Cited by 3,640Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Morris, R. G. M., Anderson, E., Lynch, G. S., Baudry, M.·1986·Nature

DOI 10.1038/319774a0

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Abstract

Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA) and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief high-frequency stimulation. We now report that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning, which is not. The L-isomer of AP5 did not produce behavioural effects. AP5 treatment also suppressed LTP in vivo. These results suggest that NMDA receptors are involved in spatial learning, and add support to the hypothesis that LTP is involved in some, but not all, forms of learning.

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Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Self-citation
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Self-citation
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Neurobiology of the hippocampus
Rawlins, J. N. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90113-1 · Cited by 1,097
The Biochemistry of Memory: A New and Specific Hypothesis
LYNCH, G. S., & Baudry, M. (1984) · Science · doi:10.1126/science.6144182 · Cited by 1,041
Self-citation

Show all 19 references

Research works printed but not linked: 3

Kolb, B., Pittman, K. & Sutherland, R. J. Behav. Brain Res. (in the press).
Kolb, B., Sutherland, R. J. & Whishaw, I. Q. Behav. Neurosci. 97, 13–27 (1983). · DOI
Hagan, J. J., Tweedie, F. M. & Morris, R. G. M. Behav. Neurosci. (in the press).

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Herberg, L. J., & Rose, I. C. (1989) · Psychopharmacology · doi:10.1007/bf00634458 · Cited by 75
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Schmajuk, N. A., & DiCarlo, J. J. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.1.82 · Cited by 74
Classical conditioning selectively increases AMPA receptor binding in rabbit hippocampus
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Self-citation
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The Neuroscience of Spatial Navigation: Focus on Behavior Yields Advances
Cain, D. P., & Saucier, D. M. (1996) · Reviews in the Neurosciences · doi:10.1515/revneuro.1996.7.3.215 · Cited by 73
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McDonald, R. J., Hong, N. S., Craig, L. A., Holahan, M. R., Louis, M., & Muller, R. U. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04272.x · Cited by 73
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Heyes, M. P., Mefford, I. N., Quearry, B. J., Dedhia, M., & Lackner, A. A. (1990) · Annals of Neurology · doi:10.1002/ana.410270614 · Cited by 73
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Wolfer, D. P., & Lipp, H. (1992) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(92)90124-v · Cited by 73
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Kaczmarek, L., SIEDLECKI, J. A., & Danysz, W. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90064-2 · Cited by 73
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Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
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Raveh, L., Weissman, B. A., Cohen, G., Alkalay, D., Rabinovitz, I., Sonego, H., & Brandeis, R. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00005-0 · Cited by 72
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Boast, C. A., Bartolomeo, A. C., Morris, H., & Moyer, J. A. (1999) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3886 · Cited by 72
NMDA receptor activation in the aged rat hippocampus
Potier, B., Poindessous‐Jazat, F., Dutar, P., & Billard, J. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00122-4 · Cited by 72
Expression of c-fos and other genes encoding transcription factors in long-term potentiation
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Hippocampal synaptic enhancement and spatial learning in the morris swim task
Korol, D. L., Abel, T. W., Church, L. T., Barnes, C. A., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030204 · Cited by 72
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Brouwers, P. Y., Heyes, M. P., Moss, H. A., Wolters, P. L., Poplack, D. G., Markey, S. P., & Pizzo, P. A. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.6.1380 · Cited by 72
Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP
Muhia, M., Yee, B. K., Feldon, J., Markopoulos, F., & Knuesel, I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07079.x · Cited by 71
The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes
Drago, A., Crisafulli, C., Sidoti, A., & Serretti, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.009 · Cited by 71
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Almaguer‐Melian, W., Bergado, J. A., Fuentes, N. P., Alberti‐Amador, E., Mercerón‐Martínez, D., & Frey, J. U. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114198109 · Cited by 71
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Acetyl-l-carnitine: Behavioral, electrophysiological, and neurochemical effects
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LYNCH, G. S., & Granger, R. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.3.189 · Cited by 71
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Self-citation
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Otis, J. M., Fitzgerald, M. K., & Mueller, D. T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4980-13.2014 · Cited by 70
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Escobar, M. L., Alcocer, I., & Chao, V. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00931-7 · Cited by 70
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Chan, K. W. S., Lee, T. M. C., Siu, A. M. H., Wong, D. P. L., Kam, C.-M., Tsang, S. K. M., & Chan, C. C. H. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.01.014 · Cited by 65
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Authors: Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M.
Affiliations: University of St Andrews (GB)
University of California, Irvine (US)
ORCID: Morris, R. G. M.
Lynch, G. S.
Baudry, M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1986-02
Volume: 319
Issue: 6056
Pages: 774-776
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/319774a0
OpenAlex: W2025801062
Cited by: 3,640
References: 19
Citations by year: 2026: 25 · 2025: 30 · 2024: 44 · 2023: 31 · 2022: 42 · 2021: 63 · 2020: 52 · 2019: 65 · 2018: 83 · 2017: 85 · 2016: 82 · 2015: 89 · 2014: 103 · 2013: 98 · 2012: 101
FWCI: 31.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: NMDA receptor, AP5, long-term potentiation, hippocampus, place learning, spatial learning, visual discrimination learning, glutamate receptors, intraventricular infusion, synaptic plasticity
MeSH terms: Animals, Electric Stimulation, Hippocampus, Isomerism, Learning, Valine, Visual Perception, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, Rats

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

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