 · Cited by 51
Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.
Hurwitz, D. R., & Chinnadurai, G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.163 · Cited by 51
Control Functions of Adenovirus Transformation Region E1A Gene Products in Rat and Human Cells
Bellett, A. J. D., Li, P., David, E. T., Mackey, E. J., Braithwaite, A. W., & Cutt, J. R. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.8.1933 · Cited by 51
ras Oncogenes in Chemical Carcinogenesis
Sukumar, S. V. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74700-7_3 · Cited by 51
Adenovirus E1a Proteins Repress Expression from Polyomavirus Early and Late Promoters
Velcich, A., Kern, F. G., Basilico, C., & Ziff, E. B. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.4019 · Cited by 51
Adenovirus Type 5 E1A and E6 Proteins of Low-Risk Cutaneous Beta-Human Papillomaviruses Suppress Cell Transformation through Interaction with FOXK1/K2 Transcription Factors
Komorek, J., Kuppuswamy, M. N., Subramanian, T., Vijayalingam, S., Lomonosova, E. E., Zhao, L., Mymryk, J. S., Schmitt, K. P., & Chinnadurai, G. (2010) · Journal of Virology · doi:10.1128/jvi.02119-09 · Cited by 52
Adenovirus E1B 55-Kilodalton Oncoprotein Binds to Daxxand Eliminates Enhancement of p53-Dependent Transcription byDaxx
Zhao, L., Colosimo, A. L., Liu, Y., Wan, Y.-P., & Liao, D. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11809-11821.2003 · Cited by 50
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer
Schaffhausen, B. S., & Roberts, T. M. (2008) · Virology · doi:10.1016/j.virol.2008.09.042 · Cited by 53
Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers
Hua, V. Y., Wang, W. K., & DUESBERG, P. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9614 · Cited by 50
SV40 immortalizes myogenic cells: DNA synthesis and mitosis in differentiating myotubes
Lujvidin, S., Fuchs, O., Nudel, U., & Yaffe, D. (1990) · Differentiation · doi:10.1111/j.1432-0436.1990.tb00446.x · Cited by 50
Interaction of Retroviral Oncogenes With The Differentiation Program of Myogenic Cells
Alemà, S., & Tatò, F. (1987) · Advances in cancer research · doi:10.1016/s0065-230x(08)60792-7 · Cited by 50
Regulation of Adenovirus Gene Expression in Human WI38 Cells by an E1B-Encoded Tumor Antigen
White, E., Faha, B., & Stillman, B. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3763 · Cited by 50
Positive Regulation of jun/ AP-1 by E1A
de Groot, R. P., Foulkes, N. S., Mulder, M., Kruijer, W., & Sassone‐Corsi, P. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.192 · Cited by 50
Inhibition of DNA synthesis in senescent-proliferating human cybrids is mediated by endogenous proteins
Drescher-Lincoln, C. K., & Smith, J. R. (1984) · Experimental Cell Research · doi:10.1016/0014-4827(84)90462-2 · Cited by 50
Genetic Modification of Neural Stem Cells
Jandial, R., Singeç, I., Ames, C. P., & Snyder, E. Y. (2008) · Molecular Therapy · doi:10.1038/sj.mt.6300402 · Cited by 51
Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes
Cuypers, H. T. M., Selten, G. C. M., Zijlstra, M., de Goede, R. E. Y., Melief, C. J. M., & Berns, A. J. M. (1986) · Journal of Virology · doi:10.1128/jvi.60.1.230-241.1986 · Cited by 49
A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.
Haber, D. A., Timmers, H. T. M., Pelletier, J., Sharp, P. A., & Housman, D. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6010 · Cited by 49
Basic Science Review: Growth Factors in Cancer and Their Relationship to Oncogenes
Salomon, D. S., & Perroteau, I. (1986) · Cancer Investigation · doi:10.3109/07357908609039826 · Cited by 49
Two functions encoded by adenovirus early region 1A are responsible for the activation and repression of the DNA‐binding protein gene.
Guilfoyle, R. A., Osheroff, W. P., & Rossini, M. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03687.x · Cited by 49
Promoter trans-activation of protooncogenes c-fos and c-myc, but not c-Ha-ras, by products of adenovirus early region 1A.
Sassone‐Corsi, P., & Borrelli, E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6430 · Cited by 49
Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A
Lee, J.-S., Zhang, X., & Shi, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17666 · Cited by 48
Transactivation of the p53 oncogene by E1a gene products
Braithwaite, A. W., Nelson, C. C., Skulimowski, A., McGovern, J., Pigott, D., & Jenkins, J. R. (1990) · Virology · doi:10.1016/0042-6822(90)90525-v · Cited by 48
Adenovirus E1A is associated with a serine/threonine protein kinase
Herrmann, C. H., Su, L. K., & Harlow, E. (1991) · Journal of Virology · doi:10.1128/jvi.65.11.5848-5859.1991 · Cited by 48
Simian virus 40 large T antigen contains two independent activities that cooperate with a ras oncogene to transform rat embryo fibroblasts
Cavender, J. F., Conn, A. R., Epler, M. J., Lacko, H. A., & Tevethia, M. J. (1995) · Journal of Virology · doi:10.1128/jvi.69.2.923-934.1995 · Cited by 48
Sequential expression and cooperative interaction of c-Ha-ras and c-erbB genes in in vivo chemical carcinogenesis.
Husain, Z., Fei, Y. B., Roy, S., Solt, D. B., Polverini, P. J., & Biswas, D. K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1264 · Cited by 48

Authors: Ruley, H. E.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Ruley, H. Earl
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1983-08
Volume: 304
Issue: 5927
Pages: 602-606
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/304602a0
OpenAlex: W2117079180
Cited by: 1,248
References: 31
Citations by year: 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 13
FWCI: 102.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: polyomavirus middle T antigen, oncogenic transformation, primary cells, DNA-mediated gene transfer
MeSH terms: Adenoviridae, Animals, Antigens, Viral, Antigens, Viral, Tumor, Cell Transformation, Viral, Cells, Cultured, Cloning, Molecular, Gene Expression Regulation, Genes, Viral, Oncogenes, Plasmids, Polyomavirus, Transfection, Transformation, Genetic, Rats

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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